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Conserved domains on  [gi|767952703|ref|XP_011515226|]
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t-SNARE domain-containing protein 1 isoform X38 [Homo sapiens]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10620649)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 124-201 5.74e-28

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


:

Pssm-ID: 433544  Cd Length: 78  Bit Score: 103.13  E-value: 5.74e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767952703  124 RKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGD 201
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLAK 78
Syntaxin_2 pfam14523
Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p ...
 265-298 3.93e-10

Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p protein.


:

Pssm-ID: 464199  Cd Length: 101  Bit Score: 56.12  E-value: 3.93e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767952703  265 SANVFRINSSVTSLERSLQSLGTPSDTQELRDSL 298
Cdd:pfam14523   2 SSNLFKINSNVSTLEKLVKQLGTKRDTQELRDKL 35
 
Name Accession Description Interval E-value
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 124-201 5.74e-28

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 103.13  E-value: 5.74e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767952703  124 RKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGD 201
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLAK 78
Syntaxin_2 pfam14523
Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p ...
 265-298 3.93e-10

Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p protein.


Pssm-ID: 464199  Cd Length: 101  Bit Score: 56.12  E-value: 3.93e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767952703  265 SANVFRINSSVTSLERSLQSLGTPSDTQELRDSL 298
Cdd:pfam14523   2 SSNLFKINSNVSTLEKLVKQLGTKRDTQELRDKL 35
 
Name Accession Description Interval E-value
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 124-201 5.74e-28

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 103.13  E-value: 5.74e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767952703  124 RKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGD 201
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLAK 78
Syntaxin_2 pfam14523
Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p ...
 265-298 3.93e-10

Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p protein.


Pssm-ID: 464199  Cd Length: 101  Bit Score: 56.12  E-value: 3.93e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767952703  265 SANVFRINSSVTSLERSLQSLGTPSDTQELRDSL 298
Cdd:pfam14523   2 SSNLFKINSNVSTLEKLVKQLGTKRDTQELRDKL 35
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 125-193 1.18e-05

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 43.02  E-value: 1.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767952703  125 KPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEptrryRVWSRILQAVNALGYcRRDVVDLKHKWRDLRA 193
Cdd:pfam13837   1 RNKWTEEETLALIEIWGERLELRFQESKKRNK-----KLWEEIAEKMAELGY-NRSPEQCKEKWENLKK 63
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 158-216 9.30e-03

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 34.57  E-value: 9.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767952703  158 TRRYRVWSRILQAVNAlgycRRDVVDLKHKWRDLRAVVRRKlgdLRKAAHGPSPGSGKP 216
Cdd:pfam10545  23 DARERAWEEIAEELGS----DVPVEDCKKRWKNLRDQYRRE---LRRKRTNSGELYKSR 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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