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Conserved domains on  [gi|767909626|ref|XP_011507969|]
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protoporphyrinogen oxidase isoform X5 [Homo sapiens]

Protein Classification

protoporphyrinogen/coproporphyrinogen oxidase( domain architecture ID 11440906)

protoporphyrinogen/coproporphyrinogen oxidase is a FAD-dependent enzyme that catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX or the oxidation of coproporphyrinogen III to coproporphyrin III, respectively

CATH:  3.50.50.60|3.50.50.60|1.10.3110.10|3.90.660.20
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0006779|GO:0071949
PubMed:  10944103
SCOP:  4000128|3000055|4000128

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-421 3.38e-71

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 233.96  E-value: 3.38e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLllacgeq 79
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLEL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  80 VSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRR 158
Cdd:COG1232   68 LRELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 159 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------W 232
Cdd:COG1232  142 FGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfG 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 233 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARAL 311
Cdd:COG1232  204 YLRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAAL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 312 SAITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvL 389
Cdd:COG1232  281 AGIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----L 354

                        410       420       430
                 ....*....|....*....|....*....|..
gi 767909626 390 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 421
Cdd:COG1232  355 SDEELVALALADLRKLLGIDAEPVDTRVVRWP 386
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-421 3.38e-71

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 233.96  E-value: 3.38e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLllacgeq 79
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLEL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  80 VSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRR 158
Cdd:COG1232   68 LRELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 159 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------W 232
Cdd:COG1232  142 FGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfG 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 233 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARAL 311
Cdd:COG1232  204 YLRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAAL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 312 SAITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvL 389
Cdd:COG1232  281 AGIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----L 354

                        410       420       430
                 ....*....|....*....|....*....|..
gi 767909626 390 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 421
Cdd:COG1232  355 SDEELVALALADLRKLLGIDAEPVDTRVVRWP 386
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-377 1.94e-58

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 200.83  E-value: 1.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626    3 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlGARTLllacgeqV 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK-SAPDL-------V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   81 SELGLDsevlPVRGDHPAAQnRFLYV-GGALHALPTglrgllRPSPPFSKPLFWAG-----LRELTKPRGKEPDETVHSF 154
Cdd:TIGR00562  74 KDLGLE----HVLVSDATGQ-RYVLVnRGKLMPVPT------KIAPFVKTGLFSLGgklraGMDFIRPASPGKDESVEEF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  155 AQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW-- 232
Cdd:TIGR00562 143 VRRRFGDEVVENLIEPLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfq 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  233 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALS 312
Cdd:TIGR00562 219 TLATGLETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLD 296

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767909626  313 AITAVSVAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGS 377
Cdd:TIGR00562 297 KIHSPPVANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA 362
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 3-367 1.72e-46

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 168.49  E-value: 1.72e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGARTLLLACgeqVSE 82
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKPSAPAL---VKE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  83 LGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG-LRGLlrpsPPFSKPLFWAGL----------RELTKPRGK-EPDET 150
Cdd:PRK11883  72 LGLEDELV-----ANTTGQSYIYVNGKLHPIPPGtVMGI----PTSIAPFLFAGLvspigklraaADLRPPRWKpGQDQS 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 151 VHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerws 230
Cdd:PRK11883 143 VGAFFRRRFGDEVVENLIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG---- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 231 qwSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplAR 309
Cdd:PRK11883 215 --TLKGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FA 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767909626 310 ALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG 367
Cdd:PRK11883 288 LFKTIPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT--TPEG 344
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-407 4.51e-39

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 148.02  E-value: 4.51e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   12 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgARTLLlacgeqvSELGLDSEVlp 91
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQPP-LLALL-------KELGLEDRL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   92 vRGDHPAAQNRFLYVGG-----ALHALPTGLRGLLRPSPPFS---------KPLFWAGLRELtKPRGKEPDETVHSFAQR 157
Cdd:pfam01593  68 -VLPDPAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSipeklrlglAALASDALDEF-DLDDFSLAESLLFLGRR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  158 RLGP--------EVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglllgagrtpqpdsalirqalaerw 229
Cdd:pfam01593 146 GPGDvevwdrliDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL--------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  230 sqWSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAP 306
Cdd:pfam01593 199 --LLPRGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPE 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  307 LARALSAITAVSVAVVNLQYQGAHLPVQgfGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAs 385
Cdd:pfam01593 274 KARAIRNLGYGPVNKVHLEFDRKFWPDL--GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG- 350

                         410       420
                  ....*....|....*....|..
gi 767909626  386 gcvLSQELFQQRAQEAAATQLG 407
Cdd:pfam01593 351 ---LSDEELLQAVLRDLRKLFG 369
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-421 3.38e-71

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 233.96  E-value: 3.38e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLllacgeq 79
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLEL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  80 VSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLRGLLRpSPPFSKPLFWAGLRE-LTKPRGKEPDETVHSFAQRR 158
Cdd:COG1232   68 LRELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGPLALLR-SPLLSLAGKLRALLElLAPRRPPGEDESLAEFVRRR 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 159 LGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------W 232
Cdd:COG1232  142 FGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfG 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 233 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARAL 311
Cdd:COG1232  204 YLRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAAL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 312 SAITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvL 389
Cdd:COG1232  281 AGIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----L 354

                        410       420       430
                 ....*....|....*....|....*....|..
gi 767909626 390 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 421
Cdd:COG1232  355 SDEELVALALADLRKLLGIDAEPVDTRVVRWP 386
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-377 1.94e-58

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 200.83  E-value: 1.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626    3 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlGARTLllacgeqV 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK-SAPDL-------V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   81 SELGLDsevlPVRGDHPAAQnRFLYV-GGALHALPTglrgllRPSPPFSKPLFWAG-----LRELTKPRGKEPDETVHSF 154
Cdd:TIGR00562  74 KDLGLE----HVLVSDATGQ-RYVLVnRGKLMPVPT------KIAPFVKTGLFSLGgklraGMDFIRPASPGKDESVEEF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  155 AQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW-- 232
Cdd:TIGR00562 143 VRRRFGDEVVENLIEPLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfq 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  233 SLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALS 312
Cdd:TIGR00562 219 TLATGLETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLD 296

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767909626  313 AITAVSVAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGS 377
Cdd:TIGR00562 297 KIHSPPVANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA 362
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 3-367 1.72e-46

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 168.49  E-value: 1.72e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGARTLLLACgeqVSE 82
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKPSAPAL---VKE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  83 LGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG-LRGLlrpsPPFSKPLFWAGL----------RELTKPRGK-EPDET 150
Cdd:PRK11883  72 LGLEDELV-----ANTTGQSYIYVNGKLHPIPPGtVMGI----PTSIAPFLFAGLvspigklraaADLRPPRWKpGQDQS 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 151 VHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerws 230
Cdd:PRK11883 143 VGAFFRRRFGDEVVENLIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG---- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 231 qwSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplAR 309
Cdd:PRK11883 215 --TLKGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FA 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767909626 310 ALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG 367
Cdd:PRK11883 288 LFKTIPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT--TPEG 344
PLN02576 PLN02576
protoporphyrinogen oxidase
 2-377 1.38e-44

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 164.03  E-value: 1.38e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   2 GRTVVVLGGGISGLAASYHLSRAPCPpKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGALgartLLLACgeqvs 81
Cdd:PLN02576  12 SKDVAVVGAGVSGLAAAYALASKHGV-NVLVTEARDRVGGNITSVSE-DGFIWEEGPNSFQPSDPE----LTSAV----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  82 ELGL-DSEVLPVrgdhPAAqNRFLYVGGALHALPTGLRGLlrpspPFSKPLFWAG-LRELTKP----RGKEPD--ETVHS 153
Cdd:PLN02576  81 DSGLrDDLVFPD----PQA-PRYVVWNGKLRPLPSNPIDL-----PTFDLLSAPGkIRAGLGAfgwkRPPPPGreESVGE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 154 FAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSI-----LLGLLLGAGRTPQP-DSALIRQalaE 227
Cdd:PLN02576 151 FVRRHLGDEVFERLIDPFVSGVYAGDPSSLSMKAAFPKLWNLEKRGGSIiggaiKAIQEAKKNPKPEPrDPRLPKP---K 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 228 RWSQWSLRGGLEMLPQALETHLTSRGVSVlrGQPVCGLSLQAEGRWKVSLRD----SSLEADHVISAIPASVLSELLPAE 303
Cdd:PLN02576 228 GQTVGSFRGGLQTLPDALAKRLGKDKVKL--NWKVLSLSKNDDGGYSLTYDTpegkVNVTAKAVVMTAPLYVVSEMLRPK 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 304 AAPLARALSAITAVSVAVVNLQY--------QGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPeqDGSPPGLRV-TVML 374
Cdd:PLN02576 306 SPAAADALPEFYYPPVAAVTTSYpkeavkreRLIDGPLEGFGQLHPRKQGVKTLGTIYSSSLFP--DRAPEGRVLlLNYI 383


                 ...
gi 767909626 375 GGS 377
Cdd:PLN02576 384 GGS 386
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-407 4.51e-39

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 148.02  E-value: 4.51e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   12 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgARTLLlacgeqvSELGLDSEVlp 91
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQPP-LLALL-------KELGLEDRL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   92 vRGDHPAAQNRFLYVGG-----ALHALPTGLRGLLRPSPPFS---------KPLFWAGLRELtKPRGKEPDETVHSFAQR 157
Cdd:pfam01593  68 -VLPDPAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSipeklrlglAALASDALDEF-DLDDFSLAESLLFLGRR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  158 RLGP--------EVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglllgagrtpqpdsalirqalaerw 229
Cdd:pfam01593 146 GPGDvevwdrliDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL--------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  230 sqWSLRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAP 306
Cdd:pfam01593 199 --LLPRGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPE 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  307 LARALSAITAVSVAVVNLQYQGAHLPVQgfGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAs 385
Cdd:pfam01593 274 KARAIRNLGYGPVNKVHLEFDRKFWPDL--GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG- 350

                         410       420
                  ....*....|....*....|..
gi 767909626  386 gcvLSQELFQQRAQEAAATQLG 407
Cdd:pfam01593 351 ---LSDEELLQAVLRDLRKLFG 369
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-326 3.59e-23

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 101.92  E-value: 3.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   2 GRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGP-NGAIFELGPRGIRPagalgARTLLLAcgeQV 80
Cdd:COG1231    7 GKDVVIVGAGLAGLAAARELRKAGL--DVTVLEARDRVGGRVWTLRFGdDGLYAELGAMRIPP-----SHTNLLA---LA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  81 SELGLDSEVLPvrgdhPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK---PLFwAGLRELTKPRGKEPDETVHSFAQR 157
Cdd:COG1231   77 RELGLPLEPFP-----NENGNALLYLGGKRVRAGEIAADLRGVAELLAKllrALA-AALDPWAHPAAELDRESLAEWLRR 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 158 RLGPEVASLAMDSLCRGVFAGNSRELSIrscfpslfqaeqthrsillglllgagrtpqpdSALIRQALAERWS--QWSLR 235
Cdd:COG1231  151 NGASPSARRLLGLLGAGEYGADPDELSL--------------------------------LDLLRYAASAGGGaqQFRIV 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 236 GGLEMLPQALETHLTSRgvsVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARALS 312
Cdd:COG1231  199 GGMDQLPRALAAELGDR---IRLGAPVTRIR-QDGDGVTVTTDDgGTVRADAVIVTVPPSVLRriEFDPPLPAAKRAAIQ 274

                        330
                 ....*....|....
gi 767909626 313 AITAVSVAVVNLQY 326
Cdd:COG1231  275 RLPYGAAIKVFLQF 288
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-336 7.03e-16

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 79.90  E-value: 7.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   1 MGRTVVVLGGGISGLAASYHLSRAPCPpkVVLVESSERLGGWIRSVR----------------GPNGAIFELGPR-GIRP 63
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFR--VTLLEARPRLGGRARSFPdpdtglpidngqhvllGCYRNTLDLLRRiGAAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  64 AGALGARTLLLACGEQVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWaglrELTKPR 143
Cdd:COG3349   80 NLVGPEPLQFPLPGGRRWTLRAPRLPAPLHLLRALLRAPGLSLADRLALLRLLTACRERRWRELDDISVA----DWLRRH 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 144 GKEPDetvhsfAQRRL-----------GPEVAS--LAMDSLCRGVFAGnsrelsirscfpslfqaeqthrsillglllga 210
Cdd:COG3349  156 GQSPR------LIRRLweplllaalntPPEQASarLALTVLRETLLAG-------------------------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 211 grtpqpdsaliRQALAERWsqwsLRGGL-EMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEADHVI 288
Cdd:COG3349  198 -----------PAASDLLV----PRGPLsELFVDPALAYLEARGGEVRLGTRVRALEFDGGRVTGLVLADgETVPADAVV 262

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767909626 289 SAIPASVLSELLPA-EAAPLARALSAITAVSVAVVNLQYQG----AHLPVQGF 336
Cdd:COG3349  263 LAVPPEVAARLLPElARLPELGLLAPLEYSPIVNVHLWLDRpvtlGPPPFAGL 315
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 3-345 2.55e-15

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 78.33  E-value: 2.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAP----CPPKVVLVESSERLGGWIRSVRGpNGAIFELGprgirpAGALGARTLLLAcgE 78
Cdd:PRK12416   2 KTVVVIGGGITGLSTMFYLEKLKkdynIDLNLILVEKEEYLGGKIHSVEE-KDFIMESG------ADSIVARNEHVM--P 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  79 QVSELGLDSEVLpvrgdHPAAQNRFLYVGGALH--------ALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDET 150
Cdd:PRK12416  73 LVKDLNLEEEMV-----YNETGISYIYSDNTLHpipsdtifGIPMSVESLFSSTLVSTKGKIVALKDFITKNKEFTKDTS 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 151 VHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILlglllgagrtpqpdsalirQALAERWS 230
Cdd:PRK12416 148 LALFLESFLGKELVERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSII-------------------KGFEENKK 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 231 QW---------SLRGGLEMLPQALETHLTSrgVSVLRGQPVCGLSLQAEgRWKVSLRD-SSLEADHVISAIPASVLSELL 300
Cdd:PRK12416 209 QFqsagnkkfvSFKGGLSTIIDRLEEVLTE--TVVKKGAVTTAVSKQGD-RYEISFANhESIQADYVVLAAPHDIAETLL 285

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 767909626 301 paEAAPLARALSAITAVSVAVVNLQYQ--GAHLPVQGFGHLVPSSED 345
Cdd:PRK12416 286 --QSNELNEQFHTFKNSSLISIYLGFDilDEQLPADGTGFIVTENSD 330
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-324 1.02e-11

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 67.18  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   1 MGRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgartlllacgEQV 80
Cdd:COG1233    2 MMYDVVVIGAGIGGLAAAALLARAGY--RVTVLEKNDTPGGRARTFERP-GFRFDVGPSVLTMPGVL----------ERL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  81 -SELGLDSEV----LPVRGDHPAAQNRFLYV------------------GGALHAL--------PTGLRGLL-RPSPPFS 128
Cdd:COG1233   69 fRELGLEDYLelvpLDPAYRVPFPDGRALDLprdlertaaelerlfpgdAEAYRRFlaelrrlyDALLEDLLyRPLLSLR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 129 KPLFWAGLRELtkprGKEPDETVHSFAQRRLGPEVAslamdslcRGVFAgnsrelsirscFPSLFqaeqthrsillglll 208
Cdd:COG1233  149 DLLRPLALARL----LRLLLRSLRDLLRRYFKDPRL--------RALLA-----------GQALY--------------- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 209 gAGRTPQPDSAL--IRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEAD 285
Cdd:COG1233  191 -LGLSPDRTPALyaLIAYLEYAGGVWYPKGGMGALADALARLAEELGGEIRTGAEVERILVEGGRATGVRLADgEEIRAD 269

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767909626 286 HVISAI-PASVLSELLPAEAAP--LARALSAIT-AVSVAVVNL 324
Cdd:COG1233  270 AVVSNAdPAHTYLRLLGEEALParYRRRLERFRySPSAFKLYL 312
PRK07233 PRK07233
hypothetical protein; Provisional
 4-322 2.54e-10

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 62.60  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626   4 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWirsvrgpnGAIFELGprgirpaG----------ALGARTLL 73
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGH--EVTVFEADDQLGGL--------AASFEFG-------GlpierfyhhiFKSDEALL 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  74 lacgEQVSELGLDSEVLPVRGdhpaaQNRFlYVGGALHALPTGLRgLLRpSPPFS--------KPLFWAGLRELTKPRGK 145
Cdd:PRK07233  64 ----ELLDELGLEDKLRWRET-----KTGY-YVDGKLYPLGTPLE-LLR-FPHLSlidkfrlgLLTLLARRIKDWRALDK 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 146 EPDETvhsFAQRRLGPEVASLAMDSLCRGVFAGNSRELS---------IRScfpslfqaeqthRSillglllgagrtpqp 216
Cdd:PRK07233 132 VPAEE---WLRRWSGEGVYEVFWEPLLESKFGDYADDVSaawlwsrikRRG------------NR--------------- 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 217 DSALIRQALAerwsqwSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVL 296
Cdd:PRK07233 182 RYSLFGEKLG------YLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPIL 255

                        330       340
                 ....*....|....*....|....*.
gi 767909626 297 SELLPAEAAPLARALSAITAVSVAVV 322
Cdd:PRK07233 256 ARLVPDLPADVLARLRRIDYQGVVCM 281
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-73 2.44e-09

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 53.69  E-value: 2.44e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909626    7 VLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGALGARTLL 73
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF--RVLVLEKRDRLGGNAYSYR-VPGYVFDYGAHIFHGSDEPNVRDLL 64
PLN02268 PLN02268
probable polyamine oxidase
 4-43 9.78e-06

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 48.15  E-value: 9.78e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767909626   4 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWI 43
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASF--KVTLLESRDRIGGRV 39
PRK07208 PRK07208
hypothetical protein; Provisional
 240-313 4.24e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 46.04  E-value: 4.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626 240 MLPQALETHLTSRGVSVLRGQPVCGLSLQAEGR-WKVSLRDS-----SLEADHVISAIPASVLSELLPAEAAPLARALSA 313
Cdd:PRK07208 219 QLWETAAEKLEALGGKVVLNAKVVGLHHDGDGRiAVVVVNDTdgteeTVTADQVISSMPLRELVAALDPPPPPEVRAAAA 298
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-41 4.74e-05

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 45.88  E-value: 4.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767909626   1 MGRTVVVLGGGISGLAASYHLSRApcpPKVVLVESSERLGG 41
Cdd:COG2907    2 ARMRIAVIGSGISGLTAAWLLSRR---HDVTLFEANDRLGG 39
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-42 1.14e-04

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 44.47  E-value: 1.14e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767909626   5 VVVLGGGISGLAASYHLSRApCPPkVVLVESSERLGG-W 42
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRA-GID-FVVLEKADDVGGtW 45
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
3-44 1.20e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.85  E-value: 1.20e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767909626   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIR 44
Cdd:COG1148  141 KRALVIGGGIAGMTAALELAEQGY--EVYLVEKEPELGGRAA 180
HpnE TIGR03467
squalene-associated FAD-dependent desaturase; The sequences in this family are members of the ...
 249-329 1.53e-04

squalene-associated FAD-dependent desaturase; The sequences in this family are members of the pfam01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, pfam01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.


Pssm-ID: 274593 [Multi-domain]  Cd Length: 419  Bit Score: 44.28  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909626  249 LTSRGVSVLRGQPVCGLSLQAEG-RWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPlaRALSAITAVSVAVVNLQYQ 327
Cdd:TIGR03467 207 LDSRGGEVRLGTRVRSIEANAGGiRALVRSGGETLPADAVVLAVPPRHAASLLPGEDLG--ALLTALGYSPITTVHLRLD 284


                  ..
gi 767909626  328 GA 329
Cdd:TIGR03467 285 RA 286
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 5-41 9.90e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 41.61  E-value: 9.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767909626    5 VVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGG 41
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARR--GLSVTLLERGDDPGS 36
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
5-62 1.25e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 41.04  E-value: 1.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767909626   5 VVVLGGGISGLAASYHLSRAPCppKVVLVE-------SSERLGGWIRSVRGP--NGAIFELGPRGIR 62
Cdd:COG0665    5 VVVIGGGIAGLSTAYHLARRGL--DVTVLErgrpgsgASGRNAGQLRPGLAAlaDRALVRLAREALD 69
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-40 4.57e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 39.55  E-value: 4.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767909626   3 RTVVVLGGGISGLAASYHLSR-APCPPKVVLVESSERLG 40
Cdd:COG4529    6 KRIAIIGGGASGTALAIHLLRrAPEPLRITLFEPRPELG 44
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
240-291 7.48e-03

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 38.74  E-value: 7.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909626 240 MLP----QALETHLTSRGVSVLRGQPVCGLSLQAEGrWKVSLRDS-SLEADHVISAI 291
Cdd:PRK04965 180 LMPpevsSRLQHRLTEMGVHLLLKSQLQGLEKTDSG-IRATLDSGrSIEVDAVIAAA 235
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 2-44 9.10e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 38.70  E-value: 9.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767909626   2 GRTVVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGGWIR 44
Cdd:PRK12771 137 GKRVAVIGGGPAGLSAAYHLRRM--GHAVTIFEAGPKLGGMMR 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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