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Conserved domains on  [gi|767946822|ref|XP_011514099|]
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putative transporter SVOPL isoform X3 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 6-328 7.74e-155

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17442:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 375  Bit Score: 439.24  E-value: 7.74e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntra 85
Cdd:cd17442  110 LIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIP-------------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  86 alatlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSD 165
Cdd:cd17442  176 -----------------------------------------RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDPS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 SAVvvTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 245
Cdd:cd17442  215 DEE--AGIKHIESESPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGL 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 246 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF 325
Cdd:cd17442  293 TIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAF 372


                 ...
gi 767946822 326 TLP 328
Cdd:cd17442  373 TLP 375
 
Name Accession Description Interval E-value
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 6-328 7.74e-155

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 439.24  E-value: 7.74e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntra 85
Cdd:cd17442  110 LIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIP-------------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  86 alatlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSD 165
Cdd:cd17442  176 -----------------------------------------RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDPS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 SAVvvTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 245
Cdd:cd17442  215 DEE--AGIKHIESESPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGL 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 246 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF 325
Cdd:cd17442  293 TIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAF 372


                 ...
gi 767946822 326 TLP 328
Cdd:cd17442  373 TLP 375
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 6-336 1.11e-51

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 178.29  E-value: 1.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822    6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAsVIIPtiGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRA 85
Cdd:TIGR00898 202 VVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVA-YFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEE 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   86 ALATLERVAKMNRSVMPEGKLVEPVLE------KRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELlerdl 158
Cdd:TIGR00898 279 ALKILQRIAKINGKKLPAEVLSLSLEKdlssskKQYSFLDLFRTPNLRkTTLCLMMLWFTTAFSYYGLVLDLGNL----- 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  159 vcgsksdsavvvtGGdsgesqspcychmfapSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI 238
Cdd:TIGR00898 354 -------------GG----------------NIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLF 404

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  239 CTSSAG--LIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQvLMSASILGALCLFSSV 316
Cdd:TIGR00898 405 VPVDLYflRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY-LGEKWLFLPLVLFGGL 483

                         330       340
                  ....*....|....*....|
gi 767946822  317 CVVCAISAFTLPiETKGRAL 336
Cdd:TIGR00898 484 ALLAGILTLFLP-ETKGVPL 502
Sugar_tr pfam00083
Sugar (and other) transporter;
11-339 3.90e-12

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 66.91  E-value: 3.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   11 EFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVII-PTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGN---TR 84
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLayIFGLGLNKTsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRleeAR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   85 AALATLERVAKMNRSVMPEG-KLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGI-------SFAYYG-VILASAELle 155
Cdd:pfam00083 209 EVLAKLRGVPDVDRELDEIKdSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqqltginAIFYYStTIFENLGL-- 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  156 rdlvcgSKSDSAVVVTGGdsgesqspcychmfapsdyrTMIISTIGEIALnplnilgINFLGRRLSLSITMGCTALFFLL 235
Cdd:pfam00083 287 ------SDSFLVTIIVGV--------------------VNFVFTFIAIFL-------VDRFGRRPLLLLGAAGMAICFVI 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  236 LNICT---------SSAGLIGFLFMLRALVAANFNTV-YIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA- 304
Cdd:pfam00083 334 LGIVAllgvsksdwAGIVAIVFIALFIAFFAMGWGPVpWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAi 413

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 767946822  305 SILGALCLFSSVCVVCAISAFTLPIETKGRALQQI 339
Cdd:pfam00083 414 GLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEI 448
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
217-332 5.38e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 217 GRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPF 296
Cdd:COG2271  246 RRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL 325

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767946822 297 ISQVLMSA-SILGALCLFSSVCVVCAISAFTLPIETK 332
Cdd:COG2271  326 LVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETR 362
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 216-327 1.09e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 216 LGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAP 295
Cdd:PRK11551 282 LRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGP 361

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767946822 296 FISQVLMSASILGALCLFSS--VCVVCAISAFTL 327
Cdd:PRK11551 362 LLAGQLLALGRSTVGVIGASipVILVAALAALLL 395
 
Name Accession Description Interval E-value
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 6-328 7.74e-155

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 439.24  E-value: 7.74e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntra 85
Cdd:cd17442  110 LIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIP-------------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  86 alatlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSD 165
Cdd:cd17442  176 -----------------------------------------RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDPS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 SAVvvTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 245
Cdd:cd17442  215 DEE--AGIKHIESESPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGL 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 246 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF 325
Cdd:cd17442  293 TIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAF 372


                 ...
gi 767946822 326 TLP 328
Cdd:cd17442  373 TLP 375
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 6-327 3.40e-124

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 361.08  E-value: 3.40e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntra 85
Cdd:cd17372  108 ASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTP-------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  86 alatlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSD 165
Cdd:cd17372  174 -----------------------------------------KTTLLLWVIWFGNAFAYYGVVLLTTELNNSHNVCGSKSD 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 SavvvtggDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 245
Cdd:cd17372  213 S-------DSGESPTEKQCRNSNDVDYRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFIL 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 246 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF 325
Cdd:cd17372  286 TVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIALLLFSVVCLVSAICVC 365


                 ..
gi 767946822 326 TL 327
Cdd:cd17372  366 LL 367
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 6-336 1.11e-51

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 178.29  E-value: 1.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822    6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAsVIIPtiGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRA 85
Cdd:TIGR00898 202 VVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVA-YFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEE 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   86 ALATLERVAKMNRSVMPEGKLVEPVLE------KRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELlerdl 158
Cdd:TIGR00898 279 ALKILQRIAKINGKKLPAEVLSLSLEKdlssskKQYSFLDLFRTPNLRkTTLCLMMLWFTTAFSYYGLVLDLGNL----- 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  159 vcgsksdsavvvtGGdsgesqspcychmfapSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI 238
Cdd:TIGR00898 354 -------------GG----------------NIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLF 404

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  239 CTSSAG--LIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQvLMSASILGALCLFSSV 316
Cdd:TIGR00898 405 VPVDLYflRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY-LGEKWLFLPLVLFGGL 483

                         330       340
                  ....*....|....*....|
gi 767946822  317 CVVCAISAFTLPiETKGRAL 336
Cdd:TIGR00898 484 ALLAGILTLFLP-ETKGVPL 502
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 11-328 1.69e-47

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 164.22  E-value: 1.69e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  11 EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFnvstgntraalatl 90
Cdd:cd17441  113 EFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARY-------------- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  91 ervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVvv 170
Cdd:cd17441  179 ------------------------------------WTTILLWFIWFSNAFSYYGLVLLTTELFQAGDVCSGSSGKKV-- 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 171 tggdsgESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLF 250
Cdd:cd17441  221 ------EGKCSLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVLLF 294

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946822 251 MLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 328
Cdd:cd17441  295 IARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 10-332 1.25e-21

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 95.25  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVASIPGIILIVAFKFIPESARF 76
Cdd:cd17363  113 AEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGWgfsmgtayqfhswRVFVIVCALPSVASVVALTFMPESPRF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  77 NVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLE-KRgrfadlldakylRTTLQIWVIWLGISFAYYGV--------- 146
Cdd:cd17363  193 LLEVGKHDEAWMILKQVHDTNMRAKGHPERVFTVSHiKR------------MNTLFLAIVWFTMSFSYYGLtvwfpdmik 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 147 ---------------------------ILASAELLERDLVCGSKSDSAVVvtgGDSGESQSPCYCHMF--APSDYRTMII 197
Cdd:cd17363  261 ylqfedslfeecyfedvtstntffencTFINTVFYNTDLFEYKFIDSRFL---NSTFFLKEKCGCHLNddEENAYLIYLV 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 198 STIGEIALNPLNILGINFLGR--RLSL---SITMGCTALFFLLLniCTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYP 272
Cdd:cd17363  338 SFLGSLSVLPGNIVSALLMDKigRLKMiggSMLLSAVCCFFLFF--GNSESAMIGLQCLFCGVSIAAWNALDVVTVELYP 415

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 273 TTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETK 332
Cdd:cd17363  416 TDKRATAFGFLNGLCKLAAILGNSIFGSFVGITKVIPILLASAALVCGGLLALKLP-ETR 474
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 7-328 4.40e-20

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 89.18  E-value: 4.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   7 IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPtigWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraa 86
Cdd:cd17317  101 VLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLWWLP--------------- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  87 latlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksds 166
Cdd:cd17317  163 ----------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNL------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 167 avvvtGGDsgesqspcychmfapsDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI---CTSSA 243
Cdd:cd17317  190 -----GGN----------------LYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALlpdDENTL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 244 GLIgFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISqVLMSASILGALCLFSSVCVVCAIS 323
Cdd:cd17317  249 ALT-LALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIV-LLGKIGPLLPLIIFGVLALLGGLL 326


                 ....*
gi 767946822 324 AFTLP 328
Cdd:cd17317  327 TLLLP 331
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 11-302 1.67e-16

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 79.71  E-value: 1.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   11 EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASI-PGIILIVAFKFIPESARFNVSTGNTRAALAT 89
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDFLVSKRPETVRRIV 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   90 LERVAKMNR---SVMPEGKLVEPVleKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIlASAELLERDLvCGSKSDS 166
Cdd:TIGR00895 212 NAIAPQMQAeaqSALPEQKSTQGT--KRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLT-NWLPKLMVEL-GFSLSLA 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  167 AVVVTGGDSGesqspcychmfapsdyrtMIISTIGEIALnplnilgINFLGRRLSLSITMGCTALFFLLLNICTSSAGLI 246
Cdd:TIGR00895 288 ATGGALFNFG------------------GVIGSIIFGWL-------ADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLL 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767946822  247 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLM 302
Cdd:TIGR00895 343 LLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 10-337 1.68e-15

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 77.32  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVASIPGIILIVAFKFIPESARF 76
Cdd:TIGR01299 281 AEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWsfqmgsayqfhswRVFVIVCAFPCVFAIGALTFMPESPRF 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   77 NVSTGNTRAALATLERVAKMN----------------RSVMPEGKLVE-----PVLEKR-------------GRFADLLD 122
Cdd:TIGR01299 361 FLENGKHDEAWMILKLIHDTNmrakghpekvfsvnhiKTIHQEDELIEiesdtGTWYQRcfvralsegggiwGNFLRCFN 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  123 AKYLRTTLQIWVIWLGISFAYYGVI---------LASAEL--------------------LERDLVCGSKSDSAVV---- 169
Cdd:TIGR01299 441 PEVREITIKLMGVWFTLSFGYYGLSvwfpdmikhLQADDYaaltknfpgdkvahfsfnftLENQIHRGGEYDNDKFiglk 520

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  170 ---VTGGDS---------------------------------------GESQSPCYCH-------MFAPSDYRTMII--- 197
Cdd:TIGR01299 521 fksVSFEDSlfeectfddvtssntffknctfidtlfentdfeeykfidSEFQNCSFLHnkegcpiDFDGDDEGAYMIyfv 600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  198 STIGEIALNPLNILGINFLGR--RLSL---SITMGCTALFFLLLNicTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYP 272
Cdd:TIGR01299 601 NFLGTLAVLPGNIVSALLMDKigRLRMlagSMVLSCISCFFLSFG--NSESAMIALLCLFGGLSIAAWNALDVLTVELYP 678

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767946822  273 TTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETKGRALQ 337
Cdd:TIGR01299 679 SDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLP-DTRGQVLM 742
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 10-327 2.04e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 76.10  E-value: 2.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTI----GWRWLIRVASIPGIILIVAFkfipesarfnvstgntra 85
Cdd:cd17316  115 AEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLLR------------------ 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  86 alatlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLerdlvcgsksd 165
Cdd:cd17316  177 -----------------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYL----------- 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 saVVVTGGDSGESqspcychmfapsdYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALF--FLLLNICTSSA 243
Cdd:cd17316  205 --QTVLGLSPATS-------------SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILalPLFYLLSGSPT 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 244 GLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAIS 323
Cdd:cd17316  270 LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349


                 ....
gi 767946822 324 AFTL 327
Cdd:cd17316  350 IVAL 353
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 10-332 7.41e-15

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 74.96  E-value: 7.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVASIPGIILIVAFKFIPESARF 76
Cdd:cd17438  113 SEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWgfsmgtnyhfhswRVFVIICALPCIASIIALKFMPESPRF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  77 NVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLE-KRgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLE 155
Cdd:cd17438  193 LLEMGKHDEAWMILKNIHDTNMRAKGTPEKVFTVSNiKR------------KNTLFLAVVWFTMAFSYYGLTVWFPDMIR 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 156 RDLVCGSKSDSAVV------VTGGDS--------------------------------GESQSPCYCHMFAPSDYRTMII 197
Cdd:cd17438  261 YLQKHVTFEDSLFDecyfedVTSTDTyfknctiestifyntdlyehkfidcrfinstfLEQKEGCHMDFEEDNDFLIYLV 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 198 STIGEIALNPLNILGINFLGR--RLSL---SITMGCTALFFLLLNicTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYP 272
Cdd:cd17438  341 SFLGSLSVLPGNIISALLMDKigRIKMiggSMLISAVCCFFLFFG--NSESAMIGWQCLFCGTSIAAWNALDVITVELYP 418

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 273 TTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETK 332
Cdd:cd17438  419 TNKRATAFGILNGLCKFAAILGNSIFASFVGITKVIPILLASTALVGGGLISLRLP-ETR 477
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 10-332 7.94e-14

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 71.98  E-value: 7.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVASIPGIILIVAFKFIPESARF 76
Cdd:cd17439  113 SEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWsfqmgsayqfhswRVFVLVCAFPSVFAIGALTTMPESPRF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  77 NVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLE-KRgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLE 155
Cdd:cd17439  193 FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHiKR------------RITLMMMAVWFTMSFSYYGLTVWFPDMIK 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 156 RDLVCGSKSDSAVV------VTGGDSGESQSPCYCHMFAPSD---------------------------------YRTMI 196
Cdd:cd17439  261 HLQKSVVFEDSLFEecyfedITSSNTFFKNCTFISTLFYNTDlfeykfinsklinstflhnkegclldfsdennaYMIYF 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 197 ISTIGEIALNPLNILGINFLG-----RRLSLSITMGCTALFFLLLNicTSSAGLIGFLFMLRALVAANFNTVYIYTAEVY 271
Cdd:cd17439  341 VSFLGTLAVLPGNIVSALLMDkigrlRMLAGSSVMSCVSCFFLSFG--NSESAMIALLCLFGGVSIASWNALDVLTVELY 418

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767946822 272 PTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETK 332
Cdd:cd17439  419 PSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAVPILLASAALAAGSSLALKLP-ETR 478
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 10-328 1.27e-13

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 71.48  E-value: 1.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFKFIPESARF 76
Cdd:cd17440  113 AEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsayqfhsWRVFVIVCALPCVSSVVALTFMPESPRF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  77 NVSTGNTRAALATLERVAKMNrsvmpegklvepvLEKRGRFADLLDAKYL--RTTLQIWVIWLGISFAYYGV-------- 146
Cdd:cd17440  193 LLEVGKHDEAWMILKQIHDTN-------------MRARGQPEKVFTVNRIkkDNTIKLTIVWLTLSFGYYGLsvwfpdvi 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 147 ---------------------------------ILASAELLERDLVCGSKSDSAVVvtggDSGESQSPCYCHMFAPSDYR 193
Cdd:cd17440  260 khlqfksvtfedslfkscffedvtsvntyfrncTFIETVFYNTDLEDYKFIDSDFI----NCTFFHNKTGCQITFDDDYS 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 194 T---MIISTIGEIALNPLNI---LGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYT 267
Cdd:cd17440  336 AywiYFVNFLGTLAVLPGNIvsaLLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVT 415

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767946822 268 AEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 328
Cdd:cd17440  416 VELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVGITKAIPILLASTVLVCGGLVGLRLP 476
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 6-328 3.42e-13

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 69.63  E-value: 3.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIptiGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntra 85
Cdd:cd17374  110 LILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIR---DWRLLQLVVSVPFFLFFLYSWWLP-------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  86 alatlervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILaSAELLERDLvcgsksd 165
Cdd:cd17374  173 -----------------------------------------KRTLILSFVWFANSFSYYGLSL-DLQHLGLNV------- 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 savvvtggdsgesqspcychmfapsdYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLN-ICTSSAG 244
Cdd:cd17374  204 --------------------------FLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIfVPQEMQT 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 245 LIGFLFMLR-ALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIsQVLMSASILGALCLFSSVCVVCAIS 323
Cdd:cd17374  258 LRTVLAVLGkGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLI-MLLGVYSPLLPMIIYGVLPILAGLL 336


                 ....*
gi 767946822 324 AFTLP 328
Cdd:cd17374  337 ALLLP 341
Sugar_tr pfam00083
Sugar (and other) transporter;
11-339 3.90e-12

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 66.91  E-value: 3.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   11 EFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVII-PTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGN---TR 84
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLayIFGLGLNKTsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRleeAR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   85 AALATLERVAKMNRSVMPEG-KLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGI-------SFAYYG-VILASAELle 155
Cdd:pfam00083 209 EVLAKLRGVPDVDRELDEIKdSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqqltginAIFYYStTIFENLGL-- 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  156 rdlvcgSKSDSAVVVTGGdsgesqspcychmfapsdyrTMIISTIGEIALnplnilgINFLGRRLSLSITMGCTALFFLL 235
Cdd:pfam00083 287 ------SDSFLVTIIVGV--------------------VNFVFTFIAIFL-------VDRFGRRPLLLLGAAGMAICFVI 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  236 LNICT---------SSAGLIGFLFMLRALVAANFNTV-YIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA- 304
Cdd:pfam00083 334 LGIVAllgvsksdwAGIVAIVFIALFIAFFAMGWGPVpWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAi 413

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 767946822  305 SILGALCLFSSVCVVCAISAFTLPIETKGRALQQI 339
Cdd:pfam00083 414 GLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEI 448
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 127-297 1.41e-11

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 64.80  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 127 RTTLQIWvIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtGGDSgesqspcychmfapsdYRTMIISTIGEIALN 206
Cdd:cd17377  178 RTLILMY-VWFVCSLVYYGLTLNAGDL------------------GGNI----------------YLNLALSGLVELPAY 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 207 PLNILGIN--FLGRRLSLS--ITMGCTALFFLLLNICTSSAGLIGFL------FMLRALVAANFNTVYIYTAEVYPTTMR 276
Cdd:cd17377  223 PLCIYLINqkWSGRRRTLAgfLFLGGIACLLVMFVPEKKDSGVFAVVnstslsLLGKLTISAAFNIVYIYTSELYPTVVR 302

                        170       180
                 ....*....|....*....|.
gi 767946822 277 ALGMGTSGSLCRIGAMVAPFI 297
Cdd:cd17377  303 NAGLGVCSMFSRVGGIIAPFI 323
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 11-328 5.27e-11

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 62.83  E-value: 5.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  11 EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPtigWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatl 90
Cdd:cd17447  115 EWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRD---WRWLILAVTLPCAPGIITWWWVP------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  91 ervakmnrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILAsaellerdlvcgsksdsavvV 170
Cdd:cd17447  173 ------------------------------------KISLCTGIVWFGVAFTYYGISFN--------------------I 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 171 TGgdsgesqspcychmFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLI--GF 248
Cdd:cd17447  197 SG--------------FGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVrtVI 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 249 LFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISqVLMSASILGALCLFSSVCVVCAISAFTLP 328
Cdd:cd17447  263 AVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVI-LLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 11-339 1.08e-10

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 62.36  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   11 EFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIP-TIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAA- 86
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITFGILVayGFGSGKVSLNnTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEAr 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   87 --LATLERVAKMNRSVMPEGKLVEP--VLEKRGRFADLLDAKYLRTTLqIWVIWLGI------------SFAYYG-VILA 149
Cdd:TIGR00879 234 ksLARLRGTSGEDKELLDELELIDIkrSIEKRSVQPSWGSLFSSTRRI-RRRLFLGVvlqwfqqftginAIMYYSpTIFE 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  150 SAellerdlvcGSKSDSAVVVTGGdsgesqspCYCHMFAPSDYRTMIISTIGEialNPLNILGinFLGRRLSLSITMGCT 229
Cdd:TIGR00879 313 NA---------GVSTDHAFLVSII--------VGAVNFAFTFVAIFLVDRFGR---RPLLLIG--AAGMAICLFVLGILG 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  230 alFFLLLNICTSSAGLIGFLFMlraLVAANFNT-----VYIYTAEVYPTTMRALGMgtsgSLCRIGAMVAPFISQVL--- 301
Cdd:TIGR00879 371 --ASFVTGSSKSSGNVAIVFIL---LFIAFFAMgwgpvPWVIVSEIFPLSLRPKGI----SIAVAANWLANFIVGFLfpt 441

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 767946822  302 MSASILGALC--LFSSVCVVCAISAFTLPIETKGRALQQI 339
Cdd:TIGR00879 442 MLESIGVGGVfiFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 11-328 1.37e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 61.93  E-value: 1.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  11 EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIP----TIGWRWLIRVASIPGIILIVAFKFIPESARFNVStgntRAA 86
Cdd:cd17371  114 EYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAA----RAA 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  87 LATLERVAKmnrsvmpegklvepvlekrgrFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELL--ERDLVCGSKS 164
Cdd:cd17371  190 RRHFADRPS---------------------LRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLtgERGLSFEGSA 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 165 DSAVVVtggdsgesqspcYCHMFapsdyrtmiistIGEIALNPLNILginfLGRRLSLSITMGCTALFFLLLNICTSSAG 244
Cdd:cd17371  249 GYLVVT------------ILGGF------------LGYLAGGFLADR----IGRRNNFALFALGSAISILLYFFLPLSPT 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 245 LIGFL-FMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILG--ALCLFSSVCVVCA 321
Cdd:cd17371  301 LILILgFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGtaIAVFAAVYYIAGL 380


                 ....*..
gi 767946822 322 ISAFTLP 328
Cdd:cd17371  381 VLALLLP 387
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 125-319 4.16e-09

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 57.04  E-value: 4.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 125 YLRTTLQIWVIWLGISFAYYGvilasaelLERDLvcgsksdsavvvtggdsgesqspcycHMFAPSDYRTMIISTIGEIA 204
Cdd:cd17446  169 FPRITFCLSLVWFSTSFAYYG--------LAMDL--------------------------QKFGVSIYLIQIIFGAVDIP 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 205 LNPLNILGINFLGRRLSLSITMGCTALFFLL-------LNICTSSAGLIGflfmlRALVAANFNTVYIYTAEVYPTTMRA 277
Cdd:cd17446  215 AKFISTLTMSYLGRRPTQAAALILAGIMILAnifvpqdLQTVRTALAVFG-----KGCLAASFNCVYLYTGELYPTVIRQ 289

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767946822 278 LGMGTSGSLCRIGAMVAPFIS-----QVLMSASILGALCLFSSVCVV 319
Cdd:cd17446  290 TGMGLGSTMARLGGIVAPLVKmlgeyYPFLPLIIYGAAPILSGIAAC 336
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 211-296 1.49e-08

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 55.53  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 211 LGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFML--RALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCR 288
Cdd:cd17375  223 IGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMtgKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCR 302


                 ....*...
gi 767946822 289 IGAMVAPF 296
Cdd:cd17375  303 VGSVVAPF 310
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 127-297 2.51e-08

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 54.78  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 127 RTTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtggdSGESQSPCYchmfapsdyrtmiISTIGEIALN 206
Cdd:cd17376  174 ITTIMSLLLWMAISVGYFGLSLNTPNL---------------------HGDPYLNCF-------------LSAVIEVPAY 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 207 PLNILGINFLGRRLSLSITM--GCTALFFLLLnICTSSAGLIGFLFMLRAL-VAANFNTVYIYTAEVYPTTMRALGMGTS 283
Cdd:cd17376  220 IIAWLLLRSLPRRYSIAATLvlGGGVLLFIQL-VPTDLQVLATALVMLGKFgITAAFSMVYVYTAELYPTVVRNMGVGVC 298

                        170
                 ....*....|....
gi 767946822 284 GSLCRIGAMVAPFI 297
Cdd:cd17376  299 STASRIGSIISPYF 312
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 10-334 2.96e-08

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 54.96  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVST-GNTRAA 86
Cdd:cd17357  131 QEISPSELRGALGSLTQIGVTLGILLgqVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDEEEA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  87 LATLER---VAKMNRSVMPEGKL--VEPVLEKRGRFADLL-DAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLvc 160
Cdd:cd17357  211 EKSLKFlrgIEDDVDQELEEIKKesEQMGDQKQVSLMQLLrDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENA-- 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 161 GSKSDSAVVVTGGdsgesqspcychmfapsdyrTMIISTIGEIalnpLNILGINFLGRRLSLSITMGCTALFFLLLNICT 240
Cdd:cd17357  289 GFSPQLAEWANLG--------------------IGIVNVLSTI----VGPFLIEKVGRRPLLLISLSVCAVALLLMSVFL 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 241 S--------SAGLIGFLFMLRALVAANFNTV-YIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALC 311
Cdd:cd17357  345 FlseqnswmSYGCIVAIFLFIFFFAIGLGPIpWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFI 424

                        330       340
                 ....*....|....*....|...
gi 767946822 312 LFSSVCVVCAISAFTLPIETKGR 334
Cdd:cd17357  425 IFAIPCALFLLYLYRYLPETKGR 447
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 216-328 8.26e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 53.36  E-value: 8.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 216 LGRRLSLSITMGCTALF-FLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVA 294
Cdd:cd17365  233 FGPKRVLALFFALGAVSlALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILG 312

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767946822 295 PFISQVLMSA--SILGALCLFSSVCVVCAISAFTLP 328
Cdd:cd17365  313 PLLGGLLLAAglGPESVFLALAIPAALGALAVLLLR 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
217-332 5.38e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 217 GRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPF 296
Cdd:COG2271  246 RRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL 325

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767946822 297 ISQVLMSA-SILGALCLFSSVCVVCAISAFTLPIETK 332
Cdd:COG2271  326 LVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 192-328 1.87e-06

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 48.89  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 192 YRTMIISTIGEIALNPLNILGINFLGRRLSLSIT-----MGCTALFFL-----LLNICTSSAGLIGflfmlralVAANFN 261
Cdd:cd17379  202 YLDFFISALVELPAAFIILLTIDRIGRRLPFAASnivagAACLITAFIppdlhWLKTTIACVGRLG--------ITMAFE 273

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767946822 262 TVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 328
Cdd:cd17379  274 IVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYRLAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 10-338 5.80e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.57  E-value: 5.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIiptiGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALAT 89
Cdd:cd17358  120 AEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKS 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  90 LERVAKMNRSVMPEGKLVEPVLE------KRGRFADLLDAKYLRTTlqiwVIWLGISFAY-----YGVILASAELLERDL 158
Cdd:cd17358  196 LQFLRGKDADISKEAAEIQEELAelekeaKESSFSDLFQRKYLKPL----VIGLGLMLFQqlsgiNAVIFYASSIFDEAG 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 159 VCGSKSDSAVVVtggdsGESQSPCYCHMFAPSDY----RTMIISTIGeIALNPLNILGINFLGRRLSLSITMGCTALFFL 234
Cdd:cd17358  272 SGLDPNTATIII-----GVVQVVGTLVATLLVDRlgrrPLLLVSAIG-MGIGLLALGLYFYLQEHGALLSSVSWLPLVGL 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 235 LLNICTSSAGLIGFLFMLralvaanfntvyiyTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA-SILGALCLF 313
Cdd:cd17358  346 VIYIISFSIGLGPLPWVI--------------MSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAwGASGTFWIF 411

                        330       340
                 ....*....|....*....|....*.
gi 767946822 314 SSVCVVCAI-SAFTLPiETKGRALQQ 338
Cdd:cd17358  412 AGICGLALVfVLLFVP-ETKGKSLEE 436
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 10-73 1.38e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 43.33  E-value: 1.38e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPES 73
Cdd:cd17315  113 SEIAPAKIRGALGTLNQLMITFGILLayLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES 178
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-294 4.58e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII-LIVAFKFIPESARFnvstgntraala 88
Cdd:COG2814  124 ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPA------------ 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  89 tlervakmnrsvmpegklvepvlEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERdlVCGSKSDSAV 168
Cdd:COG2814  192 -----------------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE--VLGLSASAAG 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 169 VVtggdsgesqspcychmfapsdyrtMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGF 248
Cdd:COG2814  247 LL------------------------LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767946822 249 LFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVA 294
Cdd:COG2814  303 LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 10-75 6.87e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 41.10  E-value: 6.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPtIGWRWLIRVASIPGIILIVAFKFIPESAR 75
Cdd:cd17360  114 AEAAPPRIRGRLVTINVLFITGGQFVayVINGAFSYLP-GGWRWMLGLAAVPAVLQFIGLLFLPESPR 180
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
216-325 7.15e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 7.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 216 LGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAP 295
Cdd:COG2271   72 FGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAP 151

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767946822 296 FISQVLMSAS-------ILGALCLFSSVCVVCAISAF 325
Cdd:COG2271  152 PLLGWLLAAFgwraaflILGLPGLLLALLRFWLLALA 188
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 10-124 9.36e-04

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 40.59  E-value: 9.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAsVIIPtigWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALAT 89
Cdd:cd17434  120 SEISHPGVRGALGACPQIMAVFGSLALYALG-LLLP---WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKA 195

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767946822  90 LERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAK 124
Cdd:cd17434  196 LAWLRGPNTDYMTEFEQIKDNIRKQSSRLSWAELK 230
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 216-327 1.09e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 216 LGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAP 295
Cdd:PRK11551 282 LRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGP 361

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767946822 296 FISQVLMSASILGALCLFSS--VCVVCAISAFTL 327
Cdd:PRK11551 362 LLAGQLLALGRSTVGVIGASipVILVAALAALLL 395
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 125-328 1.30e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 40.03  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 125 YLRTTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtggdsgesqspcychmfAPSDYRTMIISTIGEIA 204
Cdd:cd17378  171 FARRLLAVMVIGFGIGMVYYGIPLAVGNL----------------------------------KFNIYLSVALNALSELP 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 205 LNPLNILGINFLGRRLSLSITM-----GCTALFFLLLNICTSSA---GLIGFLFMlralvAANFNTVYIYTAEVYPTTMR 276
Cdd:cd17378  217 AFVITAFLLDRFGRRPSLLGFTllsgaSCLLCFVLSIGGTTSLQialELVGFFGA-----AGAFNLLYIYTVELFPTCVR 291

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767946822 277 --ALGMGTSGSlcRIGAMVAPFISQVLMSASILgALCLFSSVCVVCAISAFTLP 328
Cdd:cd17378  292 naALGMLRQAL--VVGGIFAPFIVSLGRKNAAL-SFGVFGVAILLLGLFALGLP 342
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 10-73 1.32e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 40.31  E-value: 1.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPES 73
Cdd:cd17361  130 SEMAPAKLRGALNIGFQLAITIGILIanLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPET 195
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 7-339 1.63e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 40.10  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822    7 IIKTEFLPTKYRGYMLplSQVF------WLAGSLLII-----------------GLASVIIPTIG--WRWLIRVASIPGI 61
Cdd:TIGR00887 138 IITSEFATKKWRGAMM--AAVFamqgfgILAGAIVALivlagfkhsleaaadeaSCTGSCVPAVDymWRILIGFGAVPAL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   62 ILIVAFKFIPESARFNVSTG-NTRAALATLERVAKMNRSVMPE-----GKLVE-PVLEKRGRFADLLDAKYLRTTLQIWV 134
Cdd:TIGR00887 216 LALYFRLTIPETPRYTADVAkDVEQAASDMSAVLQVKIEAEPDevekaSTAVEvPKASWSDFFTHFFKWRHGKHLLGTAG 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  135 IWLGISFAYYGVILASAELLerdlvcgsksdSAVvvtgGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGIN 214
Cdd:TIGR00887 296 SWFLLDIAFYGVNLNQKVIL-----------SAI----GYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVD 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  215 FLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLR-ALVAANFN---TVYIYTAEVYPTTMRALGMGTSGSLCRIG 290
Cdd:TIGR00887 361 IIGRKPIQLMGFFILTVLFFVLGFAYNHLSTHGFLAIYVlAQFFANFGpnaTTFIVPGEVFPTRYRSTAHGISAASGKAG 440

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767946822  291 AMVAPFISQVLMSAS--------------ILGALCLFSSVCVVCaisAFTLPiETKGRALQQI 339
Cdd:TIGR00887 441 AIIGQFGFLYLAQHGdptkgyptgiwmghVLEIFALFMFLGILF---TLLIP-ETKGKSLEEL 499
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 10-83 1.93e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 39.86  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  10 TEFLPTKYRGYMLPLSQVFWLAGSLL------IIGLASVIIPTI--GWRWLIRVASIPGIILIVAFKFIPESARFNVSTG 81
Cdd:cd17359  115 AEVAPAEIRGRLVSLNQLMIVFGQLLayivnyLIANAGGADWLGaeGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG 194


                 ..
gi 767946822  82 NT 83
Cdd:cd17359  195 KP 196
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 263-339 1.99e-03

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 39.69  E-value: 1.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767946822 263 VYIYTAEVYPTTMRALGMGTSGSLCRI--GAMVAPFISqVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQI 339
Cdd:cd17437  310 TWVYSSEIFPLRLRAQGASLGVVVNRLmsGTVSMTFLS-MSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
217-335 2.75e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.09  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 217 GRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPF 296
Cdd:COG2223  270 GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPL 349

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767946822 297 ISQVLMSA--SILGALCLFSSVCVVCAISAFTLPIETKGRA 335
Cdd:COG2223  350 LFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 6-325 2.75e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.33  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822   6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVII--PTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNT 83
Cdd:cd06174  106 LALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNE 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  84 RAALATLervakmnrsvmpegklvepvlekrgrFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSK 163
Cdd:cd06174  186 EASSKSV--------------------------LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 164 SDSAVvvtggdsgesqspcychmfapsdyrtMIISTIGEIALNPL-NILGINFLGRRLSLSITMGCTALFFLLLNICTSS 242
Cdd:cd06174  240 VAGLL--------------------------LSLFGLAGALGSLLlGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 243 AGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI-LGALCLFSSVCVVCA 321
Cdd:cd06174  294 LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLA 373


                 ....
gi 767946822 322 ISAF 325
Cdd:cd06174  374 AILL 377
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 11-339 3.16e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 39.16  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  11 EFLPTKYRGYMLPLSQVFWLAGSLLIIGL---ASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFnvstgntraal 87
Cdd:cd17356  126 EVAPKHIRGTLVSLYQLAITIGILVAYCInygTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRW----------- 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  88 atLERVakmnrsvmpegklvepvlekrgrfadlldakYLRTTLQIWVIWLGISFA-YYGV-ILASAELLERDlvcgsksd 165
Cdd:cd17356  195 --LYRT-------------------------------ILGIMLQLFQQLTGINYFfYYGTtIFQSTGLTGSS-------- 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 166 savvvtggdsgesqspcychmfapsDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICT----- 240
Cdd:cd17356  234 -------------------------PLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLFIYAAVGvryli 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 241 -----------SSAGLIGFLFMLRALVAANFN-TVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILG 308
Cdd:cd17356  289 pnpqsgtsnksAGNGMIVFICLFIFSFATTWGpIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGFK 368

                        330       340       350
                 ....*....|....*....|....*....|.
gi 767946822 309 ALCLFSSVCVVCAISAFTLPIETKGRALQQI 339
Cdd:cd17356  369 YYYIFAGCNLLAFIVVFFFVPETKGLTLEEI 399
xylE PRK10077
D-xylose transporter XylE; Provisional
 11-93 3.24e-03

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 39.29  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  11 EFLPTKYRGYMLPLSQVFWLAGSLLII--------GLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGN 82
Cdd:PRK10077 147 EIAPAHIRGKLVSFNQFAIIFGQLVVYfvnyfiarSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGK 226

                         90
                 ....*....|.
gi 767946822  83 TRAALATLERV 93
Cdd:PRK10077 227 QEQAEGILRKI 237
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 213-328 6.44e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 213 INFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAM 292
Cdd:cd17473  257 KRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQF 336

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767946822 293 VAPFISQVLMSA--SILGALCLFSSVCVVCAISAFTLP 328
Cdd:cd17473  337 LSPLVLGPLVNLtgGLSGAFLILGVLALVLAIVLLLLR 374
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 217-326 7.78e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 37.89  E-value: 7.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822 217 GRRLSLSITMGCTAL----FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTS---GSLcrI 289
Cdd:cd17369  292 GRRPVYLAGALLAALfafpFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGyqlGAI--L 369

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767946822 290 GAMVAPFISQVLMSA--SILGALCLFSSVCVVCAISAFT 326
Cdd:cd17369  370 GGGFAPLIATALVAAtgSWWPVALYLAALAVISLVAALF 408
MFS_1 pfam07690
Major Facilitator Superfamily;
216-325 9.16e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 37.40  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946822  216 LGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAP 295
Cdd:pfam07690  59 FGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP 138

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767946822  296 FISQVLMSA-SILGALCLFSSVCVVCAISAF 325
Cdd:pfam07690 139 LLGGLLASLfGWRAAFLILAILSLLAAVLLL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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