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Conserved domains on  [gi|767909085|ref|XP_011507761|]
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complement factor H-related protein 2 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 52-245 3.70e-13

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 67.37  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085  52 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKCRS 122
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085 123 TisaeKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKY 197
Cdd:PHA02927 146 V----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767909085 198 niklkwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 245
Cdd:PHA02927 221 ---------KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 52-245 3.70e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 67.37  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085  52 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKCRS 122
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085 123 TisaeKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKY 197
Cdd:PHA02927 146 V----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767909085 198 niklkwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 245
Cdd:PHA02927 221 ---------KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 129-183 9.98e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 9.98e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909085 129 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 183
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 129-183 4.35e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 4.35e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909085   129 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 183
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
129-183 9.54e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.58  E-value: 9.54e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909085  129 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 183
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 52-245 3.70e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 67.37  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085  52 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKCRS 122
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085 123 TisaeKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKY 197
Cdd:PHA02927 146 V----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767909085 198 niklkwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 245
Cdd:PHA02927 221 ---------KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 129-183 9.98e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 9.98e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909085 129 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 183
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 129-183 4.35e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 4.35e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909085   129 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 183
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
129-183 9.54e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.58  E-value: 9.54e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909085  129 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 183
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 82-225 4.66e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 4.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909085  82 QTHLEGDTVQIICNTGYrlqnNENNISCVERGWSTPPKCrstISAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQ-- 159
Cdd:PHA02831  38 KVYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMC---IGKRNCKDPVTILNGYIKN-KKDQYSFGDSVTYACKvn 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767909085 160 --NLYQLEGNNQITCRNGQW-SEPPKC-LDPC---VISQEIMEKYniklkwtnQQKLYsrTGDIVEFVCKSGY 225
Cdd:PHA02831 110 klEKYSIVGNETVKCINKQWvPKYPVCkLIRCkypALQNGFLNVF--------EKKFY--YGDIVNFKCKKGF 172
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 70-121 2.29e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.91  E-value: 2.29e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767909085  70 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WS-TPPKCR 121
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS-TITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 70-120 2.21e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.28  E-value: 2.21e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767909085    70 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WS-TPPKC 120
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGtWSpPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 117-183 8.11e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.54  E-value: 8.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909085 117 PPKCRSTISAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQN-----LYQLEGNNQITC-RNGQWS-EPPKC 183
Cdd:PHA02817  12 CNKVYSLCDLNKCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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