|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
19-471 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 753.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRWTKIGRLMPWMLACTPF 98
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 99 TVVSYFFMWYLPPFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQIV 178
Cdd:cd17452 81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 179 ASAhvshhctvtppvnttdswhdtpsfpdpsdplshqakvYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRAIPF 258
Cdd:cd17452 161 ASA-------------------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 259 CKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCAAC 338
Cdd:cd17452 204 FKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAAC 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 339 GISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNPHGKGHETIFYSSYVFFTKM*AGIGL 418
Cdd:cd17452 284 GISWMIPFAIMLVTIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIAL 363
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 723552636 419 GISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:cd17452 364 GISTLSLEFAGYETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
21-471 |
4.36e-88 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 276.88 E-value: 4.36e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 21 CYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRwTKIGRLMPWMLACTPFTV 100
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 101 VSYFFMWYLPPF-VSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQIVA 179
Cdd:pfam13347 80 VSFILLFTPPELgRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 180 sahvshhctvtppvnttdswhdtpsfpdPSDPLSHQAKVYMIAAGVIGGVYLLGIVILFLGVKEKD---DPYALNSDRAI 256
Cdd:pfam13347 160 ----------------------------ILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVsmrSKEDTGQKEAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 257 PFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCA 336
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 337 -ACGISWMIPFAVMLVTIP--NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNphGKGHETIFYSSYVFFTKM* 413
Cdd:pfam13347 292 yILGALITIAGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRT--GKRREGTFFAMWSFISKLA 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 723552636 414 AGIGLGISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-485 |
2.42e-75 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 244.04 E-value: 2.42e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 13 RLSICSKLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFfISKSRWTKIGRLMPWM 92
Cdd:COG2211 6 KLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGA-LSDRTRTRWGRRRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 93 LACTPFTVVSYFFMWYLPPF-VSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGA 171
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDLsPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 172 ALQGQIVASAHvshhctvtppvnttdswhdtpsfpdpsdplSHQAKVYMIAAGVIGGVYLLGIVILFLGVKEKDDPyaln 251
Cdd:COG2211 165 VLPPPLVAAFG------------------------------GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP---- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 252 SDRAIPFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADL-RNHFQYLVVTILVSAAVSIPFWQKFLQR 330
Cdd:COG2211 211 EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 331 FGKK--CAACGISWMIPFAVMLVTIP-NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQnpHGKGHETIFYSSYV 407
Cdd:COG2211 291 FGKKkaFIIGLLLAALGLLLLFFLGPgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWK--TGRRREGLYFGIFT 368
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 723552636 408 FFTKM*AGIGLGISAAGLEFTGYKPGIcRQSNDVILTLKILIGAVPAILILVGLFILLFYPITEESRKETNLALEVLR 485
Cdd:COG2211 369 FAIKLGQALAGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARR 445
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
19-476 |
6.29e-32 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 127.37 E-value: 6.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFI--SKSRWtkiGRLMPWML-AC 95
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVdrTRTRW---GKFRPWLLiGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 96 TPFTVVSYFFMWYLPPFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMtmevlgtlIGAALQG 175
Cdd:TIGR00792 78 IPFSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 176 QIVASAhvshhctVTPPVNttdswhdtpSFPDPSDPLshqakVYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRA 255
Cdd:TIGR00792 150 LLVAVI-------VLPLVS---------YFGGGDDKF-----GWFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 256 IPFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKK- 334
Cdd:TIGR00792 209 LSLKQIFKALFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKi 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 335 -CAACGISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNphGKGHETIFYSSYVFFTKM* 413
Cdd:TIGR00792 289 lFAGGILLMVLGYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKT--GIRAEGLVYSVRTFVRKLG 366
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723552636 414 AGIGLGISAAGLEFTGYKPGIcRQSNDVILTLKILIGAVPAILILVGLFILL-FYPITEESRKE 476
Cdd:TIGR00792 367 QALAGFFVGLILGIIGYVANA-AQSPITLNGIKILMFAVPALFLLLAAIIIGrFYKLTEKKHAE 429
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
13-485 |
4.83e-22 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 98.64 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 13 RLSICSKLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRwTKIGRLMPWM 92
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQFRPYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 93 L-ACTPFTVVSyFFMWYLPPF-VSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIG 170
Cdd:PRK09669 84 LwFAIPFGVVC-LLTFYTPDFgATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 171 AalqgqIVASAHVSHhctvtppVNTTDswhdtpsfpdpsdplshQAKVYMIAAGVIGgvyLLGIVILFLGVKEKDDPYAL 250
Cdd:PRK09669 163 S-----VIALPLVDI-------LGKGD-----------------EQKGYFYAMMVMG---LLGVVLFFCCFFMTKERYTP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 251 NSDRAIPFCKGLGLTMKHGPY-VKFTASFLLIsTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQ 329
Cdd:PRK09669 211 EVDNSSSVWKDLKLLLGNSQWrIMFIFNVVLL-TAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 330 RFGKkcaACGISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLL------LPWSMLPDVVDnfRLQNPHGKGHETIFY 403
Cdd:PRK09669 290 KFDR---VRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILFNFIqnlttpLQWSMFSDVVD--YEEKRSGRRLDGLVF 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 404 SSYVFFTKM*aGIGLGISAAG--LEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITeeSRKETNLAL 481
Cdd:PRK09669 365 STNLFAIKL--GLAIGGAVVGwiLAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLN--DARVEAIAQ 440
|
....
gi 723552636 482 EVLR 485
Cdd:PRK09669 441 ELVK 444
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
19-471 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 753.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRWTKIGRLMPWMLACTPF 98
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 99 TVVSYFFMWYLPPFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQIV 178
Cdd:cd17452 81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 179 ASAhvshhctvtppvnttdswhdtpsfpdpsdplshqakvYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRAIPF 258
Cdd:cd17452 161 ASA-------------------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 259 CKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCAAC 338
Cdd:cd17452 204 FKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAAC 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 339 GISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNPHGKGHETIFYSSYVFFTKM*AGIGL 418
Cdd:cd17452 284 GISWMIPFAIMLVTIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIAL 363
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 723552636 419 GISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:cd17452 364 GISTLSLEFAGYETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
19-471 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 578.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRWTKIGRLMPWMLACTPF 98
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 99 TVVSYFFMWYLPPFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQIV 178
Cdd:cd17392 81 IILAYFFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 179 ASAHVSHHCTVTppvnttdswhDTPSFPD-PSDPLSHQAKVYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRAIP 257
Cdd:cd17392 161 GVAHRPRRQDCT----------ATPGTSDhPVTVLPNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASGPGLS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 258 FCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCA- 336
Cdd:cd17392 231 YLAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTs 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 337 ACGISWMIPFAVMLVTIP-NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNPHGKGHETIFYSSYVFFTKM*AG 415
Cdd:cd17392 311 FIGISAMVPFLILLALVPsNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGG 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 723552636 416 IGLGISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:cd17392 391 LSLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAPVPICLILAGLVLFYVYPINE 446
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
19-471 |
2.75e-177 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 504.35 E-value: 2.75e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRWTKIGRLMPWMLACTPF 98
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 99 TVVSYFFMWYLPPFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQIV 178
Cdd:cd17451 81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 179 ASAhvshhctvtppvnttdswhdtpsfpdpsdplshqakVYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRAIPF 258
Cdd:cd17451 161 GMA------------------------------------AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 259 CKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCAA- 337
Cdd:cd17451 205 FKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVy 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 338 CGISWMIPFAVMLVTIP-NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNPHGKGHETIFYSSYVFFTKM*AGI 416
Cdd:cd17451 285 IGISSAVPFLILVVLVEsNLIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGV 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 723552636 417 GLGISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:cd17451 365 SLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
21-471 |
4.36e-88 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 276.88 E-value: 4.36e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 21 CYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRwTKIGRLMPWMLACTPFTV 100
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 101 VSYFFMWYLPPF-VSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQIVA 179
Cdd:pfam13347 80 VSFILLFTPPELgRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 180 sahvshhctvtppvnttdswhdtpsfpdPSDPLSHQAKVYMIAAGVIGGVYLLGIVILFLGVKEKD---DPYALNSDRAI 256
Cdd:pfam13347 160 ----------------------------ILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVsmrSKEDTGQKEAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 257 PFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCA 336
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 337 -ACGISWMIPFAVMLVTIP--NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNphGKGHETIFYSSYVFFTKM* 413
Cdd:pfam13347 292 yILGALITIAGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRT--GKRREGTFFAMWSFISKLA 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 723552636 414 AGIGLGISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
19-471 |
2.93e-79 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 253.68 E-value: 2.93e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRWTKiGRLMPWMLACTPF 98
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRW-GRFRPWLLWGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 99 TVVSYFFMWYLPPFV-SGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGAALQGQI 177
Cdd:cd17332 80 LALLFVLLFTTPDGSgTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 178 VAsahvshhctvtppvnttdswhdtpSFPDPSdplshQAKVYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRAIP 257
Cdd:cd17332 160 VA------------------------YFGGGN-----ASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 258 FcKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKKCA- 336
Cdd:cd17332 211 L-KSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAf 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 337 ACGISWMIPFAVMLVTIP--NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQnpHGKGHETIFYSSYVFFTKM*A 414
Cdd:cd17332 290 FIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELK--TGKRREGIFYSVMTFFRKLGL 367
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 723552636 415 GIGLGISAAGLEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITE 471
Cdd:cd17332 368 ALAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-485 |
2.42e-75 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 244.04 E-value: 2.42e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 13 RLSICSKLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFfISKSRWTKIGRLMPWM 92
Cdd:COG2211 6 KLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGA-LSDRTRTRWGRRRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 93 LACTPFTVVSYFFMWYLPPF-VSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGA 171
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDLsPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 172 ALQGQIVASAHvshhctvtppvnttdswhdtpsfpdpsdplSHQAKVYMIAAGVIGGVYLLGIVILFLGVKEKDDPyaln 251
Cdd:COG2211 165 VLPPPLVAAFG------------------------------GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP---- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 252 SDRAIPFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADL-RNHFQYLVVTILVSAAVSIPFWQKFLQR 330
Cdd:COG2211 211 EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 331 FGKK--CAACGISWMIPFAVMLVTIP-NLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQnpHGKGHETIFYSSYV 407
Cdd:COG2211 291 FGKKkaFIIGLLLAALGLLLLFFLGPgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWK--TGRRREGLYFGIFT 368
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 723552636 408 FFTKM*AGIGLGISAAGLEFTGYKPGIcRQSNDVILTLKILIGAVPAILILVGLFILLFYPITEESRKETNLALEVLR 485
Cdd:COG2211 369 FAIKLGQALAGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARR 445
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
19-476 |
6.29e-32 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 127.37 E-value: 6.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 19 KLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFI--SKSRWtkiGRLMPWML-AC 95
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVdrTRTRW---GKFRPWLLiGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 96 TPFTVVSYFFMWYLPPFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMtmevlgtlIGAALQG 175
Cdd:TIGR00792 78 IPFSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 176 QIVASAhvshhctVTPPVNttdswhdtpSFPDPSDPLshqakVYMIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRA 255
Cdd:TIGR00792 150 LLVAVI-------VLPLVS---------YFGGGDDKF-----GWFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 256 IPFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQRFGKK- 334
Cdd:TIGR00792 209 LSLKQIFKALFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKi 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 335 -CAACGISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNphGKGHETIFYSSYVFFTKM* 413
Cdd:TIGR00792 289 lFAGGILLMVLGYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKT--GIRAEGLVYSVRTFVRKLG 366
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723552636 414 AGIGLGISAAGLEFTGYKPGIcRQSNDVILTLKILIGAVPAILILVGLFILL-FYPITEESRKE 476
Cdd:TIGR00792 367 QALAGFFVGLILGIIGYVANA-AQSPITLNGIKILMFAVPALFLLLAAIIIGrFYKLTEKKHAE 429
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
13-485 |
4.83e-22 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 98.64 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 13 RLSICSKLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRwTKIGRLMPWM 92
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQFRPYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 93 L-ACTPFTVVSyFFMWYLPPF-VSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIG 170
Cdd:PRK09669 84 LwFAIPFGVVC-LLTFYTPDFgATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 171 AalqgqIVASAHVSHhctvtppVNTTDswhdtpsfpdpsdplshQAKVYMIAAGVIGgvyLLGIVILFLGVKEKDDPYAL 250
Cdd:PRK09669 163 S-----VIALPLVDI-------LGKGD-----------------EQKGYFYAMMVMG---LLGVVLFFCCFFMTKERYTP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 251 NSDRAIPFCKGLGLTMKHGPY-VKFTASFLLIsTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFLQ 329
Cdd:PRK09669 211 EVDNSSSVWKDLKLLLGNSQWrIMFIFNVVLL-TAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 330 RFGKkcaACGISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLL------LPWSMLPDVVDnfRLQNPHGKGHETIFY 403
Cdd:PRK09669 290 KFDR---VRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILFNFIqnlttpLQWSMFSDVVD--YEEKRSGRRLDGLVF 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 404 SSYVFFTKM*aGIGLGISAAG--LEFTGYKPGICRQSNDVILTLKILIGAVPAILILVGLFILLFYPITeeSRKETNLAL 481
Cdd:PRK09669 365 STNLFAIKL--GLAIGGAVVGwiLAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLN--DARVEAIAQ 440
|
....
gi 723552636 482 EVLR 485
Cdd:PRK09669 441 ELVK 444
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
22-476 |
9.45e-15 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 76.36 E-value: 9.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 22 YAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRwTKIGRLMPWML-ACTPFTV 100
Cdd:PRK09848 13 YSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVN-TRWGKFRPFLLfGTAPLMI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 101 VSYFFMWyLPPFVS--GRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMtmevlgtlIGAALQGQIV 178
Cdd:PRK09848 92 FSVLVFW-VPTDWShsSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARG--------IAASLTFVCL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 179 AsahvshhCTVTPPVnttdswhdTPSFPDPSDPLSHQAKVYMIAAGVigGVYLlgivILFLGVKEkddpyalNSDRAIP- 257
Cdd:PRK09848 163 A-------FLIGPSI--------KNSSPEEMVSVYHFWTIVLAIAGM--VLYF----ICFKSTRE-------NVVRIVAq 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 258 --FCKGLGLTMKHGPYVKFTASFL--LIST----AVQLEQSNFVLfcthaADLRNHFQYLVVTILVSAAVSIPFWQKFLQ 329
Cdd:PRK09848 215 psLKISLQTLKRNRPLFMLCIGALcvLISTfavsASSLFYVRYVL-----NDTGLFTVLVLVQNLVGTVASAPLVPGMVA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 330 RFGKK---CAACGISWMIPFAVMLVTIPNLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRLQNphGKGHETIFYSSY 406
Cdd:PRK09848 290 RIGKKntfLIGALLGTCGYLLFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLT--GVRIEGLTYSLF 367
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 407 VFFTKM*AGIGLGISAAGLEFTGYKPGICrQSNDVILTLKILIGAVPAILILVGLFILLFYPITEESRKE 476
Cdd:PRK09848 368 SFTRKCGQAIGGSIPAFILGLSGYIANQV-QTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKE 436
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
14-486 |
5.97e-13 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 70.90 E-value: 5.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 14 LSICSKLCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKSRwTKIGRLMPWML 93
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTR-SRWGKFKPWIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 94 ACTPFTVVSYFFM---WYLPPfvSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIG 170
Cdd:PRK10429 82 IGTLANSVVLFLLfsaHLFEG--TAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 171 AALQGQIVasAHVSHhctvtppvnttdswhdtpsfpdpsdplSHQAKVYMIAAGVIGGVYLLGIVILFLGVKEKDDPYAL 250
Cdd:PRK10429 160 AGFTLPFV--NYVGG---------------------------GDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 251 NSDRA--IPFCKGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTILVSAAVSIPFWQKFL 328
Cdd:PRK10429 211 VSAEGshLTLKDIVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 329 QRFGKKCAACGISWMIPFAVMLvtipnLILAYFVAFVSGL--SIAASLL-----LPWS----MLPDVVD--NFRLqnphG 395
Cdd:PRK10429 291 KSLSRRILWAGASIFPVLSCGV-----LLLMGLAAPHNALliVIAGILLnigtaLFWVlqviMVADTVDygEYKL----G 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 396 KGHETIFYSSYVFFTKM*AGIGLGISAAGLEFTGYKPGIcRQSNDVILTLKILIGAVPAILILVGLFILL-FYPITEESR 474
Cdd:PRK10429 362 IRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNV-EQSAQTLLGMQFIMIGLPTLFFMITLVLYFrYYRLNGDFL 440
|
490
....*....|..
gi 723552636 475 KETNLALEVLRK 486
Cdd:PRK10429 441 RRIQIHLLDKYR 452
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-458 |
1.32e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 24 IGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISksrwtKIGRLmPWMLACTPFTVVSY 103
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD-----RFGRK-PVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 104 FFMwylppFVSGRVAWYLTFYCLFQALTTLFQVPYSALTMFLSTDqKERDSATAYRMTMEVLGTLIGAALQGQIVASAHV 183
Cdd:cd17329 80 ALL-----GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP-ENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 184 ShhctvtppvnttdswhdtpsfpdpsdplshqakVYMIAAgvigGVYLLGIVILFLGVKEkdDPYALNSDRAIPFCKGLG 263
Cdd:cd17329 154 L---------------------------------LFLAAA----VLFLLAALVLLFLLPE--TRPKRRAAEKTEILRGYK 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 264 LTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAADLRNHFQYLVVTI--LVSAAVSIPFwQKFLQRFGKKCA-ACGI 340
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALnaLLIVLLQFPV-ARLVERFRLRKIlMIGI 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 341 SWMIPFAVMLVTIPNliLAYFVAFVSGLSIAASLLLPwsMLPDVVDNfrLQNPHGKGhetifysSYVFFTKM*AGIG--L 418
Cdd:cd17329 274 LLFAIGFAVLAFANT--LAVLILAMIVLTLGEMLVFP--AVQTLVAA--LAPPDKRG-------SYMGFYALAWGLGraI 340
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 723552636 419 GISAAGLEFTGYKPGIcrqsndVILTLKILIGAVPAILIL 458
Cdd:cd17329 341 GPLVGGLLLDLLGPGL------PWLILAALGLIAAALLLG 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-385 |
2.91e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 23 AIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKsrwtkIGRLMPWMLACTPFTVVS 102
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-----FGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 103 YFFMWylppfvsgrvAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQ---KERDSATAYRMTMEVLGTLIGAALQGQIVA 179
Cdd:pfam07690 77 LLLLF----------ASSLWLLLVLRVLQGLGAGALFPAALALIADWfppEERGRALGLVSAGFGLGAALGPLLGGLLAS 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 180 SAhvshhctvtppvnttdSWHdtpsfpdpsdplshqakvymIAAGVIGGVYLLGIVILFLGVKEKDDPYALNSDRAIPFC 259
Cdd:pfam07690 147 LF----------------GWR--------------------AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 260 KGLGLTMKHGPYVKFTASFLLISTAVQLEQSNFVLFCTHAadlrnHFQYLVVTILVS-----AAVSIPFWQKFLQRFGKK 334
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-----GLSALLAGLLLGlggllGAIGRLLLGRLSDRLGRR 265
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 723552636 335 CA---ACGISWMIPFAVMLVT-IPNLILAYFVAFVSGLSIAASLLLPWSMLPDVV 385
Cdd:pfam07690 266 RRlllALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
|
| VKOR_2 |
cd12919 |
Vitamin K epoxide reductase family in bacteria; This family includes vitamin K epoxide ... |
69-154 |
3.84e-04 |
|
Vitamin K epoxide reductase family in bacteria; This family includes vitamin K epoxide reductase (VKOR) present only in bacteria. VKOR (also named VKORC1) is an integral membrane protein that catalyzes the reduction of vitamin K 2,3-epoxide and vitamin K to vitamin K hydroquinone, an essential co-factor subsequently used in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. All homologs of VKOR contain an active site CXXC motif, which is switched between reduced and disulfide-bonded states during the reaction cycle. In some bacterial homologs, the VKOR domain is fused with domains of the thioredoxin family of oxidoreductases which may function as redox partners in initiating the reduction cascade.
Pssm-ID: 240602 Cd Length: 169 Bit Score: 41.20 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 69 TDPIAGFFISKSRWtkigRLMPWM-----LACTPFTVVSYFFMWYLPPFVSgrvAWylTFYCLFQALTTLFQVPYS---- 139
Cdd:cd12919 75 LEILTGFMGGRARW----RTMPWMvllfgVLVIPLGLVSILLIIIQPILVG---AW--CTLCLISAAIMLLMIPLAvdev 145
|
90
....*....|....*.
gi 723552636 140 -ALTMFLSTDQKERDS 154
Cdd:cd12919 146 lAMLQFLKRVRRRGQS 161
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-182 |
3.41e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.85 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 20 LCYAIGGAPNQVAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFIskSRWTKIGRLMpwMLACTPFT 99
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLS--DRLGRRRKLV--LAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 100 VVSYFFMWYLPPfvsgrVAWYLTFYCLFQALTTLFQVPYSALTMFLsTDQKERDSATAYRMTMEVLGTLIGAALQGQIVA 179
Cdd:COG2271 259 ALALLLLALLPS-----PALAIALLFLAGFGLGGAFGLLWALAAEL-FPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
...
gi 723552636 180 SAH 182
Cdd:COG2271 333 ATG 335
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
39-420 |
6.83e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.76 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 39 FLQIYLLDIAhITPFHASLVLFIGKASGAVTDPIAGFFiSKSRWTKIGRLMPWMLACTPFTVVSYFFM----WYLPPFVS 114
Cdd:cd17313 21 YVPPILQTLG-LSHALIGFVWTLGPILGLFVQPLVGSL-SDRCNSRIGRRRPFILVGAPLAALGLILIpnaaDIGLALGD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 115 GRVAWYLTFYCLFQAL----TTLFQVPYSALtMFLSTDQKERDSATAYRMTMEVLGTLIGAALqgqivasahvshhctvt 190
Cdd:cd17313 99 GPRTWALVLFVLGIVLldfaMNVCQGPVRAL-LPDLVPPEQRSKANGIINFMGGLGGVLGYLL----------------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 191 PPVNTTDSWHdtpsfpdPSDPLSHQAKVYMIAAGVIggvyLLGIVILFLGVKEKDD-PYALNSDRAIPFCKGLGLTMKHG 269
Cdd:cd17313 161 GAILWDHNWF-------GFALGGNLKVPFYIGAIIL----LVCVLVTLFFVKEPPLsPEAGEHSENPSLGEVLKSLLKLL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 270 PYVKFTASFLLIST-----AVQLEQSNFVLFCT-----HAADLRNHFQY--------LVVTILVSAAVSIPFwQKFLQRF 331
Cdd:cd17313 230 KIMPRSLLRLLLVIffwwiAFFPFELFFTDYMGeevyhGTSAASSHYGAgvrmgawgLLIFSLAFLIFSLPI-GKLGKKI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 332 GKKcAACGISWMIPFAVMLVTI--PNLILAYFVAFVSGLSIAASLLLPWSMLPDVVDNFRlqnpHGKGHETIFYSSYVFF 409
Cdd:cd17313 309 GRK-KVYLIGLVLFAVGMALMAlvHNVTVALVLFALGGIGWATININPYPLVSDYHSESG----RGQGTDTGLLNLAISL 383
|
410
....*....|.
gi 723552636 410 TKM*AGIGLGI 420
Cdd:cd17313 384 AQILVSLLAGP 394
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
12-174 |
7.88e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.31 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 12 YRLSICSKLCYAIGGApnqvAGSAAAFFLQIYLLDIAHITPFHASLVLFIGKASGAVTDPIAGFFISKsrwtkIGRLMPW 91
Cdd:cd17502 166 LRTILLSSIFGFLFGG----ALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISK-----TGRYKPL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723552636 92 MLACTPFTVVSYFFMWYLPPFVSgrvAWYLTFYCLFQALTTLFQVPYSALTMFLSTDQKERDSATAYRMTMEVLGTLIGA 171
Cdd:cd17502 237 IVIGTILMSVGAGLLTTLTLDTS---KWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGV 313
|
...
gi 723552636 172 ALQ 174
Cdd:cd17502 314 AIT 316
|
|
| |
