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Conserved domains on  [gi|767934622|ref|XP_011512416|]
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complement component C6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MACPF smart00457
membrane-attack complex / perforin;
322-523 1.26e-59

membrane-attack complex / perforin;


:

Pssm-ID: 214671  Cd Length: 195  Bit Score: 202.28  E-value: 1.26e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   322 FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT 401
Cdd:smart00457   1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKGLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   402 EEEAKHCVRIEtkkRVLFAKKTKVEHrCTTNKLSEKHEGSFiqGAEKSISLIRGGRSEYGAALAWEKGSSGLeekTFSEW 481
Cdd:smart00457  81 SEDISKCLAGS---SNSFAGSVSAEH-CLQSSSYIKYLSTS--LRRESHTQVLGGHVTVLCDLLRGPSSNSL---DFSDW 151

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 767934622   482 LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY 523
Cdd:smart00457 152 AESVPNEPVLIDVSLAPIYELLPPNPELSQKREALRQALRSY 193
FIMAC smart00057
factor I membrane attack complex;
899-971 4.49e-20

factor I membrane attack complex;


:

Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 84.90  E-value: 4.49e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934622   899 CGYDTCYDWEKCSASTskCVCLLPPQCFKGGnQLYCVKMGSStsEKTLNICEVGTIRCANRKMEILHPGKCLA 971
Cdd:smart00057   1 CAKGFCQLWQKCSAST--CVCKLPYECPKAG-TDVCVEDGRS--EKTLTYCKQGALRCLNQKYKFLHIGSCTA 68
FIMAC smart00057
factor I membrane attack complex;
796-876 1.29e-16

factor I membrane attack complex;


:

Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 74.89  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   796 KLKGHCQLGQKQSGSECICMSPEEdcrnaCFpllgsHHSEDLCVFDTDSndYFTSPACKFLAEKCLnNQQLHFLHIGSCQ 875
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYE-----CP-----KAGTDVCVEDGRS--EKTLTYCKQGALRCL-NQKYKFLHIGSCT 67


                   .
gi 767934622   876 D 876
Cdd:smart00057  68 A 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 596-651 2.58e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 2.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767934622   596 WGCWSSWSTCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDCtfsimenNGQPC 651
Cdd:smart00209   1 WSEWSEWSPCSVTcggGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC-------NEQPC 52
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 151-182 2.29e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.29e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767934622 151 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 182
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
PHA02831 super family cl31511
EEV host range protein; Provisional
 672-794 3.30e-09

EEV host range protein; Provisional


The actual alignment was detected with superfamily member PHA02831:

Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 58.85  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISC----LTGFETVGYQYFRCLpDGTWRQGDVECQRTECIKPVVQEVLtITPFQ 747
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGF-LNVFE 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767934622 748 RLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNsltCEKDTL 794
Cdd:PHA02831 156 KKFYYGDIVNFKCKKGFILLGSSVSTCDINSiWYPGIPK---CVKDKV 200
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 35-88 1.65e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622    35 HYAWTQWTSCSKTCNSGTQSRHRQIVVdkyYQENFCEQICSKQ--ETRECNWQRCP 88
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGEdvETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
94-142 8.58e-05

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 8.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767934622   94 GDFGPWSDCDPCIEKQSKVRSVLRPSQF-GGQPCTAPLVAFQPCiPSKLC 142
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFpGGEPCTGDDIETQAC-KMDKC 49
 
Name Accession Description Interval E-value
MACPF smart00457
membrane-attack complex / perforin;
322-523 1.26e-59

membrane-attack complex / perforin;


Pssm-ID: 214671  Cd Length: 195  Bit Score: 202.28  E-value: 1.26e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   322 FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT 401
Cdd:smart00457   1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKGLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   402 EEEAKHCVRIEtkkRVLFAKKTKVEHrCTTNKLSEKHEGSFiqGAEKSISLIRGGRSEYGAALAWEKGSSGLeekTFSEW 481
Cdd:smart00457  81 SEDISKCLAGS---SNSFAGSVSAEH-CLQSSSYIKYLSTS--LRRESHTQVLGGHVTVLCDLLRGPSSNSL---DFSDW 151

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 767934622   482 LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY 523
Cdd:smart00457 152 AESVPNEPVLIDVSLAPIYELLPPNPELSQKREALRQALRSY 193
MACPF pfam01823
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ...
 303-523 2.63e-54

MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.


Pssm-ID: 460349  Cd Length: 211  Bit Score: 188.00  E-value: 2.63e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622  303 NHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFT-TKAKDLHLSDVFLKALNHLPLEYNSAL---YSRIFDDFGTHYFTSG 378
Cdd:pfam01823   4 SASSEFKKMSDKSKQKKKSLIISKSTCSLYQFTlKRSNKLQLSDEFLQALSDLPDNYDYAAkatYIQFFDKYGTHYITSV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622  379 SLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIEtkkrVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRS 458
Cdd:pfam01823  84 TLGGKIVYVLKLDKSQLEDLKLKGEDVKICLSAS----AGASIGSVNLKGCSKNSSSTKEKKSFNQEIESSITLVIGGTP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767934622  459 EYGAAlawekgssglEEKTFSEWLESVKENPAVIDFELAPIVDLvrnIPCAVTKRNNLRKALQEY 523
Cdd:pfam01823 160 ESIDD----------DSKTYSDWAESVKDNPMPIDFELTPISEL---LKGVPLKKENLRKALEEY 211
FIMAC smart00057
factor I membrane attack complex;
899-971 4.49e-20

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 84.90  E-value: 4.49e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934622   899 CGYDTCYDWEKCSASTskCVCLLPPQCFKGGnQLYCVKMGSStsEKTLNICEVGTIRCANRKMEILHPGKCLA 971
Cdd:smart00057   1 CAKGFCQLWQKCSAST--CVCKLPYECPKAG-TDVCVEDGRS--EKTLTYCKQGALRCLNQKYKFLHIGSCTA 68
FIMAC smart00057
factor I membrane attack complex;
796-876 1.29e-16

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 74.89  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   796 KLKGHCQLGQKQSGSECICMSPEEdcrnaCFpllgsHHSEDLCVFDTDSndYFTSPACKFLAEKCLnNQQLHFLHIGSCQ 875
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYE-----CP-----KAGTDVCVEDGRS--EKTLTYCKQGALRCL-NQKYKFLHIGSCT 67


                   .
gi 767934622   876 D 876
Cdd:smart00057  68 A 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 596-651 2.58e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 2.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767934622   596 WGCWSSWSTCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDCtfsimenNGQPC 651
Cdd:smart00209   1 WSEWSEWSPCSVTcggGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC-------NEQPC 52
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 151-182 2.29e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.29e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767934622 151 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 182
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
PHA02831 PHA02831
EEV host range protein; Provisional
 672-794 3.30e-09

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 58.85  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISC----LTGFETVGYQYFRCLpDGTWRQGDVECQRTECIKPVVQEVLtITPFQ 747
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGF-LNVFE 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767934622 748 RLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNsltCEKDTL 794
Cdd:PHA02831 156 KKFYYGDIVNFKCKKGFILLGSSVSTCDINSiWYPGIPK---CVKDKV 200
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 672-728 3.78e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.78e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQ 728
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-182 3.89e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.89e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767934622  151 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 182
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 672-727 2.84e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 2.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622   672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 727
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 151-179 8.10e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 8.10e-08
                           10        20
                   ....*....|....*....|....*....
gi 767934622   151 NKFRCDSGRCIARKLECNGENDCGDNSDE 179
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Sushi pfam00084
Sushi repeat (SCR repeat);
672-727 8.17e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.81  E-value: 8.17e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622  672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 727
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 35-88 1.65e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622    35 HYAWTQWTSCSKTCNSGTQSRHRQIVVdkyYQENFCEQICSKQ--ETRECNWQRCP 88
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGEdvETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 37-87 8.61e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.50  E-value: 8.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767934622   37 AWTQWTSCSKTCNSGTQSRHRQIVVdkyyQENFCEQIC-SKQETRECNWQRC 87
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRTVIV----EPQNGGRPCpELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
94-142 8.58e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 8.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767934622   94 GDFGPWSDCDPCIEKQSKVRSVLRPSQF-GGQPCTAPLVAFQPCiPSKLC 142
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFpGGEPCTGDDIETQAC-KMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 38-89 1.53e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.73  E-value: 1.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767934622  38 WTQWTSCSKTCNSGTQSRHRQIVVDKyyqenfceqiCSKQETRECNWQRCPI 89
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILHEG----------CTTHMVEECEEEECPV 284
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 599-651 5.60e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.72  E-value: 5.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622  599 WSSWSTCDATY---KRSRTRECNNPaPQRGGKRCeGEKRQEEDCtfsimenNGQPC 651
Cdd:pfam19028   6 WSEWSECSVTCgggVQTRTRTVIVE-PQNGGRPC-PELLERRPC-------NLPPC 52
 
Name Accession Description Interval E-value
MACPF smart00457
membrane-attack complex / perforin;
322-523 1.26e-59

membrane-attack complex / perforin;


Pssm-ID: 214671  Cd Length: 195  Bit Score: 202.28  E-value: 1.26e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   322 FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT 401
Cdd:smart00457   1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKGLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   402 EEEAKHCVRIEtkkRVLFAKKTKVEHrCTTNKLSEKHEGSFiqGAEKSISLIRGGRSEYGAALAWEKGSSGLeekTFSEW 481
Cdd:smart00457  81 SEDISKCLAGS---SNSFAGSVSAEH-CLQSSSYIKYLSTS--LRRESHTQVLGGHVTVLCDLLRGPSSNSL---DFSDW 151

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 767934622   482 LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY 523
Cdd:smart00457 152 AESVPNEPVLIDVSLAPIYELLPPNPELSQKREALRQALRSY 193
MACPF pfam01823
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ...
 303-523 2.63e-54

MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.


Pssm-ID: 460349  Cd Length: 211  Bit Score: 188.00  E-value: 2.63e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622  303 NHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFT-TKAKDLHLSDVFLKALNHLPLEYNSAL---YSRIFDDFGTHYFTSG 378
Cdd:pfam01823   4 SASSEFKKMSDKSKQKKKSLIISKSTCSLYQFTlKRSNKLQLSDEFLQALSDLPDNYDYAAkatYIQFFDKYGTHYITSV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622  379 SLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIEtkkrVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRS 458
Cdd:pfam01823  84 TLGGKIVYVLKLDKSQLEDLKLKGEDVKICLSAS----AGASIGSVNLKGCSKNSSSTKEKKSFNQEIESSITLVIGGTP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767934622  459 EYGAAlawekgssglEEKTFSEWLESVKENPAVIDFELAPIVDLvrnIPCAVTKRNNLRKALQEY 523
Cdd:pfam01823 160 ESIDD----------DSKTYSDWAESVKDNPMPIDFELTPISEL---LKGVPLKKENLRKALEEY 211
FIMAC smart00057
factor I membrane attack complex;
899-971 4.49e-20

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 84.90  E-value: 4.49e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934622   899 CGYDTCYDWEKCSASTskCVCLLPPQCFKGGnQLYCVKMGSStsEKTLNICEVGTIRCANRKMEILHPGKCLA 971
Cdd:smart00057   1 CAKGFCQLWQKCSAST--CVCKLPYECPKAG-TDVCVEDGRS--EKTLTYCKQGALRCLNQKYKFLHIGSCTA 68
FIMAC smart00057
factor I membrane attack complex;
796-876 1.29e-16

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 74.89  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622   796 KLKGHCQLGQKQSGSECICMSPEEdcrnaCFpllgsHHSEDLCVFDTDSndYFTSPACKFLAEKCLnNQQLHFLHIGSCQ 875
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYE-----CP-----KAGTDVCVEDGRS--EKTLTYCKQGALRCL-NQKYKFLHIGSCT 67


                   .
gi 767934622   876 D 876
Cdd:smart00057  68 A 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 596-651 2.58e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 2.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767934622   596 WGCWSSWSTCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDCtfsimenNGQPC 651
Cdd:smart00209   1 WSEWSEWSPCSVTcggGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC-------NEQPC 52
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 151-182 2.29e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.29e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767934622 151 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 182
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
PHA02831 PHA02831
EEV host range protein; Provisional
 672-794 3.30e-09

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 58.85  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISC----LTGFETVGYQYFRCLpDGTWRQGDVECQRTECIKPVVQEVLtITPFQ 747
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGF-LNVFE 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767934622 748 RLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNsltCEKDTL 794
Cdd:PHA02831 156 KKFYYGDIVNFKCKKGFILLGSSVSTCDINSiWYPGIPK---CVKDKV 200
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 672-728 3.78e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.78e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQ 728
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-182 3.89e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.89e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767934622  151 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 182
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 672-727 2.84e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 2.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622   672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 727
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 151-179 8.10e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 8.10e-08
                           10        20
                   ....*....|....*....|....*....
gi 767934622   151 NKFRCDSGRCIARKLECNGENDCGDNSDE 179
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Sushi pfam00084
Sushi repeat (SCR repeat);
672-727 8.17e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.81  E-value: 8.17e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622  672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 727
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 35-88 1.65e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622    35 HYAWTQWTSCSKTCNSGTQSRHRQIVVdkyYQENFCEQICSKQ--ETRECNWQRCP 88
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGEdvETRACNEQPCP 53
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 672-783 1.67e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 53.89  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRClPDGTWRQGDVeCQRTECIKPVVQEVLTITPFQRLYR 751
Cdd:PHA02927 148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLC-SGGEWSDPPT-CQIVKCPHPTISNGYLSSGFKRSYS 225

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767934622 752 IGESIELTCPKGFVVAGPSRYTCQ-GNSWTPPI 783
Cdd:PHA02927 226 YNDNVDFKCKYGYKLSGSSSSTCSpGNTWQPEL 258
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 37-87 8.61e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.50  E-value: 8.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767934622   37 AWTQWTSCSKTCNSGTQSRHRQIVVdkyyQENFCEQIC-SKQETRECNWQRC 87
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRTVIV----EPQNGGRPCpELLERRPCNLPPC 52
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 629-781 7.35e-06

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 48.93  E-value: 7.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 629 CEGEKRQeedctFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVppengfirneKQLYLVGEDVEISCLTGFETVG 708
Cdd:PHA02954 101 CKDETKY-----FRCEEKNGNTSWNDTVTCPNAECQPLQLEHGSCQPV----------KEKYSFGEHITINCDVGYEVIG 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767934622 709 YQYFRCLPDgTWRQGDvECQRTECIKPVVQEVLTITPFQrlyrIGESIELTCPKGFVVAGPSRYTCQGNSWTP 781
Cdd:PHA02954 166 ASYISCTAN-SWNVIP-SCQQKCDIPSLSNGLISGSTFS----IGGVIHLSCKSGFTLTGSPSSTCIDGKWNP 232
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 732-783 1.48e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 43.28  E-value: 1.48e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767934622   732 CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPPI 783
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENgTWSPPP 53
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 732-790 1.72e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 732 CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPIsnsLTCE 790
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGgWSPPP---PTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 672-789 1.95e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 47.74  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 672 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPD---GTWRQGDVECQRTECIKPVVQEVLTITPFQR 748
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDknnAIWSNKAPFCMLKECNDPPSIINGKIYNKRE 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767934622 749 LYRIGESIELTCP--KG--FVVAGPSRYTC-QGNSWT--PPISNSLTC 789
Cdd:PHA02639 102 MYKVGDEIYYVCNehKGvqYSLVGNEKITCiQDKSWKpdPPICKMINC 149
PHA02817 PHA02817
EEV Host range protein; Provisional
 676-783 3.12e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.47  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 676 VPPE--NGFIRNEKQLYLVGEDVEISCltGFETVGYQY-------FRCLPDGTWRQGDVECQRTECIKPVVQE-VLTITP 745
Cdd:PHA02817  26 YPPSikNGYIYNKKTEYNIGSNVTFFC--GNNTRGVRYtlvgeknIICEKDGKWNKEFPVCKIIRCRFPALQNgFVNGIP 103

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767934622 746 FQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPI 783
Cdd:PHA02817 104 DSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSsWIPKV 142
TSP_1 pfam00090
Thrombospondin type 1 domain;
94-142 8.58e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 8.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767934622   94 GDFGPWSDCDPCIEKQSKVRSVLRPSQF-GGQPCTAPLVAFQPCiPSKLC 142
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFpGGEPCTGDDIETQAC-KMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 38-89 1.53e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.73  E-value: 1.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767934622  38 WTQWTSCSKTCNSGTQSRHRQIVVDKyyqenfceqiCSKQETRECNWQRCPI 89
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILHEG----------CTTHMVEECEEEECPV 284
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 91-136 3.00e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.57  E-value: 3.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767934622   91 CLLGDFGPWSDCD-PC-IEKQSKVRSVLRPSQFGGQPCTaPLVAFQPC 136
Cdd:pfam19028   1 CVVSEWSEWSECSvTCgGGVQTRTRTVIVEPQNGGRPCP-ELLERRPC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
38-87 6.45e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.55  E-value: 6.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767934622   38 WTQWTSCSKTCNSGTQSRHRQIVVDKyYQENFCEQicSKQETRECNWQRC 87
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPF-PGGEPCTG--DDIETQACKMDKC 49
Sushi pfam00084
Sushi repeat (SCR repeat);
750-782 9.29e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 9.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767934622  750 YRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPP 782
Cdd:pfam00084  19 YNYGASVSYECDPGYRLVGSPTITCQEDgTWSPP 52
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 687-795 1.50e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.00  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934622 687 KQLYLVGEDVEISCLTgfETvgyQYFRCLP---DGTWRQgDVECQRTECiKPVVQEVLTITPFQRLYRIGESIELTCPKG 763
Cdd:PHA02954  88 KPLYEVNSTITLICKD--ET---KYFRCEEkngNTSWND-TVTCPNAEC-QPLQLEHGSCQPVKEKYSFGEHITINCDVG 160

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767934622 764 FVVAGPSRYTCQGNSWTPPISNSLTCEKDTLT 795
Cdd:PHA02954 161 YEVIGASYISCTANSWNVIPSCQQKCDIPSLS 192
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 599-651 5.60e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.72  E-value: 5.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934622  599 WSSWSTCDATY---KRSRTRECNNPaPQRGGKRCeGEKRQEEDCtfsimenNGQPC 651
Cdd:pfam19028   6 WSEWSECSVTCgggVQTRTRTVIVE-PQNGGRPC-PELLERRPC-------NLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 41-87 8.26e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 8.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767934622   41 WTSCSKTCNSGTQSRH---RQIVVDKYYQENFCEQICSKQETRECNWQRC 87
Cdd:pfam19030   6 WGECSVTCGGGVQTRLvqcVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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