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Conserved domains on  [gi|752413651|ref|XP_011227070|]
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PREDICTED: solute carrier family 2, facilitated glucose transporter member 12 isoform X2 [Ailuropoda melanoleuca]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 46-484 3.01e-171

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17435:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 376  Bit Score: 490.46  E-value: 3.01e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  46 LSSVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGS 125
Cdd:cd17435    1 LSSVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 126 LVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFG 205
Cdd:cd17435   81 LLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSNGWKYMFG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPLGVLQAIAMYFLPPSPRFLVMkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrsKDNMRTRIMI 285
Cdd:cd17435  161 LVIPLAALQAIAMYFLPPSPRFLVM---------------------------------------------KDNMRARLLI 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 286 GLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTM 365
Cdd:cd17435  196 GLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTM 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 366 GIvnlntpmnftnicrshspinrsldesvfygpgnlsvsddtlrerfkgitantrdslmpmkndmdkrglmtlpnaglsq 445
Cdd:cd17435  276 GL------------------------------------------------------------------------------ 277

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 752413651 446 aeyqivtdpadvpaflkWLSLASLLVYVAAFSIGLGPIV 484
Cdd:cd17435  278 -----------------WLSLASLLVYVAAFSIGLGPMP 299
 
Name Accession Description Interval E-value
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 46-484 3.01e-171

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 490.46  E-value: 3.01e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  46 LSSVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGS 125
Cdd:cd17435    1 LSSVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 126 LVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFG 205
Cdd:cd17435   81 LLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSNGWKYMFG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPLGVLQAIAMYFLPPSPRFLVMkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrsKDNMRTRIMI 285
Cdd:cd17435  161 LVIPLAALQAIAMYFLPPSPRFLVM---------------------------------------------KDNMRARLLI 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 286 GLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTM 365
Cdd:cd17435  196 GLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTM 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 366 GIvnlntpmnftnicrshspinrsldesvfygpgnlsvsddtlrerfkgitantrdslmpmkndmdkrglmtlpnaglsq 445
Cdd:cd17435  276 GL------------------------------------------------------------------------------ 277

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 752413651 446 aeyqivtdpadvpaflkWLSLASLLVYVAAFSIGLGPIV 484
Cdd:cd17435  278 -----------------WLSLASLLVYVAAFSIGLGPMP 299
Sugar_tr pfam00083
Sugar (and other) transporter;
48-373 1.32e-75

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 247.19  E-value: 1.32e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   48 SVTAAVSGLLVGYELGLISGALLQI-----------RTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIIL 116
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIdffknfglsksVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  117 SSCLLGLGSLVLILS---LSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAF 193
Cdd:pfam00083  82 ANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  194 A--NVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSLK--DEYQYSF 269
Cdd:pfam00083 162 NktSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEagQEAEKAS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  270 WDLFRSKDNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSneaASLASTGVGVVKVISTIPATLLVDHVGSKT 349
Cdd:pfam00083 242 WKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD---SFLVTIIVGVVNFVFTFIAIFLVDRFGRRP 318

                         330       340
                  ....*....|....*....|....
gi 752413651  350 FLCVGSSVMAASLMTMGIVNLNTP 373
Cdd:pfam00083 319 LLLLGAAGMAICFVILGIVALLGV 342
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 41-368 7.34e-69

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 230.30  E-value: 7.34e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   41 GMFTLLSSVtAAVSGLLVGYELGLISGALLQIRTLLALTCQ--------EQEMVVSSLLIGALLASLTGGVLIDRYGRRT 112
Cdd:TIGR00879  24 WKVALLSLI-AAIGGLMFGYDTGVIGGALALPAFEFKFTSAnsdsysssLWGLVVSIFLVGGFIGALFAGWLSDRFGRKK 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  113 AIILSSCLLGLGSLVLILS---LSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYIS 189
Cdd:TIGR00879 103 SLLIIALLFVIGAILMGLAafaLSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGF 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  190 NYA--FANVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSLKDEY-- 265
Cdd:TIGR00879 183 GSGkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELIDIKRsi 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  266 -----QYSFWDLFRSKDNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVISTIPATL 340
Cdd:TIGR00879 263 ekrsvQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGV-STDHAFLVSIIVGAVNFAFTFVAIF 341

                         330       340
                  ....*....|....*....|....*...
gi 752413651  341 LVDHVGSKTFLCVGSSVMAASLMTMGIV 368
Cdd:TIGR00879 342 LVDRFGRRPLLLIGAAGMAICLFVLGIL 369
xylE PRK10077
D-xylose transporter XylE; Provisional
 51-367 1.65e-47

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 172.96  E-value: 1.65e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTLL--ALTCQEQE------MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLL- 121
Cdd:PRK10077  17 ATLGGLLFGYDTAVISGTVESLNTVFvaPQNLSESAansllgFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFf 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 122 --GLGS------LVLILSLSYAVLI---VGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISN 190
Cdd:PRK10077  97 isALGSawpefgFTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVN 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 191 YAFAN-------VSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSL-- 261
Cdd:PRK10077 177 YFIARsgdaswlNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLdh 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 262 ---KDEYQYSFWDLFrskdnmrtrIMIGLTLVFFVQVTGQPNILFYASTVLKSVGfQSNEAASLASTGVGVVKVISTIPA 338
Cdd:PRK10077 257 grkTGGKLLMFGVGV---------IVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINLTFTVLA 326

                        330       340
                 ....*....|....*....|....*....
gi 752413651 339 TLLVDHVGSKTFLCVGSSVMAASLMTMGI 367
Cdd:PRK10077 327 IMTVDKFGRKPLQIIGALGMAIGMFSLGT 355
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-369 1.14e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 125.47  E-value: 1.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  43 FTLLSSVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLG 122
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 123 LGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVsHGWKY 202
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 203 MFGLVIPLGVLQAIAMYFLPPSPRflvmkghEEAASKVLRRLRAIsdtteeltgiksslkdeyqysfwdlfrskdnMRTR 282
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESR-------PAARARLRGSLREL-------------------------------LRRP 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 283 IMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASL 362
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287


                 ....*..
gi 752413651 363 MTMGIVN 369
Cdd:COG2814  288 LLLALAG 294
 
Name Accession Description Interval E-value
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 46-484 3.01e-171

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 490.46  E-value: 3.01e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  46 LSSVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGS 125
Cdd:cd17435    1 LSSVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 126 LVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFG 205
Cdd:cd17435   81 LLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSNGWKYMFG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPLGVLQAIAMYFLPPSPRFLVMkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrsKDNMRTRIMI 285
Cdd:cd17435  161 LVIPLAALQAIAMYFLPPSPRFLVM---------------------------------------------KDNMRARLLI 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 286 GLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTM 365
Cdd:cd17435  196 GLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTM 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 366 GIvnlntpmnftnicrshspinrsldesvfygpgnlsvsddtlrerfkgitantrdslmpmkndmdkrglmtlpnaglsq 445
Cdd:cd17435  276 GL------------------------------------------------------------------------------ 277

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 752413651 446 aeyqivtdpadvpaflkWLSLASLLVYVAAFSIGLGPIV 484
Cdd:cd17435  278 -----------------WLSLASLLVYVAAFSIGLGPMP 299
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 50-483 6.22e-121

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 362.44  E-value: 6.22e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  50 TAAVSGLLVGYELGLISGALLQIRTLL-------ALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLG 122
Cdd:cd17362    1 FPALGGLLFGYDIGATSGALLSITSPAlsgtdwyNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 123 LGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKY 202
Cdd:cd17362   81 VGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 203 MFGLVIPLGVLQAIAMYFLPPSPRFlvmkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrsKDNMRTR 282
Cdd:cd17362  161 MYGLAAPPALLLGIGMWFLPPSPRW------------------------------------------------QGNYRKP 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 283 IMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASL 362
Cdd:cd17362  193 LIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSL 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 363 MTMGIVNLNTPMnftnicrshspinrsldesvfygpgnlsvsddtlrerfkgitantrdslmpmkndmdkrglmtlpnag 442
Cdd:cd17362  273 FLLAAYNLFVQM-------------------------------------------------------------------- 284

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 752413651 443 lsqaeyqivtdpadVPAFLKWLSLASLLVYVAAFSIGLGPI 483
Cdd:cd17362  285 --------------GPAGLAWLSLVALLLYVGAYQISFGPI 311
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 46-367 1.43e-85

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 270.90  E-value: 1.43e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  46 LSSVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGS 125
Cdd:cd17436    1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 126 LVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFG 205
Cdd:cd17436   81 LILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLTGWRYMFG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPLGVLQAIAMYFLPPSPrflvmkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwDLFRSKDNMRTRIMI 285
Cdd:cd17436  161 LAIIPAAIQFASILLLPKKP---------------------------------------------EVLNIKDNMRRRTLV 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 286 GLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTM 365
Cdd:cd17436  196 GLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGI 275


                 ..
gi 752413651 366 GI 367
Cdd:cd17436  276 GL 277
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 51-373 3.03e-78

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 251.34  E-value: 3.03e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTLL--ALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVL 128
Cdd:cd17315    2 AALGGLLFGYDLGVINGALLYIAKDLgfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 129 ILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFAN-VSHGWKYMFGLV 207
Cdd:cd17315   82 ALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLsPPGWWRLMFALA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 208 IPLGVLQAIAMYFLPPSPrflvmkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrskdnmrtRIMIGL 287
Cdd:cd17315  162 AVPALLQLLLMFFLPESR--------------------------------------------------------ALLVGV 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 288 TLVFFVQVTGQPNILFYASTVLKSVGfqSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGI 367
Cdd:cd17315  186 GLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAI 263


                 ....*.
gi 752413651 368 VNLNTP 373
Cdd:cd17315  264 AFLLPA 269
Sugar_tr pfam00083
Sugar (and other) transporter;
48-373 1.32e-75

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 247.19  E-value: 1.32e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   48 SVTAAVSGLLVGYELGLISGALLQI-----------RTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIIL 116
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIdffknfglsksVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  117 SSCLLGLGSLVLILS---LSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAF 193
Cdd:pfam00083  82 ANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  194 A--NVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSLK--DEYQYSF 269
Cdd:pfam00083 162 NktSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEagQEAEKAS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  270 WDLFRSKDNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSneaASLASTGVGVVKVISTIPATLLVDHVGSKT 349
Cdd:pfam00083 242 WKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD---SFLVTIIVGVVNFVFTFIAIFLVDRFGRRP 318

                         330       340
                  ....*....|....*....|....
gi 752413651  350 FLCVGSSVMAASLMTMGIVNLNTP 373
Cdd:pfam00083 319 LLLLGAAGMAICFVILGIVALLGV 342
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 48-375 9.90e-70

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 229.76  E-value: 9.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  48 SVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLV 127
Cdd:cd17359    3 SLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 128 LILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFAN-------VSHGW 200
Cdd:cd17359   83 SAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANaggadwlGAEGW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 201 KYMFGL-VIPlGVLQAIAMYFLPPSPRFLVMKGheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrskdnm 279
Cdd:cd17359  163 RWMLGLeAIP-AILFLLGMLFIPESPRWLVSKG----------------------------------------------- 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 280 RTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMA 359
Cdd:cd17359  195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGF-SENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMA 273

                        330
                 ....*....|....*.
gi 752413651 360 ASLMTMGIVNLNTPMN 375
Cdd:cd17359  274 ISLLLIGTAFYFAPGS 289
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 41-368 7.34e-69

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 230.30  E-value: 7.34e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   41 GMFTLLSSVtAAVSGLLVGYELGLISGALLQIRTLLALTCQ--------EQEMVVSSLLIGALLASLTGGVLIDRYGRRT 112
Cdd:TIGR00879  24 WKVALLSLI-AAIGGLMFGYDTGVIGGALALPAFEFKFTSAnsdsysssLWGLVVSIFLVGGFIGALFAGWLSDRFGRKK 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  113 AIILSSCLLGLGSLVLILS---LSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYIS 189
Cdd:TIGR00879 103 SLLIIALLFVIGAILMGLAafaLSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGF 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  190 NYA--FANVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSLKDEY-- 265
Cdd:TIGR00879 183 GSGkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELIDIKRsi 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  266 -----QYSFWDLFRSKDNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVISTIPATL 340
Cdd:TIGR00879 263 ekrsvQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGV-STDHAFLVSIIVGAVNFAFTFVAIF 341

                         330       340
                  ....*....|....*....|....*...
gi 752413651  341 LVDHVGSKTFLCVGSSVMAASLMTMGIV 368
Cdd:TIGR00879 342 LVDRFGRRPLLLIGAAGMAICLFVLGIL 369
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 45-366 8.44e-58

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 199.72  E-value: 8.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  45 LLSSVTAAVSGLLVGYELGLISGALLQI----RTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCL 120
Cdd:cd17358    1 LLATFVANLGSFSFGIAVGWSSPALPSLmsdnSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 121 LGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFAnvshgW 200
Cdd:cd17358   81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP-----W 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 201 KYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAI-SDTTEELTGIKSS---LKDEYQYSFWDLFRSK 276
Cdd:cd17358  156 RTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKdADISKEAAEIQEElaeLEKEAKESSFSDLFQR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 277 DNMRTrIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNeaASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSS 356
Cdd:cd17358  236 KYLKP-LVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLD--PNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAI 312

                        330
                 ....*....|
gi 752413651 357 VMAASLMTMG 366
Cdd:cd17358  313 GMGIGLLALG 322
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 51-367 1.15e-54

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 189.02  E-value: 1.15e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRT---LLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLV 127
Cdd:cd17360    2 AGIGGFLFGYDTGVISGALLYIKDdlgEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 128 LILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFGL- 206
Cdd:cd17360   82 MAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLa 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 207 VIPlGVLQAIAMYFLPPSPRFlvmkgheeaasKVLRRlraisdtteeltgiksslkdeyqysfwdlfrskdnmrtRIMIG 286
Cdd:cd17360  162 AVP-AVLQFIGLLFLPESPRW-----------PSTRR--------------------------------------ALIVG 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 287 LTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMG 366
Cdd:cd17360  192 CGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLA 271


                 .
gi 752413651 367 I 367
Cdd:cd17360  272 V 272
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 86-380 8.58e-52

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 183.62  E-value: 8.58e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSL---SYAVLIVGRIAVGVSISLSSIATCVYIAEI 162
Cdd:cd17357   54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKsakSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 163 APQHRRGLLVSLNELMIVIGILFAYI--SNYAFANVSHgWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVM-KGHEEAASK 239
Cdd:cd17357  134 SPSELRGALGSLTQIGVTLGILLGQVfgLPSVLGTETL-WPYLLFFPGIPALLQLAALPFFPESPKFLLIsKGDEEEAEK 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 240 VLRRLRAISDT-TEELTGIK---SSLKDEYQYSFWDLFRSKDNmRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFq 315
Cdd:cd17357  213 SLKFLRGIEDDvDQELEEIKkesEQMGDQKQVSLMQLLRDPSL-RLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGF- 290

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 316 SNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIV----NLNTPMNFTNIC 380
Cdd:cd17357  291 SPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFlflsEQNSWMSYGCIV 359
xylE PRK10077
D-xylose transporter XylE; Provisional
 51-367 1.65e-47

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 172.96  E-value: 1.65e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTLL--ALTCQEQE------MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLL- 121
Cdd:PRK10077  17 ATLGGLLFGYDTAVISGTVESLNTVFvaPQNLSESAansllgFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFf 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 122 --GLGS------LVLILSLSYAVLI---VGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISN 190
Cdd:PRK10077  97 isALGSawpefgFTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVN 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 191 YAFAN-------VSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSL-- 261
Cdd:PRK10077 177 YFIARsgdaswlNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLdh 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 262 ---KDEYQYSFWDLFrskdnmrtrIMIGLTLVFFVQVTGQPNILFYASTVLKSVGfQSNEAASLASTGVGVVKVISTIPA 338
Cdd:PRK10077 257 grkTGGKLLMFGVGV---------IVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINLTFTVLA 326

                        330       340
                 ....*....|....*....|....*....
gi 752413651 339 TLLVDHVGSKTFLCVGSSVMAASLMTMGI 367
Cdd:PRK10077 327 IMTVDKFGRKPLQIIGALGMAIGMFSLGT 355
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 51-367 2.12e-43

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 159.49  E-value: 2.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL 130
Cdd:cd17437    2 ASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 131 SLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSH--GWKYMFGLVI 208
Cdd:cd17437   82 APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLhvGWRLMLGVGA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 209 PLGVLQAIAMYFLPPSPRFlvmkgheeaaSKVLRRLraisdtteeltgiksslkdeyqysfwdlfrskdnmrtrIMIGLT 288
Cdd:cd17437  162 VPSLFLAIGVLAMPESPRW----------TPAVRRM--------------------------------------LIAALG 193

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 289 LVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGI 367
Cdd:cd17437  194 IHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALAT 272
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 87-371 2.62e-43

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 160.58  E-value: 2.62e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  87 VSSLLIGALLASLTGGVLIDRYGRRTAI-------ILSSCLLGLGSLvlilSLSYAVLIVGRIAVGVSISLSSIATCVYI 159
Cdd:cd17431   56 VAIFSVGGMIGSFSVGLFVNRFGRRNSMlynnllaFAGAALMGLSKL----AKSYEMLILGRFIIGLYCGLTTGLVPMYI 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 160 AEIAPQHRRGLLVSLNELMIVIGILFAYISNYAF-ANVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMK-GHEEAA 237
Cdd:cd17431  132 GEISPTALRGALGTLHQLGIVVGILISQIFGLEFiLGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINrNEEEEA 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 238 SKVLRRLRAISDTTEELTGIKS---SLKDEYQYSFWDLFRSKDNmRTRIMIGLTLVFFVQVTGqPNILFYASTVLksvgF 314
Cdd:cd17431  212 KSVLKKLRGTTDVSEDIQEMKEesrQMMREKKVTILELFRSSSY-RQPIIIAIVLQLSQQLSG-INAVFYYSTSI----F 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752413651 315 QSN--EAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMA--ASLMTMGIVNLN 371
Cdd:cd17431  286 EKAgvQQPVYATIGAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAicAILMTIALLLLE 346
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 51-368 1.28e-40

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 152.02  E-value: 1.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQ---------IRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLL 121
Cdd:cd17356    6 VSLGGFLFGYDTGSISGILNMksfqkyfadNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 122 GLGSLVLILSL-SYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANV--SH 198
Cdd:cd17356   86 IIGAIIQVAAIgKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLdgSA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 199 GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLvmkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrskdn 278
Cdd:cd17356  166 QWRIPLGLQIVWGLLLLIGMFFLPESPRWL-------------------------------------------------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 279 mrTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEaaSLASTGV-GVVKVISTIPATLLVDHVGSKTFLCVGSSV 357
Cdd:cd17356  196 --YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSS--PLLTSIIlYIVNFVSTIPGLFFVDKFGRRTCLLIGAAG 271

                        330
                 ....*....|.
gi 752413651 358 MAASLMTMGIV 368
Cdd:cd17356  272 MSICLFIYAAV 282
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 46-366 3.75e-37

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 142.71  E-value: 3.75e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  46 LSSVTAAVSGLLVGYELGLISGALLQIRTL----LALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLL 121
Cdd:cd17433    2 LATFAAVLGPLSFGFVLGYSSPAIPSLQRIadpaLRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 122 GLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFAnvshgWK 201
Cdd:cd17433   82 IAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD-----WR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 202 YMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTE-ELTGIKSSLKDEYQYSFWDLFRSKdNMR 280
Cdd:cd17433  157 WLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEwECIGIEQSFHLEEQSFSLALLKQP-GIY 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 281 TRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSneaASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAA 360
Cdd:cd17433  236 KPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKD---SSVASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVF 312


                 ....*.
gi 752413651 361 SLMTMG 366
Cdd:cd17433  313 STAAFG 318
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 54-361 4.46e-36

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 140.44  E-value: 4.46e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  54 SGLLVGYELGLISGALLQIRTLLALTCQEQ--------------EMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSC 119
Cdd:cd17432    9 SSFQYGYNLSVVNSPTPYIQNFYNETWTERygtpleestltllwSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 120 LLGLGSLVLILS---LSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISN--YAFA 194
Cdd:cd17432   89 FAIVAAILMGLSkiaKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGlrELLG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 195 NVShGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVM-KGHEEAASKVLRRLRAISDTTEELTGI---KSSLKDEYQYSFW 270
Cdd:cd17432  169 NEE-GWPLLLALTGVPALLQLLTLPFFPESPRYLLIeKGDEEAARKALQRLRGKEDVDDEMEEMleeQRAEKGVGTVSVL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 271 DLFRSKdNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEaASLASTGVGVVKVISTIPATLLVDHVGSKTF 350
Cdd:cd17432  248 ELFRDR-SVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDK-IQYVTVGTGACEVLATITCVLVIERLGRRPL 325

                        330
                 ....*....|.
gi 752413651 351 LCVGSSVMAAS 361
Cdd:cd17432  326 LIGGFGLMAVW 336
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 50-368 4.95e-35

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 136.23  E-value: 4.95e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  50 TAAVSGLLVGYELGlISGALLQIRTLLA------LTCQEQ--------------EMVVSSLLIGALLASLTGGVLIDRYG 109
Cdd:cd17361    1 VAALGGLIFGYDIG-ISGGVTSMDPFLEkffpsvYEKKKGasennyckyddqllQLFTSSLYLAGLVASLLASYVTRKWG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 110 RRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYIS 189
Cdd:cd17361   80 RKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 190 NYAFANV-SHGWKYMFGLVIPLGVLQAIAMYFLPPSPrflvmkgheeaaskvlrrlraisdTTEELTgiksslkdeyqys 268
Cdd:cd17361  160 NYGTSKIkPNGWRLSLGLAAVPALILLLGSLFLPETP------------------------NSPQLV------------- 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 269 fwdlfrskdnmrtrimIGLTLVFFVQVTGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVISTIPATLLVDHVGSK 348
Cdd:cd17361  203 ----------------IAILIPFFQQLTGINVIMFYAPVLFQTLGF-GSDASLISAVITGAVNVVSTLVSIYLVDRFGRR 265

                        330       340
                 ....*....|....*....|
gi 752413651 349 TFLCVGSSVMAASLMTMGIV 368
Cdd:cd17361  266 FLLLEGGVQMLASQVAIGIL 285
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-369 1.14e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 125.47  E-value: 1.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  43 FTLLSSVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLG 122
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 123 LGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVsHGWKY 202
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 203 MFGLVIPLGVLQAIAMYFLPPSPRflvmkghEEAASKVLRRLRAIsdtteeltgiksslkdeyqysfwdlfrskdnMRTR 282
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESR-------PAARARLRGSLREL-------------------------------LRRP 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 283 IMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASL 362
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287


                 ....*..
gi 752413651 363 MTMGIVN 369
Cdd:COG2814  288 LLLALAG 294
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 49-230 1.92e-28

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 115.29  E-value: 1.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  49 VTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVL 128
Cdd:COG0477   17 LALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 129 ILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVsHGWKYMFGLVI 208
Cdd:COG0477   97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA-LGWRWIFLINA 175

                        170       180
                 ....*....|....*....|..
gi 752413651 209 PLGVLQAIAMYFLPPSPRFLVM 230
Cdd:COG0477  176 PLGLLALVLRLRLPESRGLLLA 197
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 51-364 5.22e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 112.91  E-value: 5.22e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL 130
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 131 SLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIG-ILFAYISNYAFANVSHGWKYMFGLVIP 209
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGgILGPLLGGILASSLGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 210 LGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRlraisdtteeltgiksslkdeyqySFWDLFRSKdnmrtRIMIGLTL 289
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLK------------------------LLKRVLKNP-----GLWLLLLA 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752413651 290 VFFVQVTGQpNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMT 364
Cdd:cd06174  212 IFLVNLAYY-SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA 285
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 88-376 3.15e-25

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 108.38  E-value: 3.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  88 SSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHR 167
Cdd:cd17434   48 SVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 168 RGLLVSLNELMIVIGILFAYIsnyafanvshgwkymFGLVIPLGVLQAIA----------MYFLPPSPRFLVMKGHEEAA 237
Cdd:cd17434  128 RGALGACPQIMAVFGSLALYA---------------LGLLLPWRWLAVAGevpvvimillLCFMPNSPRFLISKGKDEKA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 238 SKVLRRLR-AISDTTEELTGIKSSLKDEYQYSFWDLFRSKDNMRTrIMIGLTLVFFVQVTGQPNILFYASTVLKS--VGF 314
Cdd:cd17434  193 LKALAWLRgPNTDYMTEFEQIKDNIRKQSSRLSWAELKTPSYYKP-ILIAVVMRFLQQLTGITPILVYLEPIFHLtaVIL 271

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 752413651 315 QSNEAASLastgVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVNLNTPMNF 376
Cdd:cd17434  272 EPKYDAAL----VGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMGLIPLIAAMLF 329
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 51-374 5.02e-21

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 94.59  E-value: 5.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTL--LALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVL 128
Cdd:cd17316    4 AGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 129 ILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANV---SHGWKYMFG 205
Cdd:cd17316   84 GLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsgDWGWRILFL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPLGVLqaiamyflppsprflvmkgheeaaskvlrrlraisdtteeltgiksslkdeyqySFWdlfrskdnMRtRIMI 285
Cdd:cd17316  164 IGALPALL------------------------------------------------------ALL--------LR-RRTL 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 286 GLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTM 365
Cdd:cd17316  181 LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260


                 ....*....
gi 752413651 366 GIVNLNTPM 374
Cdd:cd17316  261 FYLLSGSPT 269
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 50-349 6.85e-20

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 92.03  E-value: 6.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   50 TAAVSGLLV---GYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSL 126
Cdd:TIGR00895  18 AIILSFLIMlmdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  127 VLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFA-YISNYAFANvsHGWKYMF- 204
Cdd:TIGR00895  98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGgFLAGWLIPV--FGWRSLFy 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  205 -GLVIPLgVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAISDTTEELTGIKSSLKDEYQYSFWDLFRSKdnmRTRI 283
Cdd:TIGR00895 176 vGGIAPL-LLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGK---TARI 251

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 752413651  284 MIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAAS-LASTGVGVvkVISTIPATLLVDHVGSKT 349
Cdd:TIGR00895 252 TVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATgGALFNFGG--VIGSIIFGWLADRLGPRV 316
MFS_1 pfam07690
Major Facilitator Superfamily;
52-370 7.91e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 7.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   52 AVSGLLVGYELGLISGALLQ-IRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL 130
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  131 SLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFAnVSHGWKYMFGLVIPL 210
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  211 GVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRAIsdtteeltgiksslkdeyqysfwdlfrskdnmRTRIMIGLTLV 290
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL--------------------------------LRDPVLWLLLA 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  291 FFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVkVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVNL 370
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLG-AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL 287
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
44-374 7.57e-19

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 88.78  E-value: 7.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  44 TLLSSVTAAVSGLLVGYelgLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGL 123
Cdd:COG2223    6 VLLLATLAFFLAFGVWY---LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 124 GSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIG-ILFAYISNYAFAnvSHGWKY 202
Cdd:COG2223   83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGaAVAAFLAPLLIA--AFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 203 MFGL-VIPLGVLQAIAMYFLPPSPrflvmKGHEEAASKVLRRLRAIsdtteeltgikssLKDeyqYSFWdlfrskdnmrt 281
Cdd:COG2223  161 AFLIlGILLLVVAVLAWLFLRDPP-----AGAAAAAKASLRDQLEA-------------LRD---PRFW----------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 282 RIMIGLTLVFFVQVTgqpnILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAAS 361
Cdd:COG2223  209 LLSLLYFGTFGSFIG----FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284

                        330
                 ....*....|...
gi 752413651 362 LMTMGIVNLNTPM 374
Cdd:COG2223  285 LLLLALALGSLWL 297
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
49-369 3.43e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 86.46  E-value: 3.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  49 VTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVL 128
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 129 ILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANvSHGWKYMFGLVI 208
Cdd:COG2271   93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-AFGWRAAFLILG 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 209 PLGVLQAIAMyflppsprflvmkgheeaaskvlrrlraisdtteeltgiksslkdeyqysfwdlfrskdnmrtriMIGLT 288
Cdd:COG2271  172 LPGLLLALLR-----------------------------------------------------------------FWLLA 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 289 LVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGS--KTFLCVGSSVMAASLMTMG 366
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLA 266


                 ...
gi 752413651 367 IVN 369
Cdd:COG2271  267 LLP 269
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 78-370 6.86e-18

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 86.61  E-value: 6.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   78 LTCQE---QEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIA 154
Cdd:TIGR00898 121 LVCEDawkVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQ 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  155 TCVYIAEIAPQHRRGLLVSLNELMIVIGILFayISNYAFANVShgWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHE 234
Cdd:TIGR00898 201 AVVLNTEFLPKKQRAIVGTLIQVFFSLGLVL--LPLVAYFIPD--WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRI 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  235 EAASKVLRRLRAISDTTEELTGIKSSLKDE-----YQYSFWDLFRSKdNMRTRIMIGLTLVFFVQVTgqpnilfYASTVL 309
Cdd:TIGR00898 277 EEALKILQRIAKINGKKLPAEVLSLSLEKDlssskKQYSFLDLFRTP-NLRKTTLCLMMLWFTTAFS-------YYGLVL 348

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752413651  310 KSVGFQSNEAASLASTgvGVVKVISTIPATLLVDHVGSKtflcvgsSVMAASLMTMGIVNL 370
Cdd:TIGR00898 349 DLGNLGGNIYLDLFIS--GLVELPAKLITLLLIDRLGRR-------YTMAASLLLAGVALL 400
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 85-369 1.33e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 81.85  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:cd17325   35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 165 QHRRGLLVSLNELMIVIGILF-AYISNYAFAnvSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRflvmKGHEEAASKVLRR 243
Cdd:cd17325  115 PEERGRAMGIFSSAIGLGFLIgPLLGGLLAD--ALGYRAPFLVCAALALLALVLALLLLPEPR----PPPNKRAVSAARL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 244 LRaisdtteeltgiksslkdeyqySFWDLFRSKDnmrtriMIGLTLVFFVQVTGQPNILFYASTVLKSVGFQSNEAASLA 323
Cdd:cd17325  189 RS----------------------GLRLLLRDRR------LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 752413651 324 STGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVN 369
Cdd:cd17325  241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT 286
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
62-368 1.28e-15

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 78.74  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  62 LGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGR 141
Cdd:COG0738   24 TALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 142 IAVGVSISLSSIATCVYIAEIAPQHRRGLLVSL---NELMIVIGILFAyiSNYAFANVSHGWKYMFGLViplGVLQAIAM 218
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALGPETAASRLNLLhafFSLGALLGPLLG--GLLILLGLSLSWHLPYLIL---AVLLLLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 219 YFLppsprflvmkgheeaaskVLRRLRAISDTTEELTGIKSSLkdeyqysfwdlfrsKDNMRTRIMIGLTLVFFVQVTGQ 298
Cdd:COG0738  179 LLF------------------LRSKLPEIEEEEEEAAGSAASL--------------KSLLKNPRLLLGGLAIFLYVGAE 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 299 PNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLcVGSSVMAASLMTMGIV 368
Cdd:COG0738  227 GAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RLSALLAAVGLLLALL 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 52-362 1.90e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 77.97  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  52 AVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILS 131
Cdd:cd17324    5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 132 LSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILF-----AYISNYAfanvshGWKYMFGL 206
Cdd:cd17324   85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLgrplgGLLGQLL------GWRAAFLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 207 VIPLGVLQAIAMYFLPPSprflvMKGHEEAASKVLRrlraisdtteeltgiksslkdeyqySFWDLFRSKdNMRTRIMIG 286
Cdd:cd17324  159 IAVLALLAALLLWRLLPS-----LPPKKPGSLGLLS-------------------------SLLLLLRNP-RLRLAYLIT 207

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 752413651 287 LtLVFFVQVTgqpniLF-YASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASL 362
Cdd:cd17324  208 F-LLFGGFFA-----LYtYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 63-369 3.00e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 74.53  E-value: 3.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  63 GLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRI 142
Cdd:cd17474   16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 143 AVGVSIS-LSSIATCVyIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVShgWKYMFGLVIPLGVLQAIAMYFL 221
Cdd:cd17474   96 LQGIGAAgLGPLALTL-IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS--WRYPFFLLAALIPVAFLAILFL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 222 PPSPrflvmkgHEEAASKvlrrlraisdtteeltgiksslkdeYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQVTGqpnI 301
Cdd:cd17474  173 LPEP-------KEKAKSS-------------------------SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA---F 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 302 LFYASTVLKSVGFQSNEAASLASTGVGV-VKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVN 369
Cdd:cd17474  218 LTYLPFLLELLYGISPIIIGLLFAGWSVlLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP 286
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 86-225 1.16e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 72.63  E-value: 1.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQ 165
Cdd:cd17489   36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752413651 166 HRRGLLVSLNELMIVIG-ILFAYISNYAFANVSHGWKYMFGLVIPLGVLqaIAMYFLPPSP 225
Cdd:cd17489  116 SRRGEGIGYYGLATTLAmALGPALGLFLYQHLGFAVLFIVAAVLALLAL--LLVFLVKDPP 174
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 78-222 2.96e-12

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 67.99  E-value: 2.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  78 LTCQEQ---EMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIA 154
Cdd:cd17317   19 LVCDRDwlvALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTV 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 752413651 155 TCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHgwkYMFGLVIPlGVLQAIAMYFLP 222
Cdd:cd17317   99 GFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRW---LQLAISLP-GLLFLLLLWWLP 162
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 51-228 6.76e-12

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 67.33  E-value: 6.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  51 AAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL 130
Cdd:cd17371    4 AFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 131 SLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNY---AFANVSHGWKYMFGL- 206
Cdd:cd17371   84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAllfPLLPPEIAWRVLFLLg 163

                        170       180
                 ....*....|....*....|..
gi 752413651 207 VIPLGVLQAIAMyFLPPSPRFL 228
Cdd:cd17371  164 ALPALLVLFIRR-FVKEPPQWQ 184
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 92-365 7.39e-12

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 67.32  E-value: 7.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLAsltgGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYA--------VLIVGRIAVGVSISLSSIATCVYIAEIA 163
Cdd:cd17367   55 IGGWLF----GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 164 PQHRRGLLVSLNELMIVIGILFAYISNYAFANV-------SHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEA 236
Cdd:cd17367  131 PPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTlgedqmaAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEA 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 237 ASKVLRRLRaisdtteeltgiksslkdeyqysfwdlfrskdnmrtRIMIGLTLVFFVQVTGQpnILFYASTV------LK 310
Cdd:cd17367  211 SAGTLRELR------------------------------------RHPRELLLVVGLTAGGT--LAFYTWTTylqkflVN 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 752413651 311 SVGFqSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLcVGSSVMAASLMTM 365
Cdd:cd17367  253 TAGF-SKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLL-LFFGIGGTLATVP 305
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 89-374 1.42e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 66.43  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  89 SLLIGALLasLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRR 168
Cdd:cd17321   41 LLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 169 GLLVSLNELMIVIGILFAYISNYAFANVsHGWKYMFGLVIPLGVLqAIAMyflppSPRFlvmkgheeaaskvlrrlrais 248
Cdd:cd17321  119 GRALGLWGAVVGIGAALGPLLGGLLLEL-FGWRWIFLINVPIGLV-ALLL-----ARTF--------------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 249 dtteeltgiksslkdeyqysfwdlfrskdnmrTRIMIGLTLVFFVQVTgqpnILFYASTVLKSVGFQSNEAASLASTGVG 328
Cdd:cd17321  171 --------------------------------SGAVLAAFLLGAALGG----LLFLLPLYLQGVLGYSPLQAGLALLPLA 214

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 752413651 329 VVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVNLNTPM 374
Cdd:cd17321  215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSV 260
2_A_01_02 TIGR00880
Multidrug resistance protein;
85-223 1.83e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 61.90  E-value: 1.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651  165 QHRRGLLVSLNELMIVIGILFAYISNyAFANVSHGWKYMFGLVIPLGVLQAIAMYFLPP 223
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLG-GVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
90-374 2.24e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 66.08  E-value: 2.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  90 LLIGALLASLT---GGVLID----RYGRRTAIILSSCLLGLGSLVLI-------LSLSYAVLIVGRIAVGVSISLSSIAT 155
Cdd:COG2211   52 LLVARLWDAITdplIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLftapdlsPTGKLIYALVTYLLLGLAYTLVNIPY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 156 CVYIAEIAP-QHRRGLLVSLNELMIVIGILFAY-----ISNYAFANVSHGWKYMFGLViplGVLQAIAMYFLppsprFLV 229
Cdd:COG2211  132 SALGAELTPdYEERTRLSSWRFAFAGLGGLLASvlpppLVAAFGGDAALGYRLTALIF---AVLGLLAFLLT-----FFG 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 230 MKGHEEAASKvlrrlraisdtteeltgiKSSLKDeyqySFWDLFRSKDNMrtRIMIGLTLVFFVQVTGQPNILFYASTVL 309
Cdd:COG2211  204 TKERPVPEEE------------------KVSLKE----SLKALLKNRPFL--LLLLAYLLFFLALALVAALLLYYFKYVL 259

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752413651 310 KsvgfQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVNLNTPM 374
Cdd:COG2211  260 G----LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW 320
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-226 2.75e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.28  E-value: 2.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRR--TAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEI 162
Cdd:COG2271  220 LLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752413651 163 APQHRRGLLVSL-NELMIVIGILFAYISNYAFAnvSHGWKYMFGLVIPLGVLQAIAMYFLPPSPR 226
Cdd:COG2271  300 FPKKARGTASGLvNTFGFLGGALGPLLVGYLLD--ATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 68-226 1.80e-10

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 62.98  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  68 ALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVS 147
Cdd:cd17320   21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 148 ISLSSIATCVYIAEIAPQHRRGLLVSLneLMIVIGILFA-------YISNYAfanvshGWKYMFGLVIPLGVLQAIAMYF 220
Cdd:cd17320  101 AAAGSVVARAIVRDLYSGAELAKIFSL--LMMILAIAPAlapllggLLLLFF------GWRAIFVFLALLGLLLLLLVLL 172


                 ....*.
gi 752413651 221 LPPSPR 226
Cdd:cd17320  173 FLPETL 178
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 52-217 1.95e-10

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 62.60  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  52 AVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILS 131
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 132 LSYAVLIVGRIAVGVSISLSSIATCVyIAEIAPQHRRGLLVSLNELMIVIG-----ILFAYISNYAfanvshGWKYMFGL 206
Cdd:cd17504   82 PNLPVLIAGRALQGIGGAVFPLAFAL-VREEFPPERVPVAQGILSATFGIGagiglPLGGWIVQHL------GWRWIFWT 154

                        170
                 ....*....|.
gi 752413651 207 VIPLGVLQAIA 217
Cdd:cd17504  155 AAPVAVLLAAL 165
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
22-360 3.33e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 62.20  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  22 TEGSGAASGSRHPPWARGCGMFTLLSSVTAAVSGLlvgyelglisGALL-QIRTLLALTCQEQEMVVSSLLIGALLASLT 100
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSV----------GPLLpEIRADLGLSATQAGLLTTLPLLAFGLFAPL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 101 GGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPqHRRGLLVSLNELMIV 180
Cdd:COG2807   73 APRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 181 IG-ILFAYISnyAFANVSHGWKYMFGLvipLGVLQAIAMYFLPPsprflvmkgheeaaskVLRRLRAISDTTEELTGIKS 259
Cdd:COG2807  152 LGaALAAGLT--VPLAAALGWRGALAV---WALLALLALLLWLP----------------LLRRRPAAAAAAPAAASLRS 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 260 SLkdeyqysfwdlfrskdnmRTRIMIGLTLVFFVQvtgqpNILFYAS-----TVLKSVGFQSNEAASLASTgVGVVKVIS 334
Cdd:COG2807  211 LW------------------RSPLAWLLTLFFGLQ-----SLLYYAVvawlpPILRDAGLSAATAGLLLSL-FQLAGIPG 266

                        330       340
                 ....*....|....*....|....*.
gi 752413651 335 TIPATLLVDHVGSKTFLCVGSSVMAA 360
Cdd:COG2807  267 SLLVPLLADRLGDRRPLLLLLGLLGL 292
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-183 4.14e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.53  E-value: 4.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         90
                 ....*....|....*....
gi 752413651 165 QHRRGLLVSLNELMIVIGI 183
Cdd:COG2814  327 PEARGRASGLYNSAFFLGG 345
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 85-369 1.11e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 60.32  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL-----SLSYAVLIVGRIAVGVSISLSSIATCVYI 159
Cdd:cd06173   38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPARQALL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 160 AEIAPQHRRGLLVSLNELMIVIGILFAY-ISNYAFANVSHGWkyMFGLVIPLGVLQAIAMYFLPPsprflvmkghEEAAS 238
Cdd:cd06173  118 PELVPKEQLVRANALNSLATQLARIIGPaLGGLLVALLGPGG--AFAINALSFLLSALLLLFIRR----------PPPAA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 239 KVLRRLRAISDTTEELTGIKSSlkdeyqysfwdlfrskdNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSvgfqSNE 318
Cdd:cd06173  186 PGESSSLLLRDLREGLRYLRRS-----------------PLLRLLLLALALFALLGGALTVLLPLLAKEVLGG----GAA 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 752413651 319 AASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVN 369
Cdd:cd06173  245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP 295
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 90-244 1.12e-09

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 60.75  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  90 LLIGALLasltGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSS---IATCvyiAEIAPQH 166
Cdd:PRK11551  63 LLPGALL----GGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALpnlIALT---SEAVGPR 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 167 RRGLLVSL--------NELMIVIGILFAYISnyafanvshGWKYMF--GLVIPLgVLQAIAMYFLPPSPRFLVMKGHEEA 236
Cdd:PRK11551 136 LRGTAVSLmycgvpfgGALASVIGVLAAGDA---------AWRHIFyvGGVGPL-LLVPLLMRWLPESRAFAQAAGAGKQ 205


                 ....*...
gi 752413651 237 ASKVLRRL 244
Cdd:PRK11551 206 RAPVLRAL 213
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 56-204 1.52e-09

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 60.48  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  56 LLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYA 135
Cdd:PRK03893  30 LLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYW 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752413651 136 VLIVGRIAVGVSISLSSIATCVYIAEIAPQHRR----GLLVSlnelMIVIGILFAyISNYAFANVSHGWKYMF 204
Cdd:PRK03893 110 TLFIARLVIGMGMAGEYGSSATYVIESWPKHLRnkasGFLIS----GFSIGAVVA-AQVYSLVVPVWGWRALF 177
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 65-230 1.53e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.89  E-value: 1.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  65 ISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAV 144
Cdd:cd17319   22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 145 GVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIG-ILFAYISnyAFANVSHGWKYMFGLVIPLGVLQAIAMYFLpp 223
Cdd:cd17319  102 GVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGaAIGPPLS--GWLLLLFGWRWAFIIEGLLGLLLAVLWWFY-- 177


                 ....*..
gi 752413651 224 SPRFLVM 230
Cdd:cd17319  178 LRQVWGL 184
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 77-228 1.55e-09

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 59.83  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  77 ALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATC 156
Cdd:cd17441   30 RLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVT 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752413651 157 VYiAEIAPQHRRGLLVSLNELMIVIGILFAYISNYaFANVSHGWKYMFGL-VIPLGVLqAIAMYFLPPSPRFL 228
Cdd:cd17441  110 LY-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAV-FVMPTLGWRWLLILsALPLLIF-AVLCFWLPESARYW 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 85-221 2.06e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.51  E-value: 2.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 752413651 165 QHRRGLLVSLNELMIVIG-----ILFAYISNYAfanvshGWKYMFGLVIPLGVLQAIAMYFL 221
Cdd:cd17325  319 PEGRGTAMGLFNTAFSLGmvlgpLLGGFLYDAF------GFATPFLAAAALLLLAAVLFLLL 374
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 43-369 5.31e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 58.35  E-value: 5.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  43 FTLLSSVTAAV-SGLLVGYELGLISGALLQIRTLLAltcqeqEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLL 121
Cdd:cd17473    2 ITLLLASTLTVmAGAAIAPALPAIAQHFVPNSELLV------PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLY 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 122 GLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRR----GLLVSLNELMiviGILFAYISNYAfanVS 197
Cdd:cd17473   76 GIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERakmlGLQSAAMSLG---GVVFLLLGGAL---AE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 198 HGWKYMF---GLVIPLGVLqaiAMYFLPPSPRFLVMKGHEEAASKVLRRLRAIsdtteeltgiksslkdeyqysFWDLFr 274
Cdd:cd17473  150 IGWRAPFlvyLLALPVLIL---VLLFLPEPARKSKSAASPGAATAAALPWKRV---------------------LPIYF- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 275 skdnmrtrIMIGLTLVFFVQVTgqpnilfYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVG 354
Cdd:cd17473  205 --------LAFLAMLLFYVIPI-------QLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269

                        330
                 ....*....|....*
gi 752413651 355 SSVMAASLMTMGIVN 369
Cdd:cd17473  270 FALMALGFLLLALAS 284
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 92-353 1.59e-08

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 57.00  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLAsltgGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYA--------VLIVGRIAVGVSISLSSIATCVYIAEIA 163
Cdd:cd17368   55 IGAIVL----GAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 164 PQHRRGLLVSLN----ELMIVIGILFAYISNYAF---ANVSHGWK--YMFGLVI-PLGVlqaiamyflppsprflvmkgh 233
Cdd:cd17368  131 PPGRRGFYTSWQsasqQVAIVAGALVGYLLSLTLtaeALAEWGWRipFFIGLLIiPLGL--------------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 234 eeaaskVLRrlRAISDTTEELTGIKSSLKDEyqysfwdLFRSKDNMRTRIMIGLTLVFFVQVTgQPNILFYASTVLKSVG 313
Cdd:cd17368  190 ------WLR--RSLEETEAFLERKARPTRRE-------LFALLANNRRIILLGMLLVAGSTVT-FYFTTVYTPTYAKTVL 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 752413651 314 FQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCV 353
Cdd:cd17368  254 GLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLV 293
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 64-240 1.93e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 56.86  E-value: 1.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  64 LISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRtaIILSSCLLGLGSLVLILSLS--YAVLIVGR 141
Cdd:cd17328   17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRK--WILAVGILIWSAATLLSSFApnFWQLLLFR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 142 IAVGV-SISLSSIATcVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFGLVIPLGVLQAIAMYF 220
Cdd:cd17328   95 ALVGIgEASYSPIAP-TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLL 173

                        170       180
                 ....*....|....*....|
gi 752413651 221 LPPSPRFLVMKGHEEAASKV 240
Cdd:cd17328  174 FVREPPRGAAEGGVMAKSTA 193
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 59-256 2.11e-08

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 57.29  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   59 GYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLI 138
Cdd:TIGR01299 180 GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  139 VGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAyiSNYAFANVSH-GWKYMFG------------ 205
Cdd:TIGR01299 260 FCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYA--AAMAWAIIPHyGWSFQMGsayqfhswrvfv 337

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 752413651  206 LVIPLGVLQAI-AMYFLPPSPRFLVMKGHEEAASKVLRRlraISDTTEELTG 256
Cdd:TIGR01299 338 IVCAFPCVFAIgALTFMPESPRFFLENGKHDEAWMILKL---IHDTNMRAKG 386
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 60-194 2.16e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 56.40  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  60 YELGLISGALLQIRTllaltcqeQEMVVSSLLIGAL---------LASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL 130
Cdd:cd17370  212 FALGNFSFAFLILRA--------QELGLSAALIPLLyalfnlvyaLAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 752413651 131 SLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRG-------LLVSLNELM--IVIGILFAYIS-NYAFA 194
Cdd:cd17370  284 GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGtayglfnTVVGIGWLLasLIAGYLWDLISpSAAFL 357
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 92-218 2.24e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.40  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHrRGLL 171
Cdd:cd17324  245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLA 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 752413651 172 VSLNELMIVIGI-LFAYISNYAFANVshGWKYMFGLVIPLGVLQAIAM 218
Cdd:cd17324  324 SSLYLAAYNLGGaLGAALGGLVLDHG--GWAGVGWVGAALLLLALLLA 369
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 86-359 3.17e-08

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 56.10  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRtaIILSSCLLGLGsLVLILSL---SYAVLIVGRIAVGVSISlSSIATCVYI--- 159
Cdd:cd17327   46 GNTVFYVGYIIFELPGNLLLQRFPPS--KWLSVFIVLWG-LLTLLTAavkNFGGLIALRFFLGLFES-GVFPGFILYlgm 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 160 ----AEIAPqhRRGLLVSLNELMIVIGILFAY-ISNYAFANVSHGWKYMF---GLV-IPLGVlqaIAMYFLPPSP---RF 227
Cdd:cd17327  122 wykrEEQAK--RIAFFYAAAGLGSIFGGLLAYgVFKILGVGGLAGWRWLFiieGLItIIIGL---VIFFWLPDNPskaWF 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 228 LVMKGHEEAASKVLRRLRAISDTTEELTGIKSSLKDEyqysfwdlfrskdnmrtrIMIGLTLVFFVQVTGQPNILFYAST 307
Cdd:cd17327  197 LTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDP------------------RTWLLFLFFFCSQITNNGISNFLPL 258

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 752413651 308 VLKSVGFQSNEaASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMA 359
Cdd:cd17327  259 ILKSLGFYSLQ-TNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLA 309
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 48-222 3.76e-08

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 55.62  E-value: 3.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  48 SVTAAVSGLLVGYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLV 127
Cdd:cd17372    1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 128 LILSLSYAVLIVGRIAVGVSISLSSIATCVYiAEIAPQHRRGLLVSLNELMIVIGILFAyISNYAFANVSHGWKYMFGLV 207
Cdd:cd17372   81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWY-LEFLPAKSRGTWMVLFSVFWTVGTIFE-ASLAWLVMPRLGWRWLLAFS 158

                        170
                 ....*....|....*
gi 752413651 208 IPLGVLQAIAMYFLP 222
Cdd:cd17372  159 SVPSSLLLVFYRWTP 173
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 85-183 4.38e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 55.26  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:cd17477   35 LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114

                         90
                 ....*....|....*....
gi 752413651 165 QHRRGLLVSLNELMIVIGI 183
Cdd:cd17477  115 NENRGRVLGLYSTVLGLGF 133
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 85-219 6.91e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.74  E-value: 6.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLL-GLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIA 163
Cdd:cd06174  243 LLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLmALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651 164 PQHRRGLLVSLNELMIVIGILFAYISNYAFANVSHGWKYMFGLVIPLGVLQAIAMY 219
Cdd:cd06174  323 PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 86-210 1.03e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 54.13  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSI--SLSSIATCVyiAEIA 163
Cdd:cd17365   39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLgaAMPNAITLV--SEYA 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 752413651 164 PQHRRGLLVSLNELMIVIG-ILFAYISnyAFANVSHGWKYMF--GLVIPL 210
Cdd:cd17365  117 PARRRSLAVTLMFCGYPLGaALGGFLA--AALIPAFGWRSVFllGGVPPL 164
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 69-376 1.06e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 54.25  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  69 LLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSI 148
Cdd:cd17333   19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 149 SLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANV-SHGWKYMFGLVIPLGVLQAIAMYFLPPSPRf 227
Cdd:cd17333   99 GILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLLLAILILLTLFPELPS- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 228 lvmkgheeaaskvlrrlraisdtteelTGIKSSLKDEYQYSFWDLFRSkdnmrtRIMIGLTLVFFVQVTGQPNILFYAST 307
Cdd:cd17333  178 ---------------------------ARNPQQSVGAFSASASRLLRN------PSIILGALALFLYVGAETAFSSWVPS 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 308 VLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLcVGSSVMAASLMTMGIVNLNTPMNF 376
Cdd:cd17333  225 YLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLL-VLSGSGALLGLLILLLAPTLVVGL 292
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 86-244 1.11e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 54.55  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVyIAEIAPQ 165
Cdd:cd06179   37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 166 HRRGLLVSLNELMIVIGILFA-YISNYAFANVSHGWKYMFGLVIPLGVLQAIAMYFL--PPSPRFLvmkgHEEAASKVLR 242
Cdd:cd06179  116 KYRGLVQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFyhPPPRPQL----HGSSTRQKLK 191


                 ..
gi 752413651 243 RL 244
Cdd:cd06179  192 RL 193
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 59-244 1.27e-07

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 54.42  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  59 GYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLI 138
Cdd:cd17363   12 GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 139 VGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAyiSNYAFANVSH-GWKYMFG------------ 205
Cdd:cd17363   92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYA--SAMAWAIIPHyGWGFSMGtayqfhswrvfv 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPL-GVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRL 244
Cdd:cd17363  170 IVCALpSVASVVALTFMPESPRFLLEVGKHDEAWMILKQV 209
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-226 1.74e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.73  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSL-SYAVLIVGRIAVGVSISLSSIATCVYIAEIA 163
Cdd:COG2223  245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651 164 PQHRRGLLVSlneLMIVIGILFAYISNYAFA---NVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPR 226
Cdd:COG2223  325 PTKNAGAVYG---LVGAAGGLGGFLGPLLFGallDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 92-188 2.14e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 53.39  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLL 171
Cdd:cd06173  255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334

                         90
                 ....*....|....*..
gi 752413651 172 VSLNELMIVIGILFAYI 188
Cdd:cd06173  335 FSVYNALNSGAMPLGAL 351
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 86-369 2.57e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.00  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQ 165
Cdd:cd17329   40 VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 166 HRRGLLVSLNELMIVIGILF-AYISNYaFANVSHGWKYMFGLVIPLGVLqAIAMYFLPPSprflvmkgheeaaskvlRRL 244
Cdd:cd17329  120 ENRTRAFSLLYWAINLGVAIgPLLGGL-LLLYSFRLLFLAAAVLFLLAA-LVLLFLLPET-----------------RPK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 245 RAISDTTEELTGIKSSLKDeyqYSFWDLFrskdnmrtrIMIGLTLVFFVQVTgqpnilFYASTVLKSVGFQSNEAASLAS 324
Cdd:cd17329  181 RRAAEKTEILRGYKIVLRD---RAFLLFL---------LASFLISLIYFQLE------STLPVYVVEILGLGESLLGLLL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 752413651 325 TGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVN 369
Cdd:cd17329  243 ALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN 287
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 76-256 2.85e-07

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 53.39  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  76 LALTCQEQEMVVSS---------LLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGV 146
Cdd:cd17438   20 FVLPSAEKDMCLSSsnkgmlgliVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGF 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 147 SISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAyiSNYAFANVSH-GWKYMFGL--------------VIPLg 211
Cdd:cd17438  100 GIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYA--SAMAWSIIPHyGWGFSMGTnyhfhswrvfviicALPC- 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 752413651 212 VLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRlraISDTTEELTG 256
Cdd:cd17438  177 IASIIALKFMPESPRFLLEMGKHDEAWMILKN---IHDTNMRAKG 218
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 88-316 6.92e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 51.84  E-value: 6.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  88 SSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHR 167
Cdd:cd17440   41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 168 RGLLVSLNELMIVIGILFAyiSNYAFANVSH-GWKYMFG------------LVIPLGVLQA-IAMYFLPPSPRFLVMKGH 233
Cdd:cd17440  121 RGEHLSWLCMFWMIGGIYA--SAMAWAIIPHyGWSFSMGsayqfhswrvfvIVCALPCVSSvVALTFMPESPRFLLEVGK 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 234 EEAASKVLRRlraISDTTEELTGiksslKDEYQYSFwdlfrskDNMRTRIMIGLTLVFFVQVTGQPNILFYASTVLKSVG 313
Cdd:cd17440  199 HDEAWMILKQ---IHDTNMRARG-----QPEKVFTV-------NRIKKDNTIKLTIVWLTLSFGYYGLSVWFPDVIKHLQ 263


                 ...
gi 752413651 314 FQS 316
Cdd:cd17440  264 FKS 266
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 87-223 1.65e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 50.65  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  87 VSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISlSSIATCV-YIAEIAPQ 165
Cdd:cd17323   40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGS-SPLAIGAgTIADLFTP 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 752413651 166 HRRGLLVSLNELMIVIGILFAYISNyAFANVSHGWKYMFGLVIPLGVLQAIAMYFLPP 223
Cdd:cd17323  119 EERGKAMGVYSLGPLLGPALGPIIG-GFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 92-222 1.73e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLL 171
Cdd:cd17473  244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRA 323

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 752413651 172 VSLNELMIVIGILFAYISNYAFANVSHGWKYMFGLVIPLGVLQAIAMYFLP 222
Cdd:cd17473  324 MGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 85-221 1.93e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:cd17474  239 LFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAP 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 752413651 165 QHRRGLLVSLNELMIVIG-----ILFAYISNYafanvsHGWKYMFGLVIPLGVLQAIAMYFL 221
Cdd:cd17474  319 EEERGTASSLYNFVRFLGqavgpLLFGLLLEI------FGLSAPFLVGAAIALAAAVLLALL 374
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 83-367 2.22e-06

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 50.50  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   83 QEMVVSSLLIGALLASLTGGVLIDRYGRR-----TAIILSSCLLGLGSLVLILSLSY-AVLIVGRIAVGVSIS----LSS 152
Cdd:TIGR00887  58 SAAVNGSASIGTLAGQLFFGWLADKLGRKrvygmELIIMIIATVASGLSPGSSPKSVmATLCFWRFWLGVGIGgdypLSA 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  153 IATcvyiAEIAPQHRRGLLVSLNELMIVIGILFAYI----------SNYAFANVSHGWK--------YMFGLVIPLG-VL 213
Cdd:TIGR00887 138 IIT----SEFATKKWRGAMMAAVFAMQGFGILAGAIvalivlagfkHSLEAAADEASCTgscvpavdYMWRILIGFGaVP 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  214 QAIAMYF---LPPSPR--FLVMKGHEEAASKVLRRLR-AISDTTEELTGIKSSlKDEYQYSFWDLFRSKDNMRT-RIMIG 286
Cdd:TIGR00887 214 ALLALYFrltIPETPRytADVAKDVEQAASDMSAVLQvKIEAEPDEVEKASTA-VEVPKASWSDFFTHFFKWRHgKHLLG 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  287 LTLVFFVQvtgqpNILFYA-----STVLKSVGF-----QSNEAASLASTGVG--VVKVISTIPA----TLLVDHVGSKTF 350
Cdd:TIGR00887 293 TAGSWFLL-----DIAFYGvnlnqKVILSAIGYsppaaTNNAYEELYKTAVGnlIIALAGTVPGywvtVFLVDIIGRKPI 367

                         330
                  ....*....|....*..
gi 752413651  351 LCVGSSVMAASLMTMGI 367
Cdd:TIGR00887 368 QLMGFFILTVLFFVLGF 384
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 72-182 3.87e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  72 IRTLLALTCQEQ---EMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSI 148
Cdd:cd17374   23 IVTEWDLVCESQslkSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102

                         90       100       110
                 ....*....|....*....|....*....|....
gi 752413651 149 SLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIG 182
Cdd:cd17374  103 SGISINTLILGTEWTTPRHRALAITLTSCFFSIG 136
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 72-247 4.68e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.16  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  72 IRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLS 151
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 152 SIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFAnVSHGWKYMF---GLVIPLGVLQAIAMYFLPPSPrfl 228
Cdd:cd17475  102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA-LHYGWRAAFvvaGLVSILAAVLFWLFYREPPAA--- 177

                        170
                 ....*....|....*....
gi 752413651 229 vmKGHEEAASKVLRRLRAI 247
Cdd:cd17475  178 --SAATESASTLLRSLKEV 194
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
32-243 7.06e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 7.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  32 RHPPWARGCGMFTLLSSVTAAVSGLL---VGYELGLISGALlqirTLLALTcqeqemvvssLLIGALLASLTGGVLIDRY 108
Cdd:COG2211  226 KNRPFLLLLLAYLLFFLALALVAALLlyyFKYVLGLSAALV----GLLLAL----------YFLAALLGAPLWPRLAKRF 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 109 GRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVY--IAEIAP-------QHRRGLLVSLNELMI 179
Cdd:COG2211  292 GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWamLADVVDydewktgRRREGLYFGIFTFAI 371

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 752413651 180 VIGILFA------------YISNYAF-ANVSHGWKYMFGLV-IPLGVLQAIAMYFLPpsprfLVMKGHEEAASKVLRR 243
Cdd:COG2211  372 KLGQALAgalaglllalfgYVAGAAQsPSALTGIRLLFFLLpAVLLLLAALLLLFYP-----LTRERHAEIRAELAAR 444
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 82-224 7.60e-06

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 48.32  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  82 EQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLV--LILSLSYAVLIVGRIAVGV--SISLSSIATcv 157
Cdd:cd17380   35 DQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILSRILLGLgeGVHFPSMTS-- 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 752413651 158 YIAEIAPQHRRGLLVSLneLM-------IVIGILFAYISNYafanvsHGWKYMFGLVIPLGVLQAIAMYFLPPS 224
Cdd:cd17380  113 LFSRWVPVSERSRAVSI--VTagsylgtLLGGLIGPLLLEY------YGWPSVFYFFGLLGLLWALVWLIYLPP 178
PRK15075 PRK15075
tricarballylate/proton symporter TcuC;
102-173 7.73e-06

tricarballylate/proton symporter TcuC;


Pssm-ID: 237902 [Multi-domain]  Cd Length: 434  Bit Score: 48.40  E-value: 7.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 102 GVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYA---------VLIvGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLV 172
Cdd:PRK15075  77 GAYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYAtiglaapllVLL-GRLLQGFSAGVELGGVSVYLAEIATPGRKGFYT 155


                 .
gi 752413651 173 S 173
Cdd:PRK15075 156 S 156
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 86-222 7.79e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 48.33  E-value: 7.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGR----IAVGVSISLSSIAtcvyIAE 161
Cdd:cd17502   35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRaiqgIGGGGLMSLAFII----IAD 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752413651 162 IAPQHRRGLLVSLNELMIVIGILFAYISNYAFANvSHGWKYMFGLVIPLGvlqAIAMYFLP 222
Cdd:cd17502  111 LVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD-HLSWRWCFYINLPIG---GLALALLR 167
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 59-244 8.13e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 48.49  E-value: 8.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  59 GYELGLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLI 138
Cdd:cd17439   12 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 139 VGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAyiSNYAFANVSH-GWKYMFG------------ 205
Cdd:cd17439   92 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYA--SAMAWAIIPHyGWSFQMGsayqfhswrvfv 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 752413651 206 LVIPLGVLQAI-AMYFLPPSPRFLVMKGHEEAASKVLRRL 244
Cdd:cd17439  170 LVCAFPSVFAIgALTTMPESPRFFLENGKHDEAWMVLKQV 209
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 90-376 9.14e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.96  E-value: 9.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  90 LLIGALLASLTGgVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRI----AVGVSISLSSiatcVYIAEIAPQ 165
Cdd:cd17503   41 LLALAIMIPLSG-WLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRIlqgfGGGVLIPLAQ----TILLRIYPP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 166 HRRGLLVSLNELMIVIG-----ILFAYISNYAfanvshGWKYMFGLVIPLGVLQAIAMYFLppsprflvmkgheeaaskv 240
Cdd:cd17503  116 EKRGAAMGLVGLVILLApaigpTLGGWLTDNL------SWRWIFYINLPIGILALLLAPLL------------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 241 lrRLRaisdtteeltgiksslkdeyqysfwdLFRSKdNMRtrimIGLTLVFFVQvtgqpnILFYASTVLKSVGFQ----- 315
Cdd:cd17503  171 --DLR--------------------------LFKDR-NFT----LGLLLSFLLG------LGLFGAMFLLPLYLQnvlgy 211

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752413651 316 SNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLMTMGIVNLNTPMNF 376
Cdd:cd17503  212 SAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWL 272
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 87-222 2.13e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.18  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  87 VSSLLIGA--LLASLTGGVLIDRYGRRTAIILSSCLLGLGSlvLILSLSYAVLIVGRIAVGVSIsLSSIATCVYI----- 159
Cdd:cd17358  278 TATIIIGVvqVVGTLVATLLVDRLGRRPLLLVSAIGMGIGL--LALGLYFYLQEHGALLSSVSW-LPLVGLVIYIisfsi 354

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 752413651 160 ----------AEIAPQHRRGLLVSlneLMIVIGILFAYISNYAFANVSHGWK-----YMFGLVIPLGVLqaIAMYFLP 222
Cdd:cd17358  355 glgplpwvimSEIFPAKIKGLAGS---LVTLVNWLFAFIVTKTFPFLTLAWGasgtfWIFAGICGLALV--FVLLFVP 427
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 85-213 2.32e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 46.89  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLS------YAVLIVGRIAVGVSIS----LSSIA 154
Cdd:cd17364   43 LVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGgdypLSATI 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 752413651 155 TcvyiAEIAPQHRRGLLVSLNELMIVIGILFA----YISNYAFAN---------VSHGWK--YMFGLVIPLGVL 213
Cdd:cd17364  123 M----SEYANKKRRGALIAAVFAMQGFGILAGaivtLILSAIFEHplpagtyhhADLVWRivLGLGAIPALSVL 192
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 92-221 2.34e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.82  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRG-- 169
Cdd:cd17489  238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGaa 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 752413651 170 ---LLVSLNELMIVIGILFAYISNYAfanvshGWKYMFGLVIPLGVLQAIAMYFL 221
Cdd:cd17489  318 ngtFFIFFDLGIGLGGLLLGLVAELF------GYRAMFLLAAVVVLLALVLYIFL 366
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 85-167 3.00e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.40  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTaIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAP 164
Cdd:cd17478  234 LLLSLFLFAGAIGTLIGGPLSDRFGRRR-VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP 312


                 ...
gi 752413651 165 QHR 167
Cdd:cd17478  313 GNV 315
MFS_MFSD5_like cd17487
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ...
 84-150 3.02e-05

Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341040  Cd Length: 385  Bit Score: 46.44  E-value: 3.02e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752413651  84 EMVVSSLLIGALLASLTGGVLI----DRYGRRTAIILSsCLLGLGSLVLILSLSYAVLIVGRIAVGVSISL 150
Cdd:cd17487   37 EEQIAILFVTGFGSSVVFGTFVgslaDKFGRKRACLLF-CVLYSLSCLTKHSPNFGVLLLGRVLGGISTSL 106
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 85-220 3.83e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.06  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVL--ILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEI 162
Cdd:cd17316  217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 163 APQHRRGLLVSL-NELMIVIGILFAYISnyAFANVSHGWKYMFGLVIPLGVLQAIAMYF 220
Cdd:cd17316  297 FPTEVRATGVGLsYNLGRLGGGGAPPLI--ALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_1 pfam07690
Major Facilitator Superfamily;
85-186 5.61e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 5.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL---SLSYAVLIVGRIAVGVSISLSSIATCVYIAE 161
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                          90       100
                  ....*....|....*....|....*
gi 752413651  162 IAPQHRRGLLVSLNELMIVIGILFA 186
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALG 343
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 86-230 5.67e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 5.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATcVYIAEIAPQ 165
Cdd:cd17330   39 LQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ-AYIADITDE 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 166 HRR----GLLVSLNELMIVIGILFAyisnyAFANVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVM 230
Cdd:cd17330  118 EERakafGIISAAFGLGFILGPALG-----GFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLL 181
PRK10406 PRK10406
alpha-ketoglutarate transporter; Provisional
 102-219 6.12e-05

alpha-ketoglutarate transporter; Provisional


Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 45.57  E-value: 6.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 102 GVLIDRYGRRTAIILSSCLLGLGSLVL--------ILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVS 173
Cdd:PRK10406  84 GRIADKHGRKKSMLISVCMMCFGSLVIaclpgyetIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYAS 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 752413651 174 LNELMIVIGILFAYISNYAFANV-------SHGWKYMFGLViplGVLQAIAMY 219
Cdd:PRK10406 164 FQYVTLIGGQLLALLVVVVLQQTledaelrEWGWRIPFALG---AVLAVVALW 213
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 85-221 6.79e-05

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 45.35  E-value: 6.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGvLIDRYGRRTAIILSSCLLGLGSLVLILS------LSYAVLIVGRIAVGVSISLSSI-ATCV 157
Cdd:cd17386   35 MNLMGSIPPLFSSLFLGS-WSDRYGRKPPLLMSLVGLLLSSLILVLIvyfttvPSVWWFYLSAIPLALFGGFTAFlSASF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651 158 -YIAEIAPQHRRGLLVSLNELMIVIGILFAY-ISNYAFANVSHGWkyMFGLViplGVLQAIAMYFL 221
Cdd:cd17386  114 aYISDISSEKKRTYRMAILEVALGLGGFLGSlLSGHLFKALGYAW--SFSIS---AALLLIALLYI 174
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 78-247 1.15e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 44.52  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  78 LTCQEQEMVVSSLLIGALLASlTG----------GVLIDRYGRRTAIILSSCLL-GLGSLVLILSLSYAVLIVGRIAVGV 146
Cdd:cd17490   19 LSPYAESLGASLSMIGIILGA-YGisqmllriplGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSGI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 147 SISLSSIATCVYIAEIAPQHRR---GLLVSLNELMIVIGILFAYISNYAFanvshGWKYMFGLVIPLGVLQAIAMYFLPP 223
Cdd:cd17490   98 AAATWVSFTVLYASYFPPDEAAkamGLINLVNNLGQLIAFLIGGLIAEHF-----GMRAPFLLAALAGVLGFILSLFIKE 172

                        170       180
                 ....*....|....*....|....
gi 752413651 224 SPRflvmkgHEEAASKVLRRLRAI 247
Cdd:cd17490  173 ERR------EKKPVLTELKELLSV 190
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 64-221 1.39e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 44.55  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  64 LISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVL-ILSLSYAVLIVGRI 142
Cdd:cd17341   17 LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALaLAVSSYWGLLVLGF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 143 AVGvsISLSSIATCV-YIAEIAPQHRRGLLVSLNELMIVIGILFAY------ISNYAFANVSHGWKYMFGLVIPLGVLQA 215
Cdd:cd17341   97 LLG--FAGANFASGQpWASFWFPKEKIGGAAGGIAGAGNMGVAVSQllapliAGAIVFDGGFVGWRNAFFVPGILLAIAA 174


                 ....*.
gi 752413651 216 IAMYFL 221
Cdd:cd17341  175 VLVLLF 180
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 68-221 1.44e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 44.30  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   68 ALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVS 147
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651  148 ISLSSIATCVYIAEIAPQHRrgllvsLNELMIVIGILFAYISNYA-----FANVSHGWKYMFgLVIPLGVLQAIAMYFL 221
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEE------LSRIYSILMPVLALAPAVApllggYILVWLSWHAIF-AFLSLAGILLSALIFF 178
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 86-221 1.55e-04

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 44.26  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVgrIAVGVSISLSSIATCVYIA--EIA 163
Cdd:cd17396   40 VISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYV--FALLAGAANSFLDTGTYPAlmEAF 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 164 PQHrRGLLVSLNELMIVIG--ILFAYISNYAFANVSHGWkymfGLVIPLGVLQAIAMYFL 221
Cdd:cd17396  118 PKA-SGSANILVKAFVSFGqfLLPFIIAFLAANNLWYGW----SFIVPAAVLVLNALLLL 172
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 102-223 2.40e-04

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 43.50  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 102 GVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYA--------VLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGLLVS 173
Cdd:cd17366   61 GPLGDKYGRQKVLAITIILMAASTFCIGLLPTYAtigvwapiLLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGS 140

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 752413651 174 LNELMIVIGILFAYISNYAFANV-------SHGWKYMFGLVIPLGVlqaIAMYFLPP 223
Cdd:cd17366  141 WLEFGTLAGFILGAGLVTLLTLLlteaqmlDWGWRIPFLIAAPLGL---VGLYLRRP 194
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 91-222 2.84e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 43.47  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651   91 LIGALLASLtggvLIDRYGRRTAIILSSCLLGLGSLVLIL------SLSYAVLIVGRIavgvSISLSSIATCVYIAEIAP 164
Cdd:TIGR00898 369 LPAKLITLL----LIDRLGRRYTMAASLLLAGVALLLLLFvpvdlyFLRTALAVLGKF----GITSAFQMVYLYTAELYP 440

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651  165 QHRRGLLVSLNELMIVIGILFAYISNYAfANVSHGWKY-MFGLvipLGVLQAIAMYFLP 222
Cdd:TIGR00898 441 TVVRNLGVGVCSTMARVGSIISPFLVYL-GEKWLFLPLvLFGG---LALLAGILTLFLP 495
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 41-181 3.24e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 43.32  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  41 GMFTLLSSVTAAVSGLLVGyelGLISGALLQIRTLLALTC--QEQEMV--VSSLLIGALLASLTGGVLIDRYGRRTAIIL 116
Cdd:cd17477  182 SLRRLLRIAPLALLGAFVA---GFLEGAFYSLLPLYGLRLglSVAQAAllLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 752413651 117 SSCLLGLGSLVLIL--SLSYAVLIVGRIAVGVSISLSSIAtcvyIAEIAPQHRRGLLVSLNELMIVI 181
Cdd:cd17477  259 CALLGALAALLLPLvpGLPLALLVLLFLWGGAAGPLYTLA----LALAGDRLPGDELVAANAALLLL 321
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 85-226 3.38e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 43.30  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSllIGALLASLTGGVLIDRYGRRTAIILSSCLLG-LGSLVLILSLSYAVLIVgriavgVSISLSSIATCV------ 157
Cdd:cd17471   38 MTLSA--LSGIVVSQWLGRLSDRGGDRKPLILLALLAGaLGYLLFAFLRNYWVLLL------VGVVLLSLGAAAfpqlfa 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651 158 YIAEIAPQHRRGLLVSLNELM-------IVIGILFAYISNYAFanvshGWKYMFGLVIPLGVLQAIAMYFLPPSPR 226
Cdd:cd17471  110 LAREYADRSSGRDATLFNSVLraafslaWVIGPPLAFLLLDVL-----GFTGLFLLAALLYLVVALLVLFLLPSVK 180
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 86-363 3.64e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.03  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGALLASLTG---GVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGR-IAVGVSISLSSIATCVYIAE 161
Cdd:cd17355   40 ISLAFTVGLLAFGLAQpfvGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 162 IAPQHRRGLLVSLNEL-MIVIGILFAYISnyAFANVSHGWK---YMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAA 237
Cdd:cd17355  120 WWFERRRGLALGILTAgGGLGSLVFLPLG--AALIEAFGWRtalLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPA 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 238 SKVLRRLRAISDTteeltgiksslkdeyqySFWDLFRskdnmrTRIMIGLTLVFFVQVTgqpnilfyaSTVLKSVGFQSN 317
Cdd:cd17355  198 SPGSTLKEALRSA-----------------SFWLLAL------AFFLCGFAVVGLIVHL---------VPYLADRGISPA 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 752413651 318 EAASLASTgVGVVKVISTIPATLLVDHVGSKTFLCVGSSVMAASLM 363
Cdd:cd17355  246 AAAVALAL-IGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA 290
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 81-223 5.23e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 42.61  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  81 QEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLV--LILSLSYAVLIVGRIAVGVSISLSSIATCVY 158
Cdd:cd17318   56 KTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTFPAMHAL 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 752413651 159 IAEIAPQHRRGLLVSLNELMIVIGILFAY-ISNYAFAnvSHGWKYMFGLVIPLGVLQAIA-MYFLPP 223
Cdd:cd17318  136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMpLSGFLCE--SLGWPSIFYIFGGLGLLWCLLwFFLVLP 200
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
85-150 8.32e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 8.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISL 150
Cdd:COG0738  250 LGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 84-168 1.11e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 41.57  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  84 EMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEI- 162
Cdd:cd17379   36 DLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFv 115


                 ....*.
gi 752413651 163 APQHRR 168
Cdd:cd17379  116 GSKYRR 121
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 73-174 1.15e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 41.59  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  73 RTLLALTCQEQEMVvsSLLIGAL--LASLTGGVLIDRYGRRTAIILSSCLLGLGS----LVLILSLSYAVLIVGRIAVGV 146
Cdd:cd17368  250 KTVLGLSARDSFLV--TLLAGVAnfIWAPLGGALSDRIGRRPVLLVITLAALVTLypvfAWLTAAPSFGRLLLVLLVLSF 327

                         90       100
                 ....*....|....*....|....*...
gi 752413651 147 SISLSSIATCVYIAEIAPQHRRGLLVSL 174
Cdd:cd17368  328 FFGMYGGAMVVALVELFPVRVRSTGFSL 355
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 91-247 1.20e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 41.52  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  91 LIGALLASltggVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGL 170
Cdd:cd06180   48 LVGALLAS----FLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGH 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 171 LVSL----NELMIVIGILFAYISNYAFANVSHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLRRLRA 246
Cdd:cd06180  124 LIGLlfagVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLAL 203


                 .
gi 752413651 247 I 247
Cdd:cd06180  204 A 204
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 86-222 2.09e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 40.64  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  86 VVSSLLIGA--LLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL------SLSYAVLIVGRIAVGVSISLSsiatCV 157
Cdd:cd17317  194 YLNFFLSGLveIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALlpddenTLALTLALVGKFAISAAFSVI----YL 269

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651 158 YIAEIAPQHRRGLLVSLNELMIVIGILFA-YISNYAfanvSHGWKYMFGLVIPLGVLQAIAMYFLP 222
Cdd:cd17317  270 YTAELYPTVVRNTGVGLCSTVARVGAILApFIVLLG----KIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 87-377 2.16e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 40.61  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  87 VSSLLIGA-LLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGR-IAVGVSISLSSIATCVYIAEIAp 164
Cdd:cd17352   43 IGSLLLGVsLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVGQYF- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 165 QHRRGLLVSLNELMIVIG-ILFAYISNYAFANvsHGWKYMF---GLVIPLGVLQAIAMyflppsprflvmkgheeaaskv 240
Cdd:cd17352  122 EKKRGLATGIAVAGSGVGtFVFPPLLRYLLDN--YGWRGALlilGGLCLNLCVCGLLL---------------------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 241 lrrlRAISDTTeeltgiksslkdeyqysFWDLFrskdnmrtrimIGLTLVFFvqvtGQPNILFYASTVLKSVGFQSNEAA 320
Cdd:cd17352  178 ----RLLKDPT-----------------FVLLA-----------LGVSFAML----GFFVPFVYLPSYAKSLGIDESDAA 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 752413651 321 SLASTgVGVVKVISTIPATLLVDHVGSKTFlcvgsSVMAASLMTMGIVNLNTPMNFT 377
Cdd:cd17352  222 FLLSI-IGISDIVGRILLGLLADKPRIGRL-----YLYIFTLLILGLSLLAFPLATT 272
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 92-222 2.67e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.25  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  92 IGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSL-VLILSLSYAVLIVGRIAVGVSISLSSIATCVYIAEIAPQHRRGL 170
Cdd:cd17504  228 LVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLlLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGI 307

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 752413651 171 LVSLNELMIVIG----------ILFAYISNYAFANVS--HGWKYMFGLVIPLGVLQAIAMYFLP 222
Cdd:cd17504  308 ATGMNTVLRTIGsaigpaiagaILTTYTVSITSGGVPteGAYVLAFLIGAALALAALLLSLLIP 371
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 89-186 3.07e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 40.34  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  89 SLLIGALLASLTG----------GVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISLSSIATCVy 158
Cdd:cd17389   62 SVLFGGLIGSLFSllqflsspitGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAI- 140

                         90       100
                 ....*....|....*....|....*...
gi 752413651 159 IAEIAPQHRRGllvslnELMIVIGILFA 186
Cdd:cd17389  141 VADVTSPKKRS------KGMALIGVAFS 162
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 85-186 3.63e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  85 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLIL---SLSYAVLIVGRIAVGVSISLSSIATCVYIAE 161
Cdd:cd17321  208 LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALS 287

                         90       100
                 ....*....|....*....|....*
gi 752413651 162 IAPQHRRGLLVSLNELMIVIGILFA 186
Cdd:cd17321  288 SVPKEKAGAASGILNTARQLGGALG 312
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 89-213 4.71e-03

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 39.37  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  89 SLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVsiSLSSIATCVYIAEI---APQ 165
Cdd:cd17443   44 SYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGG--TLAGVFLSLYIARLelcDPS 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 752413651 166 HRrgLLVSLnelmivIGILFAYISNY---AFANVSHGWKYMFGLV-IPLGVL 213
Cdd:cd17443  122 HR--LMVSM------GAGFFSVAGELllpGLAVLCRDWRVLQGVGtLPLLLL 165
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 44-169 5.25e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.59  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  44 TLLSSVTAAvsGLLVGYelgliSGALLQIRTLLAltcQEQEM-------VVSSLLIGALLASLTGGVLIDRYGRRTAIIL 116
Cdd:cd17371  211 TLLASLLAT--GALGGY-----YGITTWLPSYLT---GERGLsfegsagYLVVTILGGFLGYLAGGFLADRIGRRNNFAL 280

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752413651 117 SSCLLGLGSLVLI-LSLSYAVLIVGRIAVG--VSISLSSIATcvYIAEIAPQHRRG 169
Cdd:cd17371  281 FALGSAISILLYFfLPLSPTLILILGFPLGffASGPFSGMGA--YLTELFPTAVRA 334
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 63-226 5.63e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 5.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  63 GLISGALLQIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRI 142
Cdd:cd17478   13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 143 AVGVSISLSSIATCVYIAEIAPqHRRGLLVSLN----ELMIVIGILFAyisnyAFANVSHGWKYMFGLVIPLGVLQAIAM 218
Cdd:cd17478   93 LAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFsvggNLGFALGPLIA-----AALVALFGGLGLLILLIIPGLAVALLL 166


                 ....*...
gi 752413651 219 YFLPPSPR 226
Cdd:cd17478  167 LRLRPLKK 174
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 104-222 6.07e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 6.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 104 LIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRI--AVGVSISLSSIATcvYIAEIAPQHRRGLLVSLNELMIVI 181
Cdd:cd17329  259 LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIvlTLGEMLVFPAVQT--LVAALAPPDKRGSYMGFYALAWGL 336

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 752413651 182 GILFAYISNYAFANVSHGWkYMFGLVIPLGVLQAIAMYFLP 222
Cdd:cd17329  337 GRAIGPLVGGLLLDLLGPG-LPWLILAALGLIAAALLLGLQ 376
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 102-246 7.41e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 38.74  E-value: 7.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 102 GVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGvSISLSSIATcVYIAEIAPQHRRGLLVSLneLMIVI 181
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVM-ALLADLTREENRTKAMAL--IGASI 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752413651 182 GILFAyiSNYAFANVSH---GWKYMFGLVIPLGVLQ-AIAMYFLPPSPRflvMKGHEEAASKVLRRLRA 246
Cdd:cd17472  129 GIAFA--ISMVLGPLLAahlGVSGLFLITAILSLVSlLILLFFVPDPPK---IVQISEKEKKKLKKLLK 192
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 91-244 8.38e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 38.66  E-value: 8.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  91 LIGALLASLT----------GGVLI----DRYGRRTAIILSSCLLGLGSLVLILSLSYA--------VLIVGRIAVGVSI 148
Cdd:cd17369   40 AAGTLAAFATfgvgflarplGGVVFghfgDRIGRKKTLVLTLLLMGIATFLIGLLPTYAqigilapiLLVLLRLLQGLAL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651 149 S--LSSIATcvYIAEIAPQHRRGLLVSLNELMIVIGILFAyisNYAFANVSH----------GWKYMFGLVIplgVLQAI 216
Cdd:cd17369  120 GgeWGGAVL--MAVEHAPPKRRGFYGSFPQLGAPVGLLLA---TGVFLLLSAllsdeaflswGWRIPFLLSA---VLVAV 191

                        170       180       190
                 ....*....|....*....|....*....|.
gi 752413651 217 AMYF---LPPSPRFLVMKGHEEAASKVLRRL 244
Cdd:cd17369  192 GLYIrlrLEETPVFRRAKEAGQVVRAPLVEV 222
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 71-154 9.06e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 38.78  E-value: 9.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752413651  71 QIRTLLALTCQEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYAVLIVGRIAVGVSISL 150
Cdd:cd17393   24 AIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGA 103


                 ....
gi 752413651 151 SSIA 154
Cdd:cd17393  104 LDVA 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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