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Conserved domains on  [gi|701336137|ref|XP_009980596|]
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PREDICTED: UDP-glucose 6-dehydrogenase isoform X2 [Tauraco erythrolophus]

Protein Classification

UDP-glucose 6-dehydrogenase( domain architecture ID 1000920)

UDP-glucose 6-dehydrogenase is involved in the biosynthesis of glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate

CATH:  3.40.50.720|1.20.5.100|3.40.50.720
EC:  1.1.1.22
Gene Ontology:  GO:0003979|GO:0051287|GO:0042802

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02353 super family cl31866
probable UDP-glucose 6-dehydrogenase
 4-397 0e+00

probable UDP-glucose 6-dehydrogenase


The actual alignment was detected with superfamily member PLN02353:

Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 669.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   4 IKKICCIGAGYVGGPTCSVIAQMCPNIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGRNLFFSTGIDDAIREAD 83
Cdd:PLN02353   1 MVKICCIGAGYVGGPTMAVIALKCPDIEVVVVDISVPRIDAWNSDQLPIYEPGLDEVVKQCRGKNLFFSTDVEKHVAEAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  84 LVFISV------------------------------------------------------------------LSNPEFLA 97
Cdd:PLN02353  81 IVFVSVntptktrglgagkaadltywesaarmiadvsksdkivvekstvpvktaeaiekilthnskginfqiLSNPEFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  98 EGTAIKDLKNPDRVLIGGDDSPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEAT 177
Cdd:PLN02353 161 EGTAIEDLFKPDRVLIGGRETPEGQKAVQALKDVYAHWVPEERIITTNLWSAELSKLAANAFLAQRISSVNAMSALCEAT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 178 GADVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFN 257
Cdd:PLN02353 241 GADVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVAEYWKQVIKMNDYQKSRFVNRVVSSMFN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 258 TVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEQIILDLSHPGVSEDNQV---------SRLV 328
Cdd:PLN02353 321 TVSGKKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEEQIQRDLSMNKFDWDHPRhlqpmsptaVKQV 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 701336137 329 TVSKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDdlHNELQVIGFQIETIGK 397
Cdd:PLN02353 401 SVVWDAYEATKGAHGICILTEWDEFKTLDYQKIYDNMQKPAFVFDGRNVLD--HEKLREIGFIVYSIGK 467
 
Name Accession Description Interval E-value
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
 4-397 0e+00

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 669.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   4 IKKICCIGAGYVGGPTCSVIAQMCPNIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGRNLFFSTGIDDAIREAD 83
Cdd:PLN02353   1 MVKICCIGAGYVGGPTMAVIALKCPDIEVVVVDISVPRIDAWNSDQLPIYEPGLDEVVKQCRGKNLFFSTDVEKHVAEAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  84 LVFISV------------------------------------------------------------------LSNPEFLA 97
Cdd:PLN02353  81 IVFVSVntptktrglgagkaadltywesaarmiadvsksdkivvekstvpvktaeaiekilthnskginfqiLSNPEFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  98 EGTAIKDLKNPDRVLIGGDDSPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEAT 177
Cdd:PLN02353 161 EGTAIEDLFKPDRVLIGGRETPEGQKAVQALKDVYAHWVPEERIITTNLWSAELSKLAANAFLAQRISSVNAMSALCEAT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 178 GADVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFN 257
Cdd:PLN02353 241 GADVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVAEYWKQVIKMNDYQKSRFVNRVVSSMFN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 258 TVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEQIILDLSHPGVSEDNQV---------SRLV 328
Cdd:PLN02353 321 TVSGKKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEEQIQRDLSMNKFDWDHPRhlqpmsptaVKQV 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 701336137 329 TVSKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDdlHNELQVIGFQIETIGK 397
Cdd:PLN02353 401 SVVWDAYEATKGAHGICILTEWDEFKTLDYQKIYDNMQKPAFVFDGRNVLD--HEKLREIGFIVYSIGK 467
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
6-398 4.05e-165

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 471.04  E-value: 4.05e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   6 KICCIGAGYVGGPTCSVIAQMCPNikVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCR-GRNLFFSTGIDDAIREADL 84
Cdd:COG1004    2 KIAVIGTGYVGLVTAACLAELGHE--VTCVDIDEEKIEALNAGEIPIYEPGLEELVARNVaAGRLRFTTDLAEAVAEADV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  85 VFISV---------------------------------------------------------------LSNPEFLAEGTA 101
Cdd:COG1004   80 VFIAVgtpsdedgsadlsyvlaaarsigealkgykvvvtkstvpvgtadrvraiiaeelrgagvdfdvVSNPEFLREGSA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 102 IKDLKNPDRVLIGGDDspegQKAVRALCAVYEHWVPKE-KILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGAD 180
Cdd:COG1004  160 VEDFLRPDRIVIGVDS----ERAAEVLRELYAPFVRNGtPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEKVGAD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 181 VEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPevARYWQQVIDMNDYQRRRFASRIIDSLFNTVT 260
Cdd:COG1004  236 VEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDVRALIATARELGYD--LRLLEAVEEVNERQKRRLVEKIREHLGGDLK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 261 DKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKE-QIILDLShpgvsednqvsrlVTVSKDPYEACD 339
Cdd:COG1004  314 GKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPVAMENaRRLLPDD-------------ITYADDAYEALE 380

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 701336137 340 GAHALVICTEWDMFKELDYERIHKKMLKPAfIFDGRRVLDdlHNELQVIGFQIETIGKK 398
Cdd:COG1004  381 GADALVILTEWPEFRALDFARLKALMKGPV-IFDGRNLLD--PEELRAAGFTYYGIGRP 436
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 5-376 8.00e-91

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 280.65  E-value: 8.00e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137    5 KKICCIGAGYVGGPTCSVIAQMcpNIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGRNLF-FSTGIDDAIREAD 83
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADL--GHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKALKAGRLrATTDYEEAIRDAD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   84 LVFISV----------------------------------------------------------------LSNPEFLAEG 99
Cdd:TIGR03026  79 VIIICVptplkedgspdlsyvesaaetiakhlrkgatvvlestvppgtteevvkpilersglklgedfylAYNPEFLREG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  100 TAIKDLKNPDRVlIGGDDSPEGQKAVRalcaVYEHWVpKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGA 179
Cdd:TIGR03026 159 NAVHDLLHPDRI-VGGETEEAGEAVAE----LYSPII-DGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  180 DVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPevARYWQQVIDMNDYQRRRFASRIIDSLFNtV 259
Cdd:TIGR03026 233 DVYEVIEAAGTDPRIGFNFLNPGPGVGGHCIPKDPLALIAKAKELGYN--PELIEAAREINDSQPDYVVEKIKDLLGP-L 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  260 TDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEQIildlshpgvsednqvsRLVTVSKDPYEACD 339
Cdd:TIGR03026 310 KGKTVLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEV----------------KGLPSIDDLEEALK 373

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 701336137  340 GAHALVICTEWDMFKELDYERIhKKMLKPAFIFDGRR 376
Cdd:TIGR03026 374 GADALVILTDHSEFKDLDLEKI-KDLMKGKVVVDTRN 409
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
 148-241 1.36e-44

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 149.84  E-value: 1.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  148 SSELSKLAANAFLAQRISSINSISALCEATGADVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLP 227
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDPRIGPKFLYPGPGVGGSCLPKDPRALIYLARELGVP 80

                          90
                  ....*....|....
gi 701336137  228 evARYWQQVIDMND 241
Cdd:pfam00984  81 --ARLLEAAREVNE 92
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
 265-379 5.55e-33

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 119.53  E-value: 5.55e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   265 AILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVpkeqiildlshpgvsEDNQVSRLVTVSKDPYEACDGAHAL 344
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPYA---------------MEEAREYGLTYVSDLEEALKGADAV 65

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 701336137   345 VICTEWDMFKELDYERIhKKMLKPAFIFDGRRVLD 379
Cdd:smart00984  66 VIATEHDEFRSLDPEEL-KDLMKKPVVVDGRNILD 99
 
Name Accession Description Interval E-value
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
 4-397 0e+00

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 669.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   4 IKKICCIGAGYVGGPTCSVIAQMCPNIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGRNLFFSTGIDDAIREAD 83
Cdd:PLN02353   1 MVKICCIGAGYVGGPTMAVIALKCPDIEVVVVDISVPRIDAWNSDQLPIYEPGLDEVVKQCRGKNLFFSTDVEKHVAEAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  84 LVFISV------------------------------------------------------------------LSNPEFLA 97
Cdd:PLN02353  81 IVFVSVntptktrglgagkaadltywesaarmiadvsksdkivvekstvpvktaeaiekilthnskginfqiLSNPEFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  98 EGTAIKDLKNPDRVLIGGDDSPEGQKAVRALCAVYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEAT 177
Cdd:PLN02353 161 EGTAIEDLFKPDRVLIGGRETPEGQKAVQALKDVYAHWVPEERIITTNLWSAELSKLAANAFLAQRISSVNAMSALCEAT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 178 GADVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFN 257
Cdd:PLN02353 241 GADVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVAEYWKQVIKMNDYQKSRFVNRVVSSMFN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 258 TVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEQIILDLSHPGVSEDNQV---------SRLV 328
Cdd:PLN02353 321 TVSGKKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEEQIQRDLSMNKFDWDHPRhlqpmsptaVKQV 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 701336137 329 TVSKDPYEACDGAHALVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDdlHNELQVIGFQIETIGK 397
Cdd:PLN02353 401 SVVWDAYEATKGAHGICILTEWDEFKTLDYQKIYDNMQKPAFVFDGRNVLD--HEKLREIGFIVYSIGK 467
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
6-398 4.05e-165

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 471.04  E-value: 4.05e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   6 KICCIGAGYVGGPTCSVIAQMCPNikVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCR-GRNLFFSTGIDDAIREADL 84
Cdd:COG1004    2 KIAVIGTGYVGLVTAACLAELGHE--VTCVDIDEEKIEALNAGEIPIYEPGLEELVARNVaAGRLRFTTDLAEAVAEADV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  85 VFISV---------------------------------------------------------------LSNPEFLAEGTA 101
Cdd:COG1004   80 VFIAVgtpsdedgsadlsyvlaaarsigealkgykvvvtkstvpvgtadrvraiiaeelrgagvdfdvVSNPEFLREGSA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 102 IKDLKNPDRVLIGGDDspegQKAVRALCAVYEHWVPKE-KILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGAD 180
Cdd:COG1004  160 VEDFLRPDRIVIGVDS----ERAAEVLRELYAPFVRNGtPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEKVGAD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 181 VEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPevARYWQQVIDMNDYQRRRFASRIIDSLFNTVT 260
Cdd:COG1004  236 VEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDVRALIATARELGYD--LRLLEAVEEVNERQKRRLVEKIREHLGGDLK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 261 DKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKE-QIILDLShpgvsednqvsrlVTVSKDPYEACD 339
Cdd:COG1004  314 GKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPVAMENaRRLLPDD-------------ITYADDAYEALE 380

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 701336137 340 GAHALVICTEWDMFKELDYERIHKKMLKPAfIFDGRRVLDdlHNELQVIGFQIETIGKK 398
Cdd:COG1004  381 GADALVILTEWPEFRALDFARLKALMKGPV-IFDGRNLLD--PEELRAAGFTYYGIGRP 436
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 5-376 8.00e-91

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 280.65  E-value: 8.00e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137    5 KKICCIGAGYVGGPTCSVIAQMcpNIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGRNLF-FSTGIDDAIREAD 83
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADL--GHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKALKAGRLrATTDYEEAIRDAD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   84 LVFISV----------------------------------------------------------------LSNPEFLAEG 99
Cdd:TIGR03026  79 VIIICVptplkedgspdlsyvesaaetiakhlrkgatvvlestvppgtteevvkpilersglklgedfylAYNPEFLREG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  100 TAIKDLKNPDRVlIGGDDSPEGQKAVRalcaVYEHWVpKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGA 179
Cdd:TIGR03026 159 NAVHDLLHPDRI-VGGETEEAGEAVAE----LYSPII-DGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  180 DVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPevARYWQQVIDMNDYQRRRFASRIIDSLFNtV 259
Cdd:TIGR03026 233 DVYEVIEAAGTDPRIGFNFLNPGPGVGGHCIPKDPLALIAKAKELGYN--PELIEAAREINDSQPDYVVEKIKDLLGP-L 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  260 TDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEQIildlshpgvsednqvsRLVTVSKDPYEACD 339
Cdd:TIGR03026 310 KGKTVLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEV----------------KGLPSIDDLEEALK 373

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 701336137  340 GAHALVICTEWDMFKELDYERIhKKMLKPAFIFDGRR 376
Cdd:TIGR03026 374 GADALVILTDHSEFKDLDLEKI-KDLMKGKVVVDTRN 409
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
 148-241 1.36e-44

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 149.84  E-value: 1.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  148 SSELSKLAANAFLAQRISSINSISALCEATGADVEEVARAIGTDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLP 227
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDPRIGPKFLYPGPGVGGSCLPKDPRALIYLARELGVP 80

                          90
                  ....*....|....
gi 701336137  228 evARYWQQVIDMND 241
Cdd:pfam00984  81 --ARLLEAAREVNE 92
WecC COG0677
UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];
6-379 3.47e-43

UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440441 [Multi-domain]  Cd Length: 413  Bit Score: 156.38  E-value: 3.47e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   6 KICCIGAGYVGGPTCSVIAQMcpNIKVTVVDVNEARINAWNSDTLPIYEPG---LKEVVESCRgrnLFFSTgiD-DAIRE 81
Cdd:COG0677    1 KIAVIGLGYVGLPLAVAFAKA--GFRVIGFDINPERVEELNAGEDPILEPGdelLAEAVAAGR---LRATT--DpEALAE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  82 ADLVFISV-----------LSN------------------------------------------------------PEFL 96
Cdd:COG0677   74 ADVVIIAVptpldedkepdLSYlesasetiaphlkpgdlvvlestvypgtteevcvpilekrsglkagedfflaysPERI 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  97 AEGTAIKDLKNPDRVlIGGDDsPEGQKAVRALcavYEHWVPKEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEA 176
Cdd:COG0677  154 NPGNKLHELRNIPKV-VGGIT-PESAERAAAL---YGSVVTAGVVPVSSIKVAEAAKLIENTYRDVNIALANELALICDR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 177 TGADVEEVARAIGTDQRIgNKFlKASVGFGGSCFQKDVLNLVYLCEALNLP----EVARywqqviDMNDYQRRRFASRII 252
Cdd:COG0677  229 LGIDVWEVIEAANTKPGF-LIF-YPGPGVGGHCIPVDPYYLTWKARELGYHprliLAAR------EINDSMPEYVVERVV 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 253 DSLFN---TVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEqiildlshpgvsednQVSRLVT 329
Cdd:COG0677  301 KALNEagkSLKGARVLVLGLAYKENVDDLRESPALDIIEELREYGAEVDVHDPYVDEE---------------EVEGEYG 365

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 701336137 330 VSKDPYEACDGAHALVICTEWDMFKELDYERIHKKmlKPAFIFDGRRVLD 379
Cdd:COG0677  366 ELVDLEEALEGADAVVLAVDHDEFDELDPEELRLK--GAKVVVDTRGVLD 413
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 5-126 4.95e-40

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 141.23  E-value: 4.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137    5 KKICCIGAGYVGGPTCSVIAQMCpnIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESCRGRNLFFSTGIDDAIREADL 84
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEIG--HDVIGVDIDEEKVDKLNSGQIPIYEPGLDELVKANVSGRLSFTTDYSTAIEEADV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   85 VFISV-----------------------------------------------------------------LSNPEFLAEG 99
Cdd:pfam03721  79 IFIAVgtpskkgggaadlkyvesaarsiaphlkkgkvvvvkstvpvgttenlvkpiieeggkkvgvdfdvASNPEFLREG 158

                         170       180
                  ....*....|....*....|....*..
gi 701336137  100 TAIKDLKNPDRVLIGGDDSPEGQKAVR 126
Cdd:pfam03721 159 SAVYDLFNPDRVVIGVTEKCAEAALEE 185
UDPG_MGDP_dh_C pfam03720
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose ...
 265-379 5.57e-38

UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 427462 [Multi-domain]  Cd Length: 103  Bit Score: 133.08  E-value: 5.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  265 AILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKEQIILDLSHpgvsednqvsrlVTVSKDPYEACDGAHAL 344
Cdd:pfam03720   1 AVLGLAFKPNTDDLRESPALDIIELLLEEGAEVKVYDPYVPEEAIEALGDG------------VTLVDDLEEALKGADAI 68

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 701336137  345 VICTEWDMFKELDYERIhKKMLKPAFIFDGRRVLD 379
Cdd:pfam03720  69 VILTDHDEFKSLDWEKL-KKLMKPPVVFDGRNVLD 102
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
 265-379 5.55e-33

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 119.53  E-value: 5.55e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   265 AILGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVpkeqiildlshpgvsEDNQVSRLVTVSKDPYEACDGAHAL 344
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPYA---------------MEEAREYGLTYVSDLEEALKGADAV 65

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 701336137   345 VICTEWDMFKELDYERIhKKMLKPAFIFDGRRVLD 379
Cdd:smart00984  66 VIATEHDEFRSLDPEEL-KDLMKKPVVVDGRNILD 99
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
 6-307 2.04e-21

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 95.09  E-value: 2.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   6 KICCIGAGYVGGPTCSVIAQmcpNIKVTVVDVNEARINAWNSDTLPIYEpglKEVVESCRGRNLFFSTGID--DAIREAD 83
Cdd:PRK15057   2 KITISGTGYVGLSNGLLIAQ---NHEVVALDILPSRVAMLNDRISPIVD---KEIQQFLQSDKIHFNATLDknEAYRDAD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  84 LVFIS-------------------------------------------------------VLSNPEFLAEGTAIKDLKNP 108
Cdd:PRK15057  76 YVIIAtptdydpktnyfntssvesvikdvveinpyavmvikstvpvgftaamhkkyrtenIIFSPEFLREGKALYDNLHP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 109 DRVLIGgddspEGQKAVRALCAVYEHWVPKEKILT--TNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVAR 186
Cdd:PRK15057 156 SRIVIG-----ERSERAERFAALLQEGAIKQNIPTlfTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 187 AIGTDQRIGNKFLKASVGFGGSCFQKDVLNLvyLCEALNLPEvaRYWQQVIDMNDYQRRRFASRIIDSlfntvTDKKIAI 266
Cdd:PRK15057 231 GVCLDPRIGNHYNNPSFGYGGYCLPKDTKQL--LANYQSVPN--NLISAIVDANRTRKDFIADAILSR-----KPQVVGI 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 701336137 267 LGFAFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVPKE 307
Cdd:PRK15057 302 YRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKED 342
wecC PRK11064
UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional
 5-292 1.80e-10

UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional


Pssm-ID: 182940 [Multi-domain]  Cd Length: 415  Bit Score: 62.31  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   5 KKICCIGAGYVGGPTCSVIAQMcpNIKVTVVDVNEARINAWNSDTLPIYEPGLKEVVESC-RGRNLFFSTGID--DAI-- 79
Cdd:PRK11064   4 ETISVIGLGYIGLPTAAAFASR--QKQVIGVDINQHAVDTINRGEIHIVEPDLDMVVKTAvEGGYLRATTTPEpaDAFli 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  80 ---------READLVFIS--------VL----------SNP--------EFLAE-------------------------- 98
Cdd:PRK11064  82 avptpfkgdHEPDLTYVEaaaksiapVLkkgdlvilesTSPvgateqmaEWLAEarpdltfpqqageqadiniaycperv 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  99 --GTAIKDLKNPDRVlIGGDDSPEGQKAVralcAVYEHWVPKEKILTtNTWSSELSKLAANAFLAQRISSINSISALCEA 176
Cdd:PRK11064 162 lpGQVMVELIKNDRV-IGGMTPVCSARAS----ELYKIFLEGECVVT-NSRTAEMCKLTENSFRDVNIAFANELSLICAD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 177 TGADVEEVARAIGTDQRIgnKFLKASVGFGGSCFQKDVLNLVYLCealnlPEVARYWQQVIDMND----YQRRRFASRII 252
Cdd:PRK11064 236 QGINVWELIRLANRHPRV--NILQPGPGVGGHCIAVDPWFIVAQN-----PQQARLIRTAREVNDgkphWVIDQVKAAVA 308

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 701336137 253 DSLFNT---VTDKKIAILGFAFKKDTGDTRESSSIYISKYLMD 292
Cdd:PRK11064 309 DCLAATdkrASEVKIACFGLAFKPNIDDLRESPAMEIAELIAQ 351
PRK15182 PRK15182
Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;
139-309 5.19e-07

Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;


Pssm-ID: 185104 [Multi-domain]  Cd Length: 425  Bit Score: 51.61  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 139 EKILTTNTWSSELSKLAANAFL---AQR---ISSINSISALCEATGADVEEVARAIGTDQrignKFLKASVGF-GGSCFQ 211
Cdd:PRK15182 188 QQIISAGTYKAESIKVAEAAKVienTQRdlnIALVNELAIIFNRLNIDTEAVLRAAGSKW----NFLPFRPGLvGGHCIG 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137 212 KDVLNLVYLCEALNL-PEVARYWQQVID-MNDYQRRRFASRIIDSLFNtVTDKKIAILGFAFKKDTGDTRESSSIYISKY 289
Cdd:PRK15182 264 VDPYYLTHKSQGIGYyPEIILAGRRLNDnMGNYVSEQLIKAMIKKGIN-VEGSSVLILGFTFKENCPDIRNTRIIDVVKE 342

                        170       180
                 ....*....|....*....|
gi 701336137 290 LMDEGAKLHIYDPKVPKEQI 309
Cdd:PRK15182 343 LGKYSCKVDIFDPWVDAEEV 362
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 3-178 7.45e-05

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 44.33  E-value: 7.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   3 EIKKICCIGAGYVGgptcSVIAQMCPN--IKVTVVDVNEARIN------AWNSDTLPIYEPGLKEVVESCRGRnLFFSTG 74
Cdd:COG1250    1 EIKKVAVIGAGTMG----AGIAAVFANagYEVVLLDISPEALErarariAKLLDKLVKKGKLTEEEADAALAR-ITPTTD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  75 IdDAIREADLVFISVLSNPEflaegtaIKdlknpdrvliggddspegQKAVRALCAVyehwVPKEKILTTNTwsselskl 154
Cdd:COG1250   76 L-AALADADLVIEAVPEDLD-------LK------------------QEVFAELDAV----APPDAILASNT-------- 117

                        170       180
                 ....*....|....*....|....
gi 701336137 155 aanaflaqriSSInSISALCEATG 178
Cdd:COG1250  118 ----------SSL-SITELAAATK 130
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 4-189 7.66e-05

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 44.18  E-value: 7.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   4 IKKICCIGAGYVGgptcSVIAQMCP--NIKVTVVDVNEARINawnsDTLPIYEPGLKEVVEscRGRnlffstgIDDAIRE 81
Cdd:PRK05808   3 IQKIGVIGAGTMG----NGIAQVCAvaGYDVVMVDISDAAVD----RGLATITKSLDRLVK--KGK-------MTEADKE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  82 ADLVFISVlsnpeflaeGTAIKDLKNPDRVLIGGDDSPE-GQKAVRALCAVyehwVPKEKILTTNTWSSELSKLAANAFL 160
Cdd:PRK05808  66 AALARITG---------TTDLDDLKDADLVIEAATENMDlKKKIFAQLDEI----AKPEAILATNTSSLSITELAAATKR 132

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 701336137 161 AQRISSIN-----SISALCE---------ATGADVEEVARAIG 189
Cdd:PRK05808 133 PDKVIGMHffnpvPVMKLVEiirglatsdATHEAVEALAKKIG 175
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 1-189 6.00e-04

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 41.68  E-value: 6.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   1 MFEIKKICCIGAGYVGGPTCSVIAQmcPNIKVTVVDVNE---ARINAWNSDTLPIYEPglKEVVESCRGRnLFFSTGIDD 77
Cdd:PRK06130   1 MNPIQNLAIIGAGTMGSGIAALFAR--KGLQVVLIDVMEgalERARGVIERALGVYAP--LGIASAGMGR-IRMEAGLAA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  78 AIREADLVFISVlsnPEFLaegtaikDLKnpdrvliggddspegqkavRALCAVYEHWVPKEKILTTNTWSSELSKLAAN 157
Cdd:PRK06130  76 AVSGADLVIEAV---PEKL-------ELK-------------------RDVFARLDGLCDPDTIFATNTSGLPITAIAQA 126

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 701336137 158 AFLAQRISS---------INSISALC-----EATGADVEEVARAIG 189
Cdd:PRK06130 127 VTRPERFVGthfftpadvIPLVEVVRgdktsPQTVATTMALLRSIG 172
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 1-156 7.17e-04

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 41.15  E-value: 7.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   1 MFEIKKICCIGAGYVGgptcSVIAQMCP--NIKVTVVDVNEARINAwnsdtlpiyepGLKEVvescrGRNLF--FSTG-I 75
Cdd:PRK07530   1 MMAIKKVGVIGAGQMG----NGIAHVCAlaGYDVLLNDVSADRLEA-----------GLATI-----NGNLArqVAKGkI 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137  76 DDAIREADLVFISVlsnpeflaeGTAIKDLKNPDRVLIGGDDSPEGQKAV-RALCAVYEhwvpKEKILTTNTWSSELSKL 154
Cdd:PRK07530  61 SEEARAAALARIST---------ATDLEDLADCDLVIEAATEDETVKRKIfAQLCPVLK----PEAILATNTSSISITRL 127


                 ..
gi 701336137 155 AA 156
Cdd:PRK07530 128 AS 129
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 5-113 8.03e-03

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 37.74  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701336137   5 KKICCIGAG-----YVGGptcsVIAQMCPNIKVTVVDVNEARINAWNSdtlpiyEPGLKevvescrgrnlfFSTGIDDAI 79
Cdd:COG0345    3 MKIGFIGAGnmgsaIIKG----LLKSGVPPEDIIVSDRSPERLEALAE------RYGVR------------VTTDNAEAA 60

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 701336137  80 READLVFISVLSN--PEFLAEgtaIKDLKNPDRVLI 113
Cdd:COG0345   61 AQADVVVLAVKPQdlAEVLEE---LAPLLDPDKLVI 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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