|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
365-745 |
1.11e-36 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 144.28 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 443
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 444 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 523
Cdd:COG2319 150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 524 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 602
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 603 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 682
Cdd:COG2319 267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755519506 683 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
365-743 |
2.68e-27 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 113.58 E-value: 2.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqRACLPSGTFLTCSSDNTIRFWNLD 444
Cdd:cd00200 14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDV---------AASADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 445 SASDTRwqknIFsdsllkvvyvendIQHLQDlshfpdrgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELHF 524
Cdd:cd00200 82 TGECVR----TL-------------TGHTSY--------------------VSSVAFSPDGRILSSSSRDKTIKVWDVET 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 525 MDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEKNYnLEQTLDDHSSSITAIKFAGTRDvQMISCGADK 604
Cdd:cd00200 125 GKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE-KLLSSSSDG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 605 SIyfrsaqqasdglhfvrthhvaekttlydmdiditqkyvavacqdrnvRVYNTVSGKQKKCYkgsQGDEGSLLKVHVDP 684
Cdd:cd00200 200 TI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSVAFSP 229
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 755519506 685 SGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
94-445 |
7.17e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.07 E-value: 7.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 94 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 173
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 174 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 251
Cdd:COG2319 222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 252 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 329
Cdd:COG2319 290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 330 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 409
Cdd:COG2319 324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376
|
330 340 350
....*....|....*....|....*....|....*..
gi 755519506 410 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 445
Cdd:COG2319 377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
112-442 |
1.55e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 99.72 E-value: 1.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 112 RKSLSALAFSPDGKYIVTG-ENGHrpaVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKD 190
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGsGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 191 IVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVTSTvplvgrsgilgelHNN-IFCGVACGRGRMA 267
Cdd:cd00200 84 ECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRG-------------HTDwVNSVAFSPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 268 gntFCVSYSGL-----LCQFNEKRVL---DKWINlkvslssCLCVSD--ELIFCGCTDGIVRIFqahsllyltNLPKPHY 337
Cdd:cd00200 151 ---ASSSQDGTiklwdLRTGKCVATLtghTGEVN-------SVAFSPdgEKLLSSSSDGTIKLW---------DLSTGKC 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 338 LGVDVAHGldssflfhrkaEAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypef 417
Cdd:cd00200 212 LGTLRGHE-----------NGVN----SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL------ 267
|
330 340
....*....|....*....|....*.
gi 755519506 418 edqrACLPSGTFL-TCSSDNTIRFWN 442
Cdd:cd00200 268 ----AWSPDGKRLaSGSADGTIRIWD 289
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
984-1458 |
2.58e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 52.46 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 984 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAGKPEYPSteelSQ 1059
Cdd:pfam03154 128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATAGPTP----SA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1060 PELPGLGNGSLPQTPEQEKFLRHHFETLTDAPTEGPmgiflelfhgslgdikisetedyffnPRLSISTqflSRLQKTSR 1139
Cdd:pfam03154 204 PSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP--------------------------QRLPSPH---PPLQPMTQ 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1140 CPPrlPLHLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSIS 1219
Cdd:pfam03154 255 PPP--PSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIH 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1220 APSSCSYLES-------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDH 1284
Cdd:pfam03154 327 TPPSQSQLQSqqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTH 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1285 EPAplswgnheARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLH 1357
Cdd:pfam03154 406 HPP--------SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITP 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1358 SSMFLPKTSASGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRL 1431
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHAS 554
|
490 500 510
....*....|....*....|....*....|....*...
gi 755519506 1432 QTA-FQEAL----------DLYRMLVSSSQLGPEQQQA 1458
Cdd:pfam03154 555 QSArFYKHLdrgynscartDLYFMPLAGSKLAKKREEA 592
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
705-744 |
2.80e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 2.80e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 755519506 705 SGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWH 744
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
706-743 |
1.84e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 1.84e-04
10 20 30
....*....|....*....|....*....|....*...
gi 755519506 706 GECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
146-186 |
4.11e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 4.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 755519506 146 KTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWD 186
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
365-745 |
1.11e-36 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 144.28 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 443
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 444 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 523
Cdd:COG2319 150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 524 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 602
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 603 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 682
Cdd:COG2319 267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755519506 683 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
365-743 |
2.68e-27 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 113.58 E-value: 2.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqRACLPSGTFLTCSSDNTIRFWNLD 444
Cdd:cd00200 14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDV---------AASADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 445 SASDTRwqknIFsdsllkvvyvendIQHLQDlshfpdrgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELHF 524
Cdd:cd00200 82 TGECVR----TL-------------TGHTSY--------------------VSSVAFSPDGRILSSSSRDKTIKVWDVET 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 525 MDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEKNYnLEQTLDDHSSSITAIKFAGTRDvQMISCGADK 604
Cdd:cd00200 125 GKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE-KLLSSSSDG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 605 SIyfrsaqqasdglhfvrthhvaekttlydmdiditqkyvavacqdrnvRVYNTVSGKQKKCYkgsQGDEGSLLKVHVDP 684
Cdd:cd00200 200 TI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSVAFSP 229
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 755519506 685 SGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
493-745 |
4.18e-27 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 112.81 E-value: 4.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 493 KAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKpetGVTLLASASRDRLIHVLNVEKNyN 572
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLWDLETG-E 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 573 LEQTLDDHSSSITAIKFAGTRDVqMISCGADKSIyfRSAQQASDGLHFVRTHHvaeKTTLYDMDIDITQKYVAVACQDRN 652
Cdd:cd00200 85 CVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTI--KVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 653 VRVYNTVSGKqkkCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLI 732
Cdd:cd00200 159 IKLWDLRTGK---CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235
|
250
....*....|...
gi 755519506 733 TVSGDSCVFIWHL 745
Cdd:cd00200 236 SGSEDGTIRVWDL 248
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
43-568 |
9.09e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 111.93 E-value: 9.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 43 LRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSP 122
Cdd:COG2319 9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 123 DGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHdmVLNVWDWKKDIVVAS-NKVSCR 201
Cdd:COG2319 89 DGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 202 VIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVtstvpLVGrsgilgelHNNIFCGVAcgrgrmagntfcVSYSGllc 280
Cdd:COG2319 165 VTSVAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTG--------HTGAVRSVA------------FSPDG--- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 281 qfnekrvldkwinlkvslssclcvsdELIFCGCTDGIVRIFQAHSLLYLTNLPkphylgvdvAHGldssflfhrkaEAVY 360
Cdd:COG2319 217 --------------------------KLLASGSADGTVRLWDLATGKLLRTLT---------GHS-----------GSVR 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 361 pdtvALTFDPVHQWLSCVYKDHSIYIWDVKDiDEVSKIWSElfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIR 439
Cdd:COG2319 251 ----SVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTG--HSGGVNSV----------AFSPDGKLLaSGSDDGTVR 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 440 FWNLDSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRI 519
Cdd:COG2319 314 LWDLATG------------------------KLLRTLTGHTGA-------------VRSVAFSPDGKTLASGSDDGTVRL 356
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 755519506 520 HELHFMDELIKVEAHDAEVLCLEYSKPEtgvTLLASASRDRLIHVLNVE 568
Cdd:COG2319 357 WDLATGELLRTLTGHTGAVTSVAFSPDG---RTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
534-743 |
2.66e-25 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 107.81 E-value: 2.66e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 534 HDAEVLCLEYSkpeTGVTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGTRDvQMISCGADKSIYFrsaqQ 613
Cdd:cd00200 8 HTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL----W 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 614 ASDGLHFVRTHHVAEKTtLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDegsLLKVHVDPSGTFLATSC 693
Cdd:cd00200 79 DLETGECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVASSS 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 755519506 694 SDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
481-751 |
1.96e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 104.61 E-value: 1.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 481 DRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkPETgvTLLASASRDR 560
Cdd:COG2319 66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDG--KTLASGSADG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 561 LIHVLNVEKNyNLEQTLDDHSSSITAIKFA--GTRdvqMISCGADKSIYFRSAQQASDgLHFVRTHhvaeKTTLYDMDID 638
Cdd:COG2319 143 TVRLWDLATG-KLLRTLTGHSGAVTSVAFSpdGKL---LASGSDDGTVRLWDLATGKL-LRTLTGH----TGAVRSVAFS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 639 ITQKYVAVACQDRNVRVYNTVSGKQKKCYKGsqgDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEI 718
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290
|
250 260 270
....*....|....*....|....*....|....*
gi 755519506 719 VTGMKFTYDCRHLITVSGDSCVFIWHL--GPEITT 751
Cdd:COG2319 291 VNSVAFSPDGKLLASGSDDGTVRLWDLatGKLLRT 325
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
94-445 |
7.17e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.07 E-value: 7.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 94 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 173
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 174 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 251
Cdd:COG2319 222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 252 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 329
Cdd:COG2319 290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 330 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 409
Cdd:COG2319 324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376
|
330 340 350
....*....|....*....|....*....|....*..
gi 755519506 410 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 445
Cdd:COG2319 377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
3-519 |
1.10e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 102.30 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 3 AALAAGGYTRSDTIEKLSSVMAGVPARRNQSSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPG 82
Cdd:COG2319 11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 83 TGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHRpaVRIWDVEEKTQVAEMLGHKYGVACV 162
Cdd:COG2319 91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTGHSGAVTSV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 163 AFSPNMKHIVSMGYqhDMVLNVWDWKKDIVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVtstvp 240
Cdd:COG2319 169 AFSPDGKLLASGSD--DGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSaDGTVRLWDLATGKLLRT----- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 241 LVGRSGILgelhnnifcgvacgrgrmagntFCVSYSGllcqfnekrvldkwinlkvslssclcvSDELIFCGCTDGIVRI 320
Cdd:COG2319 242 LTGHSGSV----------------------RSVAFSP---------------------------DGRLLASGSADGTVRL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 321 FqahsllyltnlpkphylgvDVAHGLDSSFLFHRKAeAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWS 400
Cdd:COG2319 273 W-------------------DLATGELLRTLTGHSG-GVN----SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 401 elfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNLdsasDTRWQKNIFSdsllkvvyvendiQHlqdlshf 479
Cdd:COG2319 329 ---HTGAVRSV----------AFSPDGKTLaSGSDDGTVRLWDL----ATGELLRTLT-------------GH------- 371
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 755519506 480 pdrgsengtpmdmKAGVRVMQVSPDGQHLASGDRSGNLRI 519
Cdd:COG2319 372 -------------TGAVTSVAFSPDGRTLASGSADGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
112-442 |
1.55e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 99.72 E-value: 1.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 112 RKSLSALAFSPDGKYIVTG-ENGHrpaVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKD 190
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGsGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 191 IVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVTSTvplvgrsgilgelHNN-IFCGVACGRGRMA 267
Cdd:cd00200 84 ECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRG-------------HTDwVNSVAFSPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 268 gntFCVSYSGL-----LCQFNEKRVL---DKWINlkvslssCLCVSD--ELIFCGCTDGIVRIFqahsllyltNLPKPHY 337
Cdd:cd00200 151 ---ASSSQDGTiklwdLRTGKCVATLtghTGEVN-------SVAFSPdgEKLLSSSSDGTIKLW---------DLSTGKC 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 338 LGVDVAHGldssflfhrkaEAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypef 417
Cdd:cd00200 212 LGTLRGHE-----------NGVN----SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL------ 267
|
330 340
....*....|....*....|....*.
gi 755519506 418 edqrACLPSGTFL-TCSSDNTIRFWN 442
Cdd:cd00200 268 ----AWSPDGKRLaSGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
300-606 |
9.97e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.55 E-value: 9.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 300 SCLCVSD--ELIFCGCTDGIVRIFQAHSLLYLTNLpKPHYLGV-DVAHGLDSSFLF------------------------ 352
Cdd:cd00200 13 TCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVrDVAASADGTYLAsgssdktirlwdletgecvrtltg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 353 HRKAeaVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIwseLFHSSFVWNVEVypefedqracLPSGTFLTC 432
Cdd:cd00200 92 HTSY--VS----SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL---RGHTDWVNSVAF----------SPDGTFVAS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 433 SS-DNTIRFWNLDSasdtrwqknifsdsllkvvyvendiqhlqdlshfpdrGSENGTPMDMKAGVRVMQVSPDGQHLASG 511
Cdd:cd00200 153 SSqDGTIKLWDLRT-------------------------------------GKCVATLTGHTGEVNSVAFSPDGEKLLSS 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 512 DRSGNLRIHELHfMDELIKV-EAHDAEVLCLEYSKPEtgvTLLASASRDRLIHVLNVEKNYNLeQTLDDHSSSITAIKFA 590
Cdd:cd00200 196 SSDGTIKLWDLS-TGKCLGTlRGHENGVNSVAFSPDG---YLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWS 270
|
330
....*....|....*.
gi 755519506 591 GTRDVqMISCGADKSI 606
Cdd:cd00200 271 PDGKR-LASGSADGTI 285
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
154-564 |
8.65e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.77 E-value: 8.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 154 GHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASt 231
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSsDKTIRLWDLETG- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 232 eaKVTSTvpLVGrsgilgelHNnifcgvacgrgrmaGNTFCVSYSgllcqfnekrvldkwinlkvslssclcVSDELIFC 311
Cdd:cd00200 84 --ECVRT--LTG--------HT--------------SYVSSVAFS---------------------------PDGRILSS 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 312 GCTDGIVRIFQAHSLLYLTnlpkphylgvdvahgldsSFLFHRKaeavypDTVALTFDPVHQWLSCVYKDHSIYIWDVKD 391
Cdd:cd00200 111 SSRDKTIKVWDVETGKCLT------------------TLRGHTD------WVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 392 IdevSKIWSELFHSSFVWNVEVYPEfedqraclpSGTFLTCSSDNTIRFWNLDSAsdtrwqknifsdsllkvvyvendiQ 471
Cdd:cd00200 167 G---KCVATLTGHTGEVNSVAFSPD---------GEKLLSSSSDGTIKLWDLSTG------------------------K 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 472 HLQDLshfpdRGSENgtpmdmkaGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkPETGVt 551
Cdd:cd00200 211 CLGTL-----RGHEN--------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS-PDGKR- 275
|
410
....*....|...
gi 755519506 552 lLASASRDRLIHV 564
Cdd:cd00200 276 -LASGSADGTIRI 287
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
481-751 |
9.63e-15 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 78.03 E-value: 9.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 481 DRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkpeTGVTLLASASRDR 560
Cdd:COG2319 24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS---PDGRLLASASADG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 561 LIHVLNVEKNYNLeQTLDDHSSSITAIKFAgtrdvqmiscgadksiyfrsaqqaSDGlhfvrthhvaekttlydmdidit 640
Cdd:COG2319 101 TVRLWDLATGLLL-RTLTGHTGAVRSVAFS------------------------PDG----------------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 641 qKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVT 720
Cdd:COG2319 133 -KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS---VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208
|
250 260 270
....*....|....*....|....*....|...
gi 755519506 721 GMKFTYDCRHLITVSGDSCVFIWHL--GPEITT 751
Cdd:COG2319 209 SVAFSPDGKLLASGSADGTVRLWDLatGKLLRT 241
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
633-756 |
1.40e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 70.06 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 633 YDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSqgdEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKM 712
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 755519506 713 FGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL-GPEITTCMKQH 756
Cdd:cd00200 90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGH 134
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
88-225 |
1.43e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 70.06 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 88 YLAGC----VVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHrpAVRIWDVEEKTQVAEMLGHKYGVACVA 163
Cdd:cd00200 107 ILSSSsrdkTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG--TIKLWDLRTGKCVATLTGHTGEVNSVA 184
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755519506 164 FSPNMKHIVSMGyqHDMVLNVWDWKKDIVVASNKVSC-RVIALSFSEDSSYFVTVG-NRHVRFW 225
Cdd:cd00200 185 FSPDGEKLLSSS--SDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGYLLASGSeDGTIRVW 246
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
984-1458 |
2.58e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 52.46 E-value: 2.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 984 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAGKPEYPSteelSQ 1059
Cdd:pfam03154 128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATAGPTP----SA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1060 PELPGLGNGSLPQTPEQEKFLRHHFETLTDAPTEGPmgiflelfhgslgdikisetedyffnPRLSISTqflSRLQKTSR 1139
Cdd:pfam03154 204 PSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHP--------------------------QRLPSPH---PPLQPMTQ 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1140 CPPrlPLHLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSIS 1219
Cdd:pfam03154 255 PPP--PSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIH 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1220 APSSCSYLES-------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDH 1284
Cdd:pfam03154 327 TPPSQSQLQSqqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTH 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1285 EPAplswgnheARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLH 1357
Cdd:pfam03154 406 HPP--------SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITP 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 1358 SSMFLPKTSASGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRL 1431
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHAS 554
|
490 500 510
....*....|....*....|....*....|....*...
gi 755519506 1432 QTA-FQEAL----------DLYRMLVSSSQLGPEQQQA 1458
Cdd:pfam03154 555 QSArFYKHLdrgynscartDLYFMPLAGSKLAKKREEA 592
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
705-744 |
2.80e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 2.80e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 755519506 705 SGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWH 744
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
706-743 |
1.84e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 1.84e-04
10 20 30
....*....|....*....|....*....|....*...
gi 755519506 706 GECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
635-727 |
3.25e-04 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 41.11 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519506 635 MDIditqkyVAVACQDRNVRVYNTvSGKqkKCYKGSQGDEGSLLK-VHVDPSGTFLATSCSDKSISLIDFYSGECVAKMF 713
Cdd:pfam12894 7 MDL------IALATEDGELLLHRL-NWQ--RVWTLSPDKEDLEVTsLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS 77
|
90
....*....|....
gi 755519506 714 GHSEIVTGMKFTYD 727
Cdd:pfam12894 78 AGSDLITCLGWGEN 91
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
146-186 |
4.11e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 4.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 755519506 146 KTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWD 186
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
118-171 |
4.18e-03 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 41.95 E-value: 4.18e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 755519506 118 LAFSPDGKYIV---TGENGHRpAVRIWDVEEK--TQVAEmlgHKYGVACVAFSPNMKHI 171
Cdd:COG4946 437 LAWSPDSKWLAyskPGPNQLS-QIFLYDVETGktVQLTD---GRYDDGSPAFSPDGKYL 491
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
714-762 |
6.06e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 40.40 E-value: 6.06e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 755519506 714 GHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL-GPEITTCMKQHLLEINH 762
Cdd:cd00200 7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLeTGELLRTLKGHTGPVRD 56
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
103-142 |
8.94e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 35.37 E-value: 8.94e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 755519506 103 KQQHIFNTTRKSLSALAFSPDGKYIVTG-ENGHrpaVRIWD 142
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
|
|
|