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Conserved domains on  [gi|701315570|ref|XP_009979080|]
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PREDICTED: reticulon-4 receptor-like 1 [Tauraco erythrolophus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-282 4.15e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 4.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 106 TLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKCGLSSLPSGIfGGLHNLQYLYLQDN 185
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQ-LTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 186 HIEFLQDDIFvDLVNLSHLFLHGNKLWSLHQNtFRGLINLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELqgD 265
Cdd:COG4886  193 QITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--P 266

                        170
                 ....*....|....*..
gi 701315570 266 CLAHLGALEFLRLNGNP 282
Cdd:COG4886  267 PLANLTNLKTLDLSNNQ 283
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
281-326 1.77e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 701315570   281 NPWSCDCKARSLWEWLHRFRGSSS--SVICESPEQMHGKDLKVLRVED 326
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEF 48
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-282 4.15e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 4.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 106 TLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKCGLSSLPSGIfGGLHNLQYLYLQDN 185
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQ-LTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 186 HIEFLQDDIFvDLVNLSHLFLHGNKLWSLHQNtFRGLINLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELqgD 265
Cdd:COG4886  193 QITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--P 266

                        170
                 ....*....|....*..
gi 701315570 266 CLAHLGALEFLRLNGNP 282
Cdd:COG4886  267 PLANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
200-259 9.88e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 9.88e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  200 NLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAFHDLRRLTTLFLFNNSL 259
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 152-282 2.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLPSgiFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNK------------LWSLH---Q 216
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenltnLEELHienQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 217 NTFRG--LI-----------NLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELQ--GDCLAHLGALEFLRLNGN 281
Cdd:cd21340  101 RLPPGekLTfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178


                 .
gi 701315570 282 P 282
Cdd:cd21340  179 P 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-281 8.71e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 8.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  87 LQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNrylrALAADTFQGLVKLHALYLYKCGLSSL 166
Cdd:PLN00113 125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----VLVGKIPNSLTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 167 PSGI---FGGLHNLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAF 243
Cdd:PLN00113 201 VGQIpreLGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 701315570 244 HDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGN 281
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
LRRCT smart00082
Leucine rich repeat C-terminal domain;
281-326 1.77e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 701315570   281 NPWSCDCKARSLWEWLHRFRGSSS--SVICESPEQMHGKDLKVLRVED 326
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEF 48
LRR smart00370
Leucine-rich repeats, outliers;
198-221 5.24e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.24e-03
                           10        20
                   ....*....|....*....|....
gi 701315570   198 LVNLSHLFLHGNKLWSLHQNTFRG 221
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-282 4.15e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 4.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 106 TLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKCGLSSLPSGIfGGLHNLQYLYLQDN 185
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQ-LTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 186 HIEFLQDDIFvDLVNLSHLFLHGNKLWSLHQNtFRGLINLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELqgD 265
Cdd:COG4886  193 QITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--P 266

                        170
                 ....*....|....*..
gi 701315570 266 CLAHLGALEFLRLNGNP 282
Cdd:COG4886  267 PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-281 5.21e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 5.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  83 ERIFLQNNQITLLLRGHFS-PSMVTLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKC 161
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ-LTDLPEE-LGNLTNLKELDLSNN 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 162 GLSSLPSGIfGGLHNLQYLYLQDNHIEFLQDDIfVDLVNLSHLFLHGNKLWSLHQntFRGLINLDRLLIHQNQLQWIhrR 241
Cdd:COG4886  193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--P 266

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 701315570 242 AFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGN 281
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-281 1.02e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  80 EDSERIFLQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNRYLralaadtfQGLVKLHALYLY 159
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL--------SNLTNLESLDLS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 160 KCGLSSLPSGIfGGLHNLQYLYLQDNHIEFLQDDIFvDLVNLSHLFLHGNKLWSLhQNTFRGLINLDRLLIHQNQLQWIH 239
Cdd:COG4886  122 GNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 701315570 240 rRAFHDLRRLTTLFLFNNSLSELqGDCLAHLGALEFLRLNGN 281
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
200-259 9.88e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 9.88e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  200 NLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAFHDLRRLTTLFLFNNSL 259
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-279 1.65e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  83 ERIFLQNNQITLLlRGHFS--PSMVTLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAAdtFQGLVKLHALYLYK 160
Cdd:COG4886  185 KELDLSNNQITDL-PEPLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ-LTDLPE--LGNLTNLEELDLSN 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 161 CGLSSLPSgiFGGLHNLQYLYLQDNHI-----EFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQL 235
Cdd:COG4886  260 NQLTDLPP--LANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 701315570 236 QWIHRRAFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLN 279
Cdd:COG4886  338 TTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 152-282 2.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLPSgiFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNK------------LWSLH---Q 216
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenltnLEELHienQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 217 NTFRG--LI-----------NLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELQ--GDCLAHLGALEFLRLNGN 281
Cdd:cd21340  101 RLPPGekLTfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178


                 .
gi 701315570 282 P 282
Cdd:cd21340  179 P 179
LRR_8 pfam13855
Leucine rich repeat;
176-235 4.96e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 4.96e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  176 NLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQL 235
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
152-211 4.22e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 4.22e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  152 KLHALYLYKCGLSSLPSGIFGGLHNLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKL 211
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 152-281 3.64e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLpsGIFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNKLWSLhQNtFRGLINLDRLLIH 231
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLG 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 701315570 232 QN------------QLQWIH----------------RRAFHDLRRLTTLFLFNNSLSELQgdCLAHLGALEFLRLNGN 281
Cdd:cd21340   77 GNrisvveglenltNLEELHienqrlppgekltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
224-282 5.64e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 5.64e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 701315570  224 NLDRLLIHQNQLQWIHRRAFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGNP 282
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-284 6.64e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 6.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  74 IPEGIPEDSERIFLQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNRYL----RALAADTFQG 149
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLllslLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 150 LVKLHALYLYKCGLsslpsgiFGGLHNLQYLYLQDNHIEFLQDDIFvDLVNLSHLFLHGNKLWSLHqntfrglinldrll 229
Cdd:COG4886   95 LTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLP-------------- 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 701315570 230 ihqnqlqwihrRAFHDLRRLTTLFLFNNSLSELqGDCLAHLGALEFLRLNGNPWS 284
Cdd:COG4886  153 -----------EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQIT 195
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-281 8.71e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 8.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  87 LQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNrylrALAADTFQGLVKLHALYLYKCGLSSL 166
Cdd:PLN00113 125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----VLVGKIPNSLTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 167 PSGI---FGGLHNLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAF 243
Cdd:PLN00113 201 VGQIpreLGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 701315570 244 HDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGN 281
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-233 1.02e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  85 IFLQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPntFDGFVNLEELDLGDNRyLRALAAdtFQGLVKLHALYLYK---- 160
Cdd:cd21340   29 LYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR-ISVVEG--LENLTNLEELHIENqrlp 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570 161 --CGLSSLPSGIFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNKLWSLHQ--NTFRGLINLDRLLIHQN 233
Cdd:cd21340  104 pgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
102-158 1.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.56e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570  102 PSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNRyLRALAADTFQGLVKLHALYL 158
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDL 56
LRR_8 pfam13855
Leucine rich repeat;
83-137 1.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570   83 ERIFLQNNQITLLLRGHFS--PSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNR 137
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 108-284 4.15e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 4.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 108 WIY--SNNITFIDPNTFDGFVNLEELDLGDNRyLRALAADTFQGLVKLHALYLYKCGLS-SLPSGIFGgLHNLQYLYLQD 184
Cdd:PLN00113 216 WIYlgYNNLSGEIPYEIGGLTSLNHLDLVYNN-LTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSD 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 185 NHIEFLQDDIFVDLVNLSHLFLHGNK-------------------LWSlhqNTFRGLI--------NLDRLLIHQNQLQW 237
Cdd:PLN00113 294 NSLSGEIPELVIQLQNLEILHLFSNNftgkipvaltslprlqvlqLWS---NKFSGEIpknlgkhnNLTVLDLSTNNLTG 370

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 701315570 238 IHRRAFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGNPWS 284
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFS 417
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
71-214 9.16e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 9.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  71 FVTIPEGIPEDSERIFLQNNQItLLLRGHFSPSMVTLWIYSNNITFIdPNTFDGfvNLEELDLGDNRYL----RALAAdt 146
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNEL-KSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITelpeRLPSA-- 263

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 701315570 147 fqglvkLHALYLYKCGLSSLPSGIFGGlhnLQYLYLQDNHIEFLQDDIFVDLVnlsHLFLHGNKLWSL 214
Cdd:PRK15370 264 ------LQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTAL 319
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
63-202 1.24e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570  63 TVSCQAHNFVTIPEGIPEDSERIFLQNNQITLLLRgHFSPSMVTLWIYSNNITFIDPNTFDGfvnLEELDLGDNRyLRAL 142
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINRITELPE-RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNS-IRTL 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 143 AADTFQGLVKlhaLYLYKCGLSSLPSGIfggLHNLQYLYLQDNHIEFLQDDIFVDLVNLS 202
Cdd:PRK15370 299 PAHLPSGITH---LNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLD 352
LRRCT smart00082
Leucine rich repeat C-terminal domain;
281-326 1.77e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 701315570   281 NPWSCDCKARSLWEWLHRFRGSSS--SVICESPEQMHGKDLKVLRVED 326
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEF 48
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 128-282 1.01e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 128 LEELDLGDN---RYLRALAA--DTFQGLVKLHALYLYKCGLSSLPSGIFGGLH---NLQYLYLQDNHIE-----FLQDDI 194
Cdd:cd00116   53 LKELCLSLNetgRIPRGLQSllQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGdrglrLLAKGL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 195 FVDLVNLSHLFLHGNKL-------WSlhqNTFRGLINLDRLLIHQNQL--QWIHR--RAFHDLRRLTTLFLFNNSLSELQ 263
Cdd:cd00116  133 KDLPPALEKLVLGRNRLegasceaLA---KALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEG 209

                        170       180
                 ....*....|....*....|...
gi 701315570 264 G----DCLAHLGALEFLRLNGNP 282
Cdd:cd00116  210 AsalaETLASLKSLEVLNLGDNN 232
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 102-144 1.39e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 701315570  102 PSMVTLWIYSNNITFIDPntFDGFVNLEELDLGDNRYLRALAA 144
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 176-213 2.02e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 701315570  176 NLQYLYLQDNHIEFLqdDIFVDLVNLSHLFLHGNKLWS 213
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
LRR smart00370
Leucine-rich repeats, outliers;
198-221 5.24e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.24e-03
                           10        20
                   ....*....|....*....|....
gi 701315570   198 LVNLSHLFLHGNKLWSLHQNTFRG 221
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
198-221 5.24e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.24e-03
                           10        20
                   ....*....|....*....|....
gi 701315570   198 LVNLSHLFLHGNKLWSLHQNTFRG 221
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-282 8.32e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 8.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 126 VNLEELDLGDNRYLRALAADTFQGLVKLHALYLYKCGLSSLPSGIFGGLHNLQYLYLQDNHIEFLQDDIfvDLVNLSHLF 205
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLL--SLLLLLLLS 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570 206 LHGNKLWSLHQNTFRGLINLDRLLIHQNQlqwihrrAFHDLRRLTTLFLFNNSLSELqGDCLAHLGALEFLRLNGNP 282
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQ 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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