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Conserved domains on  [gi|767934176|ref|XP_011512242|]
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solute carrier family 12 member 7 isoform X4 [Homo sapiens]

Protein Classification

APC family permease( domain architecture ID 1903533)

APC (amino acid/polyamine/organocation) family permease is involved in the uptake of a specific amino acid and/or polyamine substrate with the concomitant import of a proton

Gene Ontology:  GO:0055085|GO:0022857
TCDB:  2.A.3

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AA_permease_2 super family cl45918
Amino acid permease;
31-1074 0e+00

Amino acid permease;


The actual alignment was detected with superfamily member TIGR00930:

Pssm-ID: 459263 [Multi-domain]  Cd Length: 953  Bit Score: 1199.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176    31 NPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQG----VVEHEEDEESRRREAKAPRMGT 106
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGmkehEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   107 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 186
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   187 VGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAifqaeaagGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVF 266
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGS--------KIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   267 LACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRsfdacvkaygihnnsatsalwglfcngsqpsaacdeyfiqnn 346
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   347 vtEIQGIPGAASGvflenlwstyahagafvekkgvpsvpvaeesrasalpyvltdiaasFTLLVGIYFPSVTGIMAGSNR 426
Cdd:TIGR00930  271 --FIPGIPGPEGG----------------------------------------------FFSLFGIFFPSVTGILAGANI 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   427 SGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEA---------------------LQGNLVIGML 485
Cdd:TIGR00930  303 SGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLvtnctsaacfsecahntcsygLMNNLQVMSL 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   486 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICETGILIASLDSVA 564
Cdd:TIGR00930  383 VSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIA 462
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   565 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 644
Cdd:TIGR00930  463 PIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPD 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   645 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDaeqaVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDK 724
Cdd:TIGR00930  543 VNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLEC 618
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   725 HMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEdNPFSWKNFVDTVRDT 804
Cdd:TIGR00930  619 VKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQA-EPRAWETYIGIIHDA 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   805 TAAHQALLVAKNVDSFPQN--------------------------------------QERFGGGHIDVWWIVHDGGMLML 846
Cdd:TIGR00930  698 FDAHLAVVVVRNSEGLPISvlqvqeelendcsedsielndgkistqpdmhleastqfQKKQGKGTIDVWWLVDDGGLTLL 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   847 LPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMvenDISAftYERTLMMEQRSQMLKQMQ 926
Cdd:TIGR00930  778 LPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFR 852
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   927 LSKNEQEREAqlihdrntashtaaaartqapPTPdkvQMTWTREKLIAEKYRsrdtslsgfkdlfsmkpewgnldQSNVR 1006
Cdd:TIGR00930  853 LHKTEKDREA---------------------KDP---KMTWTKPWKITDAEL-----------------------QSNVR 885
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767934176  1007 RMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1074
Cdd:TIGR00930  886 KSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
31-1074 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1199.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176    31 NPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQG----VVEHEEDEESRRREAKAPRMGT 106
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGmkehEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   107 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 186
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   187 VGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAifqaeaagGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVF 266
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGS--------KIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   267 LACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRsfdacvkaygihnnsatsalwglfcngsqpsaacdeyfiqnn 346
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   347 vtEIQGIPGAASGvflenlwstyahagafvekkgvpsvpvaeesrasalpyvltdiaasFTLLVGIYFPSVTGIMAGSNR 426
Cdd:TIGR00930  271 --FIPGIPGPEGG----------------------------------------------FFSLFGIFFPSVTGILAGANI 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   427 SGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEA---------------------LQGNLVIGML 485
Cdd:TIGR00930  303 SGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLvtnctsaacfsecahntcsygLMNNLQVMSL 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   486 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICETGILIASLDSVA 564
Cdd:TIGR00930  383 VSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIA 462
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   565 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 644
Cdd:TIGR00930  463 PIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPD 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   645 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDaeqaVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDK 724
Cdd:TIGR00930  543 VNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLEC 618
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   725 HMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEdNPFSWKNFVDTVRDT 804
Cdd:TIGR00930  619 VKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQA-EPRAWETYIGIIHDA 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   805 TAAHQALLVAKNVDSFPQN--------------------------------------QERFGGGHIDVWWIVHDGGMLML 846
Cdd:TIGR00930  698 FDAHLAVVVVRNSEGLPISvlqvqeelendcsedsielndgkistqpdmhleastqfQKKQGKGTIDVWWLVDDGGLTLL 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   847 LPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMvenDISAftYERTLMMEQRSQMLKQMQ 926
Cdd:TIGR00930  778 LPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFR 852
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   927 LSKNEQEREAqlihdrntashtaaaartqapPTPdkvQMTWTREKLIAEKYRsrdtslsgfkdlfsmkpewgnldQSNVR 1006
Cdd:TIGR00930  853 LHKTEKDREA---------------------KDP---KMTWTKPWKITDAEL-----------------------QSNVR 885
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767934176  1007 RMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1074
Cdd:TIGR00930  886 KSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
109-681 2.39e-43

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 164.80  E-value: 2.39e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   109 GVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 188
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   189 LcFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQaeaaggeaaamlhnMRVYGTCTLVLMALVVFVGVKYVNKLALVFLA 268
Cdd:pfam00324   80 W-NYWLSWITVLALELTAASILIQFWELVPDIPY--------------LWVWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   269 CVVLSILAIYAGVIksafdppdIPVCllgnrtlsrrsfdacvkaygihnnsatsalwglfcnGSQPSAACDEYFIQNNVT 348
Cdd:pfam00324  145 IKIIAIIGFIIVGI--------ILLS------------------------------------GGNPNDGAIFRYLGDNGG 180
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   349 EIQGIPGAASGVFlenlwstyahaGAFVekkgvpsvpvaeesrasalpyvltdiaasftllvgIYFPSVTGIMAGSNRSG 428
Cdd:pfam00324  181 KNNFPPGFGKGFI-----------SVFV-----------------------------------IAFFAFTGIELVGIAAG 214
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   429 DLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEG---VVLRDKFGEALQGNLVIGMLAWPS-PWVIVIGSFFSTCGA 504
Cdd:pfam00324  215 EVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWndpGLLNDSASAASPFVIFFKFLGISGlAPLINAVILTAALSA 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   505 GLQSLTGAPRLLQAIARDGIVPFlqVFGHGKANGEPTWALLLTVLICETGILIASLdsVAPILSMFFLMCYLFVNLACAV 584
Cdd:pfam00324  295 ANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLIVWG 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   585 QTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALL 664
Cdd:pfam00324  371 LISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLI 450
                          570
                   ....*....|....*..
gi 767934176   665 RVEHGPPHTKNWRPQVL 681
Cdd:pfam00324  451 ILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
117-641 5.21e-30

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 124.62  E-value: 5.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  117 NILGVILFLRLTWIVGVAG--VLESFLIVAMCCtctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 193
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  194 GTTFAGAMYILGTIEIFLTYISPGAAIfqaeaaggeaaamlhnmrVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLS 273
Cdd:COG0531   100 SYVLAVAAVAVAFGGYLSSLFPAGGSV------------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  274 ILAIyagviksafdppdipvcllgnrtlsrrsfdacvkaygihnnsatsALWGLFcngsqpsaacdeYFIQNNVTEIQGI 353
Cdd:COG0531   162 LLLF---------------------------------------------IVVGLF------------AFDPANFTPFLPA 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  354 PGAASGVFlenlwstyahagafvekkgvpsvpvaeesrasalpyvltdIAASFTllvgiyFPSVTGIMAGSNRSGDLKDA 433
Cdd:COG0531   185 GGGLSGVL----------------------------------------AALALA------FFAFTGFEAIANLAEEAKNP 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  434 QKSIPTGTILAIVTTSFIYLSCIVLFGacieGVVLRDKFGEALQGNLVIGMLAWPSP--WVIVIGSFFSTCGAGLQSLTG 511
Cdd:COG0531   219 KRNIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILG 294
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  512 APRLLQAIARDGIVPflQVFGH-GKANGEPTWALLLTVLICETGILI--ASLDSVAPILSMFFLMCYLFVNLACAVQtLL 588
Cdd:COG0531   295 ASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-RR 371
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934176  589 RTPNWRPRFKFYHWTLSFLGMSLCLALMFIC---SWYYALSAMLIAGCIYKYIEYR 641
Cdd:COG0531   372 RRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
31-1074 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1199.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176    31 NPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQG----VVEHEEDEESRRREAKAPRMGT 106
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGmkehEEAEDAEGTKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   107 FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 186
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   187 VGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAifqaeaagGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVF 266
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGS--------KIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   267 LACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRsfdacvkaygihnnsatsalwglfcngsqpsaacdeyfiqnn 346
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   347 vtEIQGIPGAASGvflenlwstyahagafvekkgvpsvpvaeesrasalpyvltdiaasFTLLVGIYFPSVTGIMAGSNR 426
Cdd:TIGR00930  271 --FIPGIPGPEGG----------------------------------------------FFSLFGIFFPSVTGILAGANI 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   427 SGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEA---------------------LQGNLVIGML 485
Cdd:TIGR00930  303 SGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLvtnctsaacfsecahntcsygLMNNLQVMSL 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   486 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKA-NGEPTWALLLTVLICETGILIASLDSVA 564
Cdd:TIGR00930  383 VSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIA 462
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   565 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 644
Cdd:TIGR00930  463 PIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPD 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   645 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDaeqaVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDK 724
Cdd:TIGR00930  543 VNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLEC 618
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   725 HMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEdNPFSWKNFVDTVRDT 804
Cdd:TIGR00930  619 VKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQA-EPRAWETYIGIIHDA 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   805 TAAHQALLVAKNVDSFPQN--------------------------------------QERFGGGHIDVWWIVHDGGMLML 846
Cdd:TIGR00930  698 FDAHLAVVVVRNSEGLPISvlqvqeelendcsedsielndgkistqpdmhleastqfQKKQGKGTIDVWWLVDDGGLTLL 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   847 LPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMvenDISAftYERTLMMEQRSQMLKQMQ 926
Cdd:TIGR00930  778 LPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFR 852
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   927 LSKNEQEREAqlihdrntashtaaaartqapPTPdkvQMTWTREKLIAEKYRsrdtslsgfkdlfsmkpewgnldQSNVR 1006
Cdd:TIGR00930  853 LHKTEKDREA---------------------KDP---KMTWTKPWKITDAEL-----------------------QSNVR 885
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767934176  1007 RMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS 1074
Cdd:TIGR00930  886 KSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
109-681 2.39e-43

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 164.80  E-value: 2.39e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   109 GVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 188
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   189 LcFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQaeaaggeaaamlhnMRVYGTCTLVLMALVVFVGVKYVNKLALVFLA 268
Cdd:pfam00324   80 W-NYWLSWITVLALELTAASILIQFWELVPDIPY--------------LWVWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   269 CVVLSILAIYAGVIksafdppdIPVCllgnrtlsrrsfdacvkaygihnnsatsalwglfcnGSQPSAACDEYFIQNNVT 348
Cdd:pfam00324  145 IKIIAIIGFIIVGI--------ILLS------------------------------------GGNPNDGAIFRYLGDNGG 180
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   349 EIQGIPGAASGVFlenlwstyahaGAFVekkgvpsvpvaeesrasalpyvltdiaasftllvgIYFPSVTGIMAGSNRSG 428
Cdd:pfam00324  181 KNNFPPGFGKGFI-----------SVFV-----------------------------------IAFFAFTGIELVGIAAG 214
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   429 DLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEG---VVLRDKFGEALQGNLVIGMLAWPS-PWVIVIGSFFSTCGA 504
Cdd:pfam00324  215 EVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWndpGLLNDSASAASPFVIFFKFLGISGlAPLINAVILTAALSA 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   505 GLQSLTGAPRLLQAIARDGIVPFlqVFGHGKANGEPTWALLLTVLICETGILIASLdsVAPILSMFFLMCYLFVNLACAV 584
Cdd:pfam00324  295 ANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLIVWG 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   585 QTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALL 664
Cdd:pfam00324  371 LISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLI 450
                          570
                   ....*....|....*..
gi 767934176   665 RVEHGPPHTKNWRPQVL 681
Cdd:pfam00324  451 ILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
117-641 5.21e-30

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 124.62  E-value: 5.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  117 NILGVILFLRLTWIVGVAG--VLESFLIVAMCCtctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 193
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  194 GTTFAGAMYILGTIEIFLTYISPGAAIfqaeaaggeaaamlhnmrVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLS 273
Cdd:COG0531   100 SYVLAVAAVAVAFGGYLSSLFPAGGSV------------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  274 ILAIyagviksafdppdipvcllgnrtlsrrsfdacvkaygihnnsatsALWGLFcngsqpsaacdeYFIQNNVTEIQGI 353
Cdd:COG0531   162 LLLF---------------------------------------------IVVGLF------------AFDPANFTPFLPA 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  354 PGAASGVFlenlwstyahagafvekkgvpsvpvaeesrasalpyvltdIAASFTllvgiyFPSVTGIMAGSNRSGDLKDA 433
Cdd:COG0531   185 GGGLSGVL----------------------------------------AALALA------FFAFTGFEAIANLAEEAKNP 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  434 QKSIPTGTILAIVTTSFIYLSCIVLFGacieGVVLRDKFGEALQGNLVIGMLAWPSP--WVIVIGSFFSTCGAGLQSLTG 511
Cdd:COG0531   219 KRNIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILG 294
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176  512 APRLLQAIARDGIVPflQVFGH-GKANGEPTWALLLTVLICETGILI--ASLDSVAPILSMFFLMCYLFVNLACAVQtLL 588
Cdd:COG0531   295 ASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-RR 371
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767934176  589 RTPNWRPRFKFYHWTLSFLGMSLCLALMFIC---SWYYALSAMLIAGCIYKYIEYR 641
Cdd:COG0531   372 RRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
695-1074 1.58e-22

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 101.54  E-value: 1.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   695 PRLLSFTSQLKAGKGLTIVGSVLEGTyLDKHMEAQRAEENIRSLMSTeKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKH 774
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGR-LSQKLRSELQKKAYRWLRKR-KIKAFYALVDGDNLREGAQALLQASGLGKLKP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   775 NTVLMAWPASW-------------------------------------------------------------KQEDNPFS 793
Cdd:pfam03522   80 NILLMGYKSDWrtcdkeeleeyfnvihdafdlqyavailrlpegldvshllqdqdteelglgdetnssyaeqSSEEQSTS 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   794 WKNFVDTVRDTTAAHQALLVAKNVDSFPQN-----------------------------------QERFGGGHIDVWWIV 838
Cdd:pfam03522  160 NSKQDDDKSKLSKKDSNLSLSPDKSTKNPSgkdssksdklkkkspsiilrtasnekeilnnitqfQKKQKKGTIDVWWLY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   839 HDGGMLMLLPFLLRQHKVWRKCRMRIFTVAqvddnsiqmkkdlqmflyhlrisaevevvemveNDISAFTYERtlmmeqr 918
Cdd:pfam03522  240 DDGGLTLLLPYILSTRSKWSDCKLRVFALG---------------------------------NRKDELEEEQ------- 279
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   919 sqmlKQMQ--LSKNeqeR----EAQLIHDRNTashtaaaartqaPPTPDKVQMTwtrEKLIaEKYRSRDTSL-SGFKDLF 991
Cdd:pfam03522  280 ----RNMAslLSKF---RidysDLTVIPDITK------------KPKKETKKFF---DELI-EPFRLHEDDKeEESAEKI 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   992 SmKPEWGNLDQSNVRRMHtavkLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT 1071
Cdd:pfam03522  337 T-DSELEALKEKTNRQLR----LRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLT 411

                   ...
gi 767934176  1072 IYS 1074
Cdd:pfam03522  412 FYS 414
AA_permease_2 pfam13520
Amino acid permease;
396-618 3.00e-12

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 70.03  E-value: 3.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   396 PYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKdaQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLrdKFGEA 475
Cdd:pfam13520  180 HTFFPDGWPGVFAGFLGVLWSFTGFESAANVSEEVK--KRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEI--ALSSG 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   476 LQGNLVIGMLAWPSPW---VIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICE 552
Cdd:pfam13520  256 LGQVAALLFQAVGGKWgaiIVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSPIRAIILTAILSL 335
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   553 TGILIASLDSVAPI----LSMFFLMCYLFVNLACAVqtLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFI 618
Cdd:pfam13520  336 ILLLLFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGILFSLFLIVA 403
2A0308 TIGR00911
L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and ...
428-598 1.79e-04

L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273332 [Multi-domain]  Cd Length: 501  Bit Score: 45.51  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   428 GDLKDAQKSIPTGTILAIVTTSFIY-LSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPwvIVIGsfFSTCGAGL 506
Cdd:TIGR00911  259 EEVKNPYRTLPIAIIISMPIVTFIYvLTNIAYFTVLSPEELLASLAVAVDFGERLLGVMSWAMP--ALVG--LSCFGSVN 334
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767934176   507 QSLTGAPRLLQAIARDGIVPFLQVFGHGKANgEPTWALLLTvliCETGILIASLDSVAPILSMFFLMCYLFVNLACAVQT 586
Cdd:TIGR00911  335 GSLFSSSRLFFVGGREGHLPSLLSMIHVKRL-TPLPSLLIV---CTLTLLMLFSGDIYSLINLISFANWLFNALAVAGLL 410
                          170
                   ....*....|....
gi 767934176   587 LLR--TPNWRPRFK 598
Cdd:TIGR00911  411 WLRykRPEMNRPIK 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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