NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|759124808|ref|XP_011360138|]
View 

dolichyl-phosphate beta-glucosyltransferase isoform X2 [Pteropus vampyrus]

Protein Classification

dolichyl-phosphate beta-glucosyltransferase( domain architecture ID 10135784)

dolichyl-phosphate beta-glucosyltransferase is a glycosyltransferase family 2 protein that catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate

CAZY:  GT2
EC:  2.4.1.117
Gene Ontology:  GO:0004581|GO:0006486
PubMed:  12200473|10521532|12691742|9445404
SCOP:  3000077

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 73-293 1.87e-122

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


:

Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 349.94  E-value: 1.87e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALGYLEERqkqdPTFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAVK 152
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEYLEER----PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 153 MGVFSSRGENILMADADGATKFCDIEKLEKglndlQPWPDQMAIACGSRAHLKKDSIAQRSYFRTLLMYGFHFLVWFLCV 232
Cdd:cd04188   76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759124808 233 KGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 293
Cdd:cd04188  151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 73-293 1.87e-122

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 349.94  E-value: 1.87e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALGYLEERqkqdPTFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAVK 152
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEYLEER----PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 153 MGVFSSRGENILMADADGATKFCDIEKLEKglndlQPWPDQMAIACGSRAHLKKDSIAQRSYFRTLLMYGFHFLVWFLCV 232
Cdd:cd04188   76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759124808 233 KGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 293
Cdd:cd04188  151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 70-322 2.73e-118

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 344.44  E-value: 2.73e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  70 QLSVVVPSYNEEKRLPVMMDEALGYLEERQKQDPTFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKV--RVITLVKNRGK 147
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 148 GGAVKMGVFSSRGENILMADADGATKFCDIEKLEKGLNDLQPwpDQMAIACGSRAHL-KKDSIAQRSYFRTLLMYGFHFL 226
Cdd:PTZ00260 151 GGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQ--NGLGIVFGSRNHLvDSDVVAKRKWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 227 VWFLCVKGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKD 306
Cdd:PTZ00260 229 VNTICGTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARD 308

                        250
                 ....*....|....*.
gi 759124808 307 LLFIRLRYMTGAWRLE 322
Cdd:PTZ00260 309 ILLVRSFYLLGIWKVK 324
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 68-292 5.20e-30

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 113.26  E-value: 5.20e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  68 TKQLSVVVPSYNEEKRLPVMMDEALgyleerqKQDPtFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGK 147
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLL-------AQTY-PDFEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 148 GGAVKMGVFSSRGENILMADADGatkFCDIEKLEKGLNDLQPWPDqmAIACGSRaHLKKDsiaqRSYFRTLLMYGFHFLV 227
Cdd:COG0463   71 GAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAALEEGPA--DLVYGSR-LIREG----ESDLRRLGSRLFNLVR 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759124808 228 WFLCvkgIRDTQCGFKLLTREAASRTFSSlhiERWAFDVELLYIAQfFKIPIAEIAVNWTEIEGS 292
Cdd:COG0463  141 LLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDTELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 72-252 2.13e-24

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 97.08  E-value: 2.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808   72 SVVVPSYNEEKRLPVMMDEALgyleeRQKQDPtftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAV 151
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLL-----NQTYPN---FEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  152 KMGVFSSRGENILMADADGatkFCDIEKLEKGLNDLQPWPDqmAIACGSRAHLKKDSIAQRSYFRTLLMYGFHFLVWFLC 231
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADD---EVPPDWLEKLVEALEEDGA--DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLL 145

                         170       180
                  ....*....|....*....|.
gi 759124808  232 VKGIRDTQCGFKLLTREAASR 252
Cdd:pfam00535 146 GLNLPFLIGGFALYRREALEE 166
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 71-147 7.14e-08

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 52.13  E-value: 7.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759124808   71 LSVVVPSYNEEKRLPVMmdealgyLEERQKQDPTFtyEVIVVDDGSKDQTSKVAfkycqkyGSDKVRVITLVKNRGK 147
Cdd:TIGR04283   1 LSIIIPVLNEAATLPEL-------LADLQALRGDA--EVIVVDGGSTDGTVEIA-------RSLGAKVIHSPKGRAR 61
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
71-131 2.44e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 48.25  E-value: 2.44e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759124808  71 LSVVVPSYNEEKRLPVMmdealgyLEERQKQDPT--FTYEVIVVDDGSKDQTSKVAFKYCQKY 131
Cdd:NF038302   3 FTVAIPTYNGANRLPEV-------LERLRSQIGTesLSWEIIVVDNNSTDNTAQVVQEYQKNW 58
 
Name Accession Description Interval E-value
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 73-293 1.87e-122

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 349.94  E-value: 1.87e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALGYLEERqkqdPTFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDkVRVITLVKNRGKGGAVK 152
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEYLEER----PSFSYEIIVVDDGSKDGTAEVARKLARKNPAL-IRVLTLPKNRGKGGAVR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 153 MGVFSSRGENILMADADGATKFCDIEKLEKglndlQPWPDQMAIACGSRAHLKKDSIAQRSYFRTLLMYGFHFLVWFLCV 232
Cdd:cd04188   76 AGMLAARGDYILFADADLATPFEELEKLEE-----ALKTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLLLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 759124808 233 KGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSK 293
Cdd:cd04188  151 LGIKDTQCGFKLFTRDAARRLFPRLHLERWAFDVELLVLARRLGYPIEEVPVRWVEIPGSK 211
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 70-322 2.73e-118

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 344.44  E-value: 2.73e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  70 QLSVVVPSYNEEKRLPVMMDEALGYLEERQKQDPTFTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKV--RVITLVKNRGK 147
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIdiRLLSLLRNKGK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 148 GGAVKMGVFSSRGENILMADADGATKFCDIEKLEKGLNDLQPwpDQMAIACGSRAHL-KKDSIAQRSYFRTLLMYGFHFL 226
Cdd:PTZ00260 151 GGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQ--NGLGIVFGSRNHLvDSDVVAKRKWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 227 VWFLCVKGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEIAVNWTEIEGSKLVPFWSWLQMGKD 306
Cdd:PTZ00260 229 VNTICGTNLKDTQCGFKLFTRETARIIFPSLHLERWAFDIEIVMIAQKLNLPIAEVPVNWTEVEGSKLNVISASIQMARD 308

                        250
                 ....*....|....*.
gi 759124808 307 LLFIRLRYMTGAWRLE 322
Cdd:PTZ00260 309 ILLVRSFYLLGIWKVK 324
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 73-272 4.62e-58

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 185.47  E-value: 4.62e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALGYLEErqkqdpTFTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLVKNRGKGGAVK 152
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAVLEE------GYDYEIIVVDDGSTDGTAEIARELAARVP--RVRVIRLSRNFGKGAAVR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 153 MGVFSSRGENILMADADGATKFCDIEKLEKGLndlqpWPDQMAIACGSRAHlkKDSIAQRSYFRTLLMYGFHFLVWFLCV 232
Cdd:cd04179   73 AGFKAARGDIVVTMDADLQHPPEDIPKLLEKL-----LEGGADVVIGSRFV--RGGGAGMPLLRRLGSRLFNFLIRLLLG 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 759124808 233 KGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIA 272
Cdd:cd04179  146 VRISDTQSGFRLFRREVLEALLSLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 68-292 5.20e-30

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 113.26  E-value: 5.20e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  68 TKQLSVVVPSYNEEKRLPVMMDEALgyleerqKQDPtFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGK 147
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLL-------AQTY-PDFEIIVVDDGSTDGTAEILRELAAKD--PRIRVIRLERNRGK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 148 GGAVKMGVFSSRGENILMADADGatkFCDIEKLEKGLNDLQPWPDqmAIACGSRaHLKKDsiaqRSYFRTLLMYGFHFLV 227
Cdd:COG0463   71 GAARNAGLAAARGDYIAFLDADD---QLDPEKLEELVAALEEGPA--DLVYGSR-LIREG----ESDLRRLGSRLFNLVR 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759124808 228 WFLCvkgIRDTQCGFKLLTREAASRTFSSlhiERWAFDVELLYIAQfFKIPIAEIAVNWTEIEGS 292
Cdd:COG0463  141 LLTN---LPDSTSGFRLFRREVLEELGFD---EGFLEDTELLRALR-HGFRIAEVPVRYRAGESK 198
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 72-252 2.13e-24

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 97.08  E-value: 2.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808   72 SVVVPSYNEEKRLPVMMDEALgyleeRQKQDPtftYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAV 151
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLL-----NQTYPN---FEIIVVDDGSTDGTVEIAEEYAKKD--PRVRVIRLPENRGKAGAR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  152 KMGVFSSRGENILMADADGatkFCDIEKLEKGLNDLQPWPDqmAIACGSRAHLKKDSIAQRSYFRTLLMYGFHFLVWFLC 231
Cdd:pfam00535  71 NAGLRAATGDYIAFLDADD---EVPPDWLEKLVEALEEDGA--DVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLL 145

                         170       180
                  ....*....|....*....|.
gi 759124808  232 VKGIRDTQCGFKLLTREAASR 252
Cdd:pfam00535 146 GLNLPFLIGGFALYRREALEE 166
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 73-294 3.05e-19

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 84.89  E-value: 3.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALGYLEErqkqdptFTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLVKNRGKGGAVK 152
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAALKG-------IDYEIIVVDDNSPDGTAEIVRELAKEYP--RVRLIVRPGKRGLGSAYI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 153 MGVFSSRGENILMADADGATKFCDIEKL-EKGLNdlqpwpDQMAIACGSRaHLKKDSIAQRSYFRTLLMYGFHFLVWFLC 231
Cdd:cd06442   72 EGFKAARGDVIVVMDADLSHPPEYIPELlEAQLE------GGADLVIGSR-YVEGGGVEGWGLKRKLISRGANLLARLLL 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 759124808 232 VKGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEIAVNWTE-IEG-SKL 294
Cdd:cd06442  145 GRKVSDPTSGFRAYRREVLEKLIDSLVSKGYKFQLELLVRARRLGYRIVEVPITFVDrEHGeSKL 209
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 49-169 4.22e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 83.25  E-value: 4.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  49 FFLNARGQKETLPSIrdsptkqlSVVVPSYNEEKRLPvmmdEALGYLeerQKQD-PTFTYEVIVVDDGSKDQTSKVAFKY 127
Cdd:COG1215   17 ALARRRRAPADLPRV--------SVIIPAYNEEAVIE----ETLRSL---LAQDyPKEKLEVIVVDDGSTDETAEIAREL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 759124808 128 CQKYgsDKVRVITLVKNRGKGGAVKMGVFSSRGENILMADAD 169
Cdd:COG1215   82 AAEY--PRVRVIERPENGGKAAALNAGLKAARGDIVVFLDAD 121
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 73-169 1.34e-17

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 78.70  E-value: 1.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALgyleerqKQDPTFtYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAVK 152
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLL-------AQTYPN-FEVIVVDDGSTDGTLEILEEYAKKD--PRVIRVINEENQGLAAARN 70

                         90
                 ....*....|....*..
gi 759124808 153 MGVFSSRGENILMADAD 169
Cdd:cd00761   71 AGLKAARGEYILFLDAD 87
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 73-250 8.11e-16

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 74.05  E-value: 8.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALGYLEErqkqdPTFTYEVIVVDDGSKDQTSKVAFKYCQKYgsDKVRVITLVKNRGKGGAVK 152
Cdd:cd04187    1 IVVPVYNEEENLPELYERLKAVLES-----LGYDYEIIFVDDGSTDRTLEILRELAARD--PRVKVIRLSRNFGQQAALL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 153 MGVFSSRGENILMADADG------ATKFcdIEKLEKGlNDlqpwpdqmaIACGSRAHlKKDSIaqrsyFRTLLMYGFHFL 226
Cdd:cd04187   74 AGLDHARGDAVITMDADLqdppelIPEM--LAKWEEG-YD---------VVYGVRKN-RKESW-----LKRLTSKLFYRL 135

                        170       180
                 ....*....|....*....|....
gi 759124808 227 VWFLCVKGIRDTQCGFKLLTREAA 250
Cdd:cd04187  136 INKLSGVDIPDNGGDFRLMDRKVV 159
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 72-282 1.91e-15

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 74.73  E-value: 1.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  72 SVVVPSYNEEKRLPVMMdealgYLEERQKQDPTfTYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGAV 151
Cdd:PLN02726  12 SIIVPTYNERLNIALIV-----YLIFKALQDVK-DFEIIVVDDGSPDGTQDVVKQLQKVYGEDRILLRPRPGKLGLGTAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808 152 KMGVFSSRGENILMADADGA--TKFCD--IEK-LEKGLNdlqpwpdqmaIACGSRaHLKKDSIAQRSYFRTLLMYGFHFL 226
Cdd:PLN02726  86 IHGLKHASGDFVVIMDADLShhPKYLPsfIKKqRETGAD----------IVTGTR-YVKGGGVHGWDLRRKLTSRGANVL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 759124808 227 VWFLCVKGIRDTQCGFKLLTREAASRTFSSLHIERWAFDVELLYIAQFFKIPIAEI 282
Cdd:PLN02726 155 AQTLLWPGVSDLTGSFRLYKRSALEDLVSSVVSKGYVFQMEIIVRASRKGYRIEEV 210
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 73-169 1.61e-13

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 67.64  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPVMMDEALgyleeRQKQDPtftYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLvKNRGKGGAVK 152
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLL-----ALDYPK---LEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDK-ENGGKAGALN 71

                         90
                 ....*....|....*..
gi 759124808 153 MGVFSSRGENILMADAD 169
Cdd:cd06423   72 AGLRHAKGDIVVVLDAD 88
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
67-169 3.26e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 64.63  E-value: 3.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  67 PTKQLSVVVPSYNEEKRLpvmmDEALGYLEeRQKQDPtftYEVIVVDDGSKDQTSKvafkYCQKYGSDKVRVITLVKNRG 146
Cdd:COG1216    1 MRPKVSVVIPTYNRPELL----RRCLESLL-AQTYPP---FEVIVVDNGSTDGTAE----LLAALAFPRVRVIRNPENLG 68

                         90       100
                 ....*....|....*....|...
gi 759124808 147 KGGAVKMGVFSSRGENILMADAD 169
Cdd:COG1216   69 FAAARNLGLRAAGGDYLLFLDDD 91
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 53-169 3.53e-12

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 65.30  E-value: 3.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  53 ARGQKETLPSIRDSPTKQLSVVVPSYNEEKRLPVMMDE--ALGYLEERqkqdptftYEVIVVDDGSKDQTSKVAfkycQK 130
Cdd:cd06439   13 ARLRPKPPSLPDPAYLPTVTIIIPAYNEEAVIEAKLENllALDYPRDR--------LEIIVVSDGSTDGTAEIA----RE 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 759124808 131 YGSDKVRVITLVKNRGKGGAVKMGVFSSRGENILMADAD 169
Cdd:cd06439   81 YADKGVKLLRFPERRGKAAALNRALALATGEIVVFTDAN 119
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 67-169 4.47e-10

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 59.75  E-value: 4.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  67 PTKQLSVVVPSYNEEKRLPVMMDEALGYLEERQKQdptftYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVItLVKNRG 146
Cdd:PRK10714   4 PIKKVSVVIPVYNEQESLPELIRRTTAACESLGKE-----YEILLIDDGSSDNSAEMLVEAAQAPDSHIVAIL-LNRNYG 77

                         90       100
                 ....*....|....*....|...
gi 759124808 147 KGGAVKMGVFSSRGENILMADAD 169
Cdd:PRK10714  78 QHSAIMAGFSHVTGDLIITLDAD 100
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 72-170 5.31e-10

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 58.78  E-value: 5.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  72 SVVVPSYNEEKRLpvmmdEALgyLEERQKQD-PTFTYEVIVVDDGSKDQTSKVAFKYCQKYGSdkvrvITLVKNRGK--G 148
Cdd:cd02525    3 SIIIPVRNEEKYI-----EEL--LESLLNQSyPKDLIEIIVVDGGSTDGTREIVQEYAAKDPR-----IRLIDNPKRiqS 70

                         90       100
                 ....*....|....*....|..
gi 759124808 149 GAVKMGVFSSRGENILMADADG 170
Cdd:cd02525   71 AGLNIGIRNSRGDIIIRVDAHA 92
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 73-169 8.93e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 58.07  E-value: 8.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPvmmdealGYLEERQKQD-PTFTYEVIVVDDGSKDQTSKVAFKYCQKyGSDKVRVIT--LVKNRGKGG 149
Cdd:cd04192    1 VVIAARNEAENLP-------RLLQSLSALDyPKEKFEVILVDDHSTDGTVQILEFAAAK-PNFQLKILNnsRVSISGKKN 72

                         90       100
                 ....*....|....*....|
gi 759124808 150 AVKMGVFSSRGENILMADAD 169
Cdd:cd04192   73 ALTTAIKAAKGDWIVTTDAD 92
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 65-169 1.13e-09

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 58.52  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  65 DSPTKQLSVVVPSYNEEKRLPVMMDEALgyleeRQKQDptfTYEVIVVDDGSKDQTSKVAFKYCQKYGsdKVRVITLvKN 144
Cdd:PRK10073   2 MNSTPKLSIIIPLYNAGKDFRAFMESLI-----AQTWT---ALEIIIVNDGSTDNSVEIAKHYAENYP--HVRLLHQ-AN 70

                         90       100
                 ....*....|....*....|....*
gi 759124808 145 RGKGGAVKMGVFSSRGENILMADAD 169
Cdd:PRK10073  71 AGVSVARNTGLAVATGKYVAFPDAD 95
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 71-147 4.72e-08

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 52.96  E-value: 4.72e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759124808  71 LSVVVPSYNEEKRLPvmmdEALGYLEERQKQDPtftyEVIVVDDGSKDQTSKVAfkycQKYGsdkVRVITLVKNRGK 147
Cdd:cd02522    1 LSIIIPTLNEAENLP----RLLASLRRLNPLPL----EIIVVDGGSTDGTVAIA----RSAG---VVVISSPKGRAR 62
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 71-147 7.14e-08

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 52.13  E-value: 7.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 759124808   71 LSVVVPSYNEEKRLPVMmdealgyLEERQKQDPTFtyEVIVVDDGSKDQTSKVAfkycqkyGSDKVRVITLVKNRGK 147
Cdd:TIGR04283   1 LSIIIPVLNEAATLPEL-------LADLQALRGDA--EVIVVDGGSTDGTVEIA-------RSLGAKVIHSPKGRAR 61
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
71-131 2.44e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 48.25  E-value: 2.44e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 759124808  71 LSVVVPSYNEEKRLPVMmdealgyLEERQKQDPT--FTYEVIVVDDGSKDQTSKVAFKYCQKY 131
Cdd:NF038302   3 FTVAIPTYNGANRLPEV-------LERLRSQIGTesLSWEIIVVDNNSTDNTAQVVQEYQKNW 58
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 72-185 2.89e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 47.24  E-value: 2.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  72 SVVVPSYNEEKrlpvmmdealgYLEE-----RQKQDPTFtyEVIVVDDGSKDQTSKVAFKYCQKYGsdkvRVITLVKNRG 146
Cdd:cd04196    1 AVLMATYNGEK-----------YLREqldsiLAQTYKND--ELIISDDGSTDGTVEIIKEYIDKDP----FIIILIRNGK 63

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 759124808 147 KGGAVKMgvFSS-----RGENILMADADgatkfcDI---EKLEKGLN 185
Cdd:cd04196   64 NLGVARN--FESllqaaDGDYVFFCDQD------DIwlpDKLERLLK 102
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 71-169 1.84e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 45.05  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808   71 LSVVVPSYNEEKRLPVMMDEALGYLEERqkqdptftYEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRGKGGA 150
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPYPP--------VEVVVVVNPSDAETLDVAEEIAARFPDVRLRVIRNARLLGPTGK 75

                          90       100
                  ....*....|....*....|..
gi 759124808  151 VKM--GVFSS-RGENILMADAD 169
Cdd:pfam13641  76 SRGlnHGFRAvKSDLVVLHDDD 97
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 73-164 6.56e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 39.85  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  73 VVVPSYNEEKRLPvmmdEALGYLEERQKQDptftYEVIVVDDGSKDQTSKVAFKYcqkygSDKVRVITLVKNRGKGGAVK 152
Cdd:cd04186    1 IIIVNYNSLEYLK----ACLDSLLAQTYPD----FEVIVVDNASTDGSVELLREL-----FPEVRLIRNGENLGFGAGNN 67

                         90
                 ....*....|..
gi 759124808 153 MGVFSSRGENIL 164
Cdd:cd04186   68 QGIREAKGDYVL 79
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 71-169 7.55e-04

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 40.35  E-value: 7.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  71 LSVVVPSYNEEKRLPvmmdEALGYLEErqkqdptFTYEVIVVDDGSKDQTSKVAfkycQKYGsdkVRVITlVKNRGKGGA 150
Cdd:cd02511    2 LSVVIITKNEERNIE----RCLESVKW-------AVDEIIVVDSGSTDRTVEIA----KEYG---AKVYQ-RWWDGFGAQ 62

                         90
                 ....*....|....*....
gi 759124808 151 VKMGVFSSRGENILMADAD 169
Cdd:cd02511   63 RNFALELATNDWVLSLDAD 81
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 72-169 9.76e-04

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 40.29  E-value: 9.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  72 SVVVPSYNEEKRLPVMMDEALGYLEErqkqdpTFTYEVIVVDDGSKDQTSKVAfkycQKYGSdkvRVIT-------LVKN 144
Cdd:PRK13915  34 SVVLPALNEEETVGKVVDSIRPLLME------PLVDELIVIDSGSTDATAERA----AAAGA---RVVSreeilpeLPPR 100

                         90       100
                 ....*....|....*....|....*
gi 759124808 145 RGKGGAVKMGVFSSRGENILMADAD 169
Cdd:PRK13915 101 PGKGEALWRSLAATTGDIVVFVDAD 125
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 72-188 4.98e-03

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 38.03  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808   72 SVVVPSYNEEKRLPVMmdEALgyLEERQKQDPTFtyEVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITlVKNRGKGGAV 151
Cdd:pfam10111   1 SVVIPVYNGEKTHWIQ--ERI--LNQTFQYDPEF--ELIIINDGSTDKTLEEVSSIKDHNLQVYYPNAP-DTTYSLAASR 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 759124808  152 KMGVFSSRGENILMADADgatKFCDIEKLEKGLNDLQ 188
Cdd:pfam10111  74 NRGTSHAIGEYISFIDGD---CLWSPDKFEKQLKIAT 107
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 108-146 5.52e-03

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 37.95  E-value: 5.52e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 759124808 108 EVIVVDDGSKDQTSKVAFKYCQKYGSDKVRVITLVKNRG 146
Cdd:cd02510   32 EIILVDDFSDKPELKLLLEEYYKKYLPKVKVLRLKKREG 70
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 72-169 7.39e-03

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 36.91  E-value: 7.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759124808  72 SVVVPSYNEEKrlPVMMDEALGYLEERQKQdPTftyEVIVVDDGSKDQT-SKVAFKYCQKYGsdkVRVITLVKNRGKGGA 150
Cdd:cd04195    1 SVLMSVYIKEK--PEFLREALESILKQTLP-PD---EVVLVKDGPVTQSlNEVLEEFKRKLP---LKVVPLEKNRGLGKA 71

                         90
                 ....*....|....*....
gi 759124808 151 VKMGVFSSRGENILMADAD 169
Cdd:cd04195   72 LNEGLKHCTYDWVARMDTD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH