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Conserved domains on  [gi|767917095|ref|XP_011509063|]
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coiled-coil domain-containing protein 138 isoform X10 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000037)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12704 super family cl36166
phosphodiesterase; Provisional
 183-307 1.76e-04

phosphodiesterase; Provisional


The actual alignment was detected with superfamily member PRK12704:

Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 183 ISQIYDELFQihLKLQCETAAQQKFaEELQKRERFLLEREQLLFRHENALSKIkgvEEEVLTRFQIIKEQHDaEVEHLTE 262
Cdd:PRK12704  59 LLEAKEEIHK--LRNEFEKELRERR-NELQKLEKRLLQKEENLDRKLELLEKR---EEELEKKEKELEQKQQ-ELEKKEE 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767917095 263 VLKEK-NKETKRLR-----SSFDALKELNDTLKKQL-NEASEENRKIDIQAK 307
Cdd:PRK12704 132 ELEELiEEQLQELErisglTAEEAKEILLEKVEEEArHEAAVLIKEIEEEAK 183
235kDa-fam super family cl31124
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 206-410 8.60e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


The actual alignment was detected with superfamily member TIGR01612:

Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.26  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   206 KFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLT--RFQIIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKE 283
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDeiKAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKN 1187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   284 LNDTLKKQLNEAS---------EENRKIDIQ-----AKRVQARLDNLQRKYEFMtiqrLKGSSHAVHEMKSLKQEKAPVS 349
Cdd:TIGR01612 1188 IYDEIKKLLNEIAeiekdktslEEVKGINLSygknlGKLFLEKIDEEKKKSEHM----IKAMEAYIEDLDEIKEKSPEIE 1263

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917095   350 KTYKVPLNGQV-YELLTVFMDWISDHHLSKVKHEESGMDGKKPQLKFA------SQRNDIQEKCVKLL 410
Cdd:TIGR01612 1264 NEMGIEMDIKAeMETFNISHDDDKDHHIISKKHDENISDIREKSLKIIedfseeSDINDIKKELQKNL 1331
 
Name Accession Description Interval E-value
PRK12704 PRK12704
phosphodiesterase; Provisional
 183-307 1.76e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 183 ISQIYDELFQihLKLQCETAAQQKFaEELQKRERFLLEREQLLFRHENALSKIkgvEEEVLTRFQIIKEQHDaEVEHLTE 262
Cdd:PRK12704  59 LLEAKEEIHK--LRNEFEKELRERR-NELQKLEKRLLQKEENLDRKLELLEKR---EEELEKKEKELEQKQQ-ELEKKEE 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767917095 263 VLKEK-NKETKRLR-----SSFDALKELNDTLKKQL-NEASEENRKIDIQAK 307
Cdd:PRK12704 132 ELEELiEEQLQELErisglTAEEAKEILLEKVEEEArHEAAVLIKEIEEEAK 183
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 203-318 5.07e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 203 AQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTrfqiIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALK 282
Cdd:COG1196  307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEE----AEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767917095 283 ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 318
Cdd:COG1196  383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 196-346 7.95e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.52  E-value: 7.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   196 KLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLkEKNKETKRL- 274
Cdd:pfam12128  331 HGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKL-AKIREARDRq 409

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917095   275 ----RSSFDALK-ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSshAVHEMKSlKQEKA 346
Cdd:pfam12128  410 lavaEDDLQALEsELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDE--RIERARE-EQEAA 483
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 200-318 8.04e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 8.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   200 ETAAQQKFAE-ELQKRERFLLEREQLLFRHE--NALSKIKGVEEEVLTRFQII----KEQHDAEVEHLTEVLKEKNKETK 272
Cdd:TIGR02168  371 ESRLEELEEQlETLRSKVAQLELQIASLNNEieRLEARLERLEDRRERLQQEIeellKKLEEAELKELQAELEELEEELE 450

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767917095   273 RLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 318
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 206-410 8.60e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.26  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   206 KFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLT--RFQIIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKE 283
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDeiKAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKN 1187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   284 LNDTLKKQLNEAS---------EENRKIDIQ-----AKRVQARLDNLQRKYEFMtiqrLKGSSHAVHEMKSLKQEKAPVS 349
Cdd:TIGR01612 1188 IYDEIKKLLNEIAeiekdktslEEVKGINLSygknlGKLFLEKIDEEKKKSEHM----IKAMEAYIEDLDEIKEKSPEIE 1263

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917095   350 KTYKVPLNGQV-YELLTVFMDWISDHHLSKVKHEESGMDGKKPQLKFA------SQRNDIQEKCVKLL 410
Cdd:TIGR01612 1264 NEMGIEMDIKAeMETFNISHDDDKDHHIISKKHDENISDIREKSLKIIedfseeSDINDIKKELQKNL 1331
 
Name Accession Description Interval E-value
PRK12704 PRK12704
phosphodiesterase; Provisional
 183-307 1.76e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 183 ISQIYDELFQihLKLQCETAAQQKFaEELQKRERFLLEREQLLFRHENALSKIkgvEEEVLTRFQIIKEQHDaEVEHLTE 262
Cdd:PRK12704  59 LLEAKEEIHK--LRNEFEKELRERR-NELQKLEKRLLQKEENLDRKLELLEKR---EEELEKKEKELEQKQQ-ELEKKEE 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767917095 263 VLKEK-NKETKRLR-----SSFDALKELNDTLKKQL-NEASEENRKIDIQAK 307
Cdd:PRK12704 132 ELEELiEEQLQELErisglTAEEAKEILLEKVEEEArHEAAVLIKEIEEEAK 183
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 203-318 5.07e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 203 AQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTrfqiIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALK 282
Cdd:COG1196  307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEE----AEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767917095 283 ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 318
Cdd:COG1196  383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 196-346 7.95e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.52  E-value: 7.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   196 KLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLkEKNKETKRL- 274
Cdd:pfam12128  331 HGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKL-AKIREARDRq 409

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917095   275 ----RSSFDALK-ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSshAVHEMKSlKQEKA 346
Cdd:pfam12128  410 lavaEDDLQALEsELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDE--RIERARE-EQEAA 483
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 200-318 8.04e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 8.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   200 ETAAQQKFAE-ELQKRERFLLEREQLLFRHE--NALSKIKGVEEEVLTRFQII----KEQHDAEVEHLTEVLKEKNKETK 272
Cdd:TIGR02168  371 ESRLEELEEQlETLRSKVAQLELQIASLNNEieRLEARLERLEDRRERLQQEIeellKKLEEAELKELQAELEELEEELE 450

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 767917095   273 RLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQR 318
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 192-344 8.46e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 8.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095  192 QIHLkLQCETAAQQkfAEELQKRERFLLEREQLLFRHENALSKIkgveEEVLTRFQIIKEQHDAevehLTEVLKEKNKET 271
Cdd:COG3096   882 QANL-LADETLADR--LEELREELDAAQEAQAFIQQHGKALAQL----EPLVAVLQSDPEQFEQ----LQADYLQAKEQQ 950

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095  272 KRLRSSFDALKE----------------------LNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRkyefmTIQRLK 329
Cdd:COG3096   951 RRLKQQIFALSEvvqrrphfsyedavgllgensdLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQ-----VLASLK 1025

                         170
                  ....*....|....*.
gi 767917095  330 GSSHAVHEM-KSLKQE 344
Cdd:COG3096  1026 SSRDAKQQTlQELEQE 1041
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
182-328 1.41e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.43  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 182 QISQIYDELFQIHLKLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAevehLT 261
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEE----LQ 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767917095 262 EVLKEKNKETKRLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRL 328
Cdd:COG4372  115 EELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEA 181
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 192-346 1.69e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 192 QIHLKLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEvLTRFQIIKEQHDAEVEHLTEVLKEKNKET 271
Cdd:COG1196  289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEE-LEELEEELEEAEEELEEAEAELAEAEEAL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767917095 272 KRLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSSHAVHEMKSLKQEKA 346
Cdd:COG1196  368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEE 442
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 182-322 3.81e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 182 QISQIYDELFQIHLKLQcetAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVltrfQIIKEQHDAEVEHLT 261
Cdd:COG1196  268 ELEELRLELEELELELE---EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL----AELEEELEELEEELE 340

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767917095 262 EVLKEKNKETKRLRSsfdALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEF 322
Cdd:COG1196  341 ELEEELEEAEEELEE---AEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 168-327 4.40e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 40.06  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095  168 PKSKASDKRSLLPHQISQIYDELFQIH-----LKLQCETaaQQKFAEELQKR---------ERFLLEREQLLFRHENalS 233
Cdd:pfam05622  53 SGTPGGKKYLLLQKQLEQLQEENFRLEtarddYRIKCEE--LEKEVLELQHRneeltslaeEAQALKDEMDILRESS--D 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095  234 KIKGVEEEVLT-----------RFQI-IKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKELNDTLKKQLNEASEENRK 301
Cdd:pfam05622 129 KVKKLEATVETykkkledlgdlRRQVkLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQVQELHGKLSEESKKADK 208

                         170       180
                  ....*....|....*....|....*.
gi 767917095  302 IDIQAKRVQARLDNLQRKYEFMTIQR 327
Cdd:pfam05622 209 LEFEYKKLEEKLEALQKEKERLIIER 234
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 194-321 4.48e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 194 HLKLQCETAAQQKFAEELQKRErfLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLKEKNKETKR 273
Cdd:COG1196  264 ELEAELEELRLELEELELELEE--AQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767917095 274 LRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYE 321
Cdd:COG1196  342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELL 389
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
209-346 5.15e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.05  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095 209 EELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQiikeqhDAEVEHLTEVLKEKNKETKRLRSSFDALKELNDTL 288
Cdd:PRK03918 619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYS------EEEYEELREEYLELSRELAGLRAELEELEKRREEI 692

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767917095 289 KKQLNEASEENRKIdiqaKRVQARLDNLQRKYEFMTIQRLKgsshaVHEMKSLKQEKA 346
Cdd:PRK03918 693 KKTLEKLKEELEER----EKAKKELEKLEKALERVEELREK-----VKKYKALLKERA 741
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 184-317 7.42e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 39.44  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   184 SQIYDELFQIHLKL--QCETAAQQKFAEE--LQKRERFLleREQLL----------FRHENALSKIKG------VEEEVL 243
Cdd:pfam12128  386 EQNNRDIAGIKDKLakIREARDRQLAVAEddLQALESEL--REQLEagklefneeeYRLKSRLGELKLrlnqatATPELL 463

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767917095   244 TRfqiiKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKELNDtlkkqlnEASEENRKIDIQAKRVQARLDNLQ 317
Cdd:pfam12128  464 LQ----LENFDERIERAREEQEAANAEVERLQSELRQARKRRD-------QASEALRQASRRLEERQSALDELE 526
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 206-410 8.60e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.26  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   206 KFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLT--RFQIIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKE 283
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDeiKAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKN 1187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095   284 LNDTLKKQLNEAS---------EENRKIDIQ-----AKRVQARLDNLQRKYEFMtiqrLKGSSHAVHEMKSLKQEKAPVS 349
Cdd:TIGR01612 1188 IYDEIKKLLNEIAeiekdktslEEVKGINLSygknlGKLFLEKIDEEKKKSEHM----IKAMEAYIEDLDEIKEKSPEIE 1263

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767917095   350 KTYKVPLNGQV-YELLTVFMDWISDHHLSKVKHEESGMDGKKPQLKFA------SQRNDIQEKCVKLL 410
Cdd:TIGR01612 1264 NEMGIEMDIKAeMETFNISHDDDKDHHIISKKHDENISDIREKSLKIIedfseeSDINDIKKELQKNL 1331
RNase_Y_N pfam12072
RNase Y N-terminal region;
210-327 9.42e-03

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 37.94  E-value: 9.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767917095  210 ELQKRERFLLEREQLLFRHENALSK----IKGVEEEVLTRFQIIKEQHdaevEHLTEVLKEKNKETKRLR--SSFDALKE 283
Cdd:pfam12072  79 ELQRQERRLLQKEETLDRKDESLEKkeesLEKKEKELEAQQQQLEEKE----EELEELIEEQRQELERISglTSEEAKEI 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767917095  284 LNDTLKKQLN-EASEENRKIDIQAKRvQArlDNLQRKYEFMTIQR 327
Cdd:pfam12072 155 LLDEVEEELRhEAAVMIKEIEEEAKE-EA--DKKAKEIIALAIQR 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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