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Conserved domains on  [gi|767908340|ref|XP_011507462|]
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tudor domain-containing protein 10 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD10 cd20432
Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 ...
 9-147 1.33e-92

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410503  Cd Length: 139  Bit Score: 266.60  E-value: 1.33e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908340   9 LLRECFRDLSWLALIHSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAE 88
Cdd:cd20432    1 MLKDCFGDLSWLASIMKVHGEVGLLVTDTFPHTPYFWAILLTEESQQNMQQLFSTLAEVESQQPFLAKEDVHRGRRCLAE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767908340  89 YHLGDYGHAWNRCWVLDRVDTWAVVMFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPF 147
Cdd:cd20432   81 CPLGEEGGAWNRCWVLDVVEDFAVVFFVDFGSTANIPLPSLRSLDEDEFWQIPPLAQPF 139
 
Name Accession Description Interval E-value
Tudor_TDRD10 cd20432
Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 ...
 9-147 1.33e-92

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410503  Cd Length: 139  Bit Score: 266.60  E-value: 1.33e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908340   9 LLRECFRDLSWLALIHSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAE 88
Cdd:cd20432    1 MLKDCFGDLSWLASIMKVHGEVGLLVTDTFPHTPYFWAILLTEESQQNMQQLFSTLAEVESQQPFLAKEDVHRGRRCLAE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767908340  89 YHLGDYGHAWNRCWVLDRVDTWAVVMFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPF 147
Cdd:cd20432   81 CPLGEEGGAWNRCWVLDVVEDFAVVFFVDFGSTANIPLPSLRSLDEDEFWQIPPLAQPF 139
TUDOR pfam00567
Tudor domain;
53-149 4.65e-06

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 43.88  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908340   53 LHQNMQALFSTLAQaeeqqpylEGSTVMRGTRCLAEYHLGDyghAWNRCWVL-DRVDTWAVVMFIDFGQLATIPVQSLRS 131
Cdd:pfam00567  30 LTEELQEYYASKPP--------ESLPPAVGDGCVAAFSEDG---KWYRAKITeSLDDGLVEVLFIDYGNTETVPLSDLRP 98

                          90
                  ....*....|....*...
gi 767908340  132 LDSdDFWTIPPLTQPFML 149
Cdd:pfam00567  99 LPP-ELESLPPQAIKCQL 115
 
Name Accession Description Interval E-value
Tudor_TDRD10 cd20432
Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 ...
 9-147 1.33e-92

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410503  Cd Length: 139  Bit Score: 266.60  E-value: 1.33e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908340   9 LLRECFRDLSWLALIHSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAE 88
Cdd:cd20432    1 MLKDCFGDLSWLASIMKVHGEVGLLVTDTFPHTPYFWAILLTEESQQNMQQLFSTLAEVESQQPFLAKEDVHRGRRCLAE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767908340  89 YHLGDYGHAWNRCWVLDRVDTWAVVMFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPF 147
Cdd:cd20432   81 CPLGEEGGAWNRCWVLDVVEDFAVVFFVDFGSTANIPLPSLRSLDEDEFWQIPPLAQPF 139
TUDOR pfam00567
Tudor domain;
53-149 4.65e-06

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 43.88  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908340   53 LHQNMQALFSTLAQaeeqqpylEGSTVMRGTRCLAEYHLGDyghAWNRCWVL-DRVDTWAVVMFIDFGQLATIPVQSLRS 131
Cdd:pfam00567  30 LTEELQEYYASKPP--------ESLPPAVGDGCVAAFSEDG---KWYRAKITeSLDDGLVEVLFIDYGNTETVPLSDLRP 98

                          90
                  ....*....|....*...
gi 767908340  132 LDSdDFWTIPPLTQPFML 149
Cdd:pfam00567  99 LPP-ELESLPPQAIKCQL 115
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 82-132 4.75e-06

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 42.12  E-value: 4.75e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767908340  82 GTRCLAEYHLGDyghAWNRCWVLDRV-DTWAVVMFIDFGQLATIPVQSLRSL 132
Cdd:cd20379    2 GDLCAAKYEEDG---KWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 64-134 4.45e-04

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 37.67  E-value: 4.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767908340  64 LAQAEEQQPYLEGS-TVMRGTRCLAEYHLGDyghAWNRCWVLD-RVDTWAVVMFIDFGQLATIPVQSLRSLDS 134
Cdd:cd20433   12 LRFEIASNPPLPGSyTPRKGDLCAAKFVEDG---EWYRAKVEKvEGDKKVHVLYIDYGNREVLPSTRLAALPP 81
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 49-142 6.93e-04

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 38.12  E-value: 6.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908340  49 VTEALHQNMQALFSTLAQAEEQQPYlegsTVMRGTRCLAEYHLGdygHAWNRCWV--LDRVDTWAVVMFIDFGQLATIPV 126
Cdd:cd20408   21 VLESLVKLTSQLKKTYASVNNHKEY----IPEVGEVCVAKYSED---QNWYRALVqtVDVQQKKAGVFYIDYGNEETVPL 93

                         90
                 ....*....|....*.
gi 767908340 127 QSLRSLDsDDFWTIPP 142
Cdd:cd20408   94 NRIQPLK-KDIELFPP 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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