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Conserved domains on  [gi|767910836|ref|XP_011508432|]
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U4/U6 small nuclear ribonucleoprotein Prp3 isoform X2 [Homo sapiens]

Protein Classification

pre-mRNA processing factor 3 family protein( domain architecture ID 10554148)

pre-mRNA processing factor 3 (PRP3) family protein similar to Saccharomyces cerevisiae U4/U6 small nuclear ribonucleoprotein PRP3, which participates in pre-mRNA splicing as part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome

Gene Ontology:  GO:0006397|GO:0000398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRP3 pfam08572
pre-mRNA processing factor 3 (PRP3); Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated ...
 164-377 2.84e-111

pre-mRNA processing factor 3 (PRP3); Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor. The human PRP3 has been implicated in autosomal retinitis pigmentosa.


:

Pssm-ID: 462524  Cd Length: 219  Bit Score: 329.94  E-value: 2.84e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  164 NTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEgDIPEI 243
Cdd:pfam08572   1 NPYFDPRLSAKPKRRKRRSLKFNEKGKYIKQAERLRRKAQLEELKKRIAEEARKAGLLPDTDLAEKAPKKFKDE-VPPDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  244 EWWDSYIIPNGFDLTEENPKR------EDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQ 317
Cdd:pfam08572  80 EWWDEPYLPDGSYYDDLIDDKynldieDEDSPITNYVQHPVPIKPPQEKNKPPPKPLYLTKKEQKKLRRQRRKEALKEKQ 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  318 EKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLT 377
Cdd:pfam08572 160 DKIRLGLEPPPPPKVKLSNLMRVLGNEAVQDPTKVEARVRRQMAERKQKHEEANEERKLT 219
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 400-529 1.57e-62

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


:

Pssm-ID: 461943  Cd Length: 135  Bit Score: 200.98  E-value: 1.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  400 SVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEA 479
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYKKLMLRRIKWTENPHEDFEAMKEITFEWD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767910836  480 -----VKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLA 529
Cdd:pfam06544  81 ndednEGEDNKCELVWEGEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYWDLA 135
 
Name Accession Description Interval E-value
PRP3 pfam08572
pre-mRNA processing factor 3 (PRP3); Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated ...
 164-377 2.84e-111

pre-mRNA processing factor 3 (PRP3); Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor. The human PRP3 has been implicated in autosomal retinitis pigmentosa.


Pssm-ID: 462524  Cd Length: 219  Bit Score: 329.94  E-value: 2.84e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  164 NTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEgDIPEI 243
Cdd:pfam08572   1 NPYFDPRLSAKPKRRKRRSLKFNEKGKYIKQAERLRRKAQLEELKKRIAEEARKAGLLPDTDLAEKAPKKFKDE-VPPDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  244 EWWDSYIIPNGFDLTEENPKR------EDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQ 317
Cdd:pfam08572  80 EWWDEPYLPDGSYYDDLIDDKynldieDEDSPITNYVQHPVPIKPPQEKNKPPPKPLYLTKKEQKKLRRQRRKEALKEKQ 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  318 EKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLT 377
Cdd:pfam08572 160 DKIRLGLEPPPPPKVKLSNLMRVLGNEAVQDPTKVEARVRRQMAERKQKHEEANEERKLT 219
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 400-529 1.57e-62

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 200.98  E-value: 1.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  400 SVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEA 479
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYKKLMLRRIKWTENPHEDFEAMKEITFEWD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767910836  480 -----VKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLA 529
Cdd:pfam06544  81 ndednEGEDNKCELVWEGEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYWDLA 135
Prp3_C cd24162
C-terminal domain of U4/U6 small nuclear ribonucleoprotein Prp3; Prp3 is an essential U4/U6 ...
 397-518 1.67e-60

C-terminal domain of U4/U6 small nuclear ribonucleoprotein Prp3; Prp3 is an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. It may be involved in U4/U6 reassembly after splicing. The C-terminal domain of Prp3 is a single-stranded RNA-binding domain.


Pssm-ID: 467813  Cd Length: 122  Bit Score: 195.49  E-value: 1.67e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836 397 VHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESD 476
Cdd:cd24162    1 VHVAVFRVKDLSNPKHRFKVDTNAQQLHLTGVCILHPDFNLVVVEGGPKSIKKYKKLMLRRIKWNEDEEPEDDDDGEEEE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767910836 477 EEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFK 518
Cdd:cd24162   81 EEEDLSDNKCVLVWEGTVKKRAFKKFKFKVCPTEAEAREFLK 122
 
Name Accession Description Interval E-value
PRP3 pfam08572
pre-mRNA processing factor 3 (PRP3); Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated ...
 164-377 2.84e-111

pre-mRNA processing factor 3 (PRP3); Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor. The human PRP3 has been implicated in autosomal retinitis pigmentosa.


Pssm-ID: 462524  Cd Length: 219  Bit Score: 329.94  E-value: 2.84e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  164 NTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEgDIPEI 243
Cdd:pfam08572   1 NPYFDPRLSAKPKRRKRRSLKFNEKGKYIKQAERLRRKAQLEELKKRIAEEARKAGLLPDTDLAEKAPKKFKDE-VPPDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  244 EWWDSYIIPNGFDLTEENPKR------EDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQ 317
Cdd:pfam08572  80 EWWDEPYLPDGSYYDDLIDDKynldieDEDSPITNYVQHPVPIKPPQEKNKPPPKPLYLTKKEQKKLRRQRRKEALKEKQ 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  318 EKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLT 377
Cdd:pfam08572 160 DKIRLGLEPPPPPKVKLSNLMRVLGNEAVQDPTKVEARVRRQMAERKQKHEEANEERKLT 219
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 400-529 1.57e-62

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 200.98  E-value: 1.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836  400 SVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEA 479
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYKKLMLRRIKWTENPHEDFEAMKEITFEWD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767910836  480 -----VKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLA 529
Cdd:pfam06544  81 ndednEGEDNKCELVWEGEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYWDLA 135
Prp3_C cd24162
C-terminal domain of U4/U6 small nuclear ribonucleoprotein Prp3; Prp3 is an essential U4/U6 ...
 397-518 1.67e-60

C-terminal domain of U4/U6 small nuclear ribonucleoprotein Prp3; Prp3 is an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. It may be involved in U4/U6 reassembly after splicing. The C-terminal domain of Prp3 is a single-stranded RNA-binding domain.


Pssm-ID: 467813  Cd Length: 122  Bit Score: 195.49  E-value: 1.67e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836 397 VHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESD 476
Cdd:cd24162    1 VHVAVFRVKDLSNPKHRFKVDTNAQQLHLTGVCILHPDFNLVVVEGGPKSIKKYKKLMLRRIKWNEDEEPEDDDDGEEEE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767910836 477 EEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFK 518
Cdd:cd24162   81 EEEDLSDNKCVLVWEGTVKKRAFKKFKFKVCPTEAEAREFLK 122
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 398-513 3.47e-07

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 49.18  E-value: 3.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910836 398 HISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRiKWDEQTSNTKGDDDEESDE 477
Cdd:cd24140    2 HCKVFHFKHLQNKKKRFKIKENSKELSLKGLCMRIRDPGIIIVVGNEKSCKEYENLVKKR-KWNEDFELHTNTGDIKEKC 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767910836 478 eavkKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMA 513
Cdd:cd24140   81 ----HNNSISKTWEGYLQDCKFKGWFLKVCNDQYSL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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