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Conserved domains on  [gi|1843006830|ref|XP_011419367|]
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heparan sulfate glucosamine 3-O-sulfotransferase 6 [Magallana gigas]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
128-365 1.35e-34

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 127.84  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 128 LPQAIIIGVKKGGTRALLEFLRVHPDVKATGP--EPHFFDKH-YHKGLDWYRSLMPETMRNQI-TIEKTPS-YFITKEVP 202
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYPGDTYFDVAEGPvRLNALPSpRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 203 ERIFQ---MSNSTKLVLVVRDPVTRAISDYTQILSKHG----KSKSFQSSAFLRNDTTkiniswivirIGLYVKHLENWL 275
Cdd:pfam00685  81 LHLLPkslWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLlkapGTPFEFVEDFLNGKVN----------CGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 276 SVFPLKQIHIVHGENLVTNPGEEVRKVQKFLGL-----EPVITDKHFFFNERRGFPC-----IKKKLKHKRGHCLDESKg 345
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIplteeELDKIVKHLSFENMKGNPClnyskLPKEVSPFFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1843006830 346 rpHPRLPESVMSALRRFYRP 365
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
128-365 1.35e-34

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 127.84  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 128 LPQAIIIGVKKGGTRALLEFLRVHPDVKATGP--EPHFFDKH-YHKGLDWYRSLMPETMRNQI-TIEKTPS-YFITKEVP 202
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYPGDTYFDVAEGPvRLNALPSpRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 203 ERIFQ---MSNSTKLVLVVRDPVTRAISDYTQILSKHG----KSKSFQSSAFLRNDTTkiniswivirIGLYVKHLENWL 275
Cdd:pfam00685  81 LHLLPkslWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLlkapGTPFEFVEDFLNGKVN----------CGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 276 SVFPLKQIHIVHGENLVTNPGEEVRKVQKFLGL-----EPVITDKHFFFNERRGFPC-----IKKKLKHKRGHCLDESKg 345
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIplteeELDKIVKHLSFENMKGNPClnyskLPKEVSPFFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1843006830 346 rpHPRLPESVMSALRRFYRP 365
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
128-365 1.35e-34

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 127.84  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 128 LPQAIIIGVKKGGTRALLEFLRVHPDVKATGP--EPHFFDKH-YHKGLDWYRSLMPETMRNQI-TIEKTPS-YFITKEVP 202
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYPGDTYFDVAEGPvRLNALPSpRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 203 ERIFQ---MSNSTKLVLVVRDPVTRAISDYTQILSKHG----KSKSFQSSAFLRNDTTkiniswivirIGLYVKHLENWL 275
Cdd:pfam00685  81 LHLLPkslWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLlkapGTPFEFVEDFLNGKVN----------CGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 276 SVFPLKQIHIVHGENLVTNPGEEVRKVQKFLGL-----EPVITDKHFFFNERRGFPC-----IKKKLKHKRGHCLDESKg 345
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIplteeELDKIVKHLSFENMKGNPClnyskLPKEVSPFFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1843006830 346 rpHPRLPESVMSALRRFYRP 365
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
132-309 4.85e-17

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 78.10  E-value: 4.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 132 IIIGVKKGGTRALLEFLRVHPDVKATGPEPHFFD---KHYHKGLDWYRSLMPETMRNQITIEKTPSYFITKEVPERIFqm 208
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIPrilALLQAWGKSLEALARVPSYARWLCDKSPSHLFHLDLLLKAF-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843006830 209 SNStKLVLVVRDPVTRAISDYTQILSKHGKSKSFQSSAFLRNDTTKINISWIVIRiglyvkhlENWLSVFPlKQIHIVHG 288
Cdd:pfam13469  80 PDA-KFIHLHRDPVDTVISSYCSLFGFTLSSYSTAFLRDIGLALARWSRAYERLM--------AARARVPP-GRFLDVRY 149

                         170       180
                  ....*....|....*....|.
gi 1843006830 289 ENLVTNPGEEVRKVQKFLGLE 309
Cdd:pfam13469 150 EDLVADPEGTLRRILEFLGLP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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