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Conserved domains on  [gi|752887243|ref|XP_011261490|]
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methyltransferase-like protein 23 isoform X1 [Camponotus floridanus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 72-205 1.31e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 75.06  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752887243   72 WPCARVLAWYLWE------HRENLLGKRVLEIGAGTSLPGI-LASKC-GAIVTLSDsanQPRTLQHIRRCCELNGIADQV 143
Cdd:pfam10294  22 WDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIaVALLLpGASVTITD---LEEALELLKKNIELNALSSKV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752887243  144 RIVGITWGFFLSS-LFSLGQLDLIIGSDCFYEPTIFEDIVVIVAFLLEKNPraRFLCTYQERS 205
Cdd:pfam10294  99 VVKVLDWGENLPPdLFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKES--VILVAYKKRR 159
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 72-205 1.31e-16

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 75.06  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752887243   72 WPCARVLAWYLWE------HRENLLGKRVLEIGAGTSLPGI-LASKC-GAIVTLSDsanQPRTLQHIRRCCELNGIADQV 143
Cdd:pfam10294  22 WDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIaVALLLpGASVTITD---LEEALELLKKNIELNALSSKV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752887243  144 RIVGITWGFFLSS-LFSLGQLDLIIGSDCFYEPTIFEDIVVIVAFLLEKNPraRFLCTYQERS 205
Cdd:pfam10294  99 VVKVLDWGENLPPdLFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKES--VILVAYKKRR 159
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 72-181 3.02e-16

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 74.92  E-value: 3.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752887243  72 WPCARVLAWYLWEHREnLLGKRVLEIGAGTSLPGILASKCGAI-VTLSDsaNQPRTLQHIRRCCELNGIAdqVRIVGITW 150
Cdd:COG3897   53 WPSGQALARYLLDHPE-VAGKRVLELGCGLGLVGIAAAKAGAAdVTATD--YDPEALAALRLNAALNGVA--ITTRLGDW 127

                         90       100       110
                 ....*....|....*....|....*....|.
gi 752887243 151 GFFLSSlfslGQLDLIIGSDCFYEPTIFEDI 181
Cdd:COG3897  128 RDPPAA----GGFDLILGGDVLYERDLAEPL 154
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 72-205 1.31e-16

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 75.06  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752887243   72 WPCARVLAWYLWE------HRENLLGKRVLEIGAGTSLPGI-LASKC-GAIVTLSDsanQPRTLQHIRRCCELNGIADQV 143
Cdd:pfam10294  22 WDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIaVALLLpGASVTITD---LEEALELLKKNIELNALSSKV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752887243  144 RIVGITWGFFLSS-LFSLGQLDLIIGSDCFYEPTIFEDIVVIVAFLLEKNPraRFLCTYQERS 205
Cdd:pfam10294  99 VVKVLDWGENLPPdLFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKES--VILVAYKKRR 159
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 72-181 3.02e-16

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 74.92  E-value: 3.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752887243  72 WPCARVLAWYLWEHREnLLGKRVLEIGAGTSLPGILASKCGAI-VTLSDsaNQPRTLQHIRRCCELNGIAdqVRIVGITW 150
Cdd:COG3897   53 WPSGQALARYLLDHPE-VAGKRVLELGCGLGLVGIAAAKAGAAdVTATD--YDPEALAALRLNAALNGVA--ITTRLGDW 127

                         90       100       110
                 ....*....|....*....|....*....|.
gi 752887243 151 GFFLSSlfslGQLDLIIGSDCFYEPTIFEDI 181
Cdd:COG3897  128 RDPPAA----GGFDLILGGDVLYERDLAEPL 154
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 91-146 2.48e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 37.60  E-value: 2.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 752887243  91 GKRVLEIGAGTSLPGI-LASKCGAIVT-LSDSANQprtLQHIRRCCELNGIADQVRIV 146
Cdd:COG2230   52 GMRVLDIGCGWGGLALyLARRYGVRVTgVTLSPEQ---LEYARERAAEAGLADRVEVR 106
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
91-146 2.84e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.09  E-value: 2.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 752887243  91 GKRVLEIGAGTSLPGILASKCGAI-VTLSDsaNQPRTLQHIRRCCELNGIADQVRIV 146
Cdd:COG4076   36 GDVVLDIGTGSGLLSMLAARAGAKkVYAVE--VNPDIAAVARRIIAANGLSDRITVI 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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