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Conserved domains on  [gi|700373066|ref|XP_009943931|]
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PREDICTED: serine palmitoyltransferase 1 [Opisthocomus hoazin]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 13-461 5.18e-173

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02822:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 481  Bit Score: 494.26  E-value: 5.18e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  13 HLILEGILILWIIRLLFSKTYKLQERSdLTPKEKEELIEEWQPEPLVPPVPK----DHPALNYniVSGPPThiiTVNGKE 88
Cdd:PLN02822  37 HLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEemrpEPPVLES--AAGPHT---IINGKD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  89 CINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPAYS 168
Cdd:PLN02822 111 VVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFC 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 169 KRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQETEDqknpRKARVTRRFIVVEGLYMNTGDVCPLPE 248
Cdd:PLN02822 191 KKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRKKKLRRYIVVEAIYQNSGQIAPLDE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 249 LIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGINIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGYCFSA 328
Cdd:PLN02822 267 IVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYVFSA 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 329 SLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGISGLKVVGESFSPALHLQLEESCGSRENDVKLLKRVVDYC 408
Cdd:PLN02822 347 SLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRM 426

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 700373066 409 MNSG---IALTQARYLekeEKCLPPPSIRVVITVEQTEQELDKAASLLKEAAQSVL 461
Cdd:PLN02822 427 LKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESLKRVAASVL 479
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 13-461 5.18e-173

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 494.26  E-value: 5.18e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  13 HLILEGILILWIIRLLFSKTYKLQERSdLTPKEKEELIEEWQPEPLVPPVPK----DHPALNYniVSGPPThiiTVNGKE 88
Cdd:PLN02822  37 HLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEemrpEPPVLES--AAGPHT---IINGKD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  89 CINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPAYS 168
Cdd:PLN02822 111 VVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFC 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 169 KRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQETEDqknpRKARVTRRFIVVEGLYMNTGDVCPLPE 248
Cdd:PLN02822 191 KKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRKKKLRRYIVVEAIYQNSGQIAPLDE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 249 LIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGINIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGYCFSA 328
Cdd:PLN02822 267 IVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYVFSA 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 329 SLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGISGLKVVGESFSPALHLQLEESCGSRENDVKLLKRVVDYC 408
Cdd:PLN02822 347 SLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRM 426

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 700373066 409 MNSG---IALTQARYLekeEKCLPPPSIRVVITVEQTEQELDKAASLLKEAAQSVL 461
Cdd:PLN02822 427 LKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESLKRVAASVL 479
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 73-458 2.88e-81

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 256.13  E-value: 2.88e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  73 IVSGPPTHIITVNGKECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAII 152
Cdd:COG0156   23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 153 YSYGFATIASAIPAYSKRGDIVFVDEA--ACfaIQKGLQASRSNIKLFKHNDMADLERLLKEqetedqknPRKARvtRRF 230
Cdd:COG0156  103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 231 IVVEGLY-MnTGDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGInIDDIDLISANMENSLASIGGFCCG 309
Cdd:COG0156  171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAG 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 310 RSFIIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKvVGESFSPALHLQLEe 389
Cdd:COG0156  249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIVG- 325

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 700373066 390 scgsrenDVKLLKRVVDYCMNSGIALTQARYlekeekclppPS-------IRVVITVEQTEQELDKAASLLKEAAQ 458
Cdd:COG0156  326 -------DAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGK 384
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 87-456 1.10e-75

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 240.54  E-value: 1.10e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  87 KECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPA 166
Cdd:cd06454    1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 167 YSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEqetedqkNPRKARvtRRFIVVEGLYMNTGDVCPL 246
Cdd:cd06454   81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 247 PELIKLKYKYKVRIFLEESLSFGVLGEHGRGItEHFGINIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGYCF 326
Cdd:cd06454  152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 327 SASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKVVGESFSPALHLQLEESCGSRENDVKLLKRvvd 406
Cdd:cd06454  231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGDDPAKAVAFSDALLER--- 306

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 700373066 407 ycmnsGIALTQARY---LEKEEKclpppsIRVVITVEQTEQELDKAASLLKEA 456
Cdd:cd06454  307 -----GIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
87-451 3.55e-22

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 97.38  E-value: 3.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066   87 KECINFASFNFLGLLDNEKVKSAAQAslkkygvGTCGPRGFYGTFDVHLELEDRLAKFM--------KTEEAIIYSYGFA 158
Cdd:pfam00155   1 TDKINLGSNEYLGDTLPAVAKAEKDA-------LAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  159 TIASAIPAYSK-RGDIVFVDEAACFAIQKGLQASRSNIKLFK-------HNDMADLERLLKEQetedqknprkarvtRRF 230
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  231 IVVEGLYMNTGDVCPLPELIKL---KYKYKVRIFLEESLSFGVLGEHGRGITEHFGIniDDIDLISAN-MENSLASIG-- 304
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLA--EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  305 -GFCCGRSFIIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKVVGeSFSPAL 383
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 700373066  384 HLQLeescGSRENDVKLLKRVVDYCmnsGIALTQARYLEKeekclpPPSIRVVITVeQTEQELDKAAS 451
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLE 349
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 13-461 5.18e-173

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 494.26  E-value: 5.18e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  13 HLILEGILILWIIRLLFSKTYKLQERSdLTPKEKEELIEEWQPEPLVPPVPK----DHPALNYniVSGPPThiiTVNGKE 88
Cdd:PLN02822  37 HLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEemrpEPPVLES--AAGPHT---IINGKD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  89 CINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPAYS 168
Cdd:PLN02822 111 VVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFC 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 169 KRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQETEDqknpRKARVTRRFIVVEGLYMNTGDVCPLPE 248
Cdd:PLN02822 191 KKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRKKKLRRYIVVEAIYQNSGQIAPLDE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 249 LIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGINIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGYCFSA 328
Cdd:PLN02822 267 IVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYVFSA 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 329 SLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGISGLKVVGESFSPALHLQLEESCGSRENDVKLLKRVVDYC 408
Cdd:PLN02822 347 SLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRM 426

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 700373066 409 MNSG---IALTQARYLekeEKCLPPPSIRVVITVEQTEQELDKAASLLKEAAQSVL 461
Cdd:PLN02822 427 LKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESLKRVAASVL 479
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 90-462 3.14e-115

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 343.81  E-value: 3.14e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  90 INFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK 169
Cdd:PLN03227   1 LNFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 170 RGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQETEDQKNPRKARVTRRFIVVEGLYMNTGDVCPLPEL 249
Cdd:PLN03227  81 RGDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQVRAQDVALKRKPTDQRRFLVVEGLYKNTGTLAPLKEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 250 IKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGIN-IDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGYCFSA 328
Cdd:PLN03227 161 VALKEEFHYRLILDESFSFGTLGKSGRGSLEHAGLKpMVHAEIVTFSLENAFGSVGGMTVGSEEVVDHQRLSGSGYCFSA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 329 SLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIS---------GLKVVGESFSPALHLQLEESCGSREND-V 398
Cdd:PLN03227 241 SAPPFLAKADATATAGELAGPQLLNRLHDSIANLYSTLTNSShpyalklrnRLVITSDPISPIIYLRLSDQEATRRTDeT 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 700373066 399 KLLKRVVDYCMNSGIALTQAR-YLEKEEKCLPPPSIRVVITVEQTEQELDKAASLLKEAAQSVLN 462
Cdd:PLN03227 321 LILDQIAHHSLSEGVAVVSTGgHVKKFLQLVPPPCLRVVANASHTREDIDKLLTVLGEAVEAILC 385
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 73-458 2.88e-81

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 256.13  E-value: 2.88e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  73 IVSGPPTHIITVNGKECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAII 152
Cdd:COG0156   23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 153 YSYGFATIASAIPAYSKRGDIVFVDEA--ACfaIQKGLQASRSNIKLFKHNDMADLERLLKEqetedqknPRKARvtRRF 230
Cdd:COG0156  103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 231 IVVEGLY-MnTGDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGInIDDIDLISANMENSLASIGGFCCG 309
Cdd:COG0156  171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAG 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 310 RSFIIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKvVGESFSPALHLQLEe 389
Cdd:COG0156  249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIVG- 325

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 700373066 390 scgsrenDVKLLKRVVDYCMNSGIALTQARYlekeekclppPS-------IRVVITVEQTEQELDKAASLLKEAAQ 458
Cdd:COG0156  326 -------DAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGK 384
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 87-456 1.10e-75

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 240.54  E-value: 1.10e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  87 KECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPA 166
Cdd:cd06454    1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 167 YSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEqetedqkNPRKARvtRRFIVVEGLYMNTGDVCPL 246
Cdd:cd06454   81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 247 PELIKLKYKYKVRIFLEESLSFGVLGEHGRGItEHFGINIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGYCF 326
Cdd:cd06454  152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 327 SASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKVVGESFSPALHLQLEESCGSRENDVKLLKRvvd 406
Cdd:cd06454  231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGDDPAKAVAFSDALLER--- 306

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 700373066 407 ycmnsGIALTQARY---LEKEEKclpppsIRVVITVEQTEQELDKAASLLKEA 456
Cdd:cd06454  307 -----GIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
PLN02483 PLN02483
serine palmitoyltransferase
 83-460 1.36e-56

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 194.98  E-value: 1.36e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  83 TVNGKECINFASFNFLGLLD-NEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIA 161
Cdd:PLN02483  96 TTKTRRCLNLGSYNYLGFAAaDEYCTPRVIESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYATNS 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 162 SAIPAYSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQETEDQknPRKARVTRRFIV-VEGLYMNT 240
Cdd:PLN02483 176 TIIPALIGKGGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLREQIAEGQ--PRTHRPWKKIIViVEGIYSME 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 241 GDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGINIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLS 320
Cdd:PLN02483 254 GELCKLPEIVAVCKKYKAYVYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAGSKELIQYLKRT 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 321 GQGYCFSASL-PPLLAAAAIEALNIM-EDNPDI----FQTLRAKCERIHKALQGIsGLKVVGESFSPALHLQLEESCG-- 392
Cdd:PLN02483 334 CPAHLYATSMsPPAVQQVISAIKVILgEDGTNRgaqkLAQIRENSNFFRSELQKM-GFEVLGDNDSPVMPIMLYNPAKip 412

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 700373066 393 --SREndvkllkrvvdyCMNSGIALTQARYlekeeKCLPP--PSIRVVITVEQTEQELDKAASLLKEAAQSV 460
Cdd:PLN02483 413 afSRE------------CLKQNVAVVVVGF-----PATPLllARARICISASHSREDLIKALEVISEVGDLV 467
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 73-332 1.85e-48

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 170.76  E-value: 1.85e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  73 IVSGPPTHIITVNGKECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAII 152
Cdd:PRK06939  28 ITSPQGADITVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMASVRFICGTQDLHKELEEKLAKFLGTEDAIL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 153 YSYGFATIASAIPAYSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQetedqknpRKARVTRRFIV 232
Cdd:PRK06939 108 YSSCFDANGGLFETLLGKEDAIISDALNHASIIDGVRLCKAKRYRYANNDMADLEAQLKEA--------KEAGARHKLIA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 233 VEGLYMNTGDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGInIDDIDLISANMENSLA-SIGGFCCGRS 311
Cdd:PRK06939 180 TDGVFSMDGDIAPLPEICDLADKYDALVMVDDSHAVGFVGENGRGTVEHFGV-MDRVDIITGTLGKALGgASGGYTAGRK 258

                        250       260
                 ....*....|....*....|.
gi 700373066 312 FIIDHQRLSGQGYCFSASLPP 332
Cdd:PRK06939 259 EVIDWLRQRSRPYLFSNSLAP 279
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 73-457 1.92e-48

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 170.34  E-value: 1.92e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  73 IVSGPPTHIITVNGKECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAII 152
Cdd:PRK05958  25 PREGGAGRWLVVDGRRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRLVTGNSPAHEALEEELAEWFGAERALL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 153 YSYGFATIASAIPAYSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLkeqetedqknpRKARVTRRFIV 232
Cdd:PRK05958 105 FSSGYAANLAVLTALAGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVDALEALL-----------AKWRAGRALIV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 233 VEGLYMNTGDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGInIDDIDLIS-ANMENSLASIGGFCCGRS 311
Cdd:PRK05958 174 TESVFSMDGDLAPLAELVALARRHGAWLLVDEAHGTGVLGPQGRGLAAEAGL-AGEPDVILvGTLGKALGSSGAAVLGSE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 312 FIIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGISglKVVGESFSPALHLQLeesc 391
Cdd:PRK05958 253 TLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPERRERLAALIARLRAGLRALG--FQLMDSQSAIQPLIV---- 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 700373066 392 GSRENDVKLLKRvvdyCMNSGIALTqarylekeekCLPPPS-------IRVVITVEQTEQELDKAASLLKEAA 457
Cdd:PRK05958 327 GDNERALALAAA----LQEQGFWVG----------AIRPPTvpagtsrLRITLTAAHTEADIDRLLEALAEAL 385
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 87-332 1.61e-30

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 122.27  E-value: 1.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  87 KECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIPA 166
Cdd:PRK13392  46 RRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAGAGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALST 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 167 YSKR--GDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQETEDQKnprkarvtrrFIVVEGLYMNTGDVC 244
Cdd:PRK13392 126 LGKLlpGCVILSDALNHASMIEGIRRSGAEKQVFRHNDLADLEEQLASVDPDRPK----------LIAFESVYSMDGDIA 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 245 PLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGInIDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSGQGY 324
Cdd:PRK13392 196 PIEAICDLADRYNALTYVDEVHAVGLYGARGGGIAERDGL-MDRIDMIQGTLAKAFGCLGGYIAASADLIDFVRSFAPGF 274


                 ....*...
gi 700373066 325 CFSASLPP 332
Cdd:PRK13392 275 IFTTALPP 282
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
87-451 3.55e-22

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 97.38  E-value: 3.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066   87 KECINFASFNFLGLLDNEKVKSAAQAslkkygvGTCGPRGFYGTFDVHLELEDRLAKFM--------KTEEAIIYSYGFA 158
Cdd:pfam00155   1 TDKINLGSNEYLGDTLPAVAKAEKDA-------LAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  159 TIASAIPAYSK-RGDIVFVDEAACFAIQKGLQASRSNIKLFK-------HNDMADLERLLKEQetedqknprkarvtRRF 230
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  231 IVVEGLYMNTGDVCPLPELIKL---KYKYKVRIFLEESLSFGVLGEHGRGITEHFGIniDDIDLISAN-MENSLASIG-- 304
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLA--EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  305 -GFCCGRSFIIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKVVGeSFSPAL 383
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 700373066  384 HLQLeescGSRENDVKLLKRVVDYCmnsGIALTQARYLEKeekclpPPSIRVVITVeQTEQELDKAAS 451
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLE 349
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
86-460 7.37e-19

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 88.14  E-value: 7.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  86 GKECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIASAIP 165
Cdd:PRK07179  53 GPDAIILQSNDYLNLSGHPDIIKAQIAALQEEGDSLVMSAVFLHDDSPKPQFEKKLAAFTGFESCLLCQSGWAANVGLLQ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 166 AYSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLkeqetedqknprkarvtRRF----IVVEGLYMNTG 241
Cdd:PRK07179 133 TIADPNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQI-----------------ERHgpgiIVVDSVYSTTG 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 242 DVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGINiDDIDLISANMENSLASIGGFCCGRSFIIDHQRLSG 321
Cdd:PRK07179 196 TIAPLADIVDIAEEFGCVLVVDESHSLGTHGPQGAGLVAELGLT-SRVHFITASLAKAFAGRAGIITCPRELAEYVPFVS 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 322 QGYCFSASLPPLLAAAAIEALNIMEDNPDIFQTLRAKCERIHKALQGIsGLKVVGESFSPALhlqleeSCGSrENDVKLL 401
Cdd:PRK07179 275 YPAIFSSTLLPHEIAGLEATLEVIESADDRRARLHANARFLREGLSEL-GYNIRSESQIIAL------ETGS-ERNTEVL 346

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 700373066 402 KrvvdycmnsgialtqaRYLEKEEK-----CLPPPS-----IRVVITVEQTEQELDKAASLLKEAAQSV 460
Cdd:PRK07179 347 R----------------DALEERNVfgavfCAPATPknrnlIRLSLNADLTASDLDRVLEVCREARDEV 399
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 90-283 1.52e-17

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 84.06  E-value: 1.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  90 INFASFNFLGLLDNEKVKSAAQASLKKY-------GVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFATIAS 162
Cdd:PRK05937   7 IDFVTNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 163 AIPAYSKRGDIVFVDEAACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQetedqknpRKARVTRRFIVVEGLYMNTGD 242
Cdd:PRK05937  87 LCAHLSSVTDYVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLESC--------RQRSFGRIFIFVCSVYSFKGT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 700373066 243 VCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFG 283
Cdd:PRK05937 159 LAPLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGFCHSLG 199
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 87-455 1.75e-16

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 81.64  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  87 KECINFASFNFLGLLDNEKVKSAAQASLKKYGVGTCGPRGFYGTFDVHLELEDRLAKFMKTEEAIIYSYGFA-------- 158
Cdd:PLN02955 102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAanmaamva 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 159 --TIASAIPAYSK----RGDIVFVDEAACFAIQKG--LQASRSNIKLF--KHNDMADLERLLKeqetedqknprKARVTR 228
Cdd:PLN02955 182 igSVASLLAASGKplknEKVAIFSDALNHASIIDGvrLAERQGNVEVFvyRHCDMYHLNSLLS-----------SCKMKR 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 229 RFIVVEGLYMNTGDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRGITEHFGINiDDIDLISANMENSLASIGGF-- 306
Cdd:PLN02955 251 KVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCE-ADVDLCVGTLSKAAGCHGGFia 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 307 CCGRSFIIDHQRlsGQGYCFSASLPplLAAAAIEALNIMEDNPDIFQTlRAKCERIhKALQGISGLKVVgesfSPALHLQ 386
Cdd:PLN02955 330 CSKKWKQLIQSR--GRSFIFSTAIP--VPMAAAAYAAVVVARKEKWRR-KAIWERV-KEFKALSGVDIS----SPIISLV 399

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 700373066 387 LeescGSRENDVKLLKrvvdYCMNSGIALTQARylekeEKCLPPPS--IRVVITVEQTEQELDKAASLLKE 455
Cdd:PLN02955 400 V----GNQEKALKASR----YLLKSGFHVMAIR-----PPTVPPNScrLRVTLSAAHTTEDVKKLITALSS 457
PRK07505 PRK07505
hypothetical protein; Provisional
 80-330 1.54e-13

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 71.93  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066  80 HIITVNGKECINFASFNFLGLLDNEKVKSAAQASLKKYGV-GTCGPRGFYgTFDVHLELEDRLAKFMKTEEAIIYSYGFA 158
Cdd:PRK07505  39 LITLADGHTFVNFVSCSYLGLDTHPAIIEGAVDALKRTGSlHLSSSRTRV-RSQILKDLEEALSELFGASVLTFTSCSAA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 159 T------IASAIPAYSKRGDIVFVDEA-ACFAIQKGLQASRSNIKLFKHNDMADLERLLKEQEtedqknprkarvtRRFI 231
Cdd:PRK07505 118 HlgilplLASGHLTGGVPPHMVFDKNAhASLNILKGICADETEVETIDHNDLDALEDICKTNK-------------TVAY 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700373066 232 VVEGLYmNTGDVCPLPELIKLKYKYKVRIFLEESLSFGVLGEHGRG-ITEHFGINIDDIDLISANMENSLASIGGFC-CG 309
Cdd:PRK07505 185 VADGVY-SMGGIAPVKELLRLQEKYGLFLYIDDAHGLSIYGKNGEGyVRSELDYRLNERTIIAASLGKAFGASGGVImLG 263

                        250       260
                 ....*....|....*....|....*
gi 700373066 310 ----RSFIidhQRLSGqGYCFSASL 330
Cdd:PRK07505 264 daeqIELI---LRYAG-PLAFSQSL 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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