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Conserved domains on  [gi|719773920|ref|XP_010220143|]
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PREDICTED: xaa-Pro aminopeptidase 2, partial [Tinamus guttatus]

Protein Classification

aminopeptidase P family protein( domain architecture ID 11048000)

aminopeptidase P family protein (metallopeptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

EC:  3.4.-.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24B
PubMed:  30536999|16229471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP_MetAP super family cl00279
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 327-493 1.80e-81

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


The actual alignment was detected with superfamily member cd01085:

Pssm-ID: 469704 [Multi-domain]  Cd Length: 224  Bit Score: 255.18  E-value: 1.80e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 327 LRAAHVRDAVAVIQYLLWLEKMVPQG-LVDEFSGAQHVDALRQ------------------------------------- 368
Cdd:cd01085    2 MRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRqqkgyvglsfdtisgfgpngaivhyspteesnrkisp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 369 -------------DGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPADTAGRTVEAFARQALWKVGLNYGHGTG 435
Cdd:cd01085   82 dglylidsggqylDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGTG 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 436 HGIGNFLSVHEWPVG--FQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVEAQTEH 493
Cdd:cd01085  162 HGVGSFLNVHEGPQSisPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTE 221
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
116-323 1.05e-45

Creatinase/Prolidase N-terminal domain;


:

Pssm-ID: 465053  Cd Length: 159  Bit Score: 158.42  E-value: 1.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  116 RPPPASSKIYSLPAEFTGSSWQEKVTGIRQQMEQHvrsptrggrsrpvrsqhshlhggapatplpmdpaltsdRARGVLg 195
Cdd:pfam16189   2 RPALPANPVFVLPLKYAGESAAEKLARLREALKEK--------------------------------------GADALV- 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  196 kpVSTGSDI-WfltgLFNLRGEDIPYNPVFYSYTLLTSTSIRLFVDGTRLTAEAQQSLQEGcpgplCVELQEYEQVREHV 274
Cdd:pfam16189  43 --LSALDEIaW----LLNLRGSDVPYNPVFLSYALVTDDEATLFVDPEKLSDEVRAHLEEN-----GVEIRPYDDIYEDL 111

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 719773920  275 RAYAQGnVTIWLGTEYTTYGLYGVIPQEKLLEDSYSPVMTAKAVKNAKE 323
Cdd:pfam16189 112 AALAAG-KKVLLDPSRTSYALYSALPAGAKVVEAPSPITLMKAVKNETE 159
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 499-563 1.12e-25

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


:

Pssm-ID: 465052  Cd Length: 63  Bit Score: 99.79  E-value: 1.12e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 719773920  499 PFLTFEVVSLVPYDRNLIDVDLLSKEQIQYLNAYYETIRERVGPELRRQqlEEEFAWLQRNTEPF 563
Cdd:pfam16188   1 PFLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEE--EDALEWLKRATRPI 63
Creatinase_N super family cl46291
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 3-111 2.88e-03

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


The actual alignment was detected with superfamily member pfam01321:

Pssm-ID: 480631  Cd Length: 128  Bit Score: 38.05  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920    3 YISERDARLAWVSGFTGSAGTA-VVTLHKAALW-PDSRHWPG-GQMDCNWELHKTTWIESIGLWILEAVPAGGNVSLDPF 79
Cdd:pfam01321  17 ALVTSPENLRYLTGFTGSRGLLlLVTADGALLLvDALEYERAaAESAPDFDVVPYRDYEALADLLKELGAGGKRVGFEAD 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 719773920   80 LFSIDTWSSYSEALHGSgrTLLPMeTNLVDQV 111
Cdd:pfam01321  97 ALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 327-493 1.80e-81

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 255.18  E-value: 1.80e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 327 LRAAHVRDAVAVIQYLLWLEKMVPQG-LVDEFSGAQHVDALRQ------------------------------------- 368
Cdd:cd01085    2 MRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRqqkgyvglsfdtisgfgpngaivhyspteesnrkisp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 369 -------------DGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPADTAGRTVEAFARQALWKVGLNYGHGTG 435
Cdd:cd01085   82 dglylidsggqylDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGTG 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 436 HGIGNFLSVHEWPVG--FQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVEAQTEH 493
Cdd:cd01085  162 HGVGSFLNVHEGPQSisPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTE 221
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
116-323 1.05e-45

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 158.42  E-value: 1.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  116 RPPPASSKIYSLPAEFTGSSWQEKVTGIRQQMEQHvrsptrggrsrpvrsqhshlhggapatplpmdpaltsdRARGVLg 195
Cdd:pfam16189   2 RPALPANPVFVLPLKYAGESAAEKLARLREALKEK--------------------------------------GADALV- 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  196 kpVSTGSDI-WfltgLFNLRGEDIPYNPVFYSYTLLTSTSIRLFVDGTRLTAEAQQSLQEGcpgplCVELQEYEQVREHV 274
Cdd:pfam16189  43 --LSALDEIaW----LLNLRGSDVPYNPVFLSYALVTDDEATLFVDPEKLSDEVRAHLEEN-----GVEIRPYDDIYEDL 111

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 719773920  275 RAYAQGnVTIWLGTEYTTYGLYGVIPQEKLLEDSYSPVMTAKAVKNAKE 323
Cdd:pfam16189 112 AALAAG-KKVLLDPSRTSYALYSALPAGAKVVEAPSPITLMKAVKNETE 159
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
302-488 1.07e-37

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 141.50  E-value: 1.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 302 EKLLEDSYSPVMTAKAVKNAKEQELLRAAHVRDAVAVIQYLLWLEKMVP----QGLVDEF----------------SGAQ 361
Cdd:COG0006   57 ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTerevAAELEAAmrrrgaegpsfdtivaSGEN 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 362 ----H---------------VD--ALRQDGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVfPADTAGRTVEAFAR 420
Cdd:COG0006  137 aaipHytptdrplkpgdlvlIDagAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAAR 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 421 QALWKVGL--NYGHGTGHGIGnfLSVHEWPVGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVE 488
Cdd:COG0006  216 DVLAEAGYgeYFPHGTGHGVG--LDVHEGPQISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTE 283
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 353-488 3.61e-31

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 120.42  E-value: 3.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  353 LVDefSGAQHVDalrqDGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPaDTAGRTVEAFARQALWKVGL--NY 430
Cdd:pfam00557  78 LID--VGAEYDG----GYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLgeYF 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  431 GHGTGHGIGnfLSVHEWP-VGFQSNNIPLTKGMFTSIEPGYYQ-DGEFGIRIEDIALVVE 488
Cdd:pfam00557 151 PHGLGHGIG--LEVHEGPyISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 499-563 1.12e-25

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 99.79  E-value: 1.12e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 719773920  499 PFLTFEVVSLVPYDRNLIDVDLLSKEQIQYLNAYYETIRERVGPELRRQqlEEEFAWLQRNTEPF 563
Cdd:pfam16188   1 PFLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEE--EDALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
 415-492 1.05e-09

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 60.34  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 415 VEAFARQALWKVGLN--YGHGTGHGIGnfLSVHEWPVGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVEAQTE 492
Cdd:PRK09795 269 VDDAARRVITEAGYGdyFGHNTGHAIG--IEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAE 346
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 3-111 2.88e-03

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 38.05  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920    3 YISERDARLAWVSGFTGSAGTA-VVTLHKAALW-PDSRHWPG-GQMDCNWELHKTTWIESIGLWILEAVPAGGNVSLDPF 79
Cdd:pfam01321  17 ALVTSPENLRYLTGFTGSRGLLlLVTADGALLLvDALEYERAaAESAPDFDVVPYRDYEALADLLKELGAGGKRVGFEAD 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 719773920   80 LFSIDTWSSYSEALHGSgrTLLPMeTNLVDQV 111
Cdd:pfam01321  97 ALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 327-493 1.80e-81

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 255.18  E-value: 1.80e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 327 LRAAHVRDAVAVIQYLLWLEKMVPQG-LVDEFSGAQHVDALRQ------------------------------------- 368
Cdd:cd01085    2 MRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRqqkgyvglsfdtisgfgpngaivhyspteesnrkisp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 369 -------------DGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPADTAGRTVEAFARQALWKVGLNYGHGTG 435
Cdd:cd01085   82 dglylidsggqylDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGTG 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 436 HGIGNFLSVHEWPVG--FQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVEAQTEH 493
Cdd:cd01085  162 HGVGSFLNVHEGPQSisPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTE 221
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
116-323 1.05e-45

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 158.42  E-value: 1.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  116 RPPPASSKIYSLPAEFTGSSWQEKVTGIRQQMEQHvrsptrggrsrpvrsqhshlhggapatplpmdpaltsdRARGVLg 195
Cdd:pfam16189   2 RPALPANPVFVLPLKYAGESAAEKLARLREALKEK--------------------------------------GADALV- 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  196 kpVSTGSDI-WfltgLFNLRGEDIPYNPVFYSYTLLTSTSIRLFVDGTRLTAEAQQSLQEGcpgplCVELQEYEQVREHV 274
Cdd:pfam16189  43 --LSALDEIaW----LLNLRGSDVPYNPVFLSYALVTDDEATLFVDPEKLSDEVRAHLEEN-----GVEIRPYDDIYEDL 111

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 719773920  275 RAYAQGnVTIWLGTEYTTYGLYGVIPQEKLLEDSYSPVMTAKAVKNAKE 323
Cdd:pfam16189 112 AALAAG-KKVLLDPSRTSYALYSALPAGAKVVEAPSPITLMKAVKNETE 159
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
302-488 1.07e-37

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 141.50  E-value: 1.07e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 302 EKLLEDSYSPVMTAKAVKNAKEQELLRAAHVRDAVAVIQYLLWLEKMVP----QGLVDEF----------------SGAQ 361
Cdd:COG0006   57 ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTerevAAELEAAmrrrgaegpsfdtivaSGEN 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 362 ----H---------------VD--ALRQDGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVfPADTAGRTVEAFAR 420
Cdd:COG0006  137 aaipHytptdrplkpgdlvlIDagAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAAR 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 421 QALWKVGL--NYGHGTGHGIGnfLSVHEWPVGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVE 488
Cdd:COG0006  216 DVLAEAGYgeYFPHGTGHGVG--LDVHEGPQISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTE 283
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 353-488 3.61e-31

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 120.42  E-value: 3.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  353 LVDefSGAQHVDalrqDGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPaDTAGRTVEAFARQALWKVGL--NY 430
Cdd:pfam00557  78 LID--VGAEYDG----GYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLgeYF 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920  431 GHGTGHGIGnfLSVHEWP-VGFQSNNIPLTKGMFTSIEPGYYQ-DGEFGIRIEDIALVVE 488
Cdd:pfam00557 151 PHGLGHGIG--LEVHEGPyISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 499-563 1.12e-25

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 99.79  E-value: 1.12e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 719773920  499 PFLTFEVVSLVPYDRNLIDVDLLSKEQIQYLNAYYETIRERVGPELRRQqlEEEFAWLQRNTEPF 563
Cdd:pfam16188   1 PFLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEE--EDALEWLKRATRPI 63
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 371-488 7.62e-24

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 99.51  E-value: 7.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 371 TTDITRTMHWGVPTPFQKEAYTRVLMGN---IDLSRlvfpADTAGRTVEAFARQALWKVGL--NYGHGTGHGIGnfLSVH 445
Cdd:cd01092   89 CSDITRTVAVGEPSDELKEIYEIVLEAQqaaIKAVK----PGVTAKEVDKAARDVIEEAGYgeYFIHRTGHGVG--LEVH 162

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 719773920 446 EWPVGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVE 488
Cdd:cd01092  163 EAPYISPGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLVTE 205
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 363-488 1.08e-19

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 87.51  E-value: 1.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 363 VDALRQDGTTDITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPaDTAGRTVEAFARQAL--WKVGLNYGHGTGHGIGn 440
Cdd:cd01066   80 LGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRP-GVTAEEVDAAAREVLeeHGLGPNFGHRTGHGIG- 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 719773920 441 fLSVHEWPVGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVE 488
Cdd:cd01066  158 -LEIHEPPVLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTE 204
PRK09795 PRK09795
aminopeptidase; Provisional
 415-492 1.05e-09

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 60.34  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 415 VEAFARQALWKVGLN--YGHGTGHGIGnfLSVHEWPVGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVEAQTE 492
Cdd:PRK09795 269 VDDAARRVITEAGYGdyFGHNTGHAIG--IEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAE 346
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 371-488 3.40e-09

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 57.58  E-value: 3.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 371 TTDITRTmhW---GVPTPFQKEAYTRVLMGNIDLSRLVFPA---DTAGRTVEAFARQALWKVGLNYG------------- 431
Cdd:cd01087   88 ASDITRT--FpvnGKFTDEQRELYEAVLAAQKAAIAACKPGvsyEDIHLLAHRVLAEGLKELGILKGdvdeivesgayak 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 719773920 432 ---HGTGHGIGnfLSVHEWPVGFQSN--NIPLTKGMFTSIEPGYYQDGEF----------GIRIEDIALVVE 488
Cdd:cd01087  166 ffpHGLGHYLG--LDVHDVGGYLRYLrrARPLEPGMVITIEPGIYFIPDLldvpeyfrggGIRIEDDVLVTE 235
PRK15173 PRK15173
peptidase; Provisional
 373-486 2.32e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 46.63  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 373 DITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPA----DTAGRTVEAFARQALwkVGLNYGHgTGHGIGNFLSVHEWP 448
Cdd:PRK15173 190 DIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGvkmkDVFDSTMEVIKKSGL--PNYNRGH-LGHGNGVFLGLEESP 266

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 719773920 449 VGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALV 486
Cdd:PRK15173 267 FVSTHATESFTSGMVLSLETPYYGYNLGSIMIEDMILI 304
PRK14575 PRK14575
putative peptidase; Provisional
 373-486 3.53e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 46.62  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 373 DITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPA----DTAGRTVEAFARQALwkVGLNYGHgTGHGIGNFLSVHEWP 448
Cdd:PRK14575 273 DIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGvkmkDVFDSTMEVIKKSGL--PNYNRGH-LGHGNGVFLGLEESP 349

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 719773920 449 VGFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALV 486
Cdd:PRK14575 350 FVSTHATESFTSGMVLSLETPYYGYNLGSIMIEDMILI 387
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 3-111 2.88e-03

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 38.05  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920    3 YISERDARLAWVSGFTGSAGTA-VVTLHKAALW-PDSRHWPG-GQMDCNWELHKTTWIESIGLWILEAVPAGGNVSLDPF 79
Cdd:pfam01321  17 ALVTSPENLRYLTGFTGSRGLLlLVTADGALLLvDALEYERAaAESAPDFDVVPYRDYEALADLLKELGAGGKRVGFEAD 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 719773920   80 LFSIDTWSSYSEALHGSgrTLLPMeTNLVDQV 111
Cdd:pfam01321  97 ALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 373-496 3.71e-03

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 40.09  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 373 DITRTMHW-GVPTPFQKEAYTRVLMGNIDLSRLVFPADTAGRTVEAFAR---QALWKVGLNYG----------------H 432
Cdd:PRK10879 269 DITRTFPVnGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRimvSGLVKLGILKGdvdqliaenahrpffmH 348

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 719773920 433 GTGHGIGnfLSVHEwpVGF--QSNNIPLTKGMFTSIEPGYY--QDGE-------FGIRIEDIALVVEAQTEHQTA 496
Cdd:PRK10879 349 GLSHWLG--LDVHD--VGVygQDRSRILEPGMVLTVEPGLYiaPDADvpeqyrgIGIRIEDDIVITETGNENLTA 419
PRK14576 PRK14576
putative endopeptidase; Provisional
 373-492 4.94e-03

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 39.61  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719773920 373 DITRTMHWGVPTPFQKEAYTRVLMGNIDLSRLVFPAdTAGRTVEAFARQALWKVGL---NYGHgTGHGIGNFLSVHEWPV 449
Cdd:PRK14576 272 DLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPG-VKLKAVFDSTMAVIKTSGLphyNRGH-LGHGDGVFLGLEEVPF 349

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 719773920 450 GFQSNNIPLTKGMFTSIEPGYYQDGEFGIRIEDIALVVEAQTE 492
Cdd:PRK14576 350 VSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILITDSGFE 392
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 412-468 5.20e-03

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 39.05  E-value: 5.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 719773920 412 GRTVEAFARQALWKVGLNYghgTGHGIGnfLSVHEWPVGF-----QSNNIPLTKGMFTSIEP 468
Cdd:PRK12896 153 GRAIEDFAKKNGYSVVRDL---TGHGVG--RSLHEEPSVIltytdPLPNRLLRPGMTLAVEP 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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