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Conserved domains on  [gi|767909819|ref|XP_011508049|]
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protein-cysteine N-palmitoyltransferase HHAT isoform X6 [Homo sapiens]

Protein Classification

membrane-bound O-acyltransferase family protein( domain architecture ID 10503555)

membrane-bound O-acyltransferase (MBOAT) family protein catalyzes the transfer of an acyl group from acyl-CoA to an alcohol substrate to form the corresponding alcohol ester; such as sterol O-acyltransferase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
62-379 5.39e-56

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


:

Pssm-ID: 427117  Cd Length: 334  Bit Score: 188.03  E-value: 5.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819   62 FCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFS----LELCWQQLPAASTSYS 137
Cdd:pfam03062   1 ILLYSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRpvslSFRKLASAAALSQDPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  138 FPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRL--------LCWWWLAELMAHLMYMHAIYS 209
Cdd:pfam03062  81 LLEYLGYVFFYPGLLVGPIFSYSDYMSFPRDPLFRWLYYVKRNLAPALGALflgltyliLIQYLLSHLPDKDFSKFKFLS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  210 SIPLLE-TVSCWTLGGLALAQVLFFY-------VKYLVLFGVPALLmrLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHN 281
Cdd:pfam03062 161 YAFLLRfSVIMRILLGLLWLFLLIFDflgwlfaEGEDILFGLGFNG--WDRVAPENIYRCWENAVSFSEFWRAWNIPVHK 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  282 FLIRYVYIPVGgsQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQAR 361
Cdd:pfam03062 239 WLKRYVYKPLG--KKGKLNKFLATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLKTDRRRPNLSNVI 316
                         330
                  ....*....|....*...
gi 767909819  362 RRFHAALASCSTSMLILS 379
Cdd:pfam03062 317 FWLGAFLGPSLALLLSLS 334
 
Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
62-379 5.39e-56

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 188.03  E-value: 5.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819   62 FCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFS----LELCWQQLPAASTSYS 137
Cdd:pfam03062   1 ILLYSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRpvslSFRKLASAAALSQDPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  138 FPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRL--------LCWWWLAELMAHLMYMHAIYS 209
Cdd:pfam03062  81 LLEYLGYVFFYPGLLVGPIFSYSDYMSFPRDPLFRWLYYVKRNLAPALGALflgltyliLIQYLLSHLPDKDFSKFKFLS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  210 SIPLLE-TVSCWTLGGLALAQVLFFY-------VKYLVLFGVPALLmrLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHN 281
Cdd:pfam03062 161 YAFLLRfSVIMRILLGLLWLFLLIFDflgwlfaEGEDILFGLGFNG--WDRVAPENIYRCWENAVSFSEFWRAWNIPVHK 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  282 FLIRYVYIPVGgsQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQAR 361
Cdd:pfam03062 239 WLKRYVYKPLG--KKGKLNKFLATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLKTDRRRPNLSNVI 316
                         330
                  ....*....|....*...
gi 767909819  362 RRFHAALASCSTSMLILS 379
Cdd:pfam03062 317 FWLGAFLGPSLALLLSLS 334
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
116-357 2.97e-04

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 42.90  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819 116 YYT----SFSLELCWQQLPAAstsYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKAslcvLALGLgRLLCW 191
Cdd:COG1696  127 FYTfqaiSYLVDVYRGKIKPE---RNFLDYALFVSFFPQLVAGPIVRAKDLLPQLRKRRTFDYEN----FARGL-RLFLL 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819 192 -----WWLAELMAhlMYMHAIYSSIPLLETVSCWtLGGLALAQVLFF----YVkYLVLfGVpALLMRLDgltppaLPR-- 260
Cdd:COG1696  199 glfkkVVIADNLA--PYVDPVFDNPESLSGLEAW-LGALAYTLQIYFdfsgYS-DMAI-GL-ALLFGFR------LPEnf 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819 261 ---CVSTmfSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHG-GYDYLwCWAALNWLGVTVE 336
Cdd:COG1696  267 nspYFAR--SITEFWRRWHISLSTWLRDYLYIPLGGNRKGKLRTYLNLFITMLLGGLWHGaGWTFV-IWGALHGLYLVLE 343
                        250       260
                 ....*....|....*....|.
gi 767909819 337 NGVRRLVETPCIQDSLARYFS 357
Cdd:COG1696  344 RLWRKLRLKLPRLSRLGRLLG 364
 
Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
62-379 5.39e-56

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 188.03  E-value: 5.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819   62 FCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFS----LELCWQQLPAASTSYS 137
Cdd:pfam03062   1 ILLYSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRpvslSFRKLASAAALSQDPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  138 FPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRL--------LCWWWLAELMAHLMYMHAIYS 209
Cdd:pfam03062  81 LLEYLGYVFFYPGLLVGPIFSYSDYMSFPRDPLFRWLYYVKRNLAPALGALflgltyliLIQYLLSHLPDKDFSKFKFLS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  210 SIPLLE-TVSCWTLGGLALAQVLFFY-------VKYLVLFGVPALLmrLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHN 281
Cdd:pfam03062 161 YAFLLRfSVIMRILLGLLWLFLLIFDflgwlfaEGEDILFGLGFNG--WDRVAPENIYRCWENAVSFSEFWRAWNIPVHK 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819  282 FLIRYVYIPVGgsQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQAR 361
Cdd:pfam03062 239 WLKRYVYKPLG--KKGKLNKFLATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLKTDRRRPNLSNVI 316
                         330
                  ....*....|....*...
gi 767909819  362 RRFHAALASCSTSMLILS 379
Cdd:pfam03062 317 FWLGAFLGPSLALLLSLS 334
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
116-357 2.97e-04

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 42.90  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819 116 YYT----SFSLELCWQQLPAAstsYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKAslcvLALGLgRLLCW 191
Cdd:COG1696  127 FYTfqaiSYLVDVYRGKIKPE---RNFLDYALFVSFFPQLVAGPIVRAKDLLPQLRKRRTFDYEN----FARGL-RLFLL 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819 192 -----WWLAELMAhlMYMHAIYSSIPLLETVSCWtLGGLALAQVLFF----YVkYLVLfGVpALLMRLDgltppaLPR-- 260
Cdd:COG1696  199 glfkkVVIADNLA--PYVDPVFDNPESLSGLEAW-LGALAYTLQIYFdfsgYS-DMAI-GL-ALLFGFR------LPEnf 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909819 261 ---CVSTmfSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHG-GYDYLwCWAALNWLGVTVE 336
Cdd:COG1696  267 nspYFAR--SITEFWRRWHISLSTWLRDYLYIPLGGNRKGKLRTYLNLFITMLLGGLWHGaGWTFV-IWGALHGLYLVLE 343
                        250       260
                 ....*....|....*....|.
gi 767909819 337 NGVRRLVETPCIQDSLARYFS 357
Cdd:COG1696  344 RLWRKLRLKLPRLSRLGRLLG 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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