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Conserved domains on  [gi|767917550|ref|XP_011509256|]
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3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 11240944)

enoyl-CoA hydratase/isomerase family protein plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate; similar to Homo sapiens 3-hydroxyisobutyryl-CoA hydrolase and Cereibacter sphaeroides Enoyl-CoA hydratase

CATH:  3.90.226.10
EC:  3.1.2.-
Gene Ontology:  GO:0016790
PubMed:  18470480|11263873
SCOP:  4004188

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-210 1.36e-117

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


:

Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 337.90  E-value: 1.36e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550    1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLEN 80
Cdd:pfam16113 123 MPETAIGLFPDVGGSYFLSRLPGELGLYLALTGARLNGADALAAGLATHYVPSARLPALEEALAALDWSDPADVDAVLAE 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   81 YHTESKidrDKSFILEEHMDKINSCFSANTVEEIIENLQQ--DGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQE 158
Cdd:pfam16113 203 FAEESD---PPPSPLAAHREAIDRCFSADTVEEIIAALEAeaDGDEWAAETLKTLRKRSPTSLKVTLRQLRRGRKLSLAE 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767917550  159 VLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHF 210
Cdd:pfam16113 280 CLRMEYRLALRCLRRPDFVEGVRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
 
Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-210 1.36e-117

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 337.90  E-value: 1.36e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550    1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLEN 80
Cdd:pfam16113 123 MPETAIGLFPDVGGSYFLSRLPGELGLYLALTGARLNGADALAAGLATHYVPSARLPALEEALAALDWSDPADVDAVLAE 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   81 YHTESKidrDKSFILEEHMDKINSCFSANTVEEIIENLQQ--DGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQE 158
Cdd:pfam16113 203 FAEESD---PPPSPLAAHREAIDRCFSADTVEEIIAALEAeaDGDEWAAETLKTLRKRSPTSLKVTLRQLRRGRKLSLAE 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767917550  159 VLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHF 210
Cdd:pfam16113 280 CLRMEYRLALRCLRRPDFVEGVRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 1-212 1.97e-88

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 263.99  E-value: 1.97e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKE-NIASVLE 79
Cdd:PRK05617 135 MPETGIGFFPDVGGTYFLSRAPGALGTYLALTGARISAADALYAGLADHFVPSADLPALLDALISLRWDSGAdVVDAALA 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  80 NYHTESKIDRdksfiLEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEV 159
Cdd:PRK05617 215 AFATPAPASE-----LAAQRAWIDECFAGDTVEDIIAALEADGGEFAAKTADTLRSRSPTSLKVTLEQLRRARGLTLEEC 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767917550 160 LTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKS 212
Cdd:PRK05617 290 LRRELRLALAMLRSPDFVEGVRAVLIDKDRNPKWSPATLEDVTPEDVEAFFAP 342
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-56 2.42e-12

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 63.35  E-value: 2.42e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKL 56
Cdd:cd06558  128 LPEVKLGLVPGGGGTQRLPRLVGpARARELLLTGRRISAEEALELGLVDEVVPDEEL 184
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-184 2.45e-11

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 61.34  E-value: 2.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLamLEEdllalkspskeniasvle 79
Cdd:COG1024  127 LPEVRLGLIPGGGGTQRLPRLVGlARAKELLLTGRRIDAEEALELGLVNRVVPDDEL--LAA------------------ 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  80 nyhteskidrdksfileehmdkinscfsantveeiienlqqdgssfALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEV 159
Cdd:COG1024  187 ----------------------------------------------ALALAARLAAGPPLALAATKRALNAALEAPLDEA 220

                        170       180
                 ....*....|....*....|....*
gi 767917550 160 LTMEYRLSQACMRGHDFHEGVRAVL 184
Cdd:COG1024  221 LELEAEAFAELFASEDAREGIAAFL 245
 
Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-210 1.36e-117

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 337.90  E-value: 1.36e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550    1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLEN 80
Cdd:pfam16113 123 MPETAIGLFPDVGGSYFLSRLPGELGLYLALTGARLNGADALAAGLATHYVPSARLPALEEALAALDWSDPADVDAVLAE 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   81 YHTESKidrDKSFILEEHMDKINSCFSANTVEEIIENLQQ--DGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQE 158
Cdd:pfam16113 203 FAEESD---PPPSPLAAHREAIDRCFSADTVEEIIAALEAeaDGDEWAAETLKTLRKRSPTSLKVTLRQLRRGRKLSLAE 279

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767917550  159 VLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHF 210
Cdd:pfam16113 280 CLRMEYRLALRCLRRPDFVEGVRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 1-212 1.97e-88

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 263.99  E-value: 1.97e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKE-NIASVLE 79
Cdd:PRK05617 135 MPETGIGFFPDVGGTYFLSRAPGALGTYLALTGARISAADALYAGLADHFVPSADLPALLDALISLRWDSGAdVVDAALA 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  80 NYHTESKIDRdksfiLEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEV 159
Cdd:PRK05617 215 AFATPAPASE-----LAAQRAWIDECFAGDTVEDIIAALEADGGEFAAKTADTLRSRSPTSLKVTLEQLRRARGLTLEEC 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767917550 160 LTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKS 212
Cdd:PRK05617 290 LRRELRLALAMLRSPDFVEGVRAVLIDKDRNPKWSPATLEDVTPEDVEAFFAP 342
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 1-211 7.00e-66

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 207.73  E-value: 7.00e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLEN 80
Cdd:PLN02874 140 TPEASVGFHTDCGFSYILSRLPGHLGEYLALTGARLNGKEMVACGLATHFVPSEKLPELEKRLLNLNSGDESAVQEAIEE 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  81 YHTESKIDRDKsfILEEhMDKINSCFSANTVEEIIENLQ----QDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTL 156
Cdd:PLN02874 220 FSKDVQADEDS--ILNK-QSWINECFSKDTVEEIIKAFEseasKTGNEWIKETLKGLRRSSPTGLKITLRSIREGRKQSL 296

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767917550 157 QEVLTMEYRLSQACMRG---HDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFK 211
Cdd:PLN02874 297 AECLKKEFRLTMNILRStvsDDVYEGIRALVIDKDNAPKWNPSTLDEVTDEKVDLVFQ 354
PLN02851 PLN02851
3-hydroxyisobutyryl-CoA hydrolase-like protein
 2-217 1.91e-50

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178443 [Multi-domain]  Cd Length: 407  Bit Score: 168.62  E-value: 1.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   2 PETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLENY 81
Cdd:PLN02851 174 PEVQMGFHPDAGASYYLSRLPGYLGEYLALTGQKLNGVEMIACGLATHYCLNARLPLIEERLGKLLTDDPAVIEDSLAQY 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  82 HteSKIDRDKSFILEEhMDKINSCFSANTVEEIIENLQQDGSS----FALEQLKVINKMSPTSLKITLRQLMEGSSKTLQ 157
Cdd:PLN02851 254 G--DLVYPDKSSVLHK-IETIDKCFGHDTVEEIIEALENEAASsydeWCKKALKKIKEASPLSLKVTLQSIREGRFQTLD 330

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767917550 158 EVLTMEYRLSQACMR---GHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSLGSSD 217
Cdd:PLN02851 331 QCLAREYRISLCGVSkwvSGDFCEGVRARLVDKDFAPKWDPPSLGEVSKDMVDCYFTPLDESE 393
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 1-213 3.66e-48

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 162.19  E-value: 3.66e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLEN 80
Cdd:PLN02988 140 MPETALGLFPDVGASYFLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPSTRLTALEADLCRIGSNDPTFASTILDA 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  81 YHTESKIDRDKSFileEHMDKINSCFSANTVEEIIENLQ----QDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTL 156
Cdd:PLN02988 220 YTQHPRLKPQSAY---HRLDVIDRCFSRRTVEEIISALEreatQEADGWISATIQALKKASPASLKISLRSIREGRLQGV 296

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550 157 QEVLTMEYRLSQACMRGH---DFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSL 213
Cdd:PLN02988 297 GQCLIREYRMVCHVMKGEiskDFVEGCRAILVDKDKNPKWEPRRLEDMKDSMVEQYFERV 356
PLN02157 PLN02157
3-hydroxyisobutyryl-CoA hydrolase-like protein
 2-217 2.03e-43

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 177817 [Multi-domain]  Cd Length: 401  Bit Score: 150.22  E-value: 2.03e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   2 PETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLENY 81
Cdd:PLN02157 169 PETIIGFHPDAGASFNLSHLPGRLGEYLGLTGLKLSGAEMLACGLATHYIRSEEIPVMEEQLKKLLTDDPSVVESCLEKC 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  82 hteSKIDRDKSFILEEHMDKINSCFSANTVEEIIENLQQDGS----SFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQ 157
Cdd:PLN02157 249 ---AEVAHPEKTGVIRRIDLLEKCFSHDTVEEIIDSLEIEAGrrkdTWCITTLRRLKESSPLSLKVALRSIREGRLQTLD 325

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767917550 158 EVLTMEYRLSQACMRG---HDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSLGSSD 217
Cdd:PLN02157 326 QCLIREYRMSLQGLIGpmsGNFCEGVRARLIDKDEAPKWDPPSLEKVSEDMVDDYFCALTPTE 388
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-56 2.42e-12

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 63.35  E-value: 2.42e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKL 56
Cdd:cd06558  128 LPEVKLGLVPGGGGTQRLPRLVGpARARELLLTGRRISAEEALELGLVDEVVPDEEL 184
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-184 2.45e-11

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 61.34  E-value: 2.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLamLEEdllalkspskeniasvle 79
Cdd:COG1024  127 LPEVRLGLIPGGGGTQRLPRLVGlARAKELLLTGRRIDAEEALELGLVNRVVPDDEL--LAA------------------ 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  80 nyhteskidrdksfileehmdkinscfsantveeiienlqqdgssfALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEV 159
Cdd:COG1024  187 ----------------------------------------------ALALAARLAAGPPLALAATKRALNAALEAPLDEA 220

                        170       180
                 ....*....|....*....|....*
gi 767917550 160 LTMEYRLSQACMRGHDFHEGVRAVL 184
Cdd:COG1024  221 LELEAEAFAELFASEDAREGIAAFL 245
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 1-184 1.81e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 47.17  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLqgkLGYF----LALTGFRLKGRDVYRAGIATHFVDSEKLAmleedllalkspskenias 76
Cdd:PRK06688 131 LPFAKLGLCPDAGGSALLPRL---IGRAraaeMLLLGEPLSAEEALRIGLVNRVVPAAELD------------------- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550  77 vlenyhteskidrdksfileehmdkinscfsantveeiienlqqdgsSFALEQLKVINKMSPTSLKITLRQLMEGSSKTL 156
Cdd:PRK06688 189 -----------------------------------------------AEADAQAAKLAAGPASALRYTKRAINAATLTEL 221

                        170       180
                 ....*....|....*....|....*...
gi 767917550 157 QEVLTMEYRLSQACMRGHDFHEGVRAVL 184
Cdd:PRK06688 222 EEALAREAAGFGRLLRTPDFREGATAFI 249
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 6-57 2.01e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 38.36  E-value: 2.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767917550   6 IGLFPDVGGGYFLPRLQGK---LGyfLALTGFRLKGRDVYRAGIATHFVDSEKLA 57
Cdd:PRK08140 139 IGLVPDSGGTWFLPRLVGMaraLG--LALLGEKLSAEQAEQWGLIWRVVDDAALA 191
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 1-79 4.85e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 37.02  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917550   1 MPETAIGLFPDVGGGYFLPRLQGK-LGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDL---LALKSP-----SK 71
Cdd:PRK07657 132 LTETTLAIIPGAGGTQRLPRLIGVgRAKELIYTGRRISAQEAKEIGLVEFVVPAHLLEEKAIEIaekIASNGPiavrqAK 211


                 ....*...
gi 767917550  72 ENIASVLE 79
Cdd:PRK07657 212 EAISNGIQ 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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