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Conserved domains on  [gi|755512408|ref|XP_011247738|]
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volume-regulated anion channel subunit LRRC8D isoform X1 [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-385 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 618.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408    1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTppgnadittevp 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLD------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408   81 rmetatHQDQNGQTTTNDVAFGTSAVTPDIPlqathphaestlpnqeakkekrDPTGRKTNLDFQQYVFINQMCYHLALP 160
Cdd:pfam12534  69 ------DSYANSLSPTQSAPTVSSPSASMIP----------------------EPKGRKTNLDRQQYVFINQVCYEKALH 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  161 WYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVS 240
Cdd:pfam12534 121 WYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VS 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  241 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK 319
Cdd:pfam12534 200 SSSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLK 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755512408  320 FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 385
Cdd:pfam12534 280 FLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-826 5.16e-37

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 5.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 562 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 641
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 642 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLES 721
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 722 LPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 755512408 802 TQLELKGNCLDRLPaQLGQCRMLKK 826
Cdd:COG4886  231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-385 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 618.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408    1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTppgnadittevp 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLD------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408   81 rmetatHQDQNGQTTTNDVAFGTSAVTPDIPlqathphaestlpnqeakkekrDPTGRKTNLDFQQYVFINQMCYHLALP 160
Cdd:pfam12534  69 ------DSYANSLSPTQSAPTVSSPSASMIP----------------------EPKGRKTNLDRQQYVFINQVCYEKALH 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  161 WYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVS 240
Cdd:pfam12534 121 WYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VS 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  241 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK 319
Cdd:pfam12534 200 SSSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLK 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755512408  320 FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 385
Cdd:pfam12534 280 FLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-826 5.16e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 5.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 562 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 641
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 642 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLES 721
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 722 LPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 755512408 802 TQLELKGNCLDRLPaQLGQCRMLKK 826
Cdd:COG4886  231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 637-792 3.21e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.29  E-value: 3.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 637 NVAELELQNCELERIPHaIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKivaippsITHVKNLES----- 711
Cdd:cd21340   25 NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNR-------ISVVEGLENltnle 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 712 -LYFSNNKL---ESL---PTAVFSLQK-LRCLDVSYNNISTIpIEIGLLQNLQHLHITGNKVDILPKQ---LFKCVKLRT 780
Cdd:cd21340   94 eLHIENQRLppgEKLtfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRE 172

                        170
                 ....*....|..
gi 755512408 781 LNLGQNCIASLP 792
Cdd:cd21340  173 LDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 572-826 2.96e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 572 LNSENNKMIGLESLRELRHLKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLVLNSLKKMMNVAELEL----QN 645
Cdd:PLN00113 123 LNLSNNNFTGSIPRGSIPNLETLDLSNNMLsgEIPNDIGS----FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFltlaSN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 646 CELERIPHAIFSLSNLQELDLKSNNI-----RTIEEIISFQHLKRLtclklWHNKIVAIPPSITHVKNLESLYFSNNKLE 720
Cdd:PLN00113 199 QLVGQIPRELGQMKSLKWIYLGYNNLsgeipYEIGGLTSLNHLDLV-----YNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 721 -SLPTAVFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGN--------------KVDIL-----------PKQLF 773
Cdd:PLN00113 274 gPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLG 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755512408 774 KCVKLRTLNLGQNCIAS-LPEKISQLTQLTQLELKGNCLD-RLPAQLGQCRMLKK 826
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRR 408
LRR_8 pfam13855
Leucine rich repeat;
637-696 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755512408  637 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 696
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-385 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 618.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408    1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTppgnadittevp 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLD------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408   81 rmetatHQDQNGQTTTNDVAFGTSAVTPDIPlqathphaestlpnqeakkekrDPTGRKTNLDFQQYVFINQMCYHLALP 160
Cdd:pfam12534  69 ------DSYANSLSPTQSAPTVSSPSASMIP----------------------EPKGRKTNLDRQQYVFINQVCYEKALH 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  161 WYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKhVS 240
Cdd:pfam12534 121 WYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPK-VS 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  241 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS-MTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK 319
Cdd:pfam12534 200 SSSSLSSSDESAPLTRTPSVKSSPEKPVVEVPStVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLK 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755512408  320 FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTL 385
Cdd:pfam12534 280 FLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-826 5.16e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.31  E-value: 5.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 562 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKmmNVAEL 641
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL--LLLLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 642 ELQNCELERIPHAIFSLSNLQELDLKSNNirtieeiiSFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLES 721
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 722 LPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 755512408 802 TQLELKGNCLDRLPaQLGQCRMLKK 826
Cdd:COG4886  231 ETLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
489-773 1.68e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 489 DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTafsflrdHLRCLHVKFTDVAEIPAWVYLLKNLRELYL 568
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-------NLESLDLSGNQLTDLPEELANLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 569 ignlnsENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVaPHLTKLVIHNdgTKLLVL-NSLKKMMNVAELELQN 645
Cdd:COG4886  144 ------SNNQLTDLpEPLGNLTNLKSLDLSNNqLTDLPEELGNL-TNLKELDLSN--NQITDLpEPLGNLTNLEELDLSG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 646 CELERIPHAIFSLSNLQELDLKSNNIRTIEEIisfQHLKRLTCLKLWHNKIVAIPPSiTHVKNLESLYFSNNKLESLPTA 725
Cdd:COG4886  215 NQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLK 290

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 755512408 726 VFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLF 773
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
406-818 8.92e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 8.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 406 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPD 485
Cdd:COG4886   11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 486 AVFDLTDLDVLKLELIPEakipakISQMTNLQELHLCHCPAKVEQTAFSFLRdHLRCLHVKFTDVAEIPAWVYLLKNLRE 565
Cdd:COG4886   91 DLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 566 LYLignlnsENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDvAPHLTKLVIhnDGTKLLVL-NSLKKMMNVAELE 642
Cdd:COG4886  164 LDL------SNNQLTDLpEELGNLTNLKELDLSNNqITDLPEPLGN-LTNLEELDL--SGNQLTDLpEPLANLTNLETLD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 643 LQNCELERIPhAIFSLSNLQELDLKSNNIRTIEEIisfQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESL 722
Cdd:COG4886  235 LSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL---ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 723 PTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLT 802
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                        410
                 ....*....|....*.
gi 755512408 803 QLELKGNCLDRLPAQL 818
Cdd:COG4886  391 LLLLTTTAGVLLLTLA 406
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 637-792 3.21e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.29  E-value: 3.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 637 NVAELELQNCELERIPHaIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKivaippsITHVKNLES----- 711
Cdd:cd21340   25 NLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNR-------ISVVEGLENltnle 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 712 -LYFSNNKL---ESL---PTAVFSLQK-LRCLDVSYNNISTIpIEIGLLQNLQHLHITGNKVDILPKQ---LFKCVKLRT 780
Cdd:cd21340   94 eLHIENQRLppgEKLtfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELldlLSSWPSLRE 172

                        170
                 ....*....|..
gi 755512408 781 LNLGQNCIASLP 792
Cdd:cd21340  173 LDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 641-815 3.85e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 78.29  E-value: 3.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 641 LELQNCELERIPhAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVAIPPsITHVKNLESLYFSNNK-- 718
Cdd:cd21340    7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 719 -LESLPtavfSLQKLRCLDVSYNNIS----------TIpieIGLLQNLQHLHITGNKVDILpKQLFKCVKLRTLNLGQNC 787
Cdd:cd21340   82 vVEGLE----NLTNLEELHIENQRLPpgekltfdprSL---AALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQ 153

                        170       180       190
                 ....*....|....*....|....*....|.
gi 755512408 788 IASLPE---KISQLTQLTQLELKGNCLDRLP 815
Cdd:cd21340  154 ISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 572-826 2.96e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 572 LNSENNKMIGLESLRELRHLKILHVKSNLT--KVPSNITDvaphLTKLVIHNDGTKLLVLNSLKKMMNVAELEL----QN 645
Cdd:PLN00113 123 LNLSNNNFTGSIPRGSIPNLETLDLSNNMLsgEIPNDIGS----FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFltlaSN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 646 CELERIPHAIFSLSNLQELDLKSNNI-----RTIEEIISFQHLKRLtclklWHNKIVAIPPSITHVKNLESLYFSNNKLE 720
Cdd:PLN00113 199 QLVGQIPRELGQMKSLKWIYLGYNNLsgeipYEIGGLTSLNHLDLV-----YNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 721 -SLPTAVFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGN--------------KVDIL-----------PKQLF 773
Cdd:PLN00113 274 gPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLG 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755512408 774 KCVKLRTLNLGQNCIAS-LPEKISQLTQLTQLELKGNCLD-RLPAQLGQCRMLKK 826
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRR 408
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
587-818 6.80e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 6.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 587 ELRhLKILhvksNLTKVPSNITDvapHLTKLVIHNDGTKLLVLNSlkkMMNVAELELQNCELERIPHAIfsLSNLQELDL 666
Cdd:PRK15370 182 ELR-LKIL----GLTTIPACIPE---QITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPATL--PDTIQEMEL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 667 KSNNIRTIEEiisfqHL-KRLTCLKLWHNKIVAIPpsithvknleslyfsnnklESLPtavfslQKLRCLDVSYNNISTI 745
Cdd:PRK15370 249 SINRITELPE-----RLpSALQSLDLFHNKISCLP-------------------ENLP------EELRYLSVYDNSIRTL 298

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755512408 746 PIEigLLQNLQHLHITGNKVDILPKQLfkCVKLRTLNLGQNCIASLPEKISqlTQLTQLELKGNCLDRLPAQL 818
Cdd:PRK15370 299 PAH--LPSGITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 468-824 2.04e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 468 NAQDKQELHLF--MLSG-VPDAVFDLTDLDVLKL-ELIPEAKIPAKISQMTNLQELHLchcpakveqtaFSflrdhlrcl 543
Cdd:PLN00113 258 NLKNLQYLFLYqnKLSGpIPPSIFSLQKLISLDLsDNSLSGEIPELVIQLQNLEILHL-----------FS--------- 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 544 hVKFTdvAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESlrelrHLKILHVKSN-LT-KVPSNITDvAPHLTKLVIH 620
Cdd:PLN00113 318 -NNFT--GKIPVALTSLPRLQVLQLWSNkFSGEIPKNLGKHN-----NLTVLDLSTNnLTgEIPEGLCS-SGNLFKLILF 388

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 621 NDGTKLLVLNSLKKMMNVAELELQNCELE-RIPHAIFSLSNLQELDLKSNNIrtieeiisfqhLKRLTCLKlWhnkivai 699
Cdd:PLN00113 389 SNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL-----------QGRINSRK-W------- 449

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 700 ppsitHVKNLESLYFSNNK-LESLPTAvFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCV 776
Cdd:PLN00113 450 -----DMPSLQMLSLARNKfFGGLPDS-FGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCK 523

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 755512408 777 KLRTLNLGQNCIA-SLPEKISQLTQLTQLELKGNCLD-RLPAQLGQCRML 824
Cdd:PLN00113 524 KLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 683-826 1.36e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 683 LKRLTCLKLWHNKIVAIP---------------------PSITHVKNLESLYFSNNKLESLPtAVFSLQKLRCLDVSYNN 741
Cdd:cd21340    1 LKRITHLYLNDKNITKIDnlslcknlkvlylydnkitkiENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 742 ISTIpieIGL--LQNLQHLHI------TGNKVDILPKQLFKCVK-LRTLNLGQNCIASLpEKISQLTQLTQLELKGNCLD 812
Cdd:cd21340   80 ISVV---EGLenLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                        170
                 ....*....|....*..
gi 755512408 813 RLPAQ---LGQCRMLKK 826
Cdd:cd21340  156 DLEELldlLSSWPSLRE 172
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 641-809 6.10e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.50  E-value: 6.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 641 LELQNCELERIPHAIFSLSNLQELDLKSNNI--RTIEEIIS-FQHLKRLTCLKLWHNKI-----VAIPPSITHVKNLESL 712
Cdd:COG5238  190 NQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 713 YFSNNKL-----ESLPTAVFSLQKLRCLDVSYNNISTiPIEIGLLQNLQHLHItgnkvdilpkqlfkcvkLRTLNLGQNC 787
Cdd:COG5238  270 YLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQGNKT-----------------LHTLNLAYNG 331

                        170       180
                 ....*....|....*....|....*..
gi 755512408 788 IA-----SLPEKISQLTQLTQLELKGN 809
Cdd:COG5238  332 IGaqgaiALAKALQENTTLHSLDLSDN 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 541-736 1.75e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 541 RCLHVKFTD--VAEIPAwVYLLKNLRELYL-------IGNLNS---------ENNKMIGLESLRELRHLKILHVKSNltk 602
Cdd:cd21340    3 RITHLYLNDknITKIDN-LSLCKNLKVLYLydnkitkIENLEFltnlthlylQNNQIEKIENLENLVNLKKLYLGGN--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 603 vpsNITdvaphltklvihndgtkllVLNSLKKMMNVAELELQN------CELERIPHAIFSLSN-LQELDLKSNNIRTIE 675
Cdd:cd21340   79 ---RIS-------------------VVEGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNsLRVLNISGNNIDSLE 136

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755512408 676 EiisFQHLKRLTCLKLWHNKI---VAIPPSITHVKNLESLYFSNNKLESLP----TAVFSLQKLRCLD 736
Cdd:cd21340  137 P---LAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 650-819 1.10e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 650 RIPHAIFSLSNLQELDLKSNNIR-TIEEIIsFQHLKRLTCLKLWHNKIVAIPPSiTHVKNLESLYFSNNKLE-SLPTAVF 727
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDI-FTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 728 SLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGNK-VDILPKQLFKCVKLRTLNLGQNCIA-SLPEKISQLTQLTQL 804
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHL 241

                        170
                 ....*....|....*.
gi 755512408 805 ELKGNCLD-RLPAQLG 819
Cdd:PLN00113 242 DLVYNNLTgPIPSSLG 257
LRR_8 pfam13855
Leucine rich repeat;
637-696 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755512408  637 NVAELELQNCELERI-PHAIFSLSNLQELDLKSNNIRTIEEiISFQHLKRLTCLKLWHNKI 696
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
685-742 2.81e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  685 RLTCLKLWHNKIVAIPPSI-THVKNLESLYFSNNKLESLPTAVFS-LQKLRCLDVSYNNI 742
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 637-815 4.75e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 53.73  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  637 NVAELELQNCELERIPHAIFSLSNLQELDL-KSNNIRTIEEIISFQHLKRL---TCLKLwhnkiVAIPPSITHVKNLESL 712
Cdd:PLN03210  612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIPDLSMATNLETLklsDCSSL-----VELPSSIQYLNKLEDL 686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  713 YFSN-NKLESLPTAVfSLQKLRCLDV-------SYNNIST--------------IPIEIGlLQNLQHLHItgnkVDILPK 770
Cdd:PLN03210  687 DMSRcENLEILPTGI-NLKSLYRLNLsgcsrlkSFPDISTniswldldetaieeFPSNLR-LENLDELIL----CEMKSE 760

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  771 QLFKCVKLRT------------LNLGQN-CIASLPEKISQLTQLTQLELKgNC--LDRLP 815
Cdd:PLN03210  761 KLWERVQPLTplmtmlspsltrLFLSDIpSLVELPSSIQNLHKLEHLEIE-NCinLETLP 819
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
661-817 5.25e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.63  E-value: 5.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 661 LQELDLKSNNIRTIEEIISfqhlkrlTCLKLW--HNKIVAIPpsiTHVKNLESLYFSNNKLESLPTAVFSLQKL------ 732
Cdd:PRK15387 304 LQELSVSDNQLASLPALPS-------ELCKLWayNNQLTSLP---TLPSGLQELSVSDNQLASLPTLPSELYKLwaynnr 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 733 -----------RCLDVSYNNISTIPIeigLLQNLQHLHITGNKVDILPkqlFKCVKLRTLNLGQNCIASLPEKISQLTQL 801
Cdd:PRK15387 374 ltslpalpsglKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                        170
                 ....*....|....*.
gi 755512408 802 TQLELKGNCLDRLPAQ 817
Cdd:PRK15387 448 TTVNLEGNPLSERTLQ 463
LRR_8 pfam13855
Leucine rich repeat;
708-765 6.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.15e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  708 NLESLYFSNNKLESLPTAVFS-LQKLRCLDVSYNNISTI-PIEIGLLQNLQHLHITGNKV 765
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
659-719 1.00e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755512408  659 SNLQELDLKSNNIRTIEEIiSFQHLKRLTCLKLWHNKIVAIPP-SITHVKNLESLYFSNNKL 719
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 745-819 3.78e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 3.78e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755512408 745 IPIEIGLLQNLQHLHITGNKVD-ILPKQLFKCVKLRTLNLGQNCI-ASLPEKISQLTQLTQLELKGNCLD-RLPAQLG 819
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
597-828 3.80e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.46  E-value: 3.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 597 KSNLTKVPsnitDVAP-HLTKLVIHNDGtkllvLNSLKKMM-NVAELELQNCELERIPhaiFSLSNLQELDLKSNnirti 674
Cdd:PRK15387 210 ESGLTTLP----DCLPaHITTLVIPDNN-----LTSLPALPpELRTLEVSGNQLTSLP---VLPPGLLELSIFSN----- 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 675 eeiiSFQHLKRLTC--LKLW--HNKIVAIPpsiTHVKNLESLYFSNNKLESLPTAVFSLQKLRcldvSYNN-ISTIPIei 749
Cdd:PRK15387 273 ----PLTHLPALPSglCKLWifGNQLTSLP---VLPPGLQELSVSDNQLASLPALPSELCKLW----AYNNqLTSLPT-- 339

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755512408 750 gLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNlgqNCIASLPEKISQLTQLTqleLKGNCLDRLPAQLGQCRMLKKSG 828
Cdd:PRK15387 340 -LPSGLQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLPALPSGLKELI---VSGNRLTSLPVLPSELKELMVSG 411
PLN03150 PLN03150
hypothetical protein; Provisional
 699-763 4.19e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 4.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755512408 699 IPPSITHVKNLESLYFSNNKLE-SLPTAVFSLQKLRCLDVSYNNIS-TIPIEIGLLQNLQHLHITGN 763
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
753-809 4.39e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755512408  753 QNLQHLHITGNKVDILPKQLFK-CVKLRTLNLGQNCIASLPEK-ISQLTQLTQLELKGN 809
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 583-817 7.40e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 7.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 583 ESLRELRHLKILHVKSNLTKVpSNITDVAPHLTklviHNDGTKLLVLnslkKMMNVAELELQnceLERIPHAIFSLSNLQ 662
Cdd:cd00116   17 ELLPKLLCLQVLRLEGNTLGE-EAAKALASALR----PQPSLKELCL----SLNETGRIPRG---LQSLLQGLTKGCGLQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 663 ELDLkSNN---IRTIEEIISFQHLKRLTCLKLWHN-------KIVAipPSITHVK-NLESLYFSNNKL-----ESLPTAV 726
Cdd:cd00116   85 ELDL-SDNalgPDGCGVLESLLRSSSLQELKLNNNglgdrglRLLA--KGLKDLPpALEKLVLGRNRLegascEALAKAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 727 FSLQKLRCLDVSYNNISTIPIEI---GL--LQNLQHLHITGNKV-DILPKQLFKCVK----LRTLNLGQNCIAS------ 790
Cdd:cd00116  162 RANRDLKELNLANNGIGDAGIRAlaeGLkaNCNLEVLDLNNNGLtDEGASALAETLAslksLEVLNLGDNNLTDagaaal 241

                        250       260
                 ....*....|....*....|....*..
gi 755512408 791 LPEKISQLTQLTQLELKGNCLDRLPAQ 817
Cdd:cd00116  242 ASALLSPNISLLTLSLSCNDITDDGAK 268
LRR_9 pfam14580
Leucine-rich repeat;
640-746 8.35e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.98  E-value: 8.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  640 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEeiiSFQHLKRLTCLKLWHNKIVAIPPSITHV-KNLESLYFSNNK 718
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLD---GFPLLRRLKTLLLNNNRICRIGEGLGEAlPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 755512408  719 LESL----PTAvfSLQKLRCLDVSYNNISTIP 746
Cdd:pfam14580 100 LQELgdldPLA--SLKKLTFLSLLRNPVTNKP 129
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 485-789 1.34e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 45.64  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  485 DAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCpakveqtafsflrdhlrclhvkfTDVAEIPAWVYLLKNLR 564
Cdd:PLN03210  628 DGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDC-----------------------SSLVELPSSIQYLNKLE 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  565 ELYLIGNLNSENNKM-IGLESLRELRhlkiLHVKSNLTKVPsnitDVAPHLTKLVIhnDGTKLLVLNSLKKMMNVAELEL 643
Cdd:PLN03210  685 DLDMSRCENLEILPTgINLKSLYRLN----LSGCSRLKSFP----DISTNISWLDL--DETAIEEFPSNLRLENLDELIL 754

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  644 qnCELE----------RIPHAIFSLSNLQELDLkSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLY 713
Cdd:PLN03210  755 --CEMKseklwervqpLTPLMTMLSPSLTRLFL-SDIPSLVELPSSIQNLHKLEHLEIENCINLETLPTGINLESLESLD 831

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408  714 FSN-NKLESLP---TAVFSLQklrcldVSYNNISTIPIEIGLLQNLQHLHITG-NKVDILPKQLFKCVKLRTLNLgQNCI 788
Cdd:PLN03210  832 LSGcSRLRTFPdisTNISDLN------LSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLETVDF-SDCG 904


                  .
gi 755512408  789 A 789
Cdd:PLN03210  905 A 905
LRR_8 pfam13855
Leucine rich repeat;
730-786 8.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755512408  730 QKLRCLDVSYNNISTIPIEIGL-LQNLQHLHITGNKVDILPKQLFKC-VKLRTLNLGQN 786
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 707-744 2.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755512408  707 KNLESLYFSNNKLESLPtAVFSLQKLRCLDVSYNNIST 744
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKIT 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 510-696 6.83e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 6.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 510 ISQMTNLQELHLCHCPakVEQTAFSFLRDHLRclhvkftDVAEipawvyllkNLRELYLIGNlNSENNKMIGL-ESLREL 588
Cdd:cd00116  104 LLRSSSLQELKLNNNG--LGDRGLRLLAKGLK-------DLPP---------ALEKLVLGRN-RLEGASCEALaKALRAN 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755512408 589 RHLKILHVKSNltkvpsNITDVA-PHLTKLVIHNDGTKLLVLNSLKkmmnvaeLELQNCELerIPHAIFSLSNLQELDLK 667
Cdd:cd00116  165 RDLKELNLANN------GIGDAGiRALAEGLKANCNLEVLDLNNNG-------LTDEGASA--LAETLASLKSLEVLNLG 229

                        170       180       190
                 ....*....|....*....|....*....|....
gi 755512408 668 SNNIRT--IEEIISfQHLKRLTCLK---LWHNKI 696
Cdd:cd00116  230 DNNLTDagAAALAS-ALLSPNISLLtlsLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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