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Conserved domains on  [gi|729765528|ref|XP_010579871|]
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PREDICTED: ribose-phosphate pyrophosphokinase 2 isoform X3 [Haliaeetus leucocephalus]

Protein Classification

ribose-phosphate diphosphokinase( domain architecture ID 11421473)

ribose-phosphate diphosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0002189|GO:0000287|GO:0004749|GO:0005524|GO:0009156|GO:0016301|GO:0016310|GO:0006015|GO:0009165
PubMed:  11751055|7593598

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-314 7.60e-173

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 481.10  E-value: 7.60e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   1 MPNIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENIL 160
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 161 EwrNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAG 240
Cdd:COG0462  161 E--DLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729765528 241 ATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKmKHCPKIQFIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462  239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-314 7.60e-173

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 481.10  E-value: 7.60e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   1 MPNIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENIL 160
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 161 EwrNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAG 240
Cdd:COG0462  161 E--DLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729765528 241 ATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKmKHCPKIQFIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462  239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
4-313 2.44e-163

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 456.89  E-value: 2.44e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEwr 163
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 164 NCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGATK 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 244 VYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 4-314 5.34e-156

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 438.64  E-value: 5.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528    4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASS 82
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEw 162
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  163 rNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGA 241
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 729765528  242 TKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEekmKHCPKIQFIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 4-120 1.96e-70

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 214.21  E-value: 1.96e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528    4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 729765528   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 147-274 5.95e-25

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 97.47  E-value: 5.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 147 AEPAVLQWIKENILEwrNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223    1 AGRLLAEEIREDLLE--PDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 729765528 221 DMADTCGTICHAAEKLISAGATKVYAILTHGIFSGPAisRINNASFEAVVVTNT 274
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-314 7.60e-173

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 481.10  E-value: 7.60e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   1 MPNIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENIL 160
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 161 EwrNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAG 240
Cdd:COG0462  161 E--DLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729765528 241 ATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKmKHCPKIQFIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462  239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
4-313 2.44e-163

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 456.89  E-value: 2.44e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEwr 163
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 164 NCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGATK 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 244 VYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 4-314 5.34e-156

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 438.64  E-value: 5.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528    4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASS 82
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEw 162
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  163 rNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGA 241
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 729765528  242 TKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEekmKHCPKIQFIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 14-313 1.33e-115

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 335.90  E-value: 1.33e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  14 DLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFP 93
Cdd:PLN02369   2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  94 YARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEWRNCIIVSPDAG 173
Cdd:PLN02369  82 YARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 174 GAKRVTSIADRL-NVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGATKVYAILTHGI 252
Cdd:PLN02369 162 GVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAV 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 729765528 253 FSGPAISRINNASFEAVVVTNTIPQEEKmKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PLN02369 242 FSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 6-313 7.81e-114

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 332.48  E-value: 7.81e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   6 LFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRV 85
Cdd:PRK02812  24 LFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASARQI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  86 TAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEwrNC 165
Cdd:PRK02812 104 TAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASKNLE--DI 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 166 IIVSPDAGGAKRVTSIADRLN-VEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGATKV 244
Cdd:PRK02812 182 VVVSPDVGGVARARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQV 261

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 729765528 245 YAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKmKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02812 262 YACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEE-RRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
2-313 2.18e-113

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 330.74  E-value: 2.18e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   2 PNIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK04923   5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  82 SSRVTAVIPCFPYARQDKKDKS-RAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIkenil 160
Cdd:PRK04923  85 AASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADI----- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 161 eWR-----NCIIVSPDAGGAKRVTSIADRL-NVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAE 234
Cdd:PRK04923 160 -WRaygtdNLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 729765528 235 KLISAGATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-313 3.20e-113

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 334.92  E-value: 3.20e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   1 MPNIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRA 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD--IPVDNLYAEPAVLQWIKEN 158
Cdd:PTZ00145 197 SAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKK 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 159 ILewRNCIIVSPDAGGAKRVTSIADRLN------VEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHA 232
Cdd:PTZ00145 277 DL--YKPVIVSPDAGGVYRARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEA 354

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 233 AEKLISAGATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMKHCPKIQFIDISMILAEAIRRTHNGESVSYL 312
Cdd:PTZ00145 355 AKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDL 434


                 .
gi 729765528 313 F 313
Cdd:PTZ00145 435 F 435
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
3-313 7.08e-113

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 329.45  E-value: 7.08e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   3 NIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASS 82
Cdd:PRK02269   5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILEW 162
Cdd:PRK02269  85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 163 RNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK--KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAG 240
Cdd:PRK02269 165 DDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 729765528 241 ATKVYAILTHGIFSGPAISRINNASFEAVVVTNTI--PQEekmKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02269 245 ATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIylPEE---RLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
15-313 5.58e-111

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 324.21  E-value: 5.58e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  15 LSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPY 94
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  95 ARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENiLEWRNCIIVSPDAGG 174
Cdd:PRK03092  81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDK-YDLDNVTVVSPDAGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 175 AKRVTSIADRL-NVEFALIHKER--KKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGATKVYAILTHG 251
Cdd:PRK03092 160 VRVAEQWADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 729765528 252 IFSGPAISRINNASFEAVVVTNTIPQEEKmKHCPKIQFIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 2-317 4.95e-97

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 289.33  E-value: 4.95e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   2 PNIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK02458   8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  82 SSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENILE 161
Cdd:PRK02458  88 ANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 162 WRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVlVGDVKDRVAILVDDMADTCGTICHAAEKLISAGA 241
Cdd:PRK02458 168 GSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYI-IGDVAGKKAILIDDILNTGKTFAEAAKIVEREGA 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 729765528 242 TKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMkhcPK-IQFIDISMILAEAIRRTHNGESVSYLFSHVP 317
Cdd:PRK02458 247 TEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERV---PKnVTYLSASELIADAIIRIHERKPLSPLFAYNK 320
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 3-314 1.43e-86

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 262.93  E-value: 1.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   3 NIVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASS 82
Cdd:PRK00553   9 NHVIFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKEnILEW 162
Cdd:PRK00553  89 KSITAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLE-LLGK 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 163 RNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGAT 242
Cdd:PRK00553 168 KDLVVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAK 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 729765528 243 KVYAILTHGIFSGPAISRINNASFEAVV----VTNTIPQeEKMKHCPKIQFIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:PRK00553 248 KVCVMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQ-TKFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 4-120 1.96e-70

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 214.21  E-value: 1.96e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528    4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 729765528   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 4-302 1.83e-67

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 212.47  E-value: 1.83e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   4 IVLFSGSSHhdLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEiNDNLMELLIMINACKIASSS 83
Cdd:PRK00934   2 IIGGSASQL--LASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGaDHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIKENIlewR 163
Cdd:PRK00934  79 SITLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKL---D 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 164 NCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGATK 243
Cdd:PRK00934 155 DPLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKK 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 729765528 244 VYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEkmkhcpkiQFIDISMILAEAIRR 302
Cdd:PRK00934 235 VYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESEV--------SKISVAPLIADLLKK 285
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 161-313 8.06e-47

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 156.13  E-value: 8.06e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  161 EWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKA--NEVDR----------------------------MVLVGD 210
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAesDEVDGrqspppyrsrtvsrslglpeiipkekppMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  211 VKDRVAILVDDMADTCGTICHAAEKLISAGATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMKHCPKIQFI 290
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|...
gi 729765528  291 DISMILAEAIRRTHNGESVSYLF 313
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLF 183
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
4-302 3.42e-44

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 152.78  E-value: 3.42e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   4 IVLFSGSSHHDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVyIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:PRK07199   3 PLLLALPGNEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTV-VLVCSLDRPDEKLLPLLFAAEAARELGAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSvAGADHIITMD--LH-ASQIQGFFDIPVDNLYAEPAVLQWIKENIL 160
Cdd:PRK07199  82 RVGLVAPYLAYMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 161 EWrncIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDrmVLVGDV---KDRVAILVDDMADTCGTICHAAEKLI 237
Cdd:PRK07199 161 RP---LLIGPDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVE--ISLPDAapwAGRTPVLVDDIVSTGRTLIEAARQLR 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 729765528 238 SAGATKVYAILTHGIFSGPAISRINNASFEAVVVTNTIPQEEKMkhcpkiqfIDISMILAEAIRR 302
Cdd:PRK07199 236 AAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHPSNA--------ISLAPLLAEALRR 292
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 29-312 7.83e-40

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 143.55  E-value: 7.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  29 KVVTKKFSNQETSVEIGESVRGEDVYIIQ---------SGCGE-----INDNLMELLIMINACKiASSSRVTAVIPCFPY 94
Cdd:PRK06827  56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  95 ARQDKKdKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIP-VDNLYAEPAVLQWIKENILEWR----NCIIVS 169
Cdd:PRK06827 135 SRQHKR-KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgFENLYPSYQIIKALLKNEKDLEidkdHLMVIS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 170 PDAGGAKRVTSIADRLNVEFALIHKERK-------KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAEKLISAGAT 242
Cdd:PRK06827 214 PDTGAMDRAKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAK 293

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729765528 243 KVYAILTHGIFSGpAISRINNAS----FEAVVVTNTIPQEEKMKHCPKIQFIDISMILAEAIRRTHNGESVSYL 312
Cdd:PRK06827 294 KIIVAATFGFFTN-GLEKFDKAYeegyFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKL 366
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 147-274 5.95e-25

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 97.47  E-value: 5.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 147 AEPAVLQWIKENILEwrNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223    1 AGRLLAEEIREDLLE--PDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 729765528 221 DMADTCGTICHAAEKLISAGATKVYAILTHGIFSGPAisRINNASFEAVVVTNT 274
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 3-277 4.71e-11

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 62.78  E-value: 4.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528   3 NIVLFSGSSHHDLSQRVADRLG-LELGKVVTKKFSNQETSVEIG--ESVRGEDVYIIQSGcgEINDNLMELL-IMINACK 78
Cdd:PLN02297  16 QVHLFYCEETEELARKIAAESDaIELGSINWRKFPDGFPNLFINnaHGIRGQHVAFLASF--SSPAVIFEQLsVIYALPK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  79 IASSSrVTAVIPCFP---YAR-QDKKDKSRAPISAKLVANM-LSVAGADHIITMDLHASQIQGFFDIPVDNLYAE--PAV 151
Cdd:PLN02297  94 LFVAS-FTLVLPFFPtgtSERvEREGDVATAFTLARILSNIpISRGGPTSLVIFDIHALQERFYFGDNVLPCFESgiPLL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 152 LQWIKEniLEWRNCIIVS-PDAGGAKRVTSIADrlNVEFALIHKERkkanEVD-RMVLV--GDVKDRVAILVDDMADTCG 227
Cdd:PLN02297 173 KKRLQQ--LPDSDNIVIAfPDDGAWKRFHKQFE--HFPMVVCTKVR----EGDkRIVRIkeGNPAGRHVVIVDDLVQSGG 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 729765528 228 TICHAAEKLISAGATKVYAILTHGIFSGPAISRINNAS------FEAVVVTNTIPQ 277
Cdd:PLN02297 245 TLIECQKVLAAHGAAKVSAYVTHGVFPNESWERFTHDNggpeagFAYFWITDSCPQ 300
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 141-244 1.12e-09

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 56.22  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528  141 PVDNLYAEPAVLQWIKENI------LEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKAN---EVDRMVLVGDV 211
Cdd:pfam00156   1 SVDEILDNPAILKAVARLAaqinedYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDtseVMKTSSALPDL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 729765528  212 KDRVAILVDDMADTCGTICHAAEKLISAGATKV 244
Cdd:pfam00156  81 KGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 166-251 5.29e-03

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 37.26  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729765528 166 IIVSPDAGGAKRVTSIADRLNVEFALIHKERKK------ANEV------DRMVLVGDVKD-------RVAIlVDDMADTC 226
Cdd:PRK07322  55 VLVTPETKGIPLAHALSRRLGKPYVVARKSRKPymqdpiIQEVvsittgKPQLLVLDGADaeklkgkRVAI-VDDVVSTG 133

                         90       100
                 ....*....|....*....|....*...
gi 729765528 227 GTIcHAAEKLI-SAGAT--KVYAILTHG 251
Cdd:PRK07322 134 GTL-TALERLVeRAGGQvvAKAAIFAEG 160
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 178-251 6.94e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 37.06  E-value: 6.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 729765528 178 VTSIADRLNVEFALIhkeRKKANEVDRM-VLVGDVK--DRVAIlVDDMADTCGTICHAAEKLISAGAT--KVYAILTHG 251
Cdd:COG0461   78 AAAVARALGLPAIFV---RKEAKDHGTGgQIEGGLLpgERVLV-VEDVITTGGSVLEAVEALREAGAEvvGVAVIVDRE 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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