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Conserved domains on  [gi|767916461|ref|XP_011508831|]
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serine/threonine-protein kinase 11-interacting protein isoform X6 [Homo sapiens]

Protein Classification

ATP-binding protein; disease resistance protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; InlB B-repeat-containing protein; leucine-rich repeat domain-containing protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; TIR-NBS-LRR class disease resistance protein; TIR-NBS-LRR class disease resistance protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; leucine-rich repeat-containing serine/threonine-protein kinase; leucine-rich repeat domain-containing protein( domain architecture ID 11723479)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to Saccharomyces cerevisiae checkpoint protein RAD24 and Arabidopsis thaliana disease resistance protein RPS5; ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; disease resistance protein contains an N-terminal NB-ARC (also termed nucleotide-binding site, NBS) domain, which is a motif shared by plant and animal proteins whose activation results in cell death; also contains C-terminal leucine-rich repeat (LRR) motifs; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Caenorhabditis elegans acidic leucine-rich nuclear phosphoprotein 32-related protein 2; InlB B-repeat-containing protein similar to Listeria monocytogenes invasion protein Internalin B (InlB); leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Caenorhabditis elegans acidic leucine-rich nuclear phosphoprotein 32-related protein 2; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Homo sapiens leucine-rich repeat-containing protein 1 that may form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Homo sapiens lumican that binds to laminin; leucine-rich repeat (LRR)-containing serine/threonine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIP1 super family cl24471
LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It ...
 8-93 1.48e-29

LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.


The actual alignment was detected with superfamily member pfam15904:

Pssm-ID: 464931  Cd Length: 90  Bit Score: 112.20  E-value: 1.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461    8 SLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPgQTGFVALPSHPADSPVILQLQFLFDVLQKTLS 87
Cdd:pfam15904   5 PLVHSLANLLRNNGDLVLDGSSTLTLSASSLQHLTRSFEQHLLPRSH-QHGFLALPSHPADTSSLLQLQFLFDMLQKTTS 83


                  ....*.
gi 767916461   88 LKLVHV 93
Cdd:pfam15904  84 LKLIHV 89
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-291 2.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 100 GPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSlqALEELLSACGGdfCSALPWLallsaNFSYNALTALD 179
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN--QLTDLPEPLGN--LTNLKSL-----DLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 180 SSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHL 259
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767916461 260 DLAYNLLEghrELSPLWLLAELRKLYLEGNPL 291
Cdd:COG4886  256 DLSNNQLT---DLPPLANLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LIP1 pfam15904
LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It ...
 8-93 1.48e-29

LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.


Pssm-ID: 464931  Cd Length: 90  Bit Score: 112.20  E-value: 1.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461    8 SLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPgQTGFVALPSHPADSPVILQLQFLFDVLQKTLS 87
Cdd:pfam15904   5 PLVHSLANLLRNNGDLVLDGSSTLTLSASSLQHLTRSFEQHLLPRSH-QHGFLALPSHPADTSSLLQLQFLFDMLQKTTS 83


                  ....*.
gi 767916461   88 LKLVHV 93
Cdd:pfam15904  84 LKLIHV 89
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-291 2.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 100 GPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSlqALEELLSACGGdfCSALPWLallsaNFSYNALTALD 179
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN--QLTDLPEPLGN--LTNLKSL-----DLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 180 SSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHL 259
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767916461 260 DLAYNLLEghrELSPLWLLAELRKLYLEGNPL 291
Cdd:COG4886  256 DLSNNQLT---DLPPLANLTNLKTLDLSNNQL 284
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 173-321 3.64e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 173 NALTALDSsLRLLSALRFLNLSHNQVQDCQGfLMDLCELHHLDISYNRL------HLVPRmgpSGAALG----VLILRGN 242
Cdd:cd21340   56 NQIEKIEN-LENLVNLKKLYLGGNRISVVEG-LENLTNLEELHIENQRLppgeklTFDPR---SLAALSnslrVLNISGN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 243 ELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWL-LAELRKLYLEGNPLwfhpehrAATAQYlspraRD---AATGFL- 317
Cdd:cd21340  131 NIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSsWPSLRELDLTGNPV-------CKKPKY-----RDkiiLASKSLe 198


                 ....*
gi 767916461 318 -LDGK 321
Cdd:cd21340  199 vLDGK 203
LRR_8 pfam13855
Leucine rich repeat;
236-291 2.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.19e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461  236 VLILRGNELRSLHG--LEQLRNLRHLDLAYNLLEGhreLSP--LWLLAELRKLYLEGNPL 291
Cdd:pfam13855   5 SLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTT---LSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LIP1 pfam15904
LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It ...
 8-93 1.48e-29

LKB1 serine/threonine kinase interacting protein 1; LIP1 is a protein found in eukaryotes. It represents the N-terminus of a leucine-rich-repeat protein that is implicated in Peutz-Jeghers syndrome. LIP1 interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases.


Pssm-ID: 464931  Cd Length: 90  Bit Score: 112.20  E-value: 1.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461    8 SLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPgQTGFVALPSHPADSPVILQLQFLFDVLQKTLS 87
Cdd:pfam15904   5 PLVHSLANLLRNNGDLVLDGSSTLTLSASSLQHLTRSFEQHLLPRSH-QHGFLALPSHPADTSSLLQLQFLFDMLQKTTS 83


                  ....*.
gi 767916461   88 LKLVHV 93
Cdd:pfam15904  84 LKLIHV 89
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-291 2.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 100 GPIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSlqALEELLSACGGdfCSALPWLallsaNFSYNALTALD 179
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN--QLTDLPEPLGN--LTNLKSL-----DLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 180 SSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHL 259
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767916461 260 DLAYNLLEghrELSPLWLLAELRKLYLEGNPL 291
Cdd:COG4886  256 DLSNNQLT---DLPPLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-291 3.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 101 PIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSR-SLQALEELLSACggdfcSALPWLallsaNFSYNALTALD 179
Cdd:COG4886  129 PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNnQLTDLPEELGNL-----TNLKEL-----DLSNNQITDLP 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 180 SSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGpSGAALGVLILRGNELRSLHGLEQLRNLRHL 259
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPLANLTNLKTL 277

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767916461 260 DLAYNLLEGhRELSPLWLLAELRKLYLEGNPL 291
Cdd:COG4886  278 DLSNNQLTD-LKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 173-321 3.64e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 173 NALTALDSsLRLLSALRFLNLSHNQVQDCQGfLMDLCELHHLDISYNRL------HLVPRmgpSGAALG----VLILRGN 242
Cdd:cd21340   56 NQIEKIEN-LENLVNLKKLYLGGNRISVVEG-LENLTNLEELHIENQRLppgeklTFDPR---SLAALSnslrVLNISGN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 243 ELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWL-LAELRKLYLEGNPLwfhpehrAATAQYlspraRD---AATGFL- 317
Cdd:cd21340  131 NIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSsWPSLRELDLTGNPV-------CKKPKY-----RDkiiLASKSLe 198


                 ....*
gi 767916461 318 -LDGK 321
Cdd:cd21340  199 vLDGK 203
LRR_8 pfam13855
Leucine rich repeat;
236-291 2.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.19e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461  236 VLILRGNELRSLHG--LEQLRNLRHLDLAYNLLEGhreLSP--LWLLAELRKLYLEGNPL 291
Cdd:pfam13855   5 SLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTT---LSPgaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 236-289 9.09e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 9.09e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767916461 236 VLILRGNELRSLHGLEQLRNLRHLDLAYNLLEghrELSPLWLLAELRKLYLEGN 289
Cdd:cd21340   28 VLYLYDNKITKIENLEFLTNLTHLYLQNNQIE---KIENLENLVNLKKLYLGGN 78
LRR_8 pfam13855
Leucine rich repeat;
210-266 2.49e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461  210 ELHHLDISYNRLHLV-PRMGPSGAALGVLILRGNELRSLHG--LEQLRNLRHLDLAYNLL 266
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-319 3.92e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 101 PIKIFPFKSLRHLELRG-------VPLHCLHGLRGIY---SQLETLICS-RSLQALEEL-LSACGGdfcSALPWLALLSA 168
Cdd:COG4886  175 PEELGNLTNLKELDLSNnqitdlpEPLGNLTNLEELDlsgNQLTDLPEPlANLTNLETLdLSNNQL---TDLPELGNLTN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 169 ----NFSYNALTALDSSLRLlSALRFLNLSHNQVQDCQ----GFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILR 240
Cdd:COG4886  252 leelDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767916461 241 GNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLD 319
Cdd:COG4886  331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 234-264 4.96e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.96e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767916461  234 LGVLILRGNELRSLHGLEQLRNLRHLDLAYN 264
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-289 7.37e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 7.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 110 LRHLELRGVPLhCLHGLRGIYSQLEtlicSRSLQAL---EELLSACGGDF-CSAL--PWLALLSANFSYNALT-----AL 178
Cdd:cd00116   83 LQELDLSDNAL-GPDGCGVLESLLR----SSSLQELklnNNGLGDRGLRLlAKGLkdLPPALEKLVLGRNRLEgasceAL 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767916461 179 DSSLRLLSALRFLNLSHNQVQD------CQGFLMdLCELHHLDISYNRLhlvprMGPSGAALGvlilrgnelrslHGLEQ 252
Cdd:cd00116  158 AKALRANRDLKELNLANNGIGDagiralAEGLKA-NCNLEVLDLNNNGL-----TDEGASALA------------ETLAS 219

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767916461 253 LRNLRHLDLAYNLL--EGHRELSP--LWLLAELRKLYLEGN 289
Cdd:cd00116  220 LKSLEVLNLGDNNLtdAGAAALASalLSPNISLLTLSLSCN 260
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 255-291 8.97e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767916461  255 NLRHLDLAYNLLEghrELSPLWLLAELRKLYLEGNPL 291
Cdd:pfam12799   2 NLEVLDLSNNQIT---DIPPLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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