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Conserved domains on  [gi|755553577|ref|XP_011244205|]
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protein NLRC3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 665-952 1.33e-58

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 208.49  E-value: 1.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  665 VLQSLLPQLLYCQSLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIG 744
Cdd:COG5238   142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  745 PPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSS 824
Cdd:COG5238   222 DEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  825 NTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHL 904
Cdd:COG5238   302 NRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 755553577  905 DLTANLLHDRGAQAIAVAVGENhSLTHLHLQWNFIQAGAARALGQALQ 952
Cdd:COG5238   382 NLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 176-342 1.81e-36

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 135.51  E-value: 1.81e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   176 RVSLTIGVAGVGKTTLVRHFVHCWARGQVGKGFSRVLPLTFRDLNTYEK-LSADRLIQSIFSSIGEA-----SLVATAPD 249
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNaRSLADLLFSQWPEPAAPvsevwAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   250 RVLLVLDGLDECKTPLEFSNTmacsdpkkEIQVDHLITNIIRGNLFPEISVWITSRPSAAGQIPGGLVD-RMTEIRGLTE 328
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEpRYLEVRGFSE 152

                          170
                   ....*....|....
gi 755553577   329 EEIKVCLEQMFPEE 342
Cdd:pfam05729  153 SDRKQYVRKYFSDE 166
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
28-776 5.49e-19

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 92.95  E-value: 5.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   28 ALYSQLLAANTDSTRKQEVWTDRETCLAYSVGSPAEQVKALVDLLAGKGSQLLQVRDKMPDSPLGSQSNESRIPKHSEAL 107
Cdd:COG5635    29 LAALLLLALVALGLALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  108 LSRVGNDPELGSPSHRLASLMLVEGLTDLQLKEHDFTQVEAtrgvwhpaRVITLDRLFLPLSRVSIPPRVSLT------- 180
Cdd:COG5635   109 ELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADG--------LLVSLDDLYVPLNLLERIESLKRLelleakk 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  181 -----IGVAGVGKTTLVRHFVHCWARGqvGKGFSRVLPL--TFRDLNTYEKLSA--DRLIQSIFSSIGEASLVATAPDRV 251
Cdd:COG5635   181 krlliLGEPGSGKTTLLRYLALELAER--YLDAEDPIPIliELRDLAEEASLEDllAEALEKRGGEPEDALERLLRNGRL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  252 LLVLDGLDECKTPLEFSntmacsdpkkeiQVDHLITNIIRGnlFPEISVWITSRPSAAGQIPGGLVDRMtEIRGLTEEEI 331
Cdd:COG5635   259 LLLLDGLDEVPDEADRD------------EVLNQLRRFLER--YPKARVIITSRPEGYDSSELEGFEVL-ELAPLSDEQI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  332 KVCLEQMFPEEQNLLGQVLSQVQANRALYLMCTVPAFCRLtgLALGHLYRTRlavqdielpLPQTLCELYSWYFRMALgg 411
Cdd:COG5635   324 EEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTL--LALLLRERGE---------LPDTRAELYEQFVELLL-- 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  412 EGQDKEKVSPRIKQVTQGARKMVgtLGRLAFHGLVKKKYVFYEQDMKAF---------GVDLALLQNTLCSCLLQREetl 482
Cdd:COG5635   391 ERWDEQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEEIlreylgrrkDAEALLDELLLRTGLLVER--- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  483 aSSVAYCFIHLSLQEFVAATYYYSASKRAIFDLFtesgmswprlgflahfrcaaqrATQAKDGRLDVFLRFLSGLLSPR- 561
Cdd:COG5635   466 -GEGRYSFAHRSFQEYLAARALVEELDEELLELL----------------------AEHLEDPRWREVLLLLAGLLDDVk 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  562 -----VNTLLAGSLLSQGEHQSYRDQVAEVLQGFLHPDAAVCARAINVLYCLSELRHTELACSVEEAMRSGTLAGMTSPS 636
Cdd:COG5635   523 qikelIDALLARDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAAL 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  637 HRTALAYLLQMSDICSPEADFSLCLSQHVLQSLLPQLLYCQ--SLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQ 714
Cdd:COG5635   603 LLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLLALLAlvLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELL 682

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755553577  715 IGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGV 776
Cdd:COG5635   683 LALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALA 744
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 949-1068 2.37e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  949 QALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKL--NSSLRRLNLQENSLGMD 1026
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLtkGCGLQELDLSDNALGPD 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 755553577 1027 GAIFVASALSeNHGLHHINLQGNPIGESAARMISEAIKTNAP 1068
Cdd:cd00116    97 GCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPP 137
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 665-952 1.33e-58

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 208.49  E-value: 1.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  665 VLQSLLPQLLYCQSLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIG 744
Cdd:COG5238   142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  745 PPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSS 824
Cdd:COG5238   222 DEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  825 NTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHL 904
Cdd:COG5238   302 NRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 755553577  905 DLTANLLHDRGAQAIAVAVGENhSLTHLHLQWNFIQAGAARALGQALQ 952
Cdd:COG5238   382 NLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 176-342 1.81e-36

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 135.51  E-value: 1.81e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   176 RVSLTIGVAGVGKTTLVRHFVHCWARGQVGKGFSRVLPLTFRDLNTYEK-LSADRLIQSIFSSIGEA-----SLVATAPD 249
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNaRSLADLLFSQWPEPAAPvsevwAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   250 RVLLVLDGLDECKTPLEFSNTmacsdpkkEIQVDHLITNIIRGNLFPEISVWITSRPSAAGQIPGGLVD-RMTEIRGLTE 328
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEpRYLEVRGFSE 152

                          170
                   ....*....|....
gi 755553577   329 EEIKVCLEQMFPEE 342
Cdd:pfam05729  153 SDRKQYVRKYFSDE 166
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 710-995 2.99e-34

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 134.02  E-value: 2.99e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  710 LAENQIGNKGAKALARSLLVNRSLITLDLRSNSIG--PPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVaEALVSNQ 787
Cdd:cd00116    30 LEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  788 TISMLQLQKNLIGLIGAQQMADALKQNR-SLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRA 866
Cdd:cd00116   109 SLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  867 LCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVgenhslthlhlqwnfiqagaara 946
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL----------------------- 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 755553577  947 lgqaLQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDV 995
Cdd:cd00116   246 ----LSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
28-776 5.49e-19

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 92.95  E-value: 5.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   28 ALYSQLLAANTDSTRKQEVWTDRETCLAYSVGSPAEQVKALVDLLAGKGSQLLQVRDKMPDSPLGSQSNESRIPKHSEAL 107
Cdd:COG5635    29 LAALLLLALVALGLALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  108 LSRVGNDPELGSPSHRLASLMLVEGLTDLQLKEHDFTQVEAtrgvwhpaRVITLDRLFLPLSRVSIPPRVSLT------- 180
Cdd:COG5635   109 ELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADG--------LLVSLDDLYVPLNLLERIESLKRLelleakk 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  181 -----IGVAGVGKTTLVRHFVHCWARGqvGKGFSRVLPL--TFRDLNTYEKLSA--DRLIQSIFSSIGEASLVATAPDRV 251
Cdd:COG5635   181 krlliLGEPGSGKTTLLRYLALELAER--YLDAEDPIPIliELRDLAEEASLEDllAEALEKRGGEPEDALERLLRNGRL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  252 LLVLDGLDECKTPLEFSntmacsdpkkeiQVDHLITNIIRGnlFPEISVWITSRPSAAGQIPGGLVDRMtEIRGLTEEEI 331
Cdd:COG5635   259 LLLLDGLDEVPDEADRD------------EVLNQLRRFLER--YPKARVIITSRPEGYDSSELEGFEVL-ELAPLSDEQI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  332 KVCLEQMFPEEQNLLGQVLSQVQANRALYLMCTVPAFCRLtgLALGHLYRTRlavqdielpLPQTLCELYSWYFRMALgg 411
Cdd:COG5635   324 EEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTL--LALLLRERGE---------LPDTRAELYEQFVELLL-- 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  412 EGQDKEKVSPRIKQVTQGARKMVgtLGRLAFHGLVKKKYVFYEQDMKAF---------GVDLALLQNTLCSCLLQREetl 482
Cdd:COG5635   391 ERWDEQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEEIlreylgrrkDAEALLDELLLRTGLLVER--- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  483 aSSVAYCFIHLSLQEFVAATYYYSASKRAIFDLFtesgmswprlgflahfrcaaqrATQAKDGRLDVFLRFLSGLLSPR- 561
Cdd:COG5635   466 -GEGRYSFAHRSFQEYLAARALVEELDEELLELL----------------------AEHLEDPRWREVLLLLAGLLDDVk 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  562 -----VNTLLAGSLLSQGEHQSYRDQVAEVLQGFLHPDAAVCARAINVLYCLSELRHTELACSVEEAMRSGTLAGMTSPS 636
Cdd:COG5635   523 qikelIDALLARDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAAL 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  637 HRTALAYLLQMSDICSPEADFSLCLSQHVLQSLLPQLLYCQ--SLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQ 714
Cdd:COG5635   603 LLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLLALLAlvLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELL 682

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755553577  715 IGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGV 776
Cdd:COG5635   683 LALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALA 744
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 492-617 3.63e-18

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 81.57  E-value: 3.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   492 HLSLQEFVAATYYYSASKRAIFDLFTESGMSWPRLGFlahfRCAAQRATQAKDGRLDVFLRFLSGLLSPRVNTLLAGSL- 570
Cdd:pfam17776    1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESL----KSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLg 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 755553577   571 --LSQGEHQSYRDQVAEVLQGFLHPDaavcaRAINVLYCLSELRHTELA 617
Cdd:pfam17776   77 ckLSSEIKQELLQWIKSLIQKELSSE-----RFLNLFHCLYELQDESFV 120
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 949-1068 2.37e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  949 QALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKL--NSSLRRLNLQENSLGMD 1026
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLtkGCGLQELDLSDNALGPD 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 755553577 1027 GAIFVASALSeNHGLHHINLQGNPIGESAARMISEAIKTNAP 1068
Cdd:cd00116    97 GCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPP 137
LRR_6 pfam13516
Leucine Rich repeat;
954-976 2.98e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 38.76  E-value: 2.98e-04
                           10        20
                   ....*....|....*....|...
gi 755553577   954 NRTLTTLDLQENAIGDEGASSVA 976
Cdd:pfam13516    2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
730-756 7.43e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 7.43e-04
                            10        20
                    ....*....|....*....|....*..
gi 755553577    730 NRSLITLDLRSNSIGPPGAKALADALK 756
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 665-952 1.33e-58

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 208.49  E-value: 1.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  665 VLQSLLPQLLYCQSLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIG 744
Cdd:COG5238   142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  745 PPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSS 824
Cdd:COG5238   222 DEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  825 NTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHL 904
Cdd:COG5238   302 NRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 755553577  905 DLTANLLHDRGAQAIAVAVGENhSLTHLHLQWNFIQAGAARALGQALQ 952
Cdd:COG5238   382 NLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 755-1064 6.62e-51

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 186.15  E-value: 6.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  755 LKINRTLTSLSLQSNVIKDDGVMCVAEALV--------SNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNT 826
Cdd:COG5238   140 RINLIQVLKDPLGGNAVHLLGLAARLGLLAaismakalQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNP 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  827 IGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDL 906
Cdd:COG5238   220 IGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDL 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  907 TANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTli 986
Cdd:COG5238   300 SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTT-- 377

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755553577  987 alylrgndvgaagakalanalklnssLRRLNLQENSLGMDGAIFVASALSENHgLHHINLQGNPIGESAARMISEAIK 1064
Cdd:COG5238   378 --------------------------LRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 703-1066 4.44e-49

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 180.76  E-value: 4.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  703 CRIRKISLAENQIGNKGAKALARSLlVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLsLQSNVIKDDGVMCVAEA 782
Cdd:COG5238    29 TKRATIVNLRSYHLHGGAILLARYL-QSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPTQL-LVVDWEGAEEVSPVALA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  783 L---------------VSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSsNTIGDRGAIALAEALKvNQILEN 847
Cdd:COG5238   107 EtatavatpppdlrriMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLA-ARLGLLAAISMAKALQ-NNSVET 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  848 LDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGENH 927
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  928 SLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANAL 1007
Cdd:COG5238   265 TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL 344

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755553577 1008 KLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMISEAIKTN 1066
Cdd:COG5238   345 QENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 176-342 1.81e-36

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 135.51  E-value: 1.81e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   176 RVSLTIGVAGVGKTTLVRHFVHCWARGQVGKGFSRVLPLTFRDLNTYEK-LSADRLIQSIFSSIGEA-----SLVATAPD 249
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNaRSLADLLFSQWPEPAAPvsevwAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   250 RVLLVLDGLDECKTPLEFSNTmacsdpkkEIQVDHLITNIIRGNLFPEISVWITSRPSAAGQIPGGLVD-RMTEIRGLTE 328
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEpRYLEVRGFSE 152

                          170
                   ....*....|....
gi 755553577   329 EEIKVCLEQMFPEE 342
Cdd:pfam05729  153 SDRKQYVRKYFSDE 166
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 710-995 2.99e-34

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 134.02  E-value: 2.99e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  710 LAENQIGNKGAKALARSLLVNRSLITLDLRSNSIG--PPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVaEALVSNQ 787
Cdd:cd00116    30 LEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  788 TISMLQLQKNLIGLIGAQQMADALKQNR-SLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRA 866
Cdd:cd00116   109 SLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  867 LCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVgenhslthlhlqwnfiqagaara 946
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL----------------------- 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 755553577  947 lgqaLQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDV 995
Cdd:cd00116   246 ----LSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 668-955 1.44e-32

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 129.40  E-value: 1.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  668 SLLPQLLYCQSLRLDNNQFQDPVMELLGSVL-SGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPP 746
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGEEAAKALASALrPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  747 GAKALADALKiNRTLTSLSLQSNVIKDDGVMCVAEALVSNQ-TISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSN 825
Cdd:cd00116    97 GCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANN 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  826 TIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQAL-TQALCRNNTLKHL 904
Cdd:cd00116   176 GIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTL 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755553577  905 DLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNR 955
Cdd:cd00116   256 SLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPG 306
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 791-1062 1.82e-31

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 125.93  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  791 MLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIG--DRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALc 868
Cdd:cd00116    27 VLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLL- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  869 SNQTLSSLNLRENSISPEGAQALTQALCRNN-TLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAARAL 947
Cdd:cd00116   106 RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRAL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  948 GQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAA-GAKALANALKLNSSLRRLNLQENSLGMD 1026
Cdd:cd00116   186 AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAgAAALASALLSPNISLLTLSLSCNDITDD 265

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 755553577 1027 GAIFVASALSENHGLHHINLQGNPIGESAARMISEA 1062
Cdd:cd00116   266 GAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 792-1064 3.33e-31

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 125.16  E-value: 3.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  792 LQLQKNLIGLIGAQQMADALKQnrsLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSI--SDMGVTVLMRALCS 869
Cdd:cd00116     3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  870 NQTLSSLNLRENSISPEGAQALtQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGEN-HSLTHLHLQWNFIQAGAARALG 948
Cdd:cd00116    80 GCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  949 QALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGA 1028
Cdd:cd00116   159 KALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGA 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 755553577 1029 IFVASAL-SENHGLHHINLQGNPIGESAARMISEAIK 1064
Cdd:cd00116   239 AALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLA 275
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 662-863 1.10e-28

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 117.84  E-value: 1.10e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  662 SQHVLQSLLpQLLYCQSLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSN 741
Cdd:cd00116    97 GCGVLESLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANN 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  742 SIGPPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQ-NRSLKAL 820
Cdd:cd00116   176 GIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTL 255

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755553577  821 MFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVL 863
Cdd:cd00116   256 SLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL 298
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 797-1068 2.20e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 110.65  E-value: 2.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  797 NLIGLIGAQQMADALkQNRSLKALMFSSNTIGDRGAI-----ALAEALKVNQILENLD-LQSNSISDMGVTV-------- 862
Cdd:COG5238    39 SYHLHGGAILLARYL-QSRSSITQYLRFEGQGDPGLNpvaleKAAEAFPTQLLVVDWEgAEEVSPVALAETAtavatppp 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  863 -LMRALCsNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDrgAQAIAVAVGENHSLTHLHLQWNFIQA 941
Cdd:COG5238   118 dLRRIMA-KTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLL--AAISMAKALQNNSVETVYLGCNQIGD 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  942 GAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKLNSSLRRLNLQEN 1021
Cdd:COG5238   195 EGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGN 274

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 755553577 1022 SLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMISEAIKTNAP 1068
Cdd:COG5238   275 QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT 321
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
28-776 5.49e-19

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 92.95  E-value: 5.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   28 ALYSQLLAANTDSTRKQEVWTDRETCLAYSVGSPAEQVKALVDLLAGKGSQLLQVRDKMPDSPLGSQSNESRIPKHSEAL 107
Cdd:COG5635    29 LAALLLLALVALGLALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  108 LSRVGNDPELGSPSHRLASLMLVEGLTDLQLKEHDFTQVEAtrgvwhpaRVITLDRLFLPLSRVSIPPRVSLT------- 180
Cdd:COG5635   109 ELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADG--------LLVSLDDLYVPLNLLERIESLKRLelleakk 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  181 -----IGVAGVGKTTLVRHFVHCWARGqvGKGFSRVLPL--TFRDLNTYEKLSA--DRLIQSIFSSIGEASLVATAPDRV 251
Cdd:COG5635   181 krlliLGEPGSGKTTLLRYLALELAER--YLDAEDPIPIliELRDLAEEASLEDllAEALEKRGGEPEDALERLLRNGRL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  252 LLVLDGLDECKTPLEFSntmacsdpkkeiQVDHLITNIIRGnlFPEISVWITSRPSAAGQIPGGLVDRMtEIRGLTEEEI 331
Cdd:COG5635   259 LLLLDGLDEVPDEADRD------------EVLNQLRRFLER--YPKARVIITSRPEGYDSSELEGFEVL-ELAPLSDEQI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  332 KVCLEQMFPEEQNLLGQVLSQVQANRALYLMCTVPAFCRLtgLALGHLYRTRlavqdielpLPQTLCELYSWYFRMALgg 411
Cdd:COG5635   324 EEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTL--LALLLRERGE---------LPDTRAELYEQFVELLL-- 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  412 EGQDKEKVSPRIKQVTQGARKMVgtLGRLAFHGLVKKKYVFYEQDMKAF---------GVDLALLQNTLCSCLLQREetl 482
Cdd:COG5635   391 ERWDEQRGLTIYRELSREELREL--LSELALAMQENGRTEFAREELEEIlreylgrrkDAEALLDELLLRTGLLVER--- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  483 aSSVAYCFIHLSLQEFVAATYYYSASKRAIFDLFtesgmswprlgflahfrcaaqrATQAKDGRLDVFLRFLSGLLSPR- 561
Cdd:COG5635   466 -GEGRYSFAHRSFQEYLAARALVEELDEELLELL----------------------AEHLEDPRWREVLLLLAGLLDDVk 522

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  562 -----VNTLLAGSLLSQGEHQSYRDQVAEVLQGFLHPDAAVCARAINVLYCLSELRHTELACSVEEAMRSGTLAGMTSPS 636
Cdd:COG5635   523 qikelIDALLARDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAAL 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  637 HRTALAYLLQMSDICSPEADFSLCLSQHVLQSLLPQLLYCQ--SLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQ 714
Cdd:COG5635   603 LLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLLALLAlvLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELL 682

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755553577  715 IGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGV 776
Cdd:COG5635   683 LALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALA 744
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 492-617 3.63e-18

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 81.57  E-value: 3.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577   492 HLSLQEFVAATYYYSASKRAIFDLFTESGMSWPRLGFlahfRCAAQRATQAKDGRLDVFLRFLSGLLSPRVNTLLAGSL- 570
Cdd:pfam17776    1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESL----KSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLg 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 755553577   571 --LSQGEHQSYRDQVAEVLQGFLHPDaavcaRAINVLYCLSELRHTELA 617
Cdd:pfam17776   77 ckLSSEIKQELLQWIKSLIQKELSSE-----RFLNLFHCLYELQDESFV 120
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 432-490 1.32e-11

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 60.66  E-value: 1.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 755553577   432 KMVGTLGRLAFHGLVKKKYVFYEQDMKAFGVDLALLQNTLCSCLLQREETLASsvAYCF 490
Cdd:pfam17779    1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEK--VYSF 57
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
693-1054 1.91e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  693 LLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNvik 772
Cdd:COG4886    30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  773 ddgvmcvaEALVSNQTISMLQLQKNLIgligaQQMADALKQNRSLKALMFSSNTIGDrgaiaLAEALKVNQILENLDLQS 852
Cdd:COG4886   107 --------EELSNLTNLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  853 NSISDMGvtvlmRALCSNQTLSSLNLRENSISpegaqALTQALCRNNTLKHLDLTANLLHDrgaqaIAVAVGENHSLTHL 932
Cdd:COG4886   169 NQLTDLP-----EELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  933 HLQWNFIqagaaRALGQALQLNRtLTTLDLQENAIGDegassvAGALKVNTTLIALYLRGNDVGAAGAKALANALKLNSS 1012
Cdd:COG4886   234 DLSNNQL-----TDLPELGNLTN-LEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 755553577 1013 LRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGES 1054
Cdd:COG4886   302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
717-1051 4.52e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 4.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  717 NKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQK 796
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  797 NLIGLIGAQQmadaLKQNRSLKALMFSSNtigdrgaialaEALKVNQILENLDLQSNSISDMGVtvlmrALCSNQTLSSL 876
Cdd:COG4886    82 LSLLLLGLTD----LGDLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLTDLPE-----ELANLTNLKEL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  877 NLRENSISpegaqALTQALCRNNTLKHLDLTANLLHDrgaqaIAVAVGENHSLTHLHLQWNFIQagaarALGQALQLNRT 956
Cdd:COG4886   142 DLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  957 LTTLDLQENAIgdegaSSVAGALKVNTTLIALYLRGNDVGAAGAKALanalklNSSLRRLNLQENSLGmdgaifVASALS 1036
Cdd:COG4886   207 LEELDLSGNQL-----TDLPEPLANLTNLETLDLSNNQLTDLPELGN------LTNLEELDLSNNQLT------DLPPLA 269

                         330
                  ....*....|....*
gi 755553577 1037 ENHGLHHINLQGNPI 1051
Cdd:COG4886   270 NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
705-1020 4.07e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  705 IRKISLAENQIgnkgaKALARSLLVNRSLITLDLRSNSIgppgaKALADALKINRTLTSLSLQSNVIKDdgvmcVAEALV 784
Cdd:COG4886   115 LESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQL-----TDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  785 SNQTISMLQLQKNLIgligaQQMADALKQNRSLKALMFSSNTIGDrgaiaLAEALKVNQILENLDLQSNSISDMgvtvlm 864
Cdd:COG4886   180 NLTNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------ 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  865 RALCSNQTLSSLNLRENSIS--PEGAQaLTQalcrnntLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAG 942
Cdd:COG4886   244 PELGNLTNLEELDLSNNQLTdlPPLAN-LTN-------LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755553577  943 AARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKLNSSLRRLNLQE 1020
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
658-964 6.19e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  658 SLCLSQHVLQSL---LPQLLYCQSLRLDNNQFQDpvmelLGSVLSGKDcRIRKISLAENQIgnkgaKALARSLLVNRSLI 734
Cdd:COG4886   117 SLDLSGNQLTDLpeeLANLTNLKELDLSNNQLTD-----LPEPLGNLT-NLKSLDLSNNQL-----TDLPEELGNLTNLK 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  735 TLDLRSNSIgppgaKALADALKINRTLTSLSLQSNVIKDdgvmcVAEALVSNQTISMLQLQKNLIGLIgaqqmaDALKQN 814
Cdd:COG4886   186 ELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------PELGNL 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  815 RSLKALMFSSNTIGDrgaiaLAEALKVNQiLENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQA 894
Cdd:COG4886   250 TNLEELDLSNNQLTD-----LPPLANLTN-LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  895 LCRNNTLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQE 964
Cdd:COG4886   324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
732-1047 1.47e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  732 SLITLDLRSNSIgppgaKALADALKINRTLTSLSLQSNVIKDdgvmcVAEALVSNQTISMLQLQKNLIgligaQQMADAL 811
Cdd:COG4886   114 NLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQL-----TDLPEEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  812 KQNRSLKALMFSSNTIGDrgaiaLAEALKVNQILENLDLQSNSISDmgvtvLMRALCSNQTLSSLNLRENSIS--PEgaq 889
Cdd:COG4886   179 GNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTdlPE--- 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  890 altqaLCRNNTLKHLDLTANLLHDRGAQaiavavGENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGD 969
Cdd:COG4886   246 -----LGNLTNLEELDLSNNQLTDLPPL------ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755553577  970 EGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQ 1047
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 731-909 1.83e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  731 RSLITLDLRSNSIgppgakALADALKINRTLTSLSLQSNVIKddgVMCVAEALVS--------NQtISM---LQLQKNLI 799
Cdd:cd21340    24 KNLKVLYLYDNKI------TKIENLEFLTNLTHLYLQNNQIE---KIENLENLVNlkklylggNR-ISVvegLENLTNLE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  800 GL-IGAQQMADALKqnrslkaLMFSSNTIgdrgaIALAEALKVnqilenLDLQSNSISDMGVTVLMRALcsnqtlSSLNL 878
Cdd:cd21340    94 ELhIENQRLPPGEK-------LTFDPRSL-----AALSNSLRV------LNISGNNIDSLEPLAPLRNL------EQLDA 149

                         170       180       190
                  ....*....|....*....|....*....|.
gi 755553577  879 RENSISpeGAQALTQALCRNNTLKHLDLTAN 909
Cdd:cd21340   150 SNNQIS--DLEELLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 949-1068 2.37e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553577  949 QALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLRGNDVGAAGAKALANALKL--NSSLRRLNLQENSLGMD 1026
Cdd:cd00116    17 ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLtkGCGLQELDLSDNALGPD 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 755553577 1027 GAIFVASALSeNHGLHHINLQGNPIGESAARMISEAIKTNAP 1068
Cdd:cd00116    97 GCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPP 137
LRR_6 pfam13516
Leucine Rich repeat;
954-976 2.98e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 38.76  E-value: 2.98e-04
                           10        20
                   ....*....|....*....|...
gi 755553577   954 NRTLTTLDLQENAIGDEGASSVA 976
Cdd:pfam13516    2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
730-756 7.43e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 7.43e-04
                            10        20
                    ....*....|....*....|....*..
gi 755553577    730 NRSLITLDLRSNSIGPPGAKALADALK 756
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEALK 27
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
814-840 6.21e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 6.21e-03
                            10        20
                    ....*....|....*....|....*..
gi 755553577    814 NRSLKALMFSSNTIGDRGAIALAEALK 840
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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