|
Name |
Accession |
Description |
Interval |
E-value |
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
28-263 |
1.54e-94 |
|
Laminin N-terminal (Domain VI);
:
Pssm-ID: 459653 Cd Length: 230 Bit Score: 304.89 E-value: 1.54e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055 1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055 72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055 151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227
|
...
gi 767947260 261 VRG 263
Cdd:pfam00055 228 VGG 230
|
|
| Mplasa_alph_rch super family |
cl37461 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1254-1714 |
8.24e-13 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
The actual alignment was detected with superfamily member TIGR04523:
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 73.52 E-value: 8.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1254 QIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLqeeidlqsSVLNASIADSSENIKKYYHISSSAEKKINETSSTI 1332
Cdd:TIGR04523 69 KINNSNNKIKILeQQIKDLNDKLKKNKDKINKLNSDL--------SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1333 NTSANTRNDLLTILDTLTSKGN------LSLERLKQIKIPDIQILNEKvcgdpgnvpcvplpcggaLCTGRKGHRKCRgp 1406
Cdd:TIGR04523 141 DKFLTEIKKKEKELEKLNNKYNdlkkqkEELENELNLLEKEKLNIQKN------------------IDKIKNKLLKLE-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1407 gchgsLTLST--NALQKAQEAKSIIRNLDKQVRGLKNQIESisEQAEVSKNNAlQLREKLGNIRNQSDSEEENINLFIKK 1484
Cdd:TIGR04523 201 -----LLLSNlkKKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTT-EISNTQTQLNQLKDEQNKIKKQLSEK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1485 VKnflleenvppeDIEKvANGVLDihlpipsqNLTDELVKIQkhMQLcedyrtdENRLNEEADGAQKLLvkakaaekaAN 1564
Cdd:TIGR04523 273 QK-----------ELEQ-NNKKIK--------ELEKQLNQLK--SEI-------SDLNNQKEQDWNKEL---------KS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1565 ILLNLDKTLNQLQQaQITQgrANSTITQLTANITKIKKNV--LQAENQT-----REMKSELE-LAKQRSG-------LED 1629
Cdd:TIGR04523 315 ELKNQEKKLEEIQN-QISQ--NNKIISQLNEQISQLKKELtnSESENSEkqrelEEKQNEIEkLKKENQSykqeiknLES 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1630 GLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQyaILQRKTSTTGLTKE------TLGKVKQLKDAAEKL 1703
Cdd:TIGR04523 392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET--IIKNNSEIKDLTNQdsvkelIIKNLDNTRESLETQ 469
|
490
....*....|.
gi 767947260 1704 AGDTEAKIRRI 1714
Cdd:TIGR04523 470 LKVLSRSINKI 480
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1080-1128 |
1.32e-12 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 63.53 E-value: 1.32e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767947260 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
454-503 |
1.75e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 1.75e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767947260 454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055 1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
505-549 |
3.79e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.68 E-value: 3.79e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 767947260 505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
395-452 |
5.41e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 59.29 E-value: 5.41e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767947260 395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053 1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1127-1165 |
2.36e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 2.36e-10
10 20 30
....*....|....*....|....*....|....*....
gi 767947260 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
822-865 |
3.94e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 3.94e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053 6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
768-809 |
7.03e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.13 E-value: 7.03e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 767947260 768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1033-1077 |
8.68e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 52.74 E-value: 8.68e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 767947260 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053 2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
862-909 |
9.99e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 9.99e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767947260 862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055 1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
264-320 |
8.72e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.35 E-value: 8.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055 1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
970-1012 |
9.67e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 46.96 E-value: 9.67e-07
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 767947260 970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
332-382 |
8.05e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 44.65 E-value: 8.05e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053 1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
28-263 |
1.54e-94 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 304.89 E-value: 1.54e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055 1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055 72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055 151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227
|
...
gi 767947260 261 VRG 263
Cdd:pfam00055 228 VGG 230
|
|
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
23-263 |
4.49e-67 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 226.47 E-value: 4.49e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCIL-SYLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136 2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLvGHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136 74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136 152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230
|
....*...
gi 767947260 256 LYEMIVRG 263
Cdd:smart00136 231 ISDIAVGG 238
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1254-1714 |
8.24e-13 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 73.52 E-value: 8.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1254 QIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLqeeidlqsSVLNASIADSSENIKKYYHISSSAEKKINETSSTI 1332
Cdd:TIGR04523 69 KINNSNNKIKILeQQIKDLNDKLKKNKDKINKLNSDL--------SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1333 NTSANTRNDLLTILDTLTSKGN------LSLERLKQIKIPDIQILNEKvcgdpgnvpcvplpcggaLCTGRKGHRKCRgp 1406
Cdd:TIGR04523 141 DKFLTEIKKKEKELEKLNNKYNdlkkqkEELENELNLLEKEKLNIQKN------------------IDKIKNKLLKLE-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1407 gchgsLTLST--NALQKAQEAKSIIRNLDKQVRGLKNQIESisEQAEVSKNNAlQLREKLGNIRNQSDSEEENINLFIKK 1484
Cdd:TIGR04523 201 -----LLLSNlkKKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTT-EISNTQTQLNQLKDEQNKIKKQLSEK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1485 VKnflleenvppeDIEKvANGVLDihlpipsqNLTDELVKIQkhMQLcedyrtdENRLNEEADGAQKLLvkakaaekaAN 1564
Cdd:TIGR04523 273 QK-----------ELEQ-NNKKIK--------ELEKQLNQLK--SEI-------SDLNNQKEQDWNKEL---------KS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1565 ILLNLDKTLNQLQQaQITQgrANSTITQLTANITKIKKNV--LQAENQT-----REMKSELE-LAKQRSG-------LED 1629
Cdd:TIGR04523 315 ELKNQEKKLEEIQN-QISQ--NNKIISQLNEQISQLKKELtnSESENSEkqrelEEKQNEIEkLKKENQSykqeiknLES 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1630 GLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQyaILQRKTSTTGLTKE------TLGKVKQLKDAAEKL 1703
Cdd:TIGR04523 392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET--IIKNNSEIKDLTNQdsvkelIIKNLDNTRESLETQ 469
|
490
....*....|.
gi 767947260 1704 AGDTEAKIRRI 1714
Cdd:TIGR04523 470 LKVLSRSINKI 480
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1080-1128 |
1.32e-12 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 63.53 E-value: 1.32e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767947260 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
454-503 |
1.75e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 1.75e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767947260 454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055 1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1080-1125 |
3.61e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.63 E-value: 3.61e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767947260 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
505-549 |
3.79e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.68 E-value: 3.79e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 767947260 505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
395-452 |
5.41e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 59.29 E-value: 5.41e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767947260 395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053 1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1079-1121 |
2.20e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 2.20e-10
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 767947260 1079 SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDP 1121
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
455-508 |
2.23e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.36 E-value: 2.23e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053 1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1127-1165 |
2.36e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 2.36e-10
10 20 30
....*....|....*....|....*....|....*....
gi 767947260 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
822-865 |
3.94e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 3.94e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053 6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
506-549 |
6.58e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.78 E-value: 6.58e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1128-1172 |
9.27e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.40 E-value: 9.27e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767947260 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQE-FPTC 1172
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDgPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
394-453 |
2.69e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 54.28 E-value: 2.69e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055 1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1128-1165 |
3.53e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.90 E-value: 3.53e-09
10 20 30
....*....|....*....|....*....|....*...
gi 767947260 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
455-503 |
4.02e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 53.85 E-value: 4.02e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767947260 455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180 1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
768-809 |
7.03e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.13 E-value: 7.03e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 767947260 768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
769-809 |
7.21e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.13 E-value: 7.21e-09
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767947260 769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1033-1077 |
8.68e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 52.74 E-value: 8.68e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 767947260 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053 2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1021-1078 |
1.19e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 52.36 E-value: 1.19e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767947260 1021 RCSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNL-VPGRGCQ 1078
Cdd:cd00055 1 PCDCNGHGSLSGQC---------DPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
822-859 |
2.61e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 51.59 E-value: 2.61e-08
10 20 30
....*....|....*....|....*....|....*...
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS 859
Cdd:cd00055 7 HGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1022-1077 |
2.88e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.16 E-value: 2.88e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767947260 1022 CSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNlVPGRGC 1077
Cdd:smart00180 1 CDCDPGGSASGTC---------DPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
395-448 |
4.02e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 50.77 E-value: 4.02e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180 1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
862-909 |
9.99e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 9.99e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767947260 862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055 1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
769-808 |
1.23e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 49.62 E-value: 1.23e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 767947260 769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
822-860 |
3.94e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.08 E-value: 3.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFG--FPSC 860
Cdd:smart00180 6 GGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1566-1714 |
5.11e-07 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 54.14 E-value: 5.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1566 LLNLDKTLNQLQQAQitqgranstitqltANITKIKKNVLQAENQTREMKSELELAKQRsgledgLSLLQTKLQRHQDHA 1645
Cdd:COG4372 37 LFELDKLQEELEQLR--------------EELEQAREELEQLEEELEQARSELEQLEEE------LEELNEQLQAAQAEL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767947260 1646 VNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTST-----TGLTKETLGKVKQLKDAAEKLAgDTEAKIRRI 1714
Cdd:COG4372 97 AQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQleaqiAELQSEIAEREEELKELEEQLE-SLQEELAAL 169
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
264-320 |
8.72e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.35 E-value: 8.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055 1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
970-1012 |
9.67e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 46.96 E-value: 9.67e-07
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 767947260 970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
969-1020 |
1.33e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 46.58 E-value: 1.33e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767947260 969 PCACNNNIDVtdPESCSRVTGECLrCLHNTQGANCQLCKPGHYGSALN-QTCR 1020
Cdd:cd00055 1 PCDCNGHGSL--SGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
506-544 |
2.34e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 46.19 E-value: 2.34e-06
10 20 30
....*....|....*....|....*....|....*....
gi 767947260 506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
332-382 |
8.05e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 44.65 E-value: 8.05e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053 1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
331-384 |
1.19e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.88 E-value: 1.19e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767947260 331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055 1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
863-908 |
4.96e-05 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 42.34 E-value: 4.96e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767947260 863 CPCN---RFAELCDPETGSCFnCGGFTTGRNCERCIDGYYGNPS-SGQPC 908
Cdd:pfam00053 1 CDCNphgSLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSdPPQGC 49
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
1413-1639 |
9.48e-05 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 47.32 E-value: 9.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1413 TLST-NALQKAQ--EAKSIIRNLDKQVRGLKNQIES----ISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKV 1485
Cdd:PHA02562 164 VLSEmDKLNKDKirELNQQIQTLDMKIDHIQQQIKTynknIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDEL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1486 KNFLLEENVPPEDIEKVANGVLDIHLPIpsQNLTDELVKIQKHmQLC----EDYRTDENRLneeADGAQKLLVKAKAAEK 1561
Cdd:PHA02562 244 LNLVMDIEDPSAALNKLNTAAAKIKSKI--EQFQKVIKMYEKG-GVCptctQQISEGPDRI---TKIKDKLKELQHSLEK 317
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767947260 1562 AANILLNLDKTLNQLQQAQitqgranSTITQLTANITKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQ 1639
Cdd:PHA02562 318 LDTAIDELEEIMDEFNEQS-------KKLLELKNKISTNKQSLITLVDKAKKVKAAIEeLQAEFVDNAEELAKLQDELD 389
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
332-382 |
2.15e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.37 E-value: 2.15e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180 1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
863-905 |
2.65e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.99 E-value: 2.65e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767947260 863 CPCNR---FAELCDPETGSCfNCGGFTTGRNCERCIDGYYGNPSSG 905
Cdd:smart00180 1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
970-1013 |
2.67e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.99 E-value: 2.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 970 CACNNniDVTDPESCSRVTGECLrCLHNTQGANCQLCKPGHYGS 1013
Cdd:smart00180 1 CDCDP--GGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
|
|
| cc_LAMB4_C |
cd22301 |
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called ... |
1690-1715 |
3.30e-04 |
|
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called laminin beta-1-related protein, is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Mutations or loss of LAMB4 may be features of gastric and colorectal cancers. Reduced LAMB4 levels may contribute to colonic dysmotility associated with diverticulitis. This model corresponds to the C-terminal coiled-coil domain of LAMB4, which may be involved in the integrin binding activity.
Pssm-ID: 411972 [Multi-domain] Cd Length: 70 Bit Score: 40.80 E-value: 3.30e-04
10 20
....*....|....*....|....*.
gi 767947260 1690 LGKVKQLKDAAEKLAGDTEAKIRRIT 1715
Cdd:cd22301 1 NERLKNIKKEAENLAKEIEDKMKRIE 26
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
265-323 |
4.40e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.64 E-value: 4.40e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767947260 265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053 1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
291-313 |
8.13e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 38.83 E-value: 8.13e-04
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
28-263 |
1.54e-94 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 304.89 E-value: 1.54e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055 1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055 72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055 151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227
|
...
gi 767947260 261 VRG 263
Cdd:pfam00055 228 VGG 230
|
|
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
23-263 |
4.49e-67 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 226.47 E-value: 4.49e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCIL-SYLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136 2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLvGHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136 74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136 152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230
|
....*...
gi 767947260 256 LYEMIVRG 263
Cdd:smart00136 231 ISDIAVGG 238
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1254-1714 |
8.24e-13 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 73.52 E-value: 8.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1254 QIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLqeeidlqsSVLNASIADSSENIKKYYHISSSAEKKINETSSTI 1332
Cdd:TIGR04523 69 KINNSNNKIKILeQQIKDLNDKLKKNKDKINKLNSDL--------SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1333 NTSANTRNDLLTILDTLTSKGN------LSLERLKQIKIPDIQILNEKvcgdpgnvpcvplpcggaLCTGRKGHRKCRgp 1406
Cdd:TIGR04523 141 DKFLTEIKKKEKELEKLNNKYNdlkkqkEELENELNLLEKEKLNIQKN------------------IDKIKNKLLKLE-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1407 gchgsLTLST--NALQKAQEAKSIIRNLDKQVRGLKNQIESisEQAEVSKNNAlQLREKLGNIRNQSDSEEENINLFIKK 1484
Cdd:TIGR04523 201 -----LLLSNlkKKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTT-EISNTQTQLNQLKDEQNKIKKQLSEK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1485 VKnflleenvppeDIEKvANGVLDihlpipsqNLTDELVKIQkhMQLcedyrtdENRLNEEADGAQKLLvkakaaekaAN 1564
Cdd:TIGR04523 273 QK-----------ELEQ-NNKKIK--------ELEKQLNQLK--SEI-------SDLNNQKEQDWNKEL---------KS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1565 ILLNLDKTLNQLQQaQITQgrANSTITQLTANITKIKKNV--LQAENQT-----REMKSELE-LAKQRSG-------LED 1629
Cdd:TIGR04523 315 ELKNQEKKLEEIQN-QISQ--NNKIISQLNEQISQLKKELtnSESENSEkqrelEEKQNEIEkLKKENQSykqeiknLES 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1630 GLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQyaILQRKTSTTGLTKE------TLGKVKQLKDAAEKL 1703
Cdd:TIGR04523 392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET--IIKNNSEIKDLTNQdsvkelIIKNLDNTRESLETQ 469
|
490
....*....|.
gi 767947260 1704 AGDTEAKIRRI 1714
Cdd:TIGR04523 470 LKVLSRSINKI 480
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1080-1128 |
1.32e-12 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 63.53 E-value: 1.32e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767947260 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
454-503 |
1.75e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 1.75e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767947260 454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055 1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1080-1125 |
3.61e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.63 E-value: 3.61e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767947260 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
505-549 |
3.79e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 59.68 E-value: 3.79e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 767947260 505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
395-452 |
5.41e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 59.29 E-value: 5.41e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767947260 395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053 1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1079-1121 |
2.20e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 2.20e-10
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 767947260 1079 SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDP 1121
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
455-508 |
2.23e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.36 E-value: 2.23e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053 1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1127-1165 |
2.36e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 2.36e-10
10 20 30
....*....|....*....|....*....|....*....
gi 767947260 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
822-865 |
3.94e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 3.94e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053 6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
506-549 |
6.58e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.78 E-value: 6.58e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1128-1172 |
9.27e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.40 E-value: 9.27e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767947260 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQE-FPTC 1172
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDgPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
394-453 |
2.69e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 54.28 E-value: 2.69e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055 1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1253-1698 |
3.28e-09 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 61.96 E-value: 3.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1253 RQIMQLNEQLkavyefQDLKDTIERAKNEADL-LLEDLQEEIDlqssvlnaSIADSSENIKKyyHISSSaEKKINETSST 1331
Cdd:TIGR04523 281 KKIKELEKQL------NQLKSEISDLNNQKEQdWNKELKSELK--------NQEKKLEEIQN--QISQN-NKIISQLNEQ 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1332 INTSANTRNDLltilDTLTSKGNLSLERlKQIKIpdIQILNEKvcgdpgnvpcvplpcggalcTGRKGHRKcrgpgchgS 1411
Cdd:TIGR04523 344 ISQLKKELTNS----ESENSEKQRELEE-KQNEI--EKLKKEN--------------------QSYKQEIK--------N 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1412 LTLSTNAL-QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQsDSEEENInlfIKKVKNFLL 1490
Cdd:TIGR04523 389 LESQINDLeSKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQ-DSVKELI---IKNLDNTRE 464
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1491 EENVPPEDIEKVANGvLDIHLPIPSQNLTDelvKIQKHMQLcedyrTDENRLNEEadgaqKLlvkakaaekaanillnld 1570
Cdd:TIGR04523 465 SLETQLKVLSRSINK-IKQNLEQKQKELKS---KEKELKKL-----NEEKKELEE-----KV------------------ 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1571 KTLNQlQQAQItqgraNSTITQLTANITKIKKNVLQAENQTREMKSEL---ELAKQRSG--------------LEDGLSL 1633
Cdd:TIGR04523 513 KDLTK-KISSL-----KEKIEKLESEKKEKESKISDLEDELNKDDFELkkeNLEKEIDEknkeieelkqtqksLKKKQEE 586
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767947260 1634 LQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGK-VKQLKD 1698
Cdd:TIGR04523 587 KQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQeVKQIKE 652
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1128-1165 |
3.53e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.90 E-value: 3.53e-09
10 20 30
....*....|....*....|....*....|....*...
gi 767947260 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
455-503 |
4.02e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 53.85 E-value: 4.02e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767947260 455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180 1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
768-809 |
7.03e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.13 E-value: 7.03e-09
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 767947260 768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
769-809 |
7.21e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.13 E-value: 7.21e-09
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767947260 769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1033-1077 |
8.68e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 52.74 E-value: 8.68e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 767947260 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053 2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1021-1078 |
1.19e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 52.36 E-value: 1.19e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767947260 1021 RCSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNL-VPGRGCQ 1078
Cdd:cd00055 1 PCDCNGHGSLSGQC---------DPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
1223-1714 |
2.23e-08 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 59.68 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1223 NVSEIERILKHPVFPS-GK--FLKVKDYHDSVRRQIMQLNEQL-KAVYEFQDLKDTIERAKNEADLLLEDLQEEIDlqss 1298
Cdd:TIGR01612 1085 NFNEIKEKLKHYNFDDfGKeeNIKYADEINKIKDDIKNLDQKIdHHIKALEEIKKKSENYIDEIKAQINDLEDVAD---- 1160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1299 vlnasIADSSENIKKYyhisssaEKKINETSSTINTSANTRNDLLTILDTLT--SKGNLSLERLKQIKIPDIQILNEkvc 1376
Cdd:TIGR01612 1161 -----KAISNDDPEEI-------EKKIENIVTKIDKKKNIYDEIKKLLNEIAeiEKDKTSLEEVKGINLSYGKNLGK--- 1225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1377 gdpgnvpcvplpcggaLCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLDKQVRGLKNQIE--SISEQAE--- 1451
Cdd:TIGR01612 1226 ----------------LFLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMEtfNISHDDDkdh 1289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1452 --VSKNNalqlREKLGNIRNQS------DSEEENINLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELV 1523
Cdd:TIGR01612 1290 hiISKKH----DENISDIREKSlkiiedFSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKIKKIID 1365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1524 KIQKHMQLCEDYRTDenrLNEEADGAQKLLVKAKAAEKAANILLNLDKTLNQ------LQQAQITQgraNSTITQLTANI 1597
Cdd:TIGR01612 1366 EVKEYTKEIEENNKN---IKDELDKSEKLIKKIKDDINLEECKSKIESTLDDkdidecIKKIKELK---NHILSEESNID 1439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1598 TKIK------KNVLQAENQTrEM---KSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQA-------GS 1661
Cdd:TIGR01612 1440 TYFKnadennENVLLLFKNI-EMadnKSQHILKIKKDNATNDHDFNINELKEHIDKSKGCKDEADKNAKAIeknkelfEQ 1518
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 767947260 1662 LEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKL---AGDTEAKIRRI 1714
Cdd:TIGR01612 1519 YKKDVTELLNKYSALAIKNKFAKTKKDSEIIIKEIKDAHKKFileAEKSEQKIKEI 1574
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
822-859 |
2.61e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 51.59 E-value: 2.61e-08
10 20 30
....*....|....*....|....*....|....*...
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS 859
Cdd:cd00055 7 HGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1022-1077 |
2.88e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.16 E-value: 2.88e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767947260 1022 CSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNlVPGRGC 1077
Cdd:smart00180 1 CDCDPGGSASGTC---------DPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
395-448 |
4.02e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 50.77 E-value: 4.02e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180 1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
862-909 |
9.99e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 9.99e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767947260 862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055 1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
769-808 |
1.23e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 49.62 E-value: 1.23e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 767947260 769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
822-860 |
3.94e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.08 E-value: 3.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767947260 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFG--FPSC 860
Cdd:smart00180 6 GGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1566-1714 |
5.11e-07 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 54.14 E-value: 5.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1566 LLNLDKTLNQLQQAQitqgranstitqltANITKIKKNVLQAENQTREMKSELELAKQRsgledgLSLLQTKLQRHQDHA 1645
Cdd:COG4372 37 LFELDKLQEELEQLR--------------EELEQAREELEQLEEELEQARSELEQLEEE------LEELNEQLQAAQAEL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767947260 1646 VNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTST-----TGLTKETLGKVKQLKDAAEKLAgDTEAKIRRI 1714
Cdd:COG4372 97 AQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQleaqiAELQSEIAEREEELKELEEQLE-SLQEELAAL 169
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
1250-1495 |
7.87e-07 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 53.81 E-value: 7.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1250 SVRRQIMQLNEQLKAVYEFQdlkdTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHIS--SSAEKKINE 1327
Cdd:COG5185 306 DIKKATESLEEQLAAAEAEQ----ELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVelSKSSEELDS 381
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1328 TSSTINTsanTRNDLLTILDTLTSKGNLSLERL-KQIKIPDIQI--LNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCR 1404
Cdd:COG5185 382 FKDTIES---TKESLDEIPQNQRGYAQEILATLeDTLKAADRQIeeLQRQIEQATSSNEEVSKLLNELISELNKVMREAD 458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1405 GpgchGSLTLSTNALQK-AQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNalqLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:COG5185 459 E----ESQSRLEEAYDEiNRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAK---LERQLEGVRSKLDQVAESLKDFMR 531
|
250
....*....|..
gi 767947260 1484 KVKNFLLEENVP 1495
Cdd:COG5185 532 ARGYAHILALEN 543
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1426-1703 |
8.30e-07 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 53.87 E-value: 8.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1426 KSIIRNLDKQVRGLKNQIESISEQAEVSKNnalqlreKLGNIRNQSDSEEENINLFIKKVKNflLEENVppEDI---EKV 1502
Cdd:TIGR04523 25 KNIANKQDTEEKQLEKKLKTIKNELKNKEK-------ELKNLDKNLNKDEEKINNSNNKIKI--LEQQI--KDLndkLKK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1503 ANGVLDihlpipsqNLTDELVKIQKHMQLCEDY----RTDENRLNEEADGAQKLLvkakaaEKAANILLNLDKTLNQLqq 1578
Cdd:TIGR04523 94 NKDKIN--------KLNSDLSKINSEIKNDKEQknklEVELNKLEKQKKENKKNI------DKFLTEIKKKEKELEKL-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1579 aqitqgraNSTITQLTANITKIKKNVLQAENQTREMKSELELAK-QRSGLEDGLSLLQTKLQRHQdhavnakvqaesaqh 1657
Cdd:TIGR04523 158 --------NNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKnKLLKLELLLSNLKKKIQKNK--------------- 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 767947260 1658 qagSLEKEFVELKKQYAILqrKTSTTGLTKETLGKVKQLKDAAEKL 1703
Cdd:TIGR04523 215 ---SLESQISELKKQNNQL--KDNIEKKQQEINEKTTEISNTQTQL 255
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
264-320 |
8.72e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 47.35 E-value: 8.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055 1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
970-1012 |
9.67e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 46.96 E-value: 9.67e-07
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 767947260 970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
969-1020 |
1.33e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 46.58 E-value: 1.33e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767947260 969 PCACNNNIDVtdPESCSRVTGECLrCLHNTQGANCQLCKPGHYGSALN-QTCR 1020
Cdd:cd00055 1 PCDCNGHGSL--SGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
506-544 |
2.34e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 46.19 E-value: 2.34e-06
10 20 30
....*....|....*....|....*....|....*....
gi 767947260 506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
1241-1712 |
6.52e-06 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 51.12 E-value: 6.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1241 FLKVKDYHDSVRRQIMQLNEQLKAVYE-FQDLKDTIERAKNEADLLLEDLQEEIDLQSSVLNA---------SIADSSEN 1310
Cdd:TIGR00618 367 IREISCQQHTLTQHIHTLQQQKTTLTQkLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAkkqqelqqrYAELCAAA 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1311 IKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKipDIQILNEKVCGDPgNVPCVPLPCG 1390
Cdd:TIGR00618 447 ITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQ--EEPCPLCGSCIHP-NPARQDIDNP 523
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1391 GALCTgrkghRKCRGpgchgsltlstnaLQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEvsknNALQLREKLGNIRNQ 1470
Cdd:TIGR00618 524 GPLTR-----RMQRG-------------EQTYAQLETSEEDVYHQLTSERKQRASLKEQMQ----EIQQSFSILTQCDNR 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1471 SDseeeninlfikkvknflleenvppEDIEKVANGVLDIhlpipsQNLTDELVKIQKhMQLCEDYRtDENRLNEEADGAQ 1550
Cdd:TIGR00618 582 SK------------------------EDIPNLQNITVRL------QDLTEKLSEAED-MLACEQHA-LLRKLQPEQDLQD 629
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1551 KLLVKAKAAEKAANILLNLDKTLNQLQQAQITQGRANSTITQltanitkiKKNVLQAENQTREMKSELE-LAKQRSGLED 1629
Cdd:TIGR00618 630 VRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLP--------KELLASRQLALQKMQSEKEqLTYWKEMLAQ 701
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1630 GLSLLQTKLQ--------RHQ----DHAVNAKVQAE--SAQHQAGSLEKEFVE-LKKQYAILQRKTsttgltkETLGKVK 1694
Cdd:TIGR00618 702 CQTLLRELEThieeydreFNEienaSSSLGSDLAARedALNQSLKELMHQARTvLKARTEAHFNNN-------EEVTAAL 774
|
490
....*....|....*...
gi 767947260 1695 QLKDAAEKLAGDTEAKIR 1712
Cdd:TIGR00618 775 QTGAELSHLAAEIQFFNR 792
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
332-382 |
8.05e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 44.65 E-value: 8.05e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053 1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
331-384 |
1.19e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.88 E-value: 1.19e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767947260 331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055 1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1418-1716 |
1.71e-05 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 49.13 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1418 ALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVKNFLLEENVPPE 1497
Cdd:COG4372 36 ALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1498 DIEKVANGVldihlpipsQNLTDELVKI-QKHMQLCEDYRTDENRLNEeadgaqkllvkakaaekaanillnLDKTLNQL 1576
Cdd:COG4372 116 ELEELQKER---------QDLEQQRKQLeAQIAELQSEIAEREEELKE------------------------LEEQLESL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1577 QQ--AQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRSGLEDGLSLLQTKLQRHQdHAVNAKVQAES 1654
Cdd:COG4372 163 QEelAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAK-LGLALSALLDA 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767947260 1655 AQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITG 1716
Cdd:COG4372 242 LELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLN 303
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
863-908 |
4.96e-05 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 42.34 E-value: 4.96e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767947260 863 CPCN---RFAELCDPETGSCFnCGGFTTGRNCERCIDGYYGNPS-SGQPC 908
Cdd:pfam00053 1 CDCNphgSLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSdPPQGC 49
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
1413-1639 |
9.48e-05 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 47.32 E-value: 9.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1413 TLST-NALQKAQ--EAKSIIRNLDKQVRGLKNQIES----ISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKV 1485
Cdd:PHA02562 164 VLSEmDKLNKDKirELNQQIQTLDMKIDHIQQQIKTynknIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDEL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1486 KNFLLEENVPPEDIEKVANGVLDIHLPIpsQNLTDELVKIQKHmQLC----EDYRTDENRLneeADGAQKLLVKAKAAEK 1561
Cdd:PHA02562 244 LNLVMDIEDPSAALNKLNTAAAKIKSKI--EQFQKVIKMYEKG-GVCptctQQISEGPDRI---TKIKDKLKELQHSLEK 317
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767947260 1562 AANILLNLDKTLNQLQQAQitqgranSTITQLTANITKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQ 1639
Cdd:PHA02562 318 LDTAIDELEEIMDEFNEQS-------KKLLELKNKISTNKQSLITLVDKAKKVKAAIEeLQAEFVDNAEELAKLQDELD 389
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
1516-1690 |
1.85e-04 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 46.50 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1516 QNLTDELVKI---QKHMQLCEDYRTDENRLNEEADGAQKLLvkaKAAEKAANILLNLDKTLnQLQQAQITQGRANSTITQ 1592
Cdd:TIGR00618 222 QVLEKELKHLreaLQQTQQSHAYLTQKREAQEEQLKKQQLL---KQLRARIEELRAQEAVL-EETQERINRARKAAPLAA 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1593 LTANITKIKKNVLQAENQTREMKSELE--------LAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQH--QAGSL 1662
Cdd:TIGR00618 298 HIKAVTQIEQQAQRIHTELQSKMRSRAkllmkraaHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREIscQQHTL 377
|
170 180
....*....|....*....|....*...
gi 767947260 1663 EKEFVELKKQYAILQRKTSTTGLTKETL 1690
Cdd:TIGR00618 378 TQHIHTLQQQKTTLTQKLQSLCKELDIL 405
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
332-382 |
2.15e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.37 E-value: 2.15e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180 1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
863-905 |
2.65e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.99 E-value: 2.65e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767947260 863 CPCNR---FAELCDPETGSCfNCGGFTTGRNCERCIDGYYGNPSSG 905
Cdd:smart00180 1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
970-1013 |
2.67e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.99 E-value: 2.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 767947260 970 CACNNniDVTDPESCSRVTGECLrCLHNTQGANCQLCKPGHYGS 1013
Cdd:smart00180 1 CDCDP--GGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
|
|
| PTZ00440 |
PTZ00440 |
reticulocyte binding protein 2-like protein; Provisional |
1257-1625 |
3.22e-04 |
|
reticulocyte binding protein 2-like protein; Provisional
Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 45.98 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1257 QLNEQLKavyEFQDLKDTIERAKNEADLLLEDLQEE-----IDLQSSVLNASIADSSENIKKYYHiSSSAEKKINETSST 1331
Cdd:PTZ00440 1177 QINNEAK---KSKTIMEEIESYKKDIDQVKKNMSKErndhlTTFEYNAYYDKATASYENIEELTT-EAKGLKGEANRSTN 1252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1332 INTSANTRNDLLTILDTLTSKGNLSLERLKQIK-IPDIQILN--EKVCGDPGNVpcvplpcggalctgrkghrkcrgpgc 1408
Cdd:PTZ00440 1253 VDELKEIKLQVFSYLQQVIKENNKMENALHEIKnMYEFLISIdsEKILKEILNS-------------------------- 1306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1409 hgsltlSTNALQKAQEAKSIirnLDKQVRgLKNQIESISEQAEVSKNNAL------QLREKLGNIR--NQSDSE-EENIN 1479
Cdd:PTZ00440 1307 ------TKKAEEFSNDAKKE---LEKTDN-LIKQVEAKIEQAKEHKNKIYgsledkQIDDEIKKIEqiKEEISNkRKEIN 1376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1480 LFIKKVK----NFLLEENVPPEDIEKVanGVLDIHLPIPSQNLTD-ELVKIQKHMQLCEDYRTDENRLNEEADGAQKLLV 1554
Cdd:PTZ00440 1377 KYLSNIKsnkeKCDLHVRNASRGKDKI--DFLNKHEAIEPSNSKEvNIIKITDNINKCKQYSNEAMETENKADENNDSII 1454
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767947260 1555 KAKAAEKA---ANILLNLDKTL-NQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRS 1625
Cdd:PTZ00440 1455 KYEKEITNilnNSSILGKKTKLeKKKKEATNIMDDINGEHSIIKTKLTKSSEKLNQLNEQPNIKREGDVLNNDKS 1529
|
|
| cc_LAMB4_C |
cd22301 |
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called ... |
1690-1715 |
3.30e-04 |
|
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called laminin beta-1-related protein, is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Mutations or loss of LAMB4 may be features of gastric and colorectal cancers. Reduced LAMB4 levels may contribute to colonic dysmotility associated with diverticulitis. This model corresponds to the C-terminal coiled-coil domain of LAMB4, which may be involved in the integrin binding activity.
Pssm-ID: 411972 [Multi-domain] Cd Length: 70 Bit Score: 40.80 E-value: 3.30e-04
10 20
....*....|....*....|....*.
gi 767947260 1690 LGKVKQLKDAAEKLAGDTEAKIRRIT 1715
Cdd:cd22301 1 NERLKNIKKEAENLAKEIEDKMKRIE 26
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1420-1705 |
3.35e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 45.83 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1420 QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEvsknnalQLREKLGNIRNQSDSEEENINLFIKKVKNflLEENVPP--E 1497
Cdd:TIGR02169 702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEE-------KLKERLEELEEDLSSLEQEIENVKSELKE--LEARIEEleE 772
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1498 DIEKVANGVLDIHlpipsQNLTDELVK-IQKHMQLCEDYRTD-ENRLNEeadgaqkllvkakaaekaanillnLDKTLNQ 1575
Cdd:TIGR02169 773 DLHKLEEALNDLE-----ARLSHSRIPeIQAELSKLEEEVSRiEARLRE------------------------IEQKLNR 823
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1576 LQQaqitqgranstitqltanitkiKKNVLQAENQTREMKSElELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESA 1655
Cdd:TIGR02169 824 LTL----------------------EKEYLEKEIQELQEQRI-DLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDL 880
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 767947260 1656 QHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGK-VKQLKDAAEKLAG 1705
Cdd:TIGR02169 881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKrLSELKAKLEALEE 931
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
265-323 |
4.40e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.64 E-value: 4.40e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767947260 265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053 1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1249-1583 |
5.42e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1249 DSVRRQIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLQE-EIDLQSSvlNASIADSSENIKKYYHISSSAEKKIN 1326
Cdd:COG4372 41 DKLQEELEQLREELEQArEELEQLEEELEQARSELEQLEEELEElNEQLQAA--QAELAQAQEELESLQEEAEELQEELE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1327 ETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKIpDIQILNEKVcgdpgnvpcvplpcggalctgrkghrkcrgp 1406
Cdd:COG4372 119 ELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEE-QLESLQEEL------------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1407 gchGSLTLSTNALQKAQeaksIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVK 1486
Cdd:COG4372 167 ---AALEQELQALSEAE----AEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1487 NFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIqkhmqlcEDYRTDENRLNEEADGAQKLLVKAKAAEKAANIL 1566
Cdd:COG4372 240 DALELEEDKEELLEEVILKEIEELELAILVEKDTEEEEL-------EIAALELEALEEAALELKLLALLLNLAALSLIGA 312
|
330
....*....|....*..
gi 767947260 1567 LNLDKTLNQLQQAQITQ 1583
Cdd:COG4372 313 LEDALLAALLELAKKLE 329
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1462-1703 |
5.72e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 44.67 E-value: 5.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1462 EKLGNIRNQSDSEEENINLFIKKVKNF--LLEENvpPEDIEKVANGVLDIHLPIPSqnLTDELVKIQKHMQLCEDYRTDE 1539
Cdd:PRK03918 165 KNLGEVIKEIKRRIERLEKFIKRTENIeeLIKEK--EKELEEVLREINEISSELPE--LREELEKLEKEVKELEELKEEI 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1540 NRLNEEadgaqkllvkakaaekaaniLLNLDKTLNQLQqAQITQGRanSTITQLTANITKIKKNVLQAENQTREMKSELE 1619
Cdd:PRK03918 241 EELEKE--------------------LESLEGSKRKLE-EKIRELE--ERIEELKKEIEELEEKVKELKELKEKAEEYIK 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1620 LAKQRSGLEDGLSLLQTKLQR--HQDHAVNAKVQ-AESAQHQAGSLEKEFVELKKQYAILQRKTsttgltkETLGKVKQL 1696
Cdd:PRK03918 298 LSEFYEEYLDELREIEKRLSRleEEINGIEERIKeLEEKEERLEELKKKLKELEKRLEELEERH-------ELYEEAKAK 370
|
....*..
gi 767947260 1697 KDAAEKL 1703
Cdd:PRK03918 371 KEELERL 377
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1417-1705 |
6.66e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 44.67 E-value: 6.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1417 NALQKAQEaksIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEEninlFIKKVKNflLEENVpp 1496
Cdd:PRK03918 162 NAYKNLGE---VIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPE----LREELEK--LEKEV-- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1497 EDIEKVANGVldihlpipsQNLTDELVKIQKHMQ-LCEDYRTDENRLNEEADGAQKL-----LVKAKAAEKAANILLN-- 1568
Cdd:PRK03918 231 KELEELKEEI---------EELEKELESLEGSKRkLEEKIRELEERIEELKKEIEELeekvkELKELKEKAEEYIKLSef 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1569 LDKTLNQLQQAQITQGRanstitqLTANITKIKKNVLQAENQTREMKselELAKQRSGLEDGLSLLQTKLQRHQDhAVNA 1648
Cdd:PRK03918 302 YEEYLDELREIEKRLSR-------LEEEINGIEERIKELEEKEERLE---ELKKKLKELEKRLEELEERHELYEE-AKAK 370
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767947260 1649 KVQAES-----AQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETL-GKVKQLKDAAEKLAG 1705
Cdd:PRK03918 371 KEELERlkkrlTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELkKEIKELKKAIEELKK 433
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
1420-1703 |
7.67e-04 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 43.36 E-value: 7.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1420 QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEvsknnalQLREKLGNIRNQSDseeeninlfikkvknfllEENVPPEDI 1499
Cdd:COG1340 57 EEAQELREKRDELNEKVKELKEERDELNEKLN-------ELREELDELRKELA------------------ELNKAGGSI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1500 EKvangvldihlpipsqnLTDELVKIQKhMQLCEDYRTDE--------NRLNEEADGAQKLLvkakaaekaaNILLNLDK 1571
Cdd:COG1340 112 DK----------------LRKEIERLEW-RQQTEVLSPEEekelvekiKELEKELEKAKKAL----------EKNEKLKE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1572 TLNQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRsgledglslLQTKlqrhqdhavNAKVQ 1651
Cdd:COG1340 165 LRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKE---------IVEA---------QEKAD 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 767947260 1652 AESAQHQAgsLEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKL 1703
Cdd:COG1340 227 ELHEEIIE--LQKELRELRKELKKLRKKQRALKREKEKEELEEKAEEIFEKL 276
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
291-313 |
8.13e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 38.83 E-value: 8.13e-04
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1186-1703 |
1.45e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 43.51 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1186 ISSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVSEIERILKhpvfpsGKFLKVKDYHDSVRRqIMQLNEQLKAV 1265
Cdd:PRK03918 223 LEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIE------ELKKEIEELEEKVKE-LKELKEKAEEY 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1266 YEFQDLKDTIERAKNEADLLLEDLQEEIdlqsSVLNASIADSSENIKKYYHISSSaEKKINETSSTINTSANTRNDLLTI 1345
Cdd:PRK03918 296 IKLSEFYEEYLDELREIEKRLSRLEEEI----NGIEERIKELEEKEERLEELKKK-LKELEKRLEELEERHELYEEAKAK 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1346 LDTL----TSKGNLSLERLKQiKIPDIQILNEKVCGDPGNVpcvplpcggalcTGRKGHRKCRGpgchGSLTLSTNALQK 1421
Cdd:PRK03918 371 KEELerlkKRLTGLTPEKLEK-ELEELEKAKEEIEEEISKI------------TARIGELKKEI----KELKKAIEELKK 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1422 A-------------QEAKSIIRNLDKQVRGLKNQIESISEQAEvsknnalQLREKLGNIRNQSDSEEENINL-----FIK 1483
Cdd:PRK03918 434 AkgkcpvcgrelteEHRKELLEEYTAELKRIEKELKEIEEKER-------KLRKELRELEKVLKKESELIKLkelaeQLK 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1484 KVKNFLLEENVppEDIEKVANgvldihlpiPSQNLTDELVKIQKhmqlceDYRTDENRLNEEADGAQKLLVKAKAAEKAA 1563
Cdd:PRK03918 507 ELEEKLKKYNL--EELEKKAE---------EYEKLKEKLIKLKG------EIKSLKKELEKLEELKKKLAELEKKLDELE 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1564 NILLNLDKTLNQLQQAQITQgrANSTITQLtaniTKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQRhq 1642
Cdd:PRK03918 570 EELAELLKELEELGFESVEE--LEERLKEL----EPFYNEYLELKDAEKELEREEKeLKKLEEELDKAFEELAETEKR-- 641
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767947260 1643 dhavnakvqAESAQHQAGSLEKEFVElkKQYAILQRKtsTTGLTKETLGKVKQLKDAAEKL 1703
Cdd:PRK03918 642 ---------LEELRKELEELEKKYSE--EEYEELREE--YLELSRELAGLRAELEELEKRR 689
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1428-1713 |
2.81e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 42.62 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1428 IIRNLDKQVRGLKNQiesiSEQAEvsknNALQLREKLgnirnqsdsEEENINLFIKKVKNFLLEEnvppEDIEKVAngvl 1507
Cdd:COG1196 194 ILGELERQLEPLERQ----AEKAE----RYRELKEEL---------KELEAELLLLKLRELEAEL----EELEAEL---- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1508 dihlpipsQNLTDELVKIQKHMQLCE----DYRTDENRLNEEADGAQKLLvkAKAAEKAANILLNLDKTLNQLQQAQITQ 1583
Cdd:COG1196 249 --------EELEAELEELEAELAELEaeleELRLELEELELELEEAQAEE--YELLAELARLEQDIARLEERRRELEERL 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1584 GRANSTITQLTANITKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSL 1662
Cdd:COG1196 319 EELEEELAELEEELEELEEELEELEEELEEAEEELEeAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 767947260 1663 EKEFVELKKQYAILQRKTSTtgLTKETLGKVKQLKDAAEKLAGDTEAKIRR 1713
Cdd:COG1196 399 AAQLEELEEAEEALLERLER--LEEELEELEEALAELEEEEEEEEEALEEA 447
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
1432-1679 |
2.95e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 42.31 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1432 LDKQVRGLKNQIESISEQAEV--SKNNALQLREKLG---NIRNQSDSEEENINLFIKKVK------NFLLE---ENVPPE 1497
Cdd:COG3206 69 LLSGLSSLSASDSPLETQIEIlkSRPVLERVVDKLNldeDPLGEEASREAAIERLRKNLTvepvkgSNVIEisyTSPDPE 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1498 DIEKVANGVLDIHLpipSQNL---TDELVKIQKHM--QLcEDYRTD----ENRLNE--------EADGAQKLLVkakaae 1560
Cdd:COG3206 149 LAAAVANALAEAYL---EQNLelrREEARKALEFLeeQL-PELRKEleeaEAALEEfrqknglvDLSEEAKLLL------ 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1561 kaaNILLNLDKTLNQLQ-QAQITQGRANSTITQLTAN---ITKIKKNVLQAENQTREMKSELELAKQRS----------G 1626
Cdd:COG3206 219 ---QQLSELESQLAEARaELAEAEARLAALRAQLGSGpdaLPELLQSPVIQQLRAQLAELEAELAELSArytpnhpdviA 295
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 767947260 1627 LEDGLSLLQTKL-QRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRK 1679
Cdd:COG3206 296 LRAQIAALRAQLqQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPEL 349
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1420-1687 |
9.00e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 40.52 E-value: 9.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1420 QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINlfikkvknflleenvppedi 1499
Cdd:COG4942 27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA-------------------- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1500 ekvangvldihlpipsqNLTDELVKIQKhmqlceDYRTDENRLNEEADGAQKLlvkakAAEKAANILLNLD--------- 1570
Cdd:COG4942 87 -----------------ELEKEIAELRA------ELEAQKEELAELLRALYRL-----GRQPPLALLLSPEdfldavrrl 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1571 KTLNQLQQAQITQgranstITQLTANITKIKKNVLQAENQTREMKSEL-ELAKQRSGLEDGLSLLQTKLQRHQDHAVNAK 1649
Cdd:COG4942 139 QYLKYLAPARREQ------AEELRADLAELAALRAELEAERAELEALLaELEEERAALEALKAERQKLLARLEKELAELA 212
|
250 260 270
....*....|....*....|....*....|....*...
gi 767947260 1650 VQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTK 1687
Cdd:COG4942 213 AELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
1420-1678 |
9.51e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 40.77 E-value: 9.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1420 QKAQE-AKSII-----RNLDKQVRGLKNQIESISEQAEvsknnalQLREKLgnirnqSDSEeeninlfiKKVKNFlleen 1493
Cdd:COG3206 148 ELAAAvANALAeayleQNLELRREEARKALEFLEEQLP-------ELRKEL------EEAE--------AALEEF----- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1494 vppedieKVANGVLDihLPIPSQNLTDELVKIQKhmQLcEDYRTDENRLNEEADGAQKLLVKAKAAEKAAN---ILLNLD 1570
Cdd:COG3206 202 -------RQKNGLVD--LSEEAKLLLQQLSELES--QL-AEARAELAEAEARLAALRAQLGSGPDALPELLqspVIQQLR 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1571 KTLNQLQQ--AQITQ--GRANSTITQLTANITKIKKNVLQAENQTR-EMKSELELAKQRsgledgLSLLQTKLQrhqdha 1645
Cdd:COG3206 270 AQLAELEAelAELSAryTPNHPDVIALRAQIAALRAQLQQEAQRILaSLEAELEALQAR------EASLQAQLA------ 337
|
250 260 270
....*....|....*....|....*....|...
gi 767947260 1646 vnakvQAESAQHQAGSLEKEFVELKKQYAILQR 1678
Cdd:COG3206 338 -----QLEARLAELPELEAELRRLEREVEVARE 365
|
|
| ClyA-like |
cd21116 |
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ... |
1416-1612 |
9.79e-03 |
|
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).
Pssm-ID: 439149 [Multi-domain] Cd Length: 224 Bit Score: 39.70 E-value: 9.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1416 TNALQKAQEAKSIIR----NLDKQVRGLKNQIES----ISEQAEV----SKNNALQLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:cd21116 40 ALARAHALEWLNEIKpkllSLPNDIIGYNNTFQSyypdLIELADNlikgDQGAKQQLLQGLEALQSQVTKKQTSVTSFIN 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947260 1484 KVKNFLLeenvppediekvangvldiHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKLLVkakaaekaa 1563
Cdd:cd21116 120 ELTTFKN-------------------DLDDDSRNLQTDATKAQAQVAVLNALKNQLNSLAEQIDAAIDALE--------- 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 767947260 1564 nillNLDKTLNQLQQ------AQITQGRANSTITQLTANITKIKKNVLQAENQTR 1612
Cdd:cd21116 172 ----KLSNDWQTLDSdikeliTDLEDAESSIDAAFLQADLKAAKADWNQLYEQAK 222
|
|
| |
