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Conserved domains on  [gi|767925771|ref|XP_011510742|]
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protein phosphatase 1L isoform X1 [Homo sapiens]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 303)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722
PubMed:  8819174|2549856
SCOP:  3000909

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP2Cc super family cl00120
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 93-192 2.34e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


The actual alignment was detected with superfamily member cd00143:

Pssm-ID: 469621 [Multi-domain]  Cd Length: 254  Bit Score: 76.98  E-value: 2.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771  93 VAVYSIQGRRDHMEDRFEVLTDLaNKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVlsyQTILEQQ 172
Cdd:cd00143    3 AGVSDKGGDRKTNEDAVVIKPNL-NNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLSEEDI---EEALRKA 78

                         90       100
                 ....*....|....*....|
gi 767925771 173 ILSIDREMLEKLTVSYDEAG 192
Cdd:cd00143   79 FLRADEEILEEAQDEPDDAR 98
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 93-192 2.34e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 76.98  E-value: 2.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771  93 VAVYSIQGRRDHMEDRFEVLTDLaNKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVlsyQTILEQQ 172
Cdd:cd00143    3 AGVSDKGGDRKTNEDAVVIKPNL-NNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLSEEDI---EEALRKA 78

                         90       100
                 ....*....|....*....|
gi 767925771 173 ILSIDREMLEKLTVSYDEAG 192
Cdd:cd00143   79 FLRADEEILEEAQDEPDDAR 98
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 93-184 3.90e-14

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 68.56  E-value: 3.90e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771    93 VAVYSIQGRRDHMEDRFEVLTDLANKTHpsIFGIFDGHGGETAAEYVKSRLPEALKQHLQdYEKDKENSVLSyqtILEQQ 172
Cdd:smart00332  11 YGLSSMQGVRKPMEDAHVITPDLSDSGG--FFGVFDGHGGSEAAKFLSKNLPEILAEELI-KEKDELEDVEE---ALRKA 84

                           90
                   ....*....|..
gi 767925771   173 ILSIDREMLEKL 184
Cdd:smart00332  85 FLSTDEEILEEL 96
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
 92-192 2.71e-06

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 46.69  E-value: 2.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771  92 NVAVYSIQGRRDHMED-RFEVLTDLANkthpsIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensvlsyqtiLE 170
Cdd:PTZ00224  23 RCASACVNGYRESMEDaHLLYLTDDWG-----FFGVFDGHVNDECSQYLARAWPQALEKEPEPMTDER----------ME 87

                         90       100
                 ....*....|....*....|..
gi 767925771 171 QQILSIDREMLEkltvSYDEAG 192
Cdd:PTZ00224  88 ELCLEIDEEWMD----SGREGG 105
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
 97-168 6.00e-06

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 45.40  E-value: 6.00e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767925771   97 SIQGRRDHMEDRF---EVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTI 168
Cdd:pfam00481   7 RMQGWRKSMEDAHidlPNLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTILALRRSFLEGEKLEDALRKSFL 81
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 93-192 2.34e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 76.98  E-value: 2.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771  93 VAVYSIQGRRDHMEDRFEVLTDLaNKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVlsyQTILEQQ 172
Cdd:cd00143    3 AGVSDKGGDRKTNEDAVVIKPNL-NNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEETLTLSEEDI---EEALRKA 78

                         90       100
                 ....*....|....*....|
gi 767925771 173 ILSIDREMLEKLTVSYDEAG 192
Cdd:cd00143   79 FLRADEEILEEAQDEPDDAR 98
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 93-184 3.90e-14

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 68.56  E-value: 3.90e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771    93 VAVYSIQGRRDHMEDRFEVLTDLANKTHpsIFGIFDGHGGETAAEYVKSRLPEALKQHLQdYEKDKENSVLSyqtILEQQ 172
Cdd:smart00332  11 YGLSSMQGVRKPMEDAHVITPDLSDSGG--FFGVFDGHGGSEAAKFLSKNLPEILAEELI-KEKDELEDVEE---ALRKA 84

                           90
                   ....*....|..
gi 767925771   173 ILSIDREMLEKL 184
Cdd:smart00332  85 FLSTDEEILEEL 96
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
 92-192 2.71e-06

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 46.69  E-value: 2.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925771  92 NVAVYSIQGRRDHMED-RFEVLTDLANkthpsIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensvlsyqtiLE 170
Cdd:PTZ00224  23 RCASACVNGYRESMEDaHLLYLTDDWG-----FFGVFDGHVNDECSQYLARAWPQALEKEPEPMTDER----------ME 87

                         90       100
                 ....*....|....*....|..
gi 767925771 171 QQILSIDREMLEkltvSYDEAG 192
Cdd:PTZ00224  88 ELCLEIDEEWMD----SGREGG 105
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
 97-168 6.00e-06

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 45.40  E-value: 6.00e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767925771   97 SIQGRRDHMEDRF---EVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTI 168
Cdd:pfam00481   7 RMQGWRKSMEDAHidlPNLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTILALRRSFLEGEKLEDALRKSFL 81
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
 100-164 9.76e-04

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 39.13  E-value: 9.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767925771 100 GRRDHMEDRFEVLTDLANK-------THPSIF-GIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVLS 164
Cdd:PLN03145  74 GSRSSMEDVYICVDNFMSDfglknseDGPSAFyGVFDGHGGKHAADFACYHLPRFIVED-EDFPREIEKVVSS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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