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Conserved domains on  [gi|767948161|ref|XP_011514660|]
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condensin-2 complex subunit G2 isoform X8 [Homo sapiens]

Protein Classification

condensin-2 complex subunit G2 family protein( domain architecture ID 10575316)

condensin-2 complex subunit G2 (NCAPG2) family protein similar to NCAPG2, a regulatory subunit of the condensin-2 complex, which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Condensin2nSMC pfam12422
Condensin II non structural maintenance of chromosomes subunit; This domain family is found in ...
 213-362 3.21e-73

Condensin II non structural maintenance of chromosomes subunit; This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.


:

Pssm-ID: 463573  Cd Length: 149  Bit Score: 237.07  E-value: 3.21e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161  213 CFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFH 292
Cdd:pfam12422   2 CFISPAFLKTEEGRRFLAFLFSLSVQLVKEIHATIKNQLPFLTKSLLEAYGEIYFRAWKNASGDLLEEIEEDCIQDLMQH 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161  293 GIHLpRRSPVHSKVREVLSYFHHQKKvRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRD 362
Cdd:pfam12422  82 AIHA-SRPPLASKVRRVLSYFHSQKK-DKGVDEMLTRLYEPILWRSLKVANSEVRANATLLFFDAFPLED 149
COG5096 super family cl34899
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 339-484 3.98e-05

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG5096:

Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 47.42  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161 339 LKARNSEVRSNAaLLFVEAfpIRDPNLHAIEMDSeiqkqfeeLYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILID 418
Cdd:COG5096  101 LQDPNEEIRGFA-LRTLSL--LRVKELLGNIIDP--------IKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLID 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948161 419 LLKkvtgELAFDTSSADVRCSVFKClpMILDNKLSHPLL-------EQLLPAlrySLHDNSEKVRVAFVDMLL 484
Cdd:COG5096  170 ILK----ELVADSDPIVIANALASL--AEIDPELAHGYSlevilriPQLDLL---SLSVSTEWLLLIILEVLT 233
 
Name Accession Description Interval E-value
Condensin2nSMC pfam12422
Condensin II non structural maintenance of chromosomes subunit; This domain family is found in ...
 213-362 3.21e-73

Condensin II non structural maintenance of chromosomes subunit; This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.


Pssm-ID: 463573  Cd Length: 149  Bit Score: 237.07  E-value: 3.21e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161  213 CFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFH 292
Cdd:pfam12422   2 CFISPAFLKTEEGRRFLAFLFSLSVQLVKEIHATIKNQLPFLTKSLLEAYGEIYFRAWKNASGDLLEEIEEDCIQDLMQH 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161  293 GIHLpRRSPVHSKVREVLSYFHHQKKvRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRD 362
Cdd:pfam12422  82 AIHA-SRPPLASKVRRVLSYFHSQKK-DKGVDEMLTRLYEPILWRSLKVANSEVRANATLLFFDAFPLED 149
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 339-484 3.98e-05

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 47.42  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161 339 LKARNSEVRSNAaLLFVEAfpIRDPNLHAIEMDSeiqkqfeeLYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILID 418
Cdd:COG5096  101 LQDPNEEIRGFA-LRTLSL--LRVKELLGNIIDP--------IKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLID 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948161 419 LLKkvtgELAFDTSSADVRCSVFKClpMILDNKLSHPLL-------EQLLPAlrySLHDNSEKVRVAFVDMLL 484
Cdd:COG5096  170 ILK----ELVADSDPIVIANALASL--AEIDPELAHGYSlevilriPQLDLL---SLSVSTEWLLLIILEVLT 233
 
Name Accession Description Interval E-value
Condensin2nSMC pfam12422
Condensin II non structural maintenance of chromosomes subunit; This domain family is found in ...
 213-362 3.21e-73

Condensin II non structural maintenance of chromosomes subunit; This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.


Pssm-ID: 463573  Cd Length: 149  Bit Score: 237.07  E-value: 3.21e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161  213 CFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFH 292
Cdd:pfam12422   2 CFISPAFLKTEEGRRFLAFLFSLSVQLVKEIHATIKNQLPFLTKSLLEAYGEIYFRAWKNASGDLLEEIEEDCIQDLMQH 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161  293 GIHLpRRSPVHSKVREVLSYFHHQKKvRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRD 362
Cdd:pfam12422  82 AIHA-SRPPLASKVRRVLSYFHSQKK-DKGVDEMLTRLYEPILWRSLKVANSEVRANATLLFFDAFPLED 149
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 339-484 3.98e-05

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 47.42  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948161 339 LKARNSEVRSNAaLLFVEAfpIRDPNLHAIEMDSeiqkqfeeLYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILID 418
Cdd:COG5096  101 LQDPNEEIRGFA-LRTLSL--LRVKELLGNIIDP--------IKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLID 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948161 419 LLKkvtgELAFDTSSADVRCSVFKClpMILDNKLSHPLL-------EQLLPAlrySLHDNSEKVRVAFVDMLL 484
Cdd:COG5096  170 ILK----ELVADSDPIVIANALASL--AEIDPELAHGYSlevilriPQLDLL---SLSVSTEWLLLIILEVLT 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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