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Conserved domains on  [gi|767927671|ref|XP_011511494|]
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GPI mannosyltransferase 4 isoform X2 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 83-430 9.75e-33

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 130.56  E-value: 9.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671   83 LRVLWCLLPQTGyvHPDEFFQSPEVmAEDILGVQAARPWEFYPSSSCRSVLFPLLISGSTFWLLRLWEElgpwpglvSGY 162
Cdd:pfam03901   9 LRLLLALLVQTS--DPDEHFQSWEP-LHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGD--------SKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  163 ALLVGPRLLLTALSFALDgavYHLAPPMGAD-----RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTW 237
Cdd:pfam03901  78 LVFYAPRLLLGLFSALCD---YYLYRAVCRKygleiARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  238 GPTRkepapgPRWRSWLLGgIVAAGFFNRPTFLAFaVVPLYLWGTRGATNPGLKSLTREALVLLPGAA-LTAAVFVATDS 316
Cdd:pfam03901 155 SVSN------YKYLKAVLL-IAALAILGRPTSALL-WLPLVLYLLLRLRGKRLKLFLFLAISLGLLVAlLVLGAVILIDS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  317 WYFSspatsrNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAvNGFLLFGVLHAQALQAawqrlqvglqasaqmGLLRAL 396
Cdd:pfam03901 227 YFYG------RFVFTPLNFLKYNVLSNGSSFYGTHPWYFYFS-NGLPNILGPFLLAFIL---------------GPLVLL 284

                         330       340       350
                  ....*....|....*....|....*....|....
gi 767927671  397 GARSLLSSPRSYLLLLyfmPLALLSAFSHQEARF 430
Cdd:pfam03901 285 LRKVSRLSQLLAPILI---WLFIYSLQPHKEERF 315
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 83-430 9.75e-33

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 130.56  E-value: 9.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671   83 LRVLWCLLPQTGyvHPDEFFQSPEVmAEDILGVQAARPWEFYPSSSCRSVLFPLLISGSTFWLLRLWEElgpwpglvSGY 162
Cdd:pfam03901   9 LRLLLALLVQTS--DPDEHFQSWEP-LHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGD--------SKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  163 ALLVGPRLLLTALSFALDgavYHLAPPMGAD-----RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTW 237
Cdd:pfam03901  78 LVFYAPRLLLGLFSALCD---YYLYRAVCRKygleiARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  238 GPTRkepapgPRWRSWLLGgIVAAGFFNRPTFLAFaVVPLYLWGTRGATNPGLKSLTREALVLLPGAA-LTAAVFVATDS 316
Cdd:pfam03901 155 SVSN------YKYLKAVLL-IAALAILGRPTSALL-WLPLVLYLLLRLRGKRLKLFLFLAISLGLLVAlLVLGAVILIDS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  317 WYFSspatsrNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAvNGFLLFGVLHAQALQAawqrlqvglqasaqmGLLRAL 396
Cdd:pfam03901 227 YFYG------RFVFTPLNFLKYNVLSNGSSFYGTHPWYFYFS-NGLPNILGPFLLAFIL---------------GPLVLL 284

                         330       340       350
                  ....*....|....*....|....*....|....
gi 767927671  397 GARSLLSSPRSYLLLLyfmPLALLSAFSHQEARF 430
Cdd:pfam03901 285 LRKVSRLSQLLAPILI---WLFIYSLQPHKEERF 315
PLN02816 PLN02816
mannosyltransferase
 83-351 1.38e-04

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 45.02  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  83 LRVLWCLLPQTgYVHPDEFFQSPEVMAEDILGVqAARPWEFypSSSCRSVLFPLLISgstfWLLRLWEElgpwPGLVSGY 162
Cdd:PLN02816  48 FRVVNALLIQT-YFNPDEHWQSLEVAHRTIFGY-GYMTWEW--KRGIRSYLHPMLFA----FLYKLLQV----TGLDTPY 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671 163 ALLVGPRLLLTALSFALDGAVYHLAPPMGADRWNALALLSGSYVTLVFY--TRTFSNTIEGLLftwllvLVSSHVTWGPT 240
Cdd:PLN02816 116 IMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFclNRTFSNCLETVL------TIMGLYYWPCI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671 241 RKEPAPGPRWRSWLLGgIVAAGFFNRPTFlafAVVPLYLWGTRGATNPGLKSLTreALVLLPGAALTAAVFVATDSWYFS 320
Cdd:PLN02816 190 RDSSIDYPVNRKWGLV-IAALACAIRPTS---AVIWLYVGMLELFLTPNKVKFI--ILEVIPIGSLVLGFTCLLDRLMYG 263

                        250       260       270
                 ....*....|....*....|....*....|.
gi 767927671 321 SpatsrnLVLTPVNFLHYNLNPQNLARHGTH 351
Cdd:PLN02816 264 S------WVIVPLNFLKFNFLSSGGDYYGTH 288
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 83-430 9.75e-33

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 130.56  E-value: 9.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671   83 LRVLWCLLPQTGyvHPDEFFQSPEVmAEDILGVQAARPWEFYPSSSCRSVLFPLLISGSTFWLLRLWEElgpwpglvSGY 162
Cdd:pfam03901   9 LRLLLALLVQTS--DPDEHFQSWEP-LHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGD--------SKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  163 ALLVGPRLLLTALSFALDgavYHLAPPMGAD-----RWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTW 237
Cdd:pfam03901  78 LVFYAPRLLLGLFSALCD---YYLYRAVCRKygleiARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  238 GPTRkepapgPRWRSWLLGgIVAAGFFNRPTFLAFaVVPLYLWGTRGATNPGLKSLTREALVLLPGAA-LTAAVFVATDS 316
Cdd:pfam03901 155 SVSN------YKYLKAVLL-IAALAILGRPTSALL-WLPLVLYLLLRLRGKRLKLFLFLAISLGLLVAlLVLGAVILIDS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  317 WYFSspatsrNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAvNGFLLFGVLHAQALQAawqrlqvglqasaqmGLLRAL 396
Cdd:pfam03901 227 YFYG------RFVFTPLNFLKYNVLSNGSSFYGTHPWYFYFS-NGLPNILGPFLLAFIL---------------GPLVLL 284

                         330       340       350
                  ....*....|....*....|....*....|....
gi 767927671  397 GARSLLSSPRSYLLLLyfmPLALLSAFSHQEARF 430
Cdd:pfam03901 285 LRKVSRLSQLLAPILI---WLFIYSLQPHKEERF 315
PLN02816 PLN02816
mannosyltransferase
 83-351 1.38e-04

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 45.02  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671  83 LRVLWCLLPQTgYVHPDEFFQSPEVMAEDILGVqAARPWEFypSSSCRSVLFPLLISgstfWLLRLWEElgpwPGLVSGY 162
Cdd:PLN02816  48 FRVVNALLIQT-YFNPDEHWQSLEVAHRTIFGY-GYMTWEW--KRGIRSYLHPMLFA----FLYKLLQV----TGLDTPY 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671 163 ALLVGPRLLLTALSFALDGAVYHLAPPMGADRWNALALLSGSYVTLVFY--TRTFSNTIEGLLftwllvLVSSHVTWGPT 240
Cdd:PLN02816 116 IMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFclNRTFSNCLETVL------TIMGLYYWPCI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927671 241 RKEPAPGPRWRSWLLGgIVAAGFFNRPTFlafAVVPLYLWGTRGATNPGLKSLTreALVLLPGAALTAAVFVATDSWYFS 320
Cdd:PLN02816 190 RDSSIDYPVNRKWGLV-IAALACAIRPTS---AVIWLYVGMLELFLTPNKVKFI--ILEVIPIGSLVLGFTCLLDRLMYG 263

                        250       260       270
                 ....*....|....*....|....*....|.
gi 767927671 321 SpatsrnLVLTPVNFLHYNLNPQNLARHGTH 351
Cdd:PLN02816 264 S------WVIVPLNFLKFNFLSSGGDYYGTH 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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