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Conserved domains on  [gi|723578244|ref|XP_010309297|]
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PREDICTED: glucosamine 6-phosphate N-acetyltransferase [Balearica regulorum gibbericeps]

Protein Classification

GNAT family protein( domain architecture ID 106742)

GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

PubMed:  15581578

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 40-180 1.84e-42

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member PLN02706:

Pssm-ID: 473072 [Multi-domain]  Cd Length: 150  Bit Score: 139.45  E-value: 1.84e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  40 DPGDGLVLRPLCTADLNRGFFKVLGQLTETGVASPEQFIKTFEHMKRSGDY-YVTVVEDTNLGQIVATATLVIEHKFTHS 118
Cdd:PLN02706   2 DTGEKFKVRRLEISDKSKGFLELLQQLTVVGDVTEEEFEARFQELASLGDDhLICVIEDAASGRIIATGSVFVERKFIRN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723578244 119 CAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKNVDFYKKFGYSVSE 180
Cdd:PLN02706  82 CGKVGHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGYVRKE 143
 
Name Accession Description Interval E-value
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 40-180 1.84e-42

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 139.45  E-value: 1.84e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  40 DPGDGLVLRPLCTADLNRGFFKVLGQLTETGVASPEQFIKTFEHMKRSGDY-YVTVVEDTNLGQIVATATLVIEHKFTHS 118
Cdd:PLN02706   2 DTGEKFKVRRLEISDKSKGFLELLQQLTVVGDVTEEEFEARFQELASLGDDhLICVIEDAASGRIIATGSVFVERKFIRN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723578244 119 CAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKNVDFYKKFGYSVSE 180
Cdd:PLN02706  82 CGKVGHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGYVRKE 143
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 69-176 1.39e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.59  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244   69 TGVASPEQFIKTFEHMKRSGDYYVTVVEDtnlGQIVATATLVIEHKFTHscakRGRIEDVVVSRECRGKQLGKLLTSTLT 148
Cdd:pfam00583  13 PEPWPDEPLDLLEDWDEDASEGFFVAEED---GELVGFASLSIIDDEPP----VGEIEGLAVAPEYRGKGIGTALLQALL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 723578244  149 LLSKRLNCYKITLECLPKN---VDFYKKFGY 176
Cdd:pfam00583  86 EWARERGCERIFLEVAADNlaaIALYEKLGF 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 76-182 5.51e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 49.61  E-value: 5.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  76 QFIKTFEHMKRSGDYYVtVVEDtnlGQIVATATLVIehkfthSCAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLN 155
Cdd:COG1246   16 ELIRPYALEEEIGEFWV-AEED---GEIVGCAALHP------LDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELG 85

                         90       100
                 ....*....|....*....|....*..
gi 723578244 156 CYKITLECLPKNVDFYKKFGYSVSEEN 182
Cdd:COG1246   86 LKRLFLLTTSAAIHFYEKLGFEEIDKE 112
 
Name Accession Description Interval E-value
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 40-180 1.84e-42

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 139.45  E-value: 1.84e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  40 DPGDGLVLRPLCTADLNRGFFKVLGQLTETGVASPEQFIKTFEHMKRSGDY-YVTVVEDTNLGQIVATATLVIEHKFTHS 118
Cdd:PLN02706   2 DTGEKFKVRRLEISDKSKGFLELLQQLTVVGDVTEEEFEARFQELASLGDDhLICVIEDAASGRIIATGSVFVERKFIRN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723578244 119 CAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKNVDFYKKFGYSVSE 180
Cdd:PLN02706  82 CGKVGHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGYVRKE 143
PTZ00330 PTZ00330
acetyltransferase; Provisional
 45-180 7.16e-20

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 81.43  E-value: 7.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  45 LVLRPLCTADLNRgFFKVLGQLTETGVASPEQFIKTFEHMKRSGdyYVT-VVEDTNLGQIVATATLVIEHKFTHSCAKRG 123
Cdd:PTZ00330   7 LELRDLEEGDLGS-VLELLSHLTSAPALSQEELEQIAARRRLAG--VVTrVFVHSPTQRIVGTASLFVEPKFTRGGKCVG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 723578244 124 RIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKNVDFYKKFGYSVSE 180
Cdd:PTZ00330  84 HIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRACE 140
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 69-176 1.39e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.59  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244   69 TGVASPEQFIKTFEHMKRSGDYYVTVVEDtnlGQIVATATLVIEHKFTHscakRGRIEDVVVSRECRGKQLGKLLTSTLT 148
Cdd:pfam00583  13 PEPWPDEPLDLLEDWDEDASEGFFVAEED---GELVGFASLSIIDDEPP----VGEIEGLAVAPEYRGKGIGTALLQALL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 723578244  149 LLSKRLNCYKITLECLPKN---VDFYKKFGY 176
Cdd:pfam00583  86 EWARERGCERIFLEVAADNlaaIALYEKLGF 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 76-182 5.51e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 49.61  E-value: 5.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  76 QFIKTFEHMKRSGDYYVtVVEDtnlGQIVATATLVIehkfthSCAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLN 155
Cdd:COG1246   16 ELIRPYALEEEIGEFWV-AEED---GEIVGCAALHP------LDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELG 85

                         90       100
                 ....*....|....*....|....*..
gi 723578244 156 CYKITLECLPKNVDFYKKFGYSVSEEN 182
Cdd:COG1246   86 LKRLFLLTTSAAIHFYEKLGFEEIDKE 112
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
101-184 3.82e-07

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 47.10  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244 101 GQIVATATLVIEHkfthscAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKNVDFYKKFGYSVSE 180
Cdd:COG2153   43 GELVATARLLPPG------DGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVG 116


                 ....
gi 723578244 181 ENYM 184
Cdd:COG2153  117 EEFL 120
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
73-181 1.55e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 45.85  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  73 SPEQFIKTFEHMKRSGDYYVTVV--EDtnlGQIVATATLVIEHKFTHSCAkrGRIEDVVVSRECRGKQLGKLLTSTLTLL 150
Cdd:COG3153   21 GPGREAELVDRLREDPAAGLSLVaeDD---GEIVGHVALSPVDIDGEGPA--LLLGPLAVDPEYRGQGIGRALMRAALEA 95

                         90       100       110
                 ....*....|....*....|....*....|.
gi 723578244 151 SKRLNCYKITLECLPKNVDFYKKFGYSVSEE 181
Cdd:COG3153   96 ARERGARAVVLLGDPSLLPFYERFGFRPAGE 126
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 89-178 3.35e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.60  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244   89 DYYVTVVEDTnlGQIVATATLVIEHKFTHSCakrgrIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKNV 168
Cdd:pfam13508   2 GGRFFVAEDD--GKIVGFAALLPLDDEGALA-----ELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAA 74

                          90
                  ....*....|
gi 723578244  169 DFYKKFGYSV 178
Cdd:pfam13508  75 AFYEKLGFEE 84
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
68-181 1.13e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.44  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  68 ETGVASPEQFIKTFEHMKRSGDYYVTVVEDtnlGQIVATATLvieHKFTHSCAKRGRIED-VVVSRECRGKQLGKLLTST 146
Cdd:COG1247   31 ETEPPSEEEREAWFAAILAPGRPVLVAEED---GEVVGFASL---GPFRPRPAYRGTAEEsIYVDPDARGRGIGRALLEA 104

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 723578244 147 LTLLSKRLNCYKITLECLPKN---VDFYKKFGYSVSEE 181
Cdd:COG1247  105 LIERARARGYRRLVAVVLADNeasIALYEKLGFEEVGT 142
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 115-185 1.33e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 41.95  E-value: 1.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723578244 115 FTHSCAKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRLNCYKITLECLPKN---VDFYKKFGYSVSEENYMF 185
Cdd:COG0456    6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNeaaIALYEKLGFEEVGERPNY 79
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 75-181 5.39e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 41.19  E-value: 5.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244  75 EQFIKTFEHMKRSGDYYVTVVEDTNlGQIVATATLVIEHKfthscaKRGRIEDVVVSRECRGKQLGKLLTSTLTLLSKRL 154
Cdd:COG0454   18 EALDAELKAMEGSLAGAEFIAVDDK-GEPIGFAGLRRLDD------KVLELKRLYVLPEYRGKGIGKALLEALLEWARER 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 723578244 155 NCYKITLECL---PKNVDFYKKFGYSVSEE 181
Cdd:COG0454   91 GCTALELDTLdgnPAAIRFYERLGFKEIER 120
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 62-186 8.04e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 38.02  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723578244   62 VLGQLTETGVASPEQFI--KTFEHMKRSGDYYVTVVEDTnlGQIVATATLviehkfthscAKRGRIEDVVVSRECRGKQL 139
Cdd:pfam13673   1 EAPDYSEEGIETFYEFIspEALRERIDQGEYFFFVAFEG--GQIVGVIAL----------RDRGHISLLFVDPDYQGQGI 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 723578244  140 GKL--LTSTLTLLSKRLNCYKITLECLPKNVDFYKKFGYSVSEENYMFQ 186
Cdd:pfam13673  69 GKAllEAVEDYAEKDGIKLSELTVNASPYAVPFYEKLGFRATGPEQEFN 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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