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Conserved domains on  [gi|719975267|ref|XP_010247101|]
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PREDICTED: uncharacterized protein At4g06598 isoform X3 [Nelumbo nucifera]

Protein Classification

bZIP transcription factor( domain architecture ID 10200285)

basic leucine zipper (bZIP) transcription factor binds to the promoter regions of genes to control their expression

CATH:  1.20.5.170
Gene Ontology:  GO:0046983|GO:0006355|GO:0003700|GO:0003677
PubMed:  23661758|7780801|11017199|23574941
SCOP:  4003836

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bZIP_plant_RF2 cd14703
Basic leucine zipper (bZIP) domain of Plant RF2-like transcription factors: a DNA-binding and ...
 182-227 1.24e-14

Basic leucine zipper (bZIP) domain of Plant RF2-like transcription factors: a DNA-binding and dimerization domain; This subfamily is composed of plant bZIP transciption factors with similarity to Oryza sativa RF2a and RF2b, which are important for plant development. They interact with, as homodimers or heterodimers with each other, and activate transcription from the RTBV (rice tungro bacilliform virus) promoter, which is regulated by sequence-specific DNA-binding proteins that bind to the essential cis element BoxII. RF2a and RF2b show differences in binding affinities to BoxII, expression patterns in different rice organs, and subcellular localization. Transgenic rice with increased RF2a and RF2b display increased resistance to rice tungro disease (RTD) with no impact on plant development. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


:

Pssm-ID: 269851 [Multi-domain]  Cd Length: 52  Bit Score: 66.06  E-value: 1.24e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 719975267 182 AKRHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHA 227
Cdd:cd14703    7 ANRQSAQRSRERKLQYISELERKVQTLQTEVATLSAQLALLEQEKA 52
 
Name Accession Description Interval E-value
bZIP_plant_RF2 cd14703
Basic leucine zipper (bZIP) domain of Plant RF2-like transcription factors: a DNA-binding and ...
 182-227 1.24e-14

Basic leucine zipper (bZIP) domain of Plant RF2-like transcription factors: a DNA-binding and dimerization domain; This subfamily is composed of plant bZIP transciption factors with similarity to Oryza sativa RF2a and RF2b, which are important for plant development. They interact with, as homodimers or heterodimers with each other, and activate transcription from the RTBV (rice tungro bacilliform virus) promoter, which is regulated by sequence-specific DNA-binding proteins that bind to the essential cis element BoxII. RF2a and RF2b show differences in binding affinities to BoxII, expression patterns in different rice organs, and subcellular localization. Transgenic rice with increased RF2a and RF2b display increased resistance to rice tungro disease (RTD) with no impact on plant development. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269851 [Multi-domain]  Cd Length: 52  Bit Score: 66.06  E-value: 1.24e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 719975267 182 AKRHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHA 227
Cdd:cd14703    7 ANRQSAQRSRERKLQYISELERKVQTLQTEVATLSAQLALLEQEKA 52
BRLZ smart00338
basic region leucin zipper;
184-234 1.16e-04

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 39.08  E-value: 1.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 719975267   184 RHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHAILSMENT 234
Cdd:smart00338  14 REAARRSRERKKAEIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
bZIP_1 pfam00170
bZIP transcription factor; The Pfam entry includes the basic region and the leucine zipper ...
 180-234 5.34e-03

bZIP transcription factor; The Pfam entry includes the basic region and the leucine zipper region.


Pssm-ID: 395118 [Multi-domain]  Cd Length: 60  Bit Score: 34.66  E-value: 5.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 719975267  180 KAAKRHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHAILSMENT 234
Cdd:pfam00170   6 KQSNREAARRSRQRKQAYIEELERRVKALEGENKTLRSELEELKKEVEKLKSKNK 60
 
Name Accession Description Interval E-value
bZIP_plant_RF2 cd14703
Basic leucine zipper (bZIP) domain of Plant RF2-like transcription factors: a DNA-binding and ...
 182-227 1.24e-14

Basic leucine zipper (bZIP) domain of Plant RF2-like transcription factors: a DNA-binding and dimerization domain; This subfamily is composed of plant bZIP transciption factors with similarity to Oryza sativa RF2a and RF2b, which are important for plant development. They interact with, as homodimers or heterodimers with each other, and activate transcription from the RTBV (rice tungro bacilliform virus) promoter, which is regulated by sequence-specific DNA-binding proteins that bind to the essential cis element BoxII. RF2a and RF2b show differences in binding affinities to BoxII, expression patterns in different rice organs, and subcellular localization. Transgenic rice with increased RF2a and RF2b display increased resistance to rice tungro disease (RTD) with no impact on plant development. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269851 [Multi-domain]  Cd Length: 52  Bit Score: 66.06  E-value: 1.24e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 719975267 182 AKRHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHA 227
Cdd:cd14703    7 ANRQSAQRSRERKLQYISELERKVQTLQTEVATLSAQLALLEQEKA 52
BRLZ smart00338
basic region leucin zipper;
184-234 1.16e-04

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 39.08  E-value: 1.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 719975267   184 RHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHAILSMENT 234
Cdd:smart00338  14 REAARRSRERKKAEIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
bZIP cd14686
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ...
 184-241 1.56e-03

Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269834 [Multi-domain]  Cd Length: 52  Bit Score: 35.60  E-value: 1.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 719975267 184 RHSGQRSRVRKLQYIAELERTVNLLQclesdlaarvgsllQRHAILSMENTTLEQKIA 241
Cdd:cd14686    9 REAARRSRERKKERIEELEEEVEELE--------------EENEELKAELEELRAEVE 52
bZIP_plant_GBF1 cd14702
Basic leucine zipper (bZIP) domain of Plant G-box binding factor 1 (GBF1)-like transcription ...
 180-227 2.65e-03

Basic leucine zipper (bZIP) domain of Plant G-box binding factor 1 (GBF1)-like transcription factors: a DNA-binding and dimerization domain; This subfamily is composed of plant bZIP transciption factors including Arabidopsis thaliana G-box binding factor 1 (GBF1), Zea mays Opaque-2 and Ocs element-binding factor 1 (OCSBF-1), Triticum aestivum Histone-specific transcription factor HBP1 (or HBP-1a), Petroselinum crispum Light-inducible protein CPRF3 and CPRF6, and Nicotiana tabacum BZI-3, among many others. bZIP G-box binding factors (GBFs) contain an N-terminal proline-rich domain in addition to the bZIP domain. GBFs are involved in developmental and physiological processes in response to stimuli such as light or hormones. Opaque-2 plays a role in affecting lysine content and carbohydrate metabolism, acting indirectly on starch/amino acid ratio. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269850 [Multi-domain]  Cd Length: 52  Bit Score: 35.20  E-value: 2.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 719975267 180 KAAKRHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHA 227
Cdd:cd14702    5 KQSNRESARRSRMRKQAHLEELEAQVEQLRAENSTLRAELNALSQEYR 52
bZIP_1 pfam00170
bZIP transcription factor; The Pfam entry includes the basic region and the leucine zipper ...
 180-234 5.34e-03

bZIP transcription factor; The Pfam entry includes the basic region and the leucine zipper region.


Pssm-ID: 395118 [Multi-domain]  Cd Length: 60  Bit Score: 34.66  E-value: 5.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 719975267  180 KAAKRHSGQRSRVRKLQYIAELERTVNLLQCLESDLAARVGSLLQRHAILSMENT 234
Cdd:pfam00170   6 KQSNREAARRSRQRKQAYIEELERRVKALEGENKTLRSELEELKKEVEKLKSKNK 60
bZIP_HY5-like cd14704
Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription ...
 184-233 8.85e-03

Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription factors and similar proteins: a DNA-binding and dimerization domain; This subfamily is predominantly composed of plant Basic leucine zipper (bZIP) transcription factors with similarity to Solanum lycopersicum and Arabidopsis thaliana HY5. Also included are the Dictyostelium discoideum bZIP transcription factors E and F. HY5 plays an important role in seedling development and is a positive regulator of photomorphogenesis. Plants with decreased levels of HY5 show defects in light responses including inhibited photomorphogenesis, loss of alkaloid organization, and reduced carotenoid accumulation. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269852 [Multi-domain]  Cd Length: 52  Bit Score: 33.70  E-value: 8.85e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 719975267 184 RHSGQRSRVRKLQYIAELERTVNLLQclesdlaARVGSLLQRHAILSMEN 233
Cdd:cd14704    9 RESAQLSRQRKKEYLSELEAKCRELE-------AENAELEARVELLQAEN 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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