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Conserved domains on  [gi|731376510|ref|XP_010656043|]
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calmodulin-binding transcription activator 4 isoform X5 [Vitis vinifera]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 14-126 1.05e-65

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


:

Pssm-ID: 461077  Cd Length: 114  Bit Score: 215.98  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510   14 QIRWLKPAEVLFILQNYEKH--QLTQEPPQKPTSGSLFLFNKRVLRFFRKDGHSWRKKKDGRTVGEAHERLKVGTVETIN 91
Cdd:pfam03859   1 KTRWLKPQEILAILLNYDPYgfCITPEPPPRPPSGSLFLFDRKKLRYFRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 731376510   92 CYYAHGEQNPSFQRRSYWMLDPAYeHIVLVHYREI 126
Cdd:pfam03859  81 CYYAHSEDNPTFQRRIYWLLDSDY-HIVLVHYLNV 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
645-716 2.75e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 2.75e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731376510 645 LNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:COG0666  140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA------DVNARDNDGETPLHLAAENGHLEIVKLL 205
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 426-502 2.65e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.06  E-value: 2.65e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731376510  426 TICEISPEWGFSSETTKVIIAGSFLcHPSECAWTCMFGDIEVPVQIIQEGVICCQAPPHPPGKVTLCITSGNRESCS 502
Cdd:pfam01833   2 VITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISS 77
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 559-704 1.98e-07

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 559 IDLLIKSKadedswDCIIE--ALLFGSGTSSSTVDWLLQELLkdklHQWL-SSRSREGC----ESFGCSLSKKEQG---M 628
Cdd:PHA03095 156 LAVLLKSR------NANVEllRLLIDAGADVYAVDDRFRSLL----HHHLqSFKPRARIvrelIRAGCDPAATDMLgntP 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 731376510 629 IHMIAGLGFEWALN--PILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGAVTdpspqdPTGKTAASIA 704
Cdd:PHA03095 226 LHSMATGSSCKRSLvlPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS------SDGNTPLSLM 297
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 849-870 2.46e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 38.85  E-value: 2.46e-04
                           10        20
                   ....*....|....*....|..
gi 731376510   849 LRQKVVKIQAHVRGYHVRKNYK 870
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRYK 23
 
Name Accession Description Interval E-value
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 14-126 1.05e-65

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 215.98  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510   14 QIRWLKPAEVLFILQNYEKH--QLTQEPPQKPTSGSLFLFNKRVLRFFRKDGHSWRKKKDGRTVGEAHERLKVGTVETIN 91
Cdd:pfam03859   1 KTRWLKPQEILAILLNYDPYgfCITPEPPPRPPSGSLFLFDRKKLRYFRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 731376510   92 CYYAHGEQNPSFQRRSYWMLDPAYeHIVLVHYREI 126
Cdd:pfam03859  81 CYYAHSEDNPTFQRRIYWLLDSDY-HIVLVHYLNV 114
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 10-127 8.16e-58

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 194.16  E-value: 8.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510    10 LKEAQIRWLKPAEVLFILQNYEKHQ--LTQEPPQKPTSGSLFLFNKRVLRFFRKDGHSWRKKKDGRTVGEAHERLKVGTV 87
Cdd:smart01076   1 LPEAKHRWLTPEEIAAILINFDKHTewLTTSPPTRPKSGSLFLFNRKKLKYFRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 731376510    88 ETINCYYAHGEQNPSFQRRSYWMLDpaYEHIVLVHYREIS 127
Cdd:smart01076  81 ECLHCYYAHSEINPTFHRRCYWLLQ--NPDIVLVHYLNVP 118
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
645-716 2.75e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 2.75e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731376510 645 LNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:COG0666  140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA------DVNARDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
629-716 1.68e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510  629 IHMIAGLGFEWALNPILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGavtdpspqDPTGKTAASIASTSG 708
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--------KDNGRTALHYAARSG 72


                  ....*...
gi 731376510  709 HKGLAGYL 716
Cdd:pfam12796  73 HLEIVKLL 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 426-502 2.65e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.06  E-value: 2.65e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731376510  426 TICEISPEWGFSSETTKVIIAGSFLcHPSECAWTCMFGDIEVPVQIIQEGVICCQAPPHPPGKVTLCITSGNRESCS 502
Cdd:pfam01833   2 VITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISS 77
PHA03095 PHA03095
ankyrin-like protein; Provisional
 559-704 1.98e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 559 IDLLIKSKadedswDCIIE--ALLFGSGTSSSTVDWLLQELLkdklHQWL-SSRSREGC----ESFGCSLSKKEQG---M 628
Cdd:PHA03095 156 LAVLLKSR------NANVEllRLLIDAGADVYAVDDRFRSLL----HHHLqSFKPRARIvrelIRAGCDPAATDMLgntP 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 731376510 629 IHMIAGLGFEWALN--PILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGAVTdpspqdPTGKTAASIA 704
Cdd:PHA03095 226 LHSMATGSSCKRSLvlPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS------SDGNTPLSLM 297
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 426-510 3.85e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 43.22  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 426 TICEISPEWGFSSETTKVIIAGSFLChpSECAWTCMF-GDIEVPVQIIQEGVICCQAPPHP---PGKVTLCITSGNRESC 501
Cdd:cd00102    2 VITSISPSSGPVSGGTEVTITGSNFG--SGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnpgPGPVEVTVDRGNGGIT 79


                 ....*....
gi 731376510 502 SEVREFEYH 510
Cdd:cd00102   80 SSPLTFTYV 88
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 849-870 2.46e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 38.85  E-value: 2.46e-04
                           10        20
                   ....*....|....*....|..
gi 731376510   849 LRQKVVKIQAHVRGYHVRKNYK 870
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRYK 23
IPT smart00429
ig-like, plexins, transcription factors;
426-510 3.28e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510   426 TICEISPEWGFSSETTKVIIAGSFLCHPSEcaWTCMFGDIEVPVQIIQEGV--ICCQAPPHPPGKVTL---CITSGNRES 500
Cdd:smart00429   3 VITRISPTSGPVSGGTEITLCGKNLKSISV--VFVEVGVGEAPCTFSPSSStaIVCKTPPYHNIPGSVpvrTVGLRNGGV 80

                           90
                   ....*....|
gi 731376510   501 CSEVREFEYH 510
Cdd:smart00429  81 PSSPQPFTYV 90
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 657-683 4.65e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 4.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 731376510   657 NGWTALHWAARFGREKMVAALIASGAS 683
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 850-870 1.03e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 37.30  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|.
gi 731376510  850 RQKVVKIQAHVRGYHVRKNYK 870
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
CBD_MYO6-like cd21759
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ...
 829-870 2.53e-03

calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE).


Pssm-ID: 409646 [Multi-domain]  Cd Length: 149  Bit Score: 39.41  E-value: 2.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 731376510 829 AALSIQK-----KYRgwkgrkdfltlRQKVVKIQAHVRGYHVRKNYK 870
Cdd:cd21759   30 CALSVIKlknkiLYR-----------REALIKIQKTVRGYLARKKHR 65
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 644-710 4.55e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 4.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731376510 644 ILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGAVTDpspqdpTGKTAASIASTSGHK 710
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK------YGDTPLHIAILNNNK 238
 
Name Accession Description Interval E-value
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 14-126 1.05e-65

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 215.98  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510   14 QIRWLKPAEVLFILQNYEKH--QLTQEPPQKPTSGSLFLFNKRVLRFFRKDGHSWRKKKDGRTVGEAHERLKVGTVETIN 91
Cdd:pfam03859   1 KTRWLKPQEILAILLNYDPYgfCITPEPPPRPPSGSLFLFDRKKLRYFRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 731376510   92 CYYAHGEQNPSFQRRSYWMLDPAYeHIVLVHYREI 126
Cdd:pfam03859  81 CYYAHSEDNPTFQRRIYWLLDSDY-HIVLVHYLNV 114
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 10-127 8.16e-58

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 194.16  E-value: 8.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510    10 LKEAQIRWLKPAEVLFILQNYEKHQ--LTQEPPQKPTSGSLFLFNKRVLRFFRKDGHSWRKKKDGRTVGEAHERLKVGTV 87
Cdd:smart01076   1 LPEAKHRWLTPEEIAAILINFDKHTewLTTSPPTRPKSGSLFLFNRKKLKYFRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 731376510    88 ETINCYYAHGEQNPSFQRRSYWMLDpaYEHIVLVHYREIS 127
Cdd:smart01076  81 ECLHCYYAHSEINPTFHRRCYWLLQ--NPDIVLVHYLNVP 118
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
645-716 2.75e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 2.75e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731376510 645 LNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:COG0666  140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA------DVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
645-716 4.12e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 4.12e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731376510 645 LNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:COG0666  173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA------DVNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
644-716 4.48e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 4.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731376510 644 ILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:COG0666  106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA------DVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
629-716 1.68e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510  629 IHMIAGLGFEWALNPILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGavtdpspqDPTGKTAASIASTSG 708
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--------KDNGRTALHYAARSG 72


                  ....*...
gi 731376510  709 HKGLAGYL 716
Cdd:pfam12796  73 HLEIVKLL 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 426-502 2.65e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.06  E-value: 2.65e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731376510  426 TICEISPEWGFSSETTKVIIAGSFLcHPSECAWTCMFGDIEVPVQIIQEGVICCQAPPHPPGKVTLCITSGNRESCS 502
Cdd:pfam01833   2 VITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISS 77
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
628-716 3.60e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.12  E-value: 3.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 628 MIHMIAGLGFEWALNPILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTS 707
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA------DVNARDKDGETPLHLAAYN 130


                 ....*....
gi 731376510 708 GHKGLAGYL 716
Cdd:COG0666  131 GNLEIVKLL 139
PHA03095 PHA03095
ankyrin-like protein; Provisional
 559-704 1.98e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 559 IDLLIKSKadedswDCIIE--ALLFGSGTSSSTVDWLLQELLkdklHQWL-SSRSREGC----ESFGCSLSKKEQG---M 628
Cdd:PHA03095 156 LAVLLKSR------NANVEllRLLIDAGADVYAVDDRFRSLL----HHHLqSFKPRARIvrelIRAGCDPAATDMLgntP 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 731376510 629 IHMIAGLGFEWALN--PILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGAVTdpspqdPTGKTAASIA 704
Cdd:PHA03095 226 LHSMATGSSCKRSLvlPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS------SDGNTPLSLM 297
Ank_4 pfam13637
Ankyrin repeats (many copies);
644-678 3.34e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 3.34e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 731376510  644 ILNTGVSINFRDINGWTALHWAARFGREKMVAALI 678
Cdd:pfam13637  20 LLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 426-510 3.85e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 43.22  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 426 TICEISPEWGFSSETTKVIIAGSFLChpSECAWTCMF-GDIEVPVQIIQEGVICCQAPPHP---PGKVTLCITSGNRESC 501
Cdd:cd00102    2 VITSISPSSGPVSGGTEVTITGSNFG--SGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnpgPGPVEVTVDRGNGGIT 79


                 ....*....
gi 731376510 502 SEVREFEYH 510
Cdd:cd00102   80 SSPLTFTYV 88
Ank_4 pfam13637
Ankyrin repeats (many copies);
658-716 7.75e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 7.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 731376510  658 GWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA------DINAVDGNGETALHFAASNGNVEVLKLL 53
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 849-870 2.46e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 38.85  E-value: 2.46e-04
                           10        20
                   ....*....|....*....|..
gi 731376510   849 LRQKVVKIQAHVRGYHVRKNYK 870
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRYK 23
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
645-716 2.82e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.17  E-value: 2.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731376510 645 LNTGVSINFRDINGWTALHWAARFGREKMVAALIASGAsagavtDPSPQDPTGKTAASIASTSGHKGLAGYL 716
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA------DLNAKDKDGLTALLLAAAAGAALIVKLL 271
IPT smart00429
ig-like, plexins, transcription factors;
426-510 3.28e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510   426 TICEISPEWGFSSETTKVIIAGSFLCHPSEcaWTCMFGDIEVPVQIIQEGV--ICCQAPPHPPGKVTL---CITSGNRES 500
Cdd:smart00429   3 VITRISPTSGPVSGGTEITLCGKNLKSISV--VFVEVGVGEAPCTFSPSSStaIVCKTPPYHNIPGSVpvrTVGLRNGGV 80

                           90
                   ....*....|
gi 731376510   501 CSEVREFEYH 510
Cdd:smart00429  81 PSSPQPFTYV 90
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 657-689 3.80e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 3.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 731376510  657 NGWTALHWAA-RFGREKMVAALIASGASAGAVTD 689
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
657-683 4.50e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.10  E-value: 4.50e-04
                          10        20
                  ....*....|....*....|....*..
gi 731376510  657 NGWTALHWAARFGREKMVAALIASGAS 683
Cdd:pfam12796  60 NGRTALHYAARSGHLEIVKLLLEKGAD 86
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 657-683 4.65e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 4.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 731376510   657 NGWTALHWAARFGREKMVAALIASGAS 683
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 657-683 7.99e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 7.99e-04
                          10        20
                  ....*....|....*....|....*..
gi 731376510  657 NGWTALHWAARFGREKMVAALIASGAS 683
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 850-870 1.03e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 37.30  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|.
gi 731376510  850 RQKVVKIQAHVRGYHVRKNYK 870
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
CBD_MYO6-like cd21759
calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, ...
 829-870 2.53e-03

calmodulin binding domain found in unconventional myosin-VI and similar proteins; Myosins, which are actin-based motor molecules with ATPase activity, include unconventional myosins that serve in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Myosin-VI appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP (DOCK7-Induced Septin disPlacement) complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by gene MYO6, the human homolog of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant non-syndromic hearing loss. This family also includes Drosophila melanogaster unconventional myosin VI Jaguar (Jar; also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. Jar may link endocytic vesicles to microtubules and possibly be involved in transport in the early embryo and in the dynamic process of dorsal closure; its function is believed to change during the life cycle. This model corresponds to the calmodulin (CaM) binding domain (CBD), which consists of three subdomains: a unique insert (Insert 2 or Ins2), an IQ motif, and a proximal tail domain (PTD, also known as lever arm extension or LAE).


Pssm-ID: 409646 [Multi-domain]  Cd Length: 149  Bit Score: 39.41  E-value: 2.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 731376510 829 AALSIQK-----KYRgwkgrkdfltlRQKVVKIQAHVRGYHVRKNYK 870
Cdd:cd21759   30 CALSVIKlknkiLYR-----------REALIKIQKTVRGYLARKKHR 65
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 644-710 4.55e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 4.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731376510 644 ILNTGVSINFRDINGWTALHWAARFGREKMVAALIASGASAGAVTDpspqdpTGKTAASIASTSGHK 710
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK------YGDTPLHIAILNNNK 238
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 426-509 4.85e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 37.43  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731376510 426 TICEISPEWGFSSETTKVIIAGSFLcHPSECAWTCMFGDIEVPVQIIQEGVICCQAPPHP---PGKVTLCITSGNRESCS 502
Cdd:cd00603    2 VITSISPSSGPLSGGTRLTITGSNL-GSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtpgEGPVEVTVDGANVSARV 80


                 ....*...
gi 731376510 503 EVRE-FEY 509
Cdd:cd00603   81 LSNTtFTY 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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