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Conserved domains on  [gi|767946779|ref|XP_011514081|]
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probable 18S rRNA (guanine-N(7))-methyltransferase isoform X3 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 42-184 4.13e-18

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  42 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG2226   13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946779 118 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 184
Cdd:COG2226   90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 42-184 4.13e-18

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  42 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG2226   13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946779 118 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 184
Cdd:COG2226   90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-156 1.09e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.59  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779   58 LDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnan 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|....
gi 767946779  133 kksenPAKRLYCFFASLFSVLVRG 156
Cdd:pfam13649  77 -----PDPDLEAALREIARVLKPG 95
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 34-130 1.10e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.55  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  34 DIQTRMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMgQGIPFKP 113
Cdd:PRK10258  25 ELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLAT 101

                         90
                 ....*....|....*..
gi 767946779 114 GTFDGCISISAVQWlCN 130
Cdd:PRK10258 102 ATFDLAWSNLAVQW-CG 117
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 35-153 1.81e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 59.22  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779   35 IQTRMAGRALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEGHY--WVGLDISPAMLDEAVDREIEGDL-LLGDMGQgIP 110
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767946779  111 FKPGTFDGCISISAVQWLCNANKksenpakrlycFFASLFSVL 153
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-164 2.09e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  57 LLDIGCGTGLSGSYL-SDEGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKPGTFDGCISISAVQWLcn 130
Cdd:cd02440    2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767946779 131 ankksenpAKRLYCFFASLFSVLVRGSRAVLQLY 164
Cdd:cd02440   80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 42-184 4.13e-18

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  42 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG2226   13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946779 118 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 184
Cdd:COG2226   90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-118 2.80e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 71.57  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  38 RMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG4976   33 LLAEELLARL--PPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLAD-LAEPDGRFD 109


                 .
gi 767946779 118 G 118
Cdd:COG4976  110 L 110
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-156 1.09e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.59  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779   58 LDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnan 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|....
gi 767946779  133 kksenPAKRLYCFFASLFSVLVRG 156
Cdd:pfam13649  77 -----PDPDLEAALREIARVLKPG 95
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-161 2.88e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 63.84  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779   58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDL--LLGDMGQgIPFKPGTFDGCISISAVQWLcnankks 135
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLtfVVGDAED-LPFPDNSFDLVLSSEVLHHV------- 72

                          90       100
                  ....*....|....*....|....*.
gi 767946779  136 ENPAKrlycFFASLFSVLVRGSRAVL 161
Cdd:pfam08241  73 EDPER----ALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 40-183 6.19e-13

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 65.32  E-value: 6.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  40 AGRALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWV-GLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKP 113
Cdd:COG0500   15 AALLALLERLPKGGR--VLDLGCGTGRNLLALAARFGGRViGIDLSPEAIALARARAAKAglgnvEFLVADLAELDPLPA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779 114 GTFDGCISISAVQWLcnankkseNPAKRLYcFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGF 183
Cdd:COG0500   93 ESFDLVVAFGVLHHL--------PPEEREA-LLRELARALKPGGVLLLSASDAAAALSLARLLLLATASL 153
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 57-161 6.24e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 63.88  E-value: 6.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  57 LLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR--EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnankk 134
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERaaELNVDFVQGDL-EDLPLEDGSFDLVICSEVLEHL------ 100

                         90       100
                 ....*....|....*....|....*..
gi 767946779 135 sENPAKrlycFFASLFSVLVRGSRAVL 161
Cdd:COG2227  101 -PDPAA----LLRELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
58-162 8.19e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 8.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  58 LDIGCGTGLSGSYLSDE--GHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPfkPGTFDGCISISAVQWLcnankks 135
Cdd:COG4106    6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP--PEPFDLVVSNAALHWL------- 76

                         90       100
                 ....*....|....*....|....*..
gi 767946779 136 ENPAKrlycFFASLFSVLVRGSRAVLQ 162
Cdd:COG4106   77 PDHAA----LLARLAAALAPGGVLAVQ 99
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 34-130 1.10e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.55  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  34 DIQTRMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMgQGIPFKP 113
Cdd:PRK10258  25 ELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLAT 101

                         90
                 ....*....|....*..
gi 767946779 114 GTFDGCISISAVQWlCN 130
Cdd:PRK10258 102 ATFDLAWSNLAVQW-CG 117
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 36-162 3.71e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 59.56  E-value: 3.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  36 QTRMAGRALELLYLPENKPcyLLDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR-EIEG-----DLLLGDMGQg 108
Cdd:COG2230   36 QEAKLDLILRKLGLKPGMR--VLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERaAEAGladrvEVRLADYRD- 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767946779 109 iPFKPGTFDGCISISAVQWLCNANKKSenpakrlycFFASLFSVLVRGSRAVLQ 162
Cdd:COG2230  113 -LPADGQFDAIVSIGMFEHVGPENYPA---------YFAKVARLLKPGGRLLLH 156
PRK08317 PRK08317
hypothetical protein; Provisional
 58-161 1.76e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 59.18  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  58 LDIGCGTGLSGSYLSD----EGHYwVGLDISPAMLDEAVDReIEGDLL-----LGDmGQGIPFKPGTFDGCISISAVQWL 128
Cdd:PRK08317  24 LDVGCGPGNDARELARrvgpEGRV-VGIDRSEAMLALAKER-AAGLGPnvefvRGD-ADGLPFPDGSFDAVRSDRVLQHL 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767946779 129 cnankksENPAKRLycffASLFSVLVRGSRAVL 161
Cdd:PRK08317 101 -------EDPARAL----AEIARVLRPGGRVVV 122
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 35-153 1.81e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 59.22  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779   35 IQTRMAGRALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEGHY--WVGLDISPAMLDEAVDREIEGDL-LLGDMGQgIP 110
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767946779  111 FKPGTFDGCISISAVQWLCNANKksenpakrlycFFASLFSVL 153
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-164 2.09e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  57 LLDIGCGTGLSGSYL-SDEGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKPGTFDGCISISAVQWLcn 130
Cdd:cd02440    2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767946779 131 ankksenpAKRLYCFFASLFSVLVRGSRAVLQLY 164
Cdd:cd02440   80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-128 3.63e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 3.63e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946779   58 LDIGCGTGLSGSYLSDEGHYW--VGLDISPAMLDEAVDREIEGDLLLGDM-----GQGIPFKPGTFDGCISISAVQWL 128
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARERLAALGLLNAVRvelfqLDLGELDPGSFDVVVASNVLHHL 78
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 35-94 1.95e-05

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 44.40  E-value: 1.95e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767946779   35 IQTRMAGRALELLYLPENKPC--YLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR 94
Cdd:TIGR02021  35 REGRAAMRRKLLDWLPKDPLKgkRVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNR 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 57-123 2.81e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.99  E-value: 2.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767946779  57 LLDIGCGTG-LSGSY---LSDEGHYWvGLDISPAMLDEAVDREIEG------DLLLGDmGQGIPFKPGTFDgCISIS 123
Cdd:PRK00216  55 VLDLACGTGdLAIALakaVGKTGEVV-GLDFSEGMLAVGREKLRDLglsgnvEFVQGD-AEALPFPDNSFD-AVTIA 128
PRK14968 PRK14968
putative methyltransferase; Provisional
 58-117 5.41e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.88  E-value: 5.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767946779  58 LDIGCGTGLSGSYLSDEGHYWVGLDISPamldEAVDREIEGDLLLGDMGQGI---------PFKPGTFD 117
Cdd:PRK14968  28 LEVGTGSGIVAIVAAKNGKKVVGVDINP----YAVECAKCNAKLNNIRNNGVevirsdlfePFRGDKFD 92
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 40-125 1.06e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.56  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779   40 AGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMldeaVDREIEGDLLLGDMGQGIPFKPGTFDgC 119
Cdd:pfam13489   9 LADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA----IERALLNVRFDQFDEQEAAVPAGKFD-V 83


                  ....*.
gi 767946779  120 ISISAV 125
Cdd:pfam13489  84 IVAREV 89
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 43-128 2.14e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 38.39  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946779  43 ALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEghyW-----VGLDISPAMLDEAVDREIEGDLLLGDMGQgipFKPGTF 116
Cdd:PRK01683  20 ARDLLaRVPLENPRYVVDLGCGPGNSTELLVER---WpaariTGIDSSPAMLAEARSRLPDCQFVEADIAS---WQPPQA 93

                         90
                 ....*....|...
gi 767946779 117 DGCISISAV-QWL 128
Cdd:PRK01683  94 LDLIFANASlQWL 106
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 24-94 2.49e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 38.28  E-value: 2.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767946779  24 RKYVRNSRmidiqTRMAGRALEllYLPEN---KPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR 94
Cdd:PRK07580  38 RATVRAGH-----QRMRDTVLS--WLPADgdlTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARER 104
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
58-123 4.52e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 37.42  E-value: 4.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767946779   58 LDIGCGTGLSGSYLSD---EGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDmGQGIPFKPGTFDgCISIS 123
Cdd:pfam01209  47 LDVAGGTGDWTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEgkyniEFLQGN-AEELPFEDDSFD-IVTIS 118
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 51-91 5.56e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 36.24  E-value: 5.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767946779   51 ENKPCYLLDIGCGTG----LSGSYLSDEGHYwVGLDISPAMLDEA 91
Cdd:pfam13847   1 IDKGMRVLDLGCGTGhlsfELAEELGPNAEV-VGIDISEEAIEKA 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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