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Conserved domains on  [gi|767951771|ref|XP_011515825|]
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interleukin-7 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL7 super family cl11602
Interleukin 7; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of ...
 27-138 4.45e-67

Interleukin 7; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-7 and IL-7Ralpha bind the gamma-c receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells.


The actual alignment was detected with superfamily member smart00127:

Pssm-ID: 472230  Cd Length: 146  Bit Score: 199.89  E-value: 4.45e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951771    27 CDIEGKDGKQYESVLMVSIDQLlDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLK 106
Cdd:smart00127   1 CDIKGKDGKAYESVLMVSIDQL-DKMTGTDSNCLNNEPNFFKKHSCDDNKEAAFLNRAARKLRQFLKMNISEDFNLHLLT 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767951771   107 VSEGTTILLNCTGQVKGRKPAALGEAQPTKSL 138
Cdd:smart00127  80 VSQGTQTLLNCTSKGKGRKPPSLGEAQPTKNL 111
 
Name Accession Description Interval E-value
IL7 smart00127
Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for ...
 27-138 4.45e-67

Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


Pssm-ID: 128432  Cd Length: 146  Bit Score: 199.89  E-value: 4.45e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951771    27 CDIEGKDGKQYESVLMVSIDQLlDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLK 106
Cdd:smart00127   1 CDIKGKDGKAYESVLMVSIDQL-DKMTGTDSNCLNNEPNFFKKHSCDDNKEAAFLNRAARKLRQFLKMNISEDFNLHLLT 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767951771   107 VSEGTTILLNCTGQVKGRKPAALGEAQPTKSL 138
Cdd:smart00127  80 VSQGTQTLLNCTSKGKGRKPPSLGEAQPTKNL 111
IL7 pfam01415
Interleukin 7; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of ...
 26-138 1.99e-59

Interleukin 7; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-7 and IL-7Ralpha bind the gamma-c receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells.


Pssm-ID: 460203  Cd Length: 152  Bit Score: 180.55  E-value: 1.99e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951771   26 DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLL 105
Cdd:pfam01415   1 DCDIEGKDGKEYENVLMVSINELLDSMIEFDSNCLNNEYNFFKKHSCDDNKEATFLNRAACKLKQFLKMNISEDFNLHLS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767951771  106 KVSEGTTILLNCTGQVKGRKPAALGEAQPTKSL 138
Cdd:pfam01415  81 KVSEGTLKLLNCTSKVKGRKPCSLGEAQPTKNL 113
 
Name Accession Description Interval E-value
IL7 smart00127
Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for ...
 27-138 4.45e-67

Interleukin-7 and interleukin-9 family; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multifunctional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.


Pssm-ID: 128432  Cd Length: 146  Bit Score: 199.89  E-value: 4.45e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951771    27 CDIEGKDGKQYESVLMVSIDQLlDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLK 106
Cdd:smart00127   1 CDIKGKDGKAYESVLMVSIDQL-DKMTGTDSNCLNNEPNFFKKHSCDDNKEAAFLNRAARKLRQFLKMNISEDFNLHLLT 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 767951771   107 VSEGTTILLNCTGQVKGRKPAALGEAQPTKSL 138
Cdd:smart00127  80 VSQGTQTLLNCTSKGKGRKPPSLGEAQPTKNL 111
IL7 pfam01415
Interleukin 7; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of ...
 26-138 1.99e-59

Interleukin 7; IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-7 and IL-7Ralpha bind the gamma-c receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells.


Pssm-ID: 460203  Cd Length: 152  Bit Score: 180.55  E-value: 1.99e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951771   26 DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLL 105
Cdd:pfam01415   1 DCDIEGKDGKEYENVLMVSINELLDSMIEFDSNCLNNEYNFFKKHSCDDNKEATFLNRAACKLKQFLKMNISEDFNLHLS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767951771  106 KVSEGTTILLNCTGQVKGRKPAALGEAQPTKSL 138
Cdd:pfam01415  81 KVSEGTLKLLNCTSKVKGRKPCSLGEAQPTKNL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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