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Conserved domains on  [gi|767949175|ref|XP_011515041|]
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cyclin-D-binding Myb-like transcription factor 1 isoform X2 [Homo sapiens]

Protein Classification

cyclin-D-binding Myb-like transcription factor 1( domain architecture ID 13419776)

cyclin-D-binding Myb-like transcription factor 1 (DMTF1) is a transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest

Gene Symbol:  DMTF1
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8887674|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 39-117 1.28e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


:

Pssm-ID: 466737  Cd Length: 72  Bit Score: 91.71  E-value: 1.28e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175   39 ENDQSFEVTMTattEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 117
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 233-288 1.79e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.44  E-value: 1.79e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767949175  233 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 187-243 4.73e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.78  E-value: 4.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175  187 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 243
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 48-397 1.57e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.88  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175  48 MTATTEVADDEVtegtvtqiqilQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNI 127
Cdd:COG5147  167 RLRVPRVSKADV-----------KPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEI 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 128 ERYLKargIKDATEIIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKL 194
Cdd:COG5147  234 NEYKE---KKGLSRKQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQEL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 195 KELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAER 271
Cdd:COG5147  303 AKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQN 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 272 VGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlr 340
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY-- 457

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767949175 341 skwwtikrqianhkdvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 397
Cdd:COG5147  458 ------------------------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 39-117 1.28e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 91.71  E-value: 1.28e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175   39 ENDQSFEVTMTattEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 117
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 233-288 1.79e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.44  E-value: 1.79e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767949175  233 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 187-243 4.73e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.78  E-value: 4.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175  187 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 243
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 234-288 5.57e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.89  E-value: 5.57e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767949175 234 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:cd00167    1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
233-289 8.01e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 54.54  E-value: 8.01e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767949175   233 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 289
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 48-397 1.57e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.88  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175  48 MTATTEVADDEVtegtvtqiqilQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNI 127
Cdd:COG5147  167 RLRVPRVSKADV-----------KPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEI 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 128 ERYLKargIKDATEIIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKL 194
Cdd:COG5147  234 NEYKE---KKGLSRKQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQEL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 195 KELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAER 271
Cdd:COG5147  303 AKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQN 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 272 VGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlr 340
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY-- 457

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767949175 341 skwwtikrqianhkdvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 397
Cdd:COG5147  458 ------------------------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
184-229 7.77e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.45  E-value: 7.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767949175   184 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 229
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 185-227 9.51e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 46.03  E-value: 9.51e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767949175 185 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 227
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
295-348 3.68e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 38.74  E-value: 3.68e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767949175   295 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 348
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 297-347 3.20e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.01  E-value: 3.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767949175 297 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 347
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 39-117 1.28e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 91.71  E-value: 1.28e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175   39 ENDQSFEVTMTattEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 117
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 233-288 1.79e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.44  E-value: 1.79e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767949175  233 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 187-243 4.73e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.78  E-value: 4.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175  187 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 243
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 234-288 5.57e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.89  E-value: 5.57e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767949175 234 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:cd00167    1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
233-289 8.01e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 54.54  E-value: 8.01e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767949175   233 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 289
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 48-397 1.57e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.88  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175  48 MTATTEVADDEVtegtvtqiqilQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNI 127
Cdd:COG5147  167 RLRVPRVSKADV-----------KPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEI 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 128 ERYLKargIKDATEIIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKL 194
Cdd:COG5147  234 NEYKE---KKGLSRKQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQEL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 195 KELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAER 271
Cdd:COG5147  303 AKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQN 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 272 VGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlr 340
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY-- 457

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767949175 341 skwwtikrqianhkdvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 397
Cdd:COG5147  458 ------------------------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 184-227 2.09e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 50.58  E-value: 2.09e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767949175  184 GKYTPEEIEKLKELRIKHGNDWATIGAAL-GRSASSVKDRCRLMK 227
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 235-306 2.83e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 47.69  E-value: 2.83e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767949175  235 WTEEEEKRLAEVVHELTSTepgdivtqgvsWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGtEWTKEDEINL 306
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-----------WKQIAKELGRRTPKQCFDRWRRKLNPKISRG-PWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
184-229 7.77e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.45  E-value: 7.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767949175   184 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 229
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 185-227 9.51e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 46.03  E-value: 9.51e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767949175 185 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 227
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
295-348 3.68e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 38.74  E-value: 3.68e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767949175   295 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 348
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 297-347 3.20e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.01  E-value: 3.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767949175 297 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 347
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 234-286 4.58e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 36.86  E-value: 4.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767949175  234 KWTEEEEKRLAEVVHEL------TSTEPGDIVTQGVSwAAVAERVGTRSEKQCRSKWLN 286
Cdd:pfam13837   3 KWTEEETLALIEIWGERlelrfqESKKRNKKLWEEIA-EKMAELGYNRSPEQCKEKWEN 60
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 233-402 7.23e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 39.39  E-value: 7.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 233 GKWTEEEEKRLAEVVHELtSTEpgdivtqgvSWAAVAERVGTRSEKQCRSKWLNYLNwKQSGGTEWTKEDEINLILRIAE 312
Cdd:COG5147   21 GSWKRTEDEDLKALVKKL-GPN---------NWSKVASLLISSTGKQSSNRWNNHLN-PQLKKKNWSEEEDEQLIDLDKE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767949175 313 LdvADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSfpvLIKGLKQLHENQKNNPTLLENKSGSGVPNSNT 392
Cdd:COG5147   90 L--GTQWSTIADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN---EFDKIDPFNENSARRPDIYEDELLEREVNREA 164

                        170
                 ....*....|
gi 767949175 393 NSSVQHVQIR 402
Cdd:COG5147  165 SYRLRVPRVS 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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