|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
106-282 |
4.15e-27 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 113.10 E-value: 4.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 106 TLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKCGLSSLPSGIfGGLHNLQYLYLQDN 185
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQ-LTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 186 HIEFLQDDIFvDLVNLSHLFLHGNKLWSLHQNtFRGLINLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELqgD 265
Cdd:COG4886 193 QITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--P 266
|
170
....*....|....*..
gi 701315570 266 CLAHLGALEFLRLNGNP 282
Cdd:COG4886 267 PLANLTNLKTLDLSNNQ 283
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
200-259 |
9.88e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.85 E-value: 9.88e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 200 NLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAFHDLRRLTTLFLFNNSL 259
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
152-282 |
2.65e-11 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 63.27 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLPSgiFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNK------------LWSLH---Q 216
Cdd:cd21340 25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenltnLEELHienQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 217 NTFRG--LI-----------NLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELQ--GDCLAHLGALEFLRLNGN 281
Cdd:cd21340 101 RLPPGekLTfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
.
gi 701315570 282 P 282
Cdd:cd21340 179 P 179
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
87-281 |
8.71e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 54.85 E-value: 8.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 87 LQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNrylrALAADTFQGLVKLHALYLYKCGLSSL 166
Cdd:PLN00113 125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----VLVGKIPNSLTNLTSLEFLTLASNQL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 167 PSGI---FGGLHNLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAF 243
Cdd:PLN00113 201 VGQIpreLGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280
|
170 180 190
....*....|....*....|....*....|....*...
gi 701315570 244 HDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGN 281
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
281-326 |
1.77e-04 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.34 E-value: 1.77e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 701315570 281 NPWSCDCKARSLWEWLHRFRGSSS--SVICESPEQMHGKDLKVLRVED 326
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEF 48
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
198-221 |
5.24e-03 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 34.25 E-value: 5.24e-03
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
106-282 |
4.15e-27 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 113.10 E-value: 4.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 106 TLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKCGLSSLPSGIfGGLHNLQYLYLQDN 185
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQ-LTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 186 HIEFLQDDIFvDLVNLSHLFLHGNKLWSLHQNtFRGLINLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELqgD 265
Cdd:COG4886 193 QITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--P 266
|
170
....*....|....*..
gi 701315570 266 CLAHLGALEFLRLNGNP 282
Cdd:COG4886 267 PLANLTNLKTLDLSNNQ 283
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
83-281 |
5.21e-25 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 106.94 E-value: 5.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 83 ERIFLQNNQITLLLRGHFS-PSMVTLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAADtFQGLVKLHALYLYKC 161
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ-LTDLPEE-LGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 162 GLSSLPSGIfGGLHNLQYLYLQDNHIEFLQDDIfVDLVNLSHLFLHGNKLWSLHQntFRGLINLDRLLIHQNQLQWIhrR 241
Cdd:COG4886 193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--P 266
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 701315570 242 AFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGN 281
Cdd:COG4886 267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
80-281 |
1.02e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 100.01 E-value: 1.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 80 EDSERIFLQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNRYLralaadtfQGLVKLHALYLY 159
Cdd:COG4886 50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL--------SNLTNLESLDLS 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 160 KCGLSSLPSGIfGGLHNLQYLYLQDNHIEFLQDDIFvDLVNLSHLFLHGNKLWSLhQNTFRGLINLDRLLIHQNQLQWIH 239
Cdd:COG4886 122 GNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP 198
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 701315570 240 rRAFHDLRRLTTLFLFNNSLSELqGDCLAHLGALEFLRLNGN 281
Cdd:COG4886 199 -EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
200-259 |
9.88e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.85 E-value: 9.88e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 200 NLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAFHDLRRLTTLFLFNNSL 259
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
83-279 |
1.65e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 66.11 E-value: 1.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 83 ERIFLQNNQITLLlRGHFS--PSMVTLWIYSNNITFIdPNTFDGFVNLEELDLGDNRyLRALAAdtFQGLVKLHALYLYK 160
Cdd:COG4886 185 KELDLSNNQITDL-PEPLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ-LTDLPE--LGNLTNLEELDLSN 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 161 CGLSSLPSgiFGGLHNLQYLYLQDNHI-----EFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQL 235
Cdd:COG4886 260 NQLTDLPP--LANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 701315570 236 QWIHRRAFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLN 279
Cdd:COG4886 338 TTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
152-282 |
2.65e-11 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 63.27 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLPSgiFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNK------------LWSLH---Q 216
Cdd:cd21340 25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvveglenltnLEELHienQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 217 NTFRG--LI-----------NLDRLLIHQNQLQWIhrRAFHDLRRLTTLFLFNNSLSELQ--GDCLAHLGALEFLRLNGN 281
Cdd:cd21340 101 RLPPGekLTfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
.
gi 701315570 282 P 282
Cdd:cd21340 179 P 179
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
176-235 |
4.96e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 4.96e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 176 NLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQL 235
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
152-211 |
4.22e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.22 E-value: 4.22e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLPSGIFGGLHNLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKL 211
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
152-281 |
3.64e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 56.72 E-value: 3.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 152 KLHALYLYKCGLSSLpsGIFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNKLWSLhQNtFRGLINLDRLLIH 231
Cdd:cd21340 3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLG 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 701315570 232 QN------------QLQWIH----------------RRAFHDLRRLTTLFLFNNSLSELQgdCLAHLGALEFLRLNGN 281
Cdd:cd21340 77 GNrisvveglenltNLEELHienqrlppgekltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
224-282 |
5.64e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.14 E-value: 5.64e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 701315570 224 NLDRLLIHQNQLQWIHRRAFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGNP 282
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
74-284 |
6.64e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 6.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 74 IPEGIPEDSERIFLQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNRYL----RALAADTFQG 149
Cdd:COG4886 15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLllslLLLGLTDLGD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 150 LVKLHALYLYKCGLsslpsgiFGGLHNLQYLYLQDNHIEFLQDDIFvDLVNLSHLFLHGNKLWSLHqntfrglinldrll 229
Cdd:COG4886 95 LTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLP-------------- 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 701315570 230 ihqnqlqwihrRAFHDLRRLTTLFLFNNSLSELqGDCLAHLGALEFLRLNGNPWS 284
Cdd:COG4886 153 -----------EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQIT 195
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
87-281 |
8.71e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 54.85 E-value: 8.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 87 LQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNrylrALAADTFQGLVKLHALYLYKCGLSSL 166
Cdd:PLN00113 125 LSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN----VLVGKIPNSLTNLTSLEFLTLASNQL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 167 PSGI---FGGLHNLQYLYLQDNHIEFLQDDIFVDLVNLSHLFLHGNKLWSLHQNTFRGLINLDRLLIHQNQLQWIHRRAF 243
Cdd:PLN00113 201 VGQIpreLGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSI 280
|
170 180 190
....*....|....*....|....*....|....*...
gi 701315570 244 HDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGN 281
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
85-233 |
1.02e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 52.48 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 85 IFLQNNQITLLLRGHFSPSMVTLWIYSNNITFIDPntFDGFVNLEELDLGDNRyLRALAAdtFQGLVKLHALYLYK---- 160
Cdd:cd21340 29 LYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR-ISVVEG--LENLTNLEELHIENqrlp 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570 161 --CGLSSLPSGIFGGLHNLQYLYLQDNHIEFLQDdiFVDLVNLSHLFLHGNKLWSLHQ--NTFRGLINLDRLLIHQN 233
Cdd:cd21340 104 pgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
102-158 |
1.56e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 1.56e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570 102 PSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNRyLRALAADTFQGLVKLHALYL 158
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDL 56
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
83-137 |
1.66e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 1.66e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570 83 ERIFLQNNQITLLLRGHFS--PSMVTLWIYSNNITFIDPNTFDGFVNLEELDLGDNR 137
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
108-284 |
4.15e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.46 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 108 WIY--SNNITFIDPNTFDGFVNLEELDLGDNRyLRALAADTFQGLVKLHALYLYKCGLS-SLPSGIFGgLHNLQYLYLQD 184
Cdd:PLN00113 216 WIYlgYNNLSGEIPYEIGGLTSLNHLDLVYNN-LTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSD 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 185 NHIEFLQDDIFVDLVNLSHLFLHGNK-------------------LWSlhqNTFRGLI--------NLDRLLIHQNQLQW 237
Cdd:PLN00113 294 NSLSGEIPELVIQLQNLEILHLFSNNftgkipvaltslprlqvlqLWS---NKFSGEIpknlgkhnNLTVLDLSTNNLTG 370
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 701315570 238 IHRRAFHDLRRLTTLFLFNNSLSELQGDCLAHLGALEFLRLNGNPWS 284
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFS 417
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
71-214 |
9.16e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.07 E-value: 9.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 71 FVTIPEGIPEDSERIFLQNNQItLLLRGHFSPSMVTLWIYSNNITFIdPNTFDGfvNLEELDLGDNRYL----RALAAdt 146
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNEL-KSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITelpeRLPSA-- 263
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 701315570 147 fqglvkLHALYLYKCGLSSLPSGIFGGlhnLQYLYLQDNHIEFLQDDIFVDLVnlsHLFLHGNKLWSL 214
Cdd:PRK15370 264 ------LQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTAL 319
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
63-202 |
1.24e-04 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 44.69 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 63 TVSCQAHNFVTIPEGIPEDSERIFLQNNQITLLLRgHFSPSMVTLWIYSNNITFIDPNTFDGfvnLEELDLGDNRyLRAL 142
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINRITELPE-RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNS-IRTL 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 143 AADTFQGLVKlhaLYLYKCGLSSLPSGIfggLHNLQYLYLQDNHIEFLQDDIFVDLVNLS 202
Cdd:PRK15370 299 PAHLPSGITH---LNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLD 352
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
281-326 |
1.77e-04 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 39.34 E-value: 1.77e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 701315570 281 NPWSCDCKARSLWEWLHRFRGSSS--SVICESPEQMHGKDLKVLRVED 326
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGPLLELLHSEF 48
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
128-282 |
1.01e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 41.19 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 128 LEELDLGDN---RYLRALAA--DTFQGLVKLHALYLYKCGLSSLPSGIFGGLH---NLQYLYLQDNHIE-----FLQDDI 194
Cdd:cd00116 53 LKELCLSLNetgRIPRGLQSllQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGdrglrLLAKGL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 195 FVDLVNLSHLFLHGNKL-------WSlhqNTFRGLINLDRLLIHQNQL--QWIHR--RAFHDLRRLTTLFLFNNSLSELQ 263
Cdd:cd00116 133 KDLPPALEKLVLGRNRLegasceaLA---KALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEG 209
|
170 180
....*....|....*....|...
gi 701315570 264 G----DCLAHLGALEFLRLNGNP 282
Cdd:cd00116 210 AsalaETLASLKSLEVLNLGDNN 232
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
102-144 |
1.39e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 1.39e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 701315570 102 PSMVTLWIYSNNITFIDPntFDGFVNLEELDLGDNRYLRALAA 144
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
176-213 |
2.02e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.07 E-value: 2.02e-03
10 20 30
....*....|....*....|....*....|....*...
gi 701315570 176 NLQYLYLQDNHIEFLqdDIFVDLVNLSHLFLHGNKLWS 213
Cdd:pfam12799 2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
198-221 |
5.24e-03 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 34.25 E-value: 5.24e-03
|
| LRR_TYP |
smart00369 |
Leucine-rich repeats, typical (most populated) subfamily; |
198-221 |
5.24e-03 |
|
Leucine-rich repeats, typical (most populated) subfamily;
Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 34.25 E-value: 5.24e-03
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
126-282 |
8.32e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 38.38 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701315570 126 VNLEELDLGDNRYLRALAADTFQGLVKLHALYLYKCGLSSLPSGIFGGLHNLQYLYLQDNHIEFLQDDIfvDLVNLSHLF 205
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLL--SLLLLLLLS 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 701315570 206 LHGNKLWSLHQNTFRGLINLDRLLIHQNQlqwihrrAFHDLRRLTTLFLFNNSLSELqGDCLAHLGALEFLRLNGNP 282
Cdd:COG4886 79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQ 147
|
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|