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Conserved domains on  [gi|1370512107|ref|XP_011515239|]
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DENN domain-containing protein 3 isoform X16 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10263992)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 185-371 4.64e-52

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 180.85  E-value: 4.64e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  185 FVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEvdsHIKDFAAK-LSLIPSPPPGPLHLVFNM-KSLQIVLPARADP 262
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPN---PIERFIANlLYEVPFPPPGRTQKLKPLgGTEPILLQRPEDS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  263 ESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 342
Cdd:pfam02141   78 ELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPT 157

                          170       180
                   ....*....|....*....|....*....
gi 1370512107  343 SFLMGCHLDHFEEVSKEADGLVLINIDHG 371
Cdd:pfam02141  158 PFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 435-497 3.16e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.39  E-value: 3.16e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370512107   435 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 497
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN super family cl04085
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 108-158 2.43e-04

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


The actual alignment was detected with superfamily member pfam03456:

Pssm-ID: 470944  Cd Length: 59  Bit Score: 39.90  E-value: 2.43e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1370512107  108 PEDVAvPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFlVLTDVCGNRTYGV 158
Cdd:pfam03456    8 PEDDW-SDPPLPDGIPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 185-371 4.64e-52

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 180.85  E-value: 4.64e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  185 FVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEvdsHIKDFAAK-LSLIPSPPPGPLHLVFNM-KSLQIVLPARADP 262
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPN---PIERFIANlLYEVPFPPPGRTQKLKPLgGTEPILLQRPEDS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  263 ESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 342
Cdd:pfam02141   78 ELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPT 157

                          170       180
                   ....*....|....*....|....*....
gi 1370512107  343 SFLMGCHLDHFEEVSKEADGLVLINIDHG 371
Cdd:pfam02141  158 PFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 186-371 2.05e-49

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 173.15  E-value: 2.05e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107   186 VPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKdfaakLSLIPSPPPGPLHLVFNMKSL-QIVLPARADPES 264
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLIS-----LLLYPVPPPGGSLVLVSLGPGdLIELQRPLDSSL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107   265 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSF 344
Cdd:smart00799   76 PLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPF 155

                           170       180
                    ....*....|....*....|....*...
gi 1370512107   345 LMGCHLDHFEEVSKEADG-LVLINIDHG 371
Cdd:smart00799  156 IIGVHSSYFEEVKELPDEdVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 435-497 3.16e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.39  E-value: 3.16e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370512107   435 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 497
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 108-158 2.43e-04

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 39.90  E-value: 2.43e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1370512107  108 PEDVAvPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFlVLTDVCGNRTYGV 158
Cdd:pfam03456    8 PEDDW-SDPPLPDGIPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 464-501 2.60e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 39.48  E-value: 2.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1370512107  464 FNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRR 501
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS 38
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 185-371 4.64e-52

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 180.85  E-value: 4.64e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  185 FVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEvdsHIKDFAAK-LSLIPSPPPGPLHLVFNM-KSLQIVLPARADP 262
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPN---PIERFIANlLYEVPFPPPGRTQKLKPLgGTEPILLQRPEDS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  263 ESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 342
Cdd:pfam02141   78 ELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPT 157

                          170       180
                   ....*....|....*....|....*....
gi 1370512107  343 SFLMGCHLDHFEEVSKEADGLVLINIDHG 371
Cdd:pfam02141  158 PFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 186-371 2.05e-49

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 173.15  E-value: 2.05e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107   186 VPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKdfaakLSLIPSPPPGPLHLVFNMKSL-QIVLPARADPES 264
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLIS-----LLLYPVPPPGGSLVLVSLGPGdLIELQRPLDSSL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107   265 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSF 344
Cdd:smart00799   76 PLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPF 155

                           170       180
                    ....*....|....*....|....*...
gi 1370512107   345 LMGCHLDHFEEVSKEADG-LVLINIDHG 371
Cdd:smart00799  156 IIGVHSSYFEEVKELPDEdVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 435-497 3.16e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.39  E-value: 3.16e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370512107   435 NCQIQQTTLQLLVSIFRDVKNHLNY------EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 497
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 108-158 2.43e-04

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 39.90  E-value: 2.43e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1370512107  108 PEDVAvPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFlVLTDVCGNRTYGV 158
Cdd:pfam03456    8 PEDDW-SDPPLPDGIPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 464-501 2.60e-04

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 39.48  E-value: 2.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1370512107  464 FNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRR 501
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS 38
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 283-377 4.18e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 38.04  E-value: 4.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370512107  283 VLQILTCILTEQRIVFFSSDW----------ALLTLVTECFMAYlYPLQWQHPFVPIlsdQMLDFVMAPTSFLMGCHLDH 352
Cdd:pfam08616   15 IILLINALLTSKRIIFLSYQRsagevsefvlALCNLISGGFVLR-GFTNNSFPYVDL---SKLDALRKVPGYIAGVTNPI 90

                           90       100
                   ....*....|....*....|....*
gi 1370512107  353 FEEVSKEADglVLINIDHGSITYSK 377
Cdd:pfam08616   91 FENQDQWWD--VLCDLDSGSVKLSK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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