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Conserved domains on  [gi|723146423|ref|XP_010290427|]
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PREDICTED: lactosylceramide alpha-2,3-sialyltransferase [Phaethon lepturus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 138-342 1.13e-152

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 428.39  E-value: 1.13e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 138 HCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPASLFVAVLFKSVD 217
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 218 FNWLQAMVKNETLPLWVRLFFWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPEPRSKFWGWDKNVPTIGVTAVVLAT 297
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 723146423 298 HLCDEVSLAGFGYDLDQPSTPLHYYNNLCMAAMNGQTMHNVTSET 342
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKET 205
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 80-186 9.19e-11

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23972:

Pssm-ID: 480271  Cd Length: 308  Bit Score: 62.15  E-value: 9.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  80 FAEKYSMDVSPFVRK---NINEDEALFKYEPPFGF----HKFFDKLKNLLE------LLPEHDLPEDwkskhCKRCVVVG 146
Cdd:cd23972   15 FRGLFNFDIPVLLWGqhfTPALWDRLSQRKVPYGWkglsHQVVASTLSLLNdsanakLFFPRDTPGK-----CIRCAVVG 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 723146423 147 SGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTT 186
Cdd:cd23972   90 NGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 138-342 1.13e-152

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 428.39  E-value: 1.13e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 138 HCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPASLFVAVLFKSVD 217
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 218 FNWLQAMVKNETLPLWVRLFFWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPEPRSKFWGWDKNVPTIGVTAVVLAT 297
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 723146423 298 HLCDEVSLAGFGYDLDQPSTPLHYYNNLCMAAMNGQTMHNVTSET 342
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKET 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 93-342 6.30e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 270.63  E-value: 6.30e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423   93 RKNINEDEALFKYEppfgFHKFFDKLKNLLELLPEhdlPEDWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDA 172
Cdd:pfam00777   4 KENFPLGEWIRYSE----WWLPFTVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  173 PVQGYTDHVGNKTTIRMTYPEGAPLS-------EHEYPPASLFVAVLFKSVDFNWLQAMVKNETLPL-WVRLFFWKEVae 244
Cdd:pfam00777  77 PTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV-- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  245 KIPFPSKQFRILNPVIIKETALDILQFPEPRSkfwgwdkNVPTIGVTAVVLATHLCDEVSLAGFGYDLDQPSTPLHYYNN 324
Cdd:pfam00777 155 KIPVDPDKVLFLHPDFLRYVANFWLRSHGLKG-------RRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDN 227

                         250
                  ....*....|....*...
gi 723146423  325 LCMAAMNGQTMHNVTSET 342
Cdd:pfam00777 228 VLMKKGGFYGVHDMPFEF 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 80-186 9.19e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 62.15  E-value: 9.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  80 FAEKYSMDVSPFVRK---NINEDEALFKYEPPFGF----HKFFDKLKNLLE------LLPEHDLPEDwkskhCKRCVVVG 146
Cdd:cd23972   15 FRGLFNFDIPVLLWGqhfTPALWDRLSQRKVPYGWkglsHQVVASTLSLLNdsanakLFFPRDTPGK-----CIRCAVVG 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 723146423 147 SGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTT 186
Cdd:cd23972   90 NGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 138-342 1.13e-152

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 428.39  E-value: 1.13e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 138 HCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPASLFVAVLFKSVD 217
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 218 FNWLQAMVKNETLPLWVRLFFWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPEPRSKFWGWDKNVPTIGVTAVVLAT 297
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 723146423 298 HLCDEVSLAGFGYDLDQPSTPLHYYNNLCMAAMNGQTMHNVTSET 342
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKET 205
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 139-342 2.22e-106

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 310.76  E-value: 2.22e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPASLFVAVLFKSVDF 218
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 219 NWLQAMVKNETLPLWVrlFFWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPEPRSKfwgwDKNVPTIGVTAVVLATH 298
Cdd:cd23967   82 LWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNGKQ----GKNVPTTGIIAIVMALH 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 723146423 299 LCDEVSLAGFGYDLDQPSTPLHYYNNLCMAAMNGQTMHNVTSET 342
Cdd:cd23967  156 YCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEK 199
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 93-342 6.30e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 270.63  E-value: 6.30e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423   93 RKNINEDEALFKYEppfgFHKFFDKLKNLLELLPEhdlPEDWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDA 172
Cdd:pfam00777   4 KENFPLGEWIRYSE----WWLPFTVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  173 PVQGYTDHVGNKTTIRMTYPEGAPLS-------EHEYPPASLFVAVLFKSVDFNWLQAMVKNETLPL-WVRLFFWKEVae 244
Cdd:pfam00777  77 PTKGYEKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV-- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  245 KIPFPSKQFRILNPVIIKETALDILQFPEPRSkfwgwdkNVPTIGVTAVVLATHLCDEVSLAGFGYDLDQPSTPLHYYNN 324
Cdd:pfam00777 155 KIPVDPDKVLFLHPDFLRYVANFWLRSHGLKG-------RRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDN 227

                         250
                  ....*....|....*...
gi 723146423  325 LCMAAMNGQTMHNVTSET 342
Cdd:pfam00777 228 VLMKKGGFYGVHDMPFEF 245
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 139-341 8.89e-67

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 209.91  E-value: 8.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGA---PLSEHEypPASLFVAVLFKS 215
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAqfdPGIEND--PDTLLVLVPFKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 216 VDFNWLQAMVKNETLplwVRLFFWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPEPRSKfwgwdKNVPTIGVTAVVL 295
Cdd:cd23982   80 LDFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRKK-----KQKPTTGLLAITL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 723146423 296 ATHLCDEVSLAGFGY-DLDQPSTPLHYYNNLCMAAMNGqTMHNVTSE 341
Cdd:cd23982  152 ALHLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSMAN-SGHNLNAE 197
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 139-341 1.52e-63

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 201.69  E-value: 1.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPASLFVAVLFKSVDF 218
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 219 NWLQAMVKNETlplwVRLF--FWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPEpRSKFWGwDKNVPTIGVTAVVLA 296
Cdd:cd23981   82 KWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPF-NNGLMG-RGNIPTLGSVAITMA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 723146423 297 THLCDEVSLAGFGYDLDQPSTPLHYYNNLCMAAMNGQTMHNVTSE 341
Cdd:cd23981  156 LHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQRE 200
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 139-341 5.08e-60

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 192.65  E-value: 5.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPASLFVAVLFKSVDF 218
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 219 NWLQAMVKNETlplwVRLF-FWKEVAEKIPFPSKQFRILNPVIIKETALDILQFPE--PRSKfwgwDKNVPTIGVTAVVL 295
Cdd:cd23984   82 RWLLDLLMGKK----VSAKgFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKrfPKEK----KPKHPTTGIIAITL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 723146423 296 ATHLCDEVSLAGFGYDLDQPSTPLHYYNNLCMAAMNGQTMHNVTSE 341
Cdd:cd23984  154 ALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAE 199
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 67-341 5.50e-35

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 129.68  E-value: 5.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  67 CRPSYVKK-EMGKLFAEKYSMDVSPFV-RKNINEDE--ALFKYEPPFGFHKF-FDKLKNLLELL--PEHDLPEDWKSKH- 138
Cdd:cd23964    1 CPSSLRKKlQKSPWFRERFIPDIKVLLdSEDFNPEEynRLSHYKLPFGWGGLnREVVERLLRNLnlTSSRYMFVLRGGRp 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 139 -CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYPPAS---LFVAVLFK 214
Cdd:cd23964   81 rCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 215 SVDFNWLQAMVKNETLPLWVRLFFWKEVAEKIPFPSKQFRILNPviiketalDILqfpepRSKFWGW----DKNVPTIGV 290
Cdd:cd23964  161 IRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRLLHP--------DFI-----RYLFNRWlnssTSYRPTTGA 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 723146423 291 TAVVLATHLCDEVSLAGFGYDldqPSTPLHYYNNLCMAAMNGQTMHNVTSE 341
Cdd:cd23964  228 LMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDFTNE 275
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 142-332 4.79e-33

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 121.70  E-value: 4.79e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 142 CVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRM-------TYPEGAPLSEHEYPPASLFVAVLFK 214
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVlnskwagFYLRGPRCGCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 215 SvdfnwlqamvknetlplWVRLFFWKEVAEKIPFPSkqfrilnPVIIKETALDILQ-----FPEPRSKFWGwDKNVPTIG 289
Cdd:cd19952   81 A-----------------AAADFKRLKRRKKRHDNA-------VLLLTDPAPDLLSyvrkrLEKLGLKSFF-GGNAPSSG 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 723146423 290 VTAVVLATHLCDEVSLAGFGYD-LDQPSTPLHYYNNLCMAAMNG 332
Cdd:cd19952  136 LLAVLLALQLCDSVDLYGFGVDsGHAPKVPYHYYDLVEAEEGTA 179
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 67-311 6.01e-33

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 123.93  E-value: 6.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  67 CRPSYVKKEMGKLFAEKYSMDVSPF-VRKNINEDEALFKY---EPPFGFHKFFDKLKNLLELLPEHDLPEDWKSKHCKRC 142
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEPLlTRKNKELPPDVLKWwlsLQSSKNSDLREVLEKLFQVVPGENPYRTRDPNRCRRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 143 VVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEgaplSEHEYPPASLFVAVLFKSVDFNWLQ 222
Cdd:cd23966   81 AVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPE----SAVDLDPGVHLVLVPFKVLDLQWLI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 223 AMVKNETLplwvrLFFWKEVAEKIPFPSKQFRILNPVIIK---ETALdilqfpEPRSKFwgwdknvPTIGVTAVVLATHL 299
Cdd:cd23966  157 SALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKyvhDNWT------EHHGRY-------PSTGFLALIFALHI 218

                        250
                 ....*....|..
gi 723146423 300 CDEVSLAGFGYD 311
Cdd:cd23966  219 CDEVSVFGFGAD 230
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 80-311 1.14e-25

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 104.57  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  80 FAEKYSMDVSP-FVRKNINEDEALFKY----EPPFGFHKFFDKLKNLLELLPEHDLPEDWKSKHCKRCVVVGSGGILHGS 154
Cdd:cd23979   16 FDEHYDPDISPvWTKENMELPPDVQYWwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRRCAVVGNSGNLRGS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 155 ELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAplseHEYPPASLFVAVLFKSVDFNWLQAMVKNETLPlwv 234
Cdd:cd23979   96 GYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA----KNLPANVSFVLVPFKTLDLLWITSALSTGQIR--- 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 723146423 235 rlFFWKEVAEKIPFPSKQFRILNPVIIKETaldilqfpepRSKFWGWDKNVPTIGVTAVVLATHLCDEVSLAGFGYD 311
Cdd:cd23979  169 --FTYAPVKQFLRVDKDKVQIYNPAFFKYI----------HDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGAD 233
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 80-324 1.42e-21

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 93.02  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  80 FAEKYSMDVSPFV-RKNINEDEALFKYEPPFGFHK----FFDKLKNLLELLP-EHDLPEDWKSKHCKRCVVVGSGGILHG 153
Cdd:cd23980   16 FDERFNRS*QPLLtAQNAHLEEDTYKWWLRLQREKkpknLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 154 SELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEgaplSEHEYPPASLFVAVLFKSVDFNWLQAMVKNETLPlw 233
Cdd:cd23980   96 SYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE----SFRELAQNVSMILVPFKTLDLEWVISATTTGTIS-- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 234 vrlFFWKEVAEKIPFPSKQFRILNPVIIKETaldilqfpeprskFWGWDKN---VPTIGVTAVVLATHLCDEVSLAGFGy 310
Cdd:cd23980  170 ---HTYVPVPRKIKVKKEKILIYHPAFIKYV-------------FDRWLQGhgrYPSTGILSVIFSLHVCDEVDLYGFG- 232

                        250
                 ....*....|....
gi 723146423 311 dLDQPSTPLHYYNN 324
Cdd:cd23980  233 -ADSKGNWHHYWEN 245
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 114-341 8.70e-21

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 90.79  E-value: 8.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 114 FFDKLKNLLELLPEHDLPEdwkSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPE 193
Cdd:cd23968   23 PFKDLLSLRYPFPESSLEN---TKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 194 gaplseheyppaslfvaVLFKSVDFNWLQAMVKNETLPLW------VRLFFWKEVAEKIPFPS-KQFRILNPviikETAL 266
Cdd:cd23968  100 -----------------ILSKPEFNFLTDPLYRNVTLLVWdpssynVNLEKWYKKPDFDFFPNyIKYRRRHP----EEPF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 267 DILQfpePRS--KFWGW---------DKNVPTIGVTAVVLATHLCDEVSLAGFgydldQPS---TPL-HYYNNLCMAAMN 331
Cdd:cd23968  159 YLID---PRFlwRLWDIlqeytpekiKPNPPSSGFIGIVLMLHLCDWVDVYEY-----VPSvrqTDRcHYYDVEKDLACT 230

                        250
                 ....*....|
gi 723146423 332 GQTMHNVTSE 341
Cdd:cd23968  231 LGAWHPLAAE 240
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 81-341 2.86e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 89.24  E-value: 2.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  81 AEKYSMDVSPFVRKNINEDealFKYEPPFGFHKFFDKL-KNLLELLPEHDLpedWKSKHCKRCVVVGSGGILHGSELGRL 159
Cdd:cd23963   10 LERLLNTRKLFLTQKNTPL---GDVLYYSYFKKKTFKItKSLYELLPKTSP---FSHKRYKTCAVVGNSGILLGSGCGKE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 160 LNQFDIVIRLNDAPVQGYTDHVGNKT--------TIRMTYpegaplseheyppaSLFVAVLFKSVDFNWLQAMvkNETLp 231
Cdd:cd23963   84 IDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRY--------------NSLKKNRDRDKFLNRLKEY--NGSI- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 232 LWVRLFFWKEVAEKIpFPSKQFRILNPVIIKeTALDILQFPEPRSKFWGWDKN--VPTIGVTAVVLATHLCDEVSLAGF- 308
Cdd:cd23963  147 LWYPKFSFKSSTNLL-LKAARALKKNGLNLT-VVYSNPEHFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFw 224

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 723146423 309 GYDLDQPSTPL--HYYNNlcMAAMNGQTMHNVTSE 341
Cdd:cd23963  225 PFPTDPNGRPVpyHYYDD--LSPSTKNKVHNMPEE 257
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 80-323 1.07e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 85.57  E-value: 1.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  80 FAEKYSMDVSPFVRK---NINEDEALFKYEPPFGFHKF-FDKLKNLLELLPEhdLPEDW-------KSKHCKRCVVVGSG 148
Cdd:cd23973   15 FKKLFLPNITLFLDKdhfNMSEWDRLEHFNPPFGFMGLnYTLVKEVVELIPK--PKEQQllalsppGGDGCIRCAVVGNG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 149 GILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTI-----------RMTYPE----GAPLSEHeyppaSLFVAVLF 213
Cdd:cd23973   93 GILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFyvhtahsitssLMILQKrgfkNIPQDKD-----IKYILFPE 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 214 KSVDFNWLQAMVKNETLPlwvRLFFWKEVAEKI---PFPSKQFRILNPVIIKETALDILQFPEPRSKFWGWDKnvPTIGV 290
Cdd:cd23973  168 GPRDYQWLEALLKNKTIP---SGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR--PTTGA 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 723146423 291 TAVVLATHLCDEVSLAGFGYDlDQPSTPLHYYN 323
Cdd:cd23973  243 FLLLTALHLCDTVSAYGFITE-DYRKYPDHYYD 274
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 92-325 2.49e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 83.84  E-value: 2.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  92 VRKNI------NEDEALFK--YEPPFGFHKFFDK------LKNLLELLPEhdlPEDWKSKHCKRCVVVGSGGILHGSELG 157
Cdd:cd23987    6 IRKQIlkfldaERDISVLKgtLKPGDVIHYVFDRdstmniSQNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 158 RLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPegaplseheyppaSLFVAVLFKSVDFNWLQAMVK-----NETLpL 232
Cdd:cd23987   83 REIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-------------SVVQRAFEDLVNETWKEKFLQrlqslNGSI-L 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 233 WVRLFFWKEVAEKIPFpskqfriLNPVIIK-----ETALDILQFPEPRSKFWGWDK---NVPTIGVTAVVLATHLCDEVS 304
Cdd:cd23987  149 WIPAFMAKGGEERVEW-------VNDLILKhhinvRTAYPSLRLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIH 221

                        250       260
                 ....*....|....*....|....
gi 723146423 305 LAG---FGYDLDQPSTPLHYYNNL 325
Cdd:cd23987  222 LYGfwpFPRDQNQNPVKYHYYDSL 245
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 125-322 5.97e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 82.45  E-value: 5.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 125 LPEHDLPEDWKskHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIR------MTYPEGAPLS 198
Cdd:cd23985   33 LPKKSLREEVG--PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKFLK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 199 EHEYPPASLFVavlfksvdfnWLQAmVKNETLPLWVRL----FFWKEVAEKIPFPSKQFRILNPV-------IIKETALD 267
Cdd:cd23985  111 DSLYNEGILIV----------WDPA-PYHSDIPEWYKNpdynFFENYKTYRRLNPNQPFYILHPQmqwelwdIIQENSPE 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 723146423 268 ILQfpeprskfwgwdKNVPTIGVTAVVLATHLCDEVSLAGFgydldQPS---TPL-HYY 322
Cdd:cd23985  180 EIQ------------PNPPSSGMLGIILMMTLCDQVDVYEF-----LPSkrkTDVcHYY 221
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 103-332 2.16e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 81.31  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 103 FKYEppFGFHKFFDKLKNLLELLPEHDlPedWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVG 182
Cdd:cd23969   33 MHYE--IDRHKTVNITQDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 183 NKTTIRMTYPegaPLSEHEYppaSLFVavlFKSVDFNWLQAMVKNETLPLWVRLFFWKEVAEKIpfpskqfRILNPVIIK 262
Cdd:cd23969  108 TKSNLTTMNP---SVIPHAY---GDLV---NATDKEKFVERLRQLGDSILWIPAFVSKGGEEHV-------QWTNEIILK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 263 ETALDILQFPEPR-----SKFWGWDK---NVPTIGVTAVVLATHLCDEVSLAGF-GYDLDQPSTPL--HYYNNLCMAAMN 331
Cdd:cd23969  172 HKLNVKTAYPPLRlnhaiRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGFyPFSEDGNGRAVkyHYYDNRKYLTTA 251


                 .
gi 723146423 332 G 332
Cdd:cd23969  252 R 252
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 139-322 1.44e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 74.97  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMtypegaplseheyppaslfvaVLFKSVDF 218
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRV---------------------VSHSSLPR 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 219 NWLQAMVKNETLPLWVRLFFW-------KEVAEKIP--------FPSKQFRILNPVII--------KETALDILQfpepr 275
Cdd:cd23965   60 LLRNAILLLAGTRAPTVVVFWgpetkmnKDGAGKYNllrslskkYPDVEFYSLTPEKMdyadelfeKETGKSRIK----- 134

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 723146423 276 SKFW---GWdknvptigvTAVVLATHLCDEVSLAGF---GYDLDQP--STPLHYY 322
Cdd:cd23965  135 SGTWlstGW---------FTMLLALDVCDEIKVYGMvpeNYCREHPnsKVPYHYY 180
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 119-325 3.34e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 74.99  E-value: 3.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 119 KNLLELLPEhdlPEDWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPE----- 193
Cdd:cd23988   47 QNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqra 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 194 -GAPLSEHEYPPASLFVAVLFKSVdfnwlqamvknetlpLWVRLFFWKEvaekipfPSKQFRILNPVIIK-----ETALD 267
Cdd:cd23988  124 fGGFRNESDREKFVHRLSMLNDSV---------------LWIPAFMVKG-------GEKHVEWVNALILKnklkvRTAYP 181

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723146423 268 ILQFPEPRSKFWGWDK---NVPTIGVTAVVLATHLCDEVSLAGF-GYDLDQPSTPL--HYYNNL 325
Cdd:cd23988  182 SLRLIHAVRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGFwPFPKDANGNPVkyHYYDDL 245
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 120-325 7.95e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 70.89  E-value: 7.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 120 NLLELLPEHDLpedWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPegaplSE 199
Cdd:cd23970   52 NLRSLLPEVSP---FQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 200 HEYppaslFVAVLFKSVDFN-WLQAMVKNETLPLWVRLFFWKEVAekipfpsKQFRILNPVIIKETALDILQFPEPR--- 275
Cdd:cd23970  124 LEK-----YYNNLLTIQDRNnFFLSLKKLDGAILWIPAFFFHTSA-------TVTRTLVDFFVEHRGQLKVQLAWPGnim 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 276 ---SKFWgWDKNVP----TIGVTAVVLATHLCDEVSLAGF---GYDLDQPSTPLHYYNNL 325
Cdd:cd23970  192 qhvNRYW-KTKHLSpkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKK 250
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 119-324 1.87e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 69.59  E-value: 1.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 119 KNLLELLPEhDLPedWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQgYTDHVGNKT----------TIR 188
Cdd:cd23971   47 EKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTnlvtanpsilREK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 189 MTYPEGAPL----SEHEYPPASLfvavlfksvdfnWLQAMVKNETLPLWVRLFFWKEvaekiPFPSKQFRI-LNPviike 263
Cdd:cd23971  123 FHNLKKRRRpfveRMKVYGNALL------------LLPAFSYTSNTEPSLRALYTLE-----DFGSPQKVLfFNP----- 180

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 723146423 264 taldilQFPEPRSKFW---GWDKNVPTIGVTAVVLATHLCDEVSLAGF---GYDLDQPSTPLHYYNN 324
Cdd:cd23971  181 ------EYLRNLSRYWkskGLKARRLSTGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDN 241
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 106-322 8.94e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 67.94  E-value: 8.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 106 EPPF---GFHKFFDKLKnlLELLPEHDLpedwkskhcKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVG 182
Cdd:cd23986   24 EAPFsalGWEKYVPKIP--LSKLHLRGF---------RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 183 NKTTIRMTYPEGAPLSEHEYPPASLFVAVLfksvdfnwlqaMVKNETLPLWVRLFFWKE----------VAEKIPFPSKQ 252
Cdd:cd23986   93 NKTTIRIINSQILTNPNHHFIDSSLYKDVI-----------LVAWDPAPYSANLHKWYKkpdynlftpyVQYRKRNPNQP 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 723146423 253 FRILNPV-------IIKETALDILQfPEPrskfwgwdknvPTIGVTAVVLATHLCDEVSLAGFGYDLDQpsTPL-HYY 322
Cdd:cd23986  162 FYILHPKfiwqlwdIIQENTQEKIQ-PNP-----------PSSGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYH 225
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 115-324 6.12e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 65.54  E-value: 6.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 115 FDKLKNLLELLPEH------DLPEDW-KSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTI 187
Cdd:cd23974   53 WDVLKDALNLLNSSangqmfDWWDRPnGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 188 RMTYPEGAPLSEHEY-------PPASLFVAVLF---KSVDFNWLQAMVKNETL---------PlwvRLFFWKEV-AEKip 247
Cdd:cd23974  133 YTFSTNTLMNSLRAYagvgfngPPQSKETRYIFlpdHDRDYLLVKAALTHTPIdrgrdkskrP---SKYFGKDVtAEK-- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 248 fpskqFRILNPVIIKETALDILQFPEPRSKFwgWDKNVPTIGVTAVVLATHLCDEVSLAGF---GYDL------DQPSTP 318
Cdd:cd23974  208 -----FKIYHPDFIRYLRNRFLWSPILNTKQ--RDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKysdhyyDKTYHK 280


                 ....*.
gi 723146423 319 LHYYNN 324
Cdd:cd23974  281 VVFYAN 286
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 138-322 8.79e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 64.50  E-value: 8.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 138 HCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPL---SEHEYPPASLFVAVLF- 213
Cdd:cd23976   14 HCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRilrNRNELLNVSQGTVFIFw 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 214 ----------KSVDFNWLQAMvkNETLPLwvrlffwkevaekipfpskqfriLNPVIIkeTALDILQFPEPRSKFWGWDK 283
Cdd:cd23976   94 gpsnymrrdgKGLVYNNLQLM--NQILPK-----------------------LKVYTI--TRHKMLQFDELFKRETGKDR 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 723146423 284 NVP----TIGVTAVVLATHLCDEVSLAG-----FGYDLDQPSTPLHYY 322
Cdd:cd23976  147 KISntwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYY 194
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 139-203 7.49e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.42  E-value: 7.49e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPLSEHEYP 203
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQG 65
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 80-186 9.19e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 62.15  E-value: 9.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423  80 FAEKYSMDVSPFVRK---NINEDEALFKYEPPFGF----HKFFDKLKNLLE------LLPEHDLPEDwkskhCKRCVVVG 146
Cdd:cd23972   15 FRGLFNFDIPVLLWGqhfTPALWDRLSQRKVPYGWkglsHQVVASTLSLLNdsanakLFFPRDTPGK-----CIRCAVVG 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 723146423 147 SGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTT 186
Cdd:cd23972   90 NGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 139-189 1.04e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 61.02  E-value: 1.04e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRM 189
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 119-325 5.90e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 56.30  E-value: 5.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 119 KNLLELLPEHdlpEDWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQG-YTDHVGNKTTIRMTYPEgapL 197
Cdd:cd23991   47 ENIFRMFPKS---QPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPS---I 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 198 SEHEYppaslfvAVLFKSVDFNWLQAMVKNETLPLWVRLFFWKEVAEKI-------PFPSKQFRI-LNPVIIKETAldil 269
Cdd:cd23991  121 ISIKY-------AKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFkvyytleDFKAKQKVIfFHPIYLKHLA---- 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723146423 270 qfpeprsKFW---GWDKNVPTIGVTAVVLATHLCDEVSLAG---FGYDLDQPSTPLHYYNNL 325
Cdd:cd23991  190 -------QFWrskGVQVYRLSTGLMITSAALELCEEVKLYGfwpFSKNTEGKPISHHYYDNQ 244
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 140-325 6.21e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 53.30  E-value: 6.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 140 KRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPV-QGYTDHVGNKTTIRMTYPEgaplseheyppaslFVAVLFKSVDF 218
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPS--------------IIDKRFQNLLW 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 219 NwLQAMVknETLPLWVRLFFWKEVAEKIPFPSKQFRI---LNPVIIKETALdilqFPEPR-----SKFW---GWDKNVPT 287
Cdd:cd23989  130 S-RKSFV--ESMKVYGRSYIYMPAFSMKTGTDPSLRVyytLADVGANQTVL----FANPNflrnvGKFWkskGVHAKRLS 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 723146423 288 IGVTAVVLATHLCDEVSLAG---FGYDLDQPSTPLHYYNNL 325
Cdd:cd23989  203 TGLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV 243
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 139-197 1.98e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.47  E-value: 1.98e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 723146423 139 CKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPVQGYTDHVGNKTTIRMTYPEGAPL 197
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPL 59
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 121-325 7.11e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 47.14  E-value: 7.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 121 LLELLPEhDLPedWKSKHCKRCVVVGSGGILHGSELGRLLNQFDIVIRLNDAPV-QGYTDHVGNKTTIRMTYPE------ 193
Cdd:cd23990   49 IFKMFPK-DMP--YSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSiiterf 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723146423 194 ------GAPLSE--HEYPPASLFVAVLFKSvdfnwlqamvKNETLPLWVRLFFwkevaekIPFPSKQ-FRILNPviiket 264
Cdd:cd23990  126 hklekwRRPFYEvlQVYENASVVLPAFYNT----------RNTDVSIRVKYVL-------DDFESQQaVYYFHP------ 182

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 723146423 265 aldilQFPEPRSKFW---GWDKNVPTIGVTAVVLATHLCDEVSLAGF-GYDLDqPSTPL---HYYNNL 325
Cdd:cd23990  183 -----QYLLNVSRFWlrqGVRAKRISSGLMLVTAALELCEEVHLYGFwAFPMN-PSGIFithHYYDNV 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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