NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767946739|ref|XP_011514064|]
View 

fas-activated serine/threonine kinase isoform X4 [Homo sapiens]

Protein Classification

FAST_1 and FAST_2 domain-containing protein( domain architecture ID 10535833)

FAST_1 and FAST_2 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FAST_2 super family cl07113
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 355-430 1.67e-14

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


The actual alignment was detected with superfamily member pfam08368:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 68.75  E-value: 1.67e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767946739  355 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCT 430
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTI 75
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 277-343 1.13e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.89  E-value: 1.13e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767946739  277 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 343
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
 
Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 355-430 1.67e-14

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 68.75  E-value: 1.67e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767946739  355 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCT 430
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTI 75
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 277-343 1.13e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.89  E-value: 1.13e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767946739  277 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 343
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
 
Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 355-430 1.67e-14

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 68.75  E-value: 1.67e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767946739  355 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCT 430
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTI 75
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 277-343 1.13e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.89  E-value: 1.13e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767946739  277 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 343
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH