|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
1-452 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 731.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 1 MPPATvAPQYPPPDGGWGWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVN 80
Cdd:TIGR00892 1 MPPAL-PPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 81 KYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTL 160
Cdd:TIGR00892 80 RFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 161 APLNQFLFNAFGWKGSFLILGGLLLNCCVAGSLMRPVGPKTVPPVKKDVEKGTGDSALHKNNKKSFWQTMNKYLDLSLFK 240
Cdd:TIGR00892 160 APLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 241 HRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFY 320
Cdd:TIGR00892 240 HRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 321 NGVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEY 400
Cdd:TIGR00892 320 NGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNY 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 700380260 401 QYMYFVCGVIVIVASIWLFIGNAINYRLLAKEKKLEDEKQKAQKNADSKEAE 452
Cdd:TIGR00892 400 KYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQKAALEREGARDKKDAEGDS 451
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
18-422 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 674.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVGPktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------LFKHRGFLIYLSGNVIMFLG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17427 203 FFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17427 283 VIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIW 362
|
....*
gi 700380260 418 LFIGN 422
Cdd:cd17427 363 LFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
18-421 |
0e+00 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 579.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVGPKtvppvkkdvekgtgdsalhknnkksfwqtmnKYLDLSLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPK-------------------------------PFLDLTLFTHRGFLLYLSGNVIMFFG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17426 210 LFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17426 290 CIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIY 369
|
....
gi 700380260 418 LFIG 421
Cdd:cd17426 370 LFIG 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
18-422 |
4.96e-158 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 452.65 E-value: 4.96e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyLDLSLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-------------------------------------LDFSVFRDRGFVIYTIAKFIMVLG 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17430 204 LFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17430 284 VVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALF 363
|
....*
gi 700380260 418 LFIGN 422
Cdd:cd17430 364 LALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-420 |
3.24e-125 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 368.80 E-value: 3.24e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR------------------------------------------LLKDPTFVLLALGVSFAMLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANskFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17352 199 FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSLLAFPLATTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
...
gi 700380260 418 LFI 420
Cdd:cd17352 357 LFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
18-421 |
2.24e-109 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 328.65 E-value: 2.24e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP-----------------------------------------FCSNTRYQIYTLGVTWMVLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17425 200 FVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASiw 417
Cdd:cd17425 280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAA-- 357
|
....
gi 700380260 418 LFIG 421
Cdd:cd17425 358 LFMG 361
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
18-418 |
5.34e-89 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 276.97 E-value: 5.34e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVGPKTVPPVKkdvekgtgdsalhknnkksfWQTMNKYLDLSLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPAP--------------------PRSLSAAFGLSLLTHRAFLRYALATTLINTG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPkiQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17423 221 YFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGSL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17423 299 LALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLI 378
|
.
gi 700380260 418 L 418
Cdd:cd17423 379 L 379
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-418 |
1.18e-79 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 251.98 E-value: 1.18e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17422 161 LVVGALQLNIVVCGALLR------------------------------------------VLKEPGFICYALFGLFATLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRpKIQYFFSFAVFYnGVCHVMCPLATNYTGL 337
Cdd:cd17422 199 FFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFWSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLM--DLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVAS 415
Cdd:cd17422 277 LVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356
|
...
gi 700380260 416 IWL 418
Cdd:cd17422 357 VFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-419 |
3.20e-68 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 222.38 E-value: 3.20e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17424 161 LILGGFVLNLCVCGALMR------------------------------------------FLLMPDFLVLAVSVLFLAYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGL 337
Cdd:cd17424 199 CSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17424 279 VPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLL 358
|
..
gi 700380260 418 LF 419
Cdd:cd17424 359 LG 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
3.49e-55 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 188.49 E-value: 3.49e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLStLAPLNQFLFNAFGWKGSF 177
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVgpktvppvkkdvekgtgdsalhknnkksfwqtmnkylDLSLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI-------------------------------------DFSLLKDPFFCIYTWSFVFSQLA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRpKIQYFFSFAVFYnGVCHVMCPLATNYTGL 337
Cdd:cd17421 203 YFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK-KYHYHKAYLILC-GVTNLLAPLATTYPLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17421 281 MTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVS 360
|
...
gi 700380260 418 LFI 420
Cdd:cd17421 361 FFL 363
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
6.65e-44 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 158.07 E-value: 6.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR------------------------------------------LFTNKVFVAFIFWALFAYCS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAF-LLSILAFVDMFARPSMGLVANSKFIrpKIQYFFSFAVFYNGVCHVMCPLATNYTG 336
Cdd:cd17429 199 FVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILANFTLGVCILILPLMHTYTG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 337 LVIYAVFFGFAFGMVSSVLFETlMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASI 416
Cdd:cd17429 277 LAIVCALIGFSSGYFSLMPVVT-EDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGII 355
|
....
gi 700380260 417 WLFI 420
Cdd:cd17429 356 CLLL 359
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
18-420 |
1.06e-41 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 153.07 E-value: 1.06e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHT-----SYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGG 92
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 93 ILCSFGMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFG 172
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 173 WKGSFLILGGLLLNCCVAGSLMRPVGPKTVPPvkkdvEKGTGDSALHKNnkksFWQTMNKYLDLSLFKHRGFLIYLSGNV 252
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDP-----KSKPGRRTLHSR----INLFLRKIFNVEIFKRKRYVIWALGIP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 253 IMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIqYFFSFAVFYNGVCHVMCPLAT 332
Cdd:cd17420 232 LALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMIPLCN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 333 NYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVI 412
Cdd:cd17420 311 SFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPL 390
|
....*...
gi 700380260 413 VASIWLFI 420
Cdd:cd17420 391 IGSSLLFF 398
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-420 |
5.17e-40 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 148.49 E-value: 5.17e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFG 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 99 MIASSFCNSvLELYLCIGVVGGLGLAFNLQPALTMIGKYFYK-KRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVGPKTVPPVKKDVEKGTgdsalhknnkksfwqtmnkyldLSLFKHRGFLIYLSGNVIMFIG 257
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ----------------------LEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHK-GIDEYSAAFLLSILAFVDMFARPSMGLVANsKFIRPKIqYFFSFAVFynGVCHVMCPLAT-NYT 335
Cdd:COG2223 221 FIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRV-LLIVFALM--ALGLLLLALALgSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 336 GLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVAS 415
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVAL 376
|
....*
gi 700380260 416 IWLFI 420
Cdd:COG2223 377 VLTLL 381
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-420 |
1.32e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 138.46 E-value: 1.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 15 GGWGWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGIL 94
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 95 CSFGMIASSFCNSVLELYLCIGVVgGLGLAFNLQPALTMIGKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLFNAFGW 173
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLL-GLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 174 KGSFLILGGLllncCVAGSLMRpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlslfkhrgFLIYLSGNVI 253
Cdd:COG2271 164 RAAFLILGLP----GLLLALLR------------------------------------------------FWLLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 254 MFIGFFAPIVFLAPYAK-HKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFynGVCHVMCPLAT 332
Cdd:COG2271 192 VYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA--ALALLLLALLP 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 333 NYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVI 412
Cdd:COG2271 270 SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALAL 348
|
....*...
gi 700380260 413 VASIWLFI 420
Cdd:COG2271 349 LAALLALL 356
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-416 |
4.64e-35 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 134.71 E-value: 4.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPA-LTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGS 176
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 177 FLILGGLLLNCCVAGSLM--RPVGPKTVPPVKKDVEKGTGDSALHknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIM 254
Cdd:cd17355 161 LLVLALLALLVLVPVLLLlrRRPADLALRAYDDASPASPGSTLKE------------------ALRSASFWLLALAFFLC 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 255 FIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFynGVCHVMCPLATN- 333
Cdd:cd17355 223 GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYALR--ALGLALLLLLPFp 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 334 YTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIV 413
Cdd:cd17355 299 PLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLI 378
|
...
gi 700380260 414 ASI 416
Cdd:cd17355 379 AAL 381
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
18-418 |
1.08e-34 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 133.76 E-value: 1.08e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSE-----IAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGG 92
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 93 ILCSFGMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFG 172
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 173 WKGSFLILGGLLLNCCVAGSLMRPVGPKtvppvKKDVEKGtgdsalhknNKKSFWQTMNKYLDLSLFKHRGFLIYLSGNV 252
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPM-----KKDKEGK---------KRKFKCPPLKKIFNFNIWKSTGYRIWAFGIP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 253 IMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIqYFFSFAVFYNGVCHVMCPLAT 332
Cdd:cd17464 227 AALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKV-YLQVSSFFFIGLMSMMIPLCH 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 333 NYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVI 412
Cdd:cd17464 306 VFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPI 385
|
....*.
gi 700380260 413 VASIWL 418
Cdd:cd17464 386 IGGIIL 391
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
18-420 |
6.83e-34 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 131.09 E-value: 6.83e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17428 161 LIVGALALNLLACGSLMR------------------------------------------LFKNRVFSALFIAILLFDIG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYSAAF-LLSILAFVDMFARPSMGLVANSKFIRPkiQYFFSFAVFYNGVCHVMCPLATNYTG 336
Cdd:cd17428 199 AFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 337 LVIYAVFFGFAFGMVSSVLFETlMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASI 416
Cdd:cd17428 277 LAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGF 355
|
....
gi 700380260 417 WLFI 420
Cdd:cd17428 356 LLLL 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-387 |
9.47e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 119.06 E-value: 9.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 21 VVFGAFISIGFSYAFpkaITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMI 100
Cdd:pfam07690 1 LFLAAFLAALGRSLL---GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 101 ASSFCNSVLELYLCiGVVGGLGLAFNLQPALTMIGKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSFLI 179
Cdd:pfam07690 78 LLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 180 LGGLLLNCCVAGSLMRPVGPKTVPPVKKDVEKGTGdsalhknnkksfwqtmnkyLDLSLFKHRGFLIYLSGNVIMFIGFF 259
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-------------------VAWKALLRDPVLWLLLALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 260 APIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFYnGVCHVMCPLATNYTGLVI 339
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA-ALGLLLLSLTLSSLWLLL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 700380260 340 YAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGP 387
Cdd:pfam07690 297 ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-415 |
2.43e-29 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 118.67 E-value: 2.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVGPKTVPpvkkdvekgtgdSALHKNNKKSFWQtmnkyldLSLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQ------------ARLHVQKKKTQTM-------GEIFRDKVFWILFIAIFLVLIG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHKGIDEYS-AAFLLSILAFVDMFARPSMGLVANsKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTG 336
Cdd:cd17314 222 GFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTILGLGLCAFLFLLKMTPVG 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 700380260 337 LVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVAS 415
Cdd:cd17314 301 LVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLAS 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-378 |
4.28e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 117.38 E-value: 4.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 12 PPDGGWGWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAG 91
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 92 GILCSFGMIASSFCNSVLELYLCiGVVGGLGLAFNLQPALTMIGKYF-YKKRPIANGLAMAGSPVFLSTLAPLNQFLFNA 170
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 171 FGWKGSFLILGGLllnCCVAGSLMRPVGPKTVPPVKKDVEKGTGDsalhknnkksfwqtmnkyldlsLFKHRGFLIYLSG 250
Cdd:COG2814 161 FGWRWVFLVNAVL---ALLALLLLLRLLPESRPAARARLRGSLRE----------------------LLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 251 NVIMFIGFFAPIVFLAPYAKHK-GIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFynGVCHVMCP 329
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADR--FGRRRLLLIGLLLL--ALGLLLLA 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 700380260 330 LATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIV 378
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-416 |
2.63e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 110.35 E-value: 2.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 5 TVAPQYPPPDGGWGWVVVFGAFISIGFSYAFP-KAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYG 83
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 84 SRPVMIAGGILCSFGMIASSFCNSVLELYLCIGVVG-GLGLAFNLQPALtmIGKYFYKKRPIANGLAMAGSPVFLSTLAP 162
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 163 LNQFLFNAFGWKGSFLILGGLLLnccVAGSLMRPVGPKTVPPVKKDVEKGTGDSALHknnKKSFWQtmnkyldLSLFkhr 242
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLAL---LALLLWLPLLRRRPAAAAAAPAAASLRSLWR---SPLAWL-------LTLF--- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 243 gFLIYLSgnvimfiGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVAnSKFIRPKIQYFFSFAVfynG 322
Cdd:COG2807 224 -FGLQSL-------LYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA-DRLGDRRPLLLLLGLL---G 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 323 VCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVG----AARFSSAVGLVTIVECCpvlIGPPLGGWLVDVTG 398
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtpaeAAALSGMAQSVGYLLAA---LGPLLVGALHDATG 368
|
410
....*....|....*...
gi 700380260 399 EYQYMYFVCGVIVIVASI 416
Cdd:COG2807 369 SWTAALLLLAALAVLMLV 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-419 |
2.54e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 107.13 E-value: 2.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 22 VFGAFISIGFSYAfpkAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIA 101
Cdd:cd06174 1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 102 SSFCNSVLELYLCiGVVGGLGLAFNLQPALTMIGKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLF--NAFGWKGSFL 178
Cdd:cd06174 78 FAFAPSFWLLLLG-RFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 179 ILGGLLLNCCVAGSLMRPVGPKTVPPVKKdvekgtgdSALHKNNKKSFWqtmnkyldlSLFKHRGFLIYLSGNVIMFIGF 258
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNE--------EASSKSVLKLLK---------RVLKNPGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 259 FAPIVFLAPYAK-HKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVfynGVCHVMCPLATNYTGL 337
Cdd:cd06174 220 YSFSTLLPLFLLdLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM---ALGLALLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 338 VIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd06174 297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
..
gi 700380260 418 LF 419
Cdd:cd06174 377 LL 378
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-416 |
5.13e-25 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 106.16 E-value: 5.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFI---SIGFSYAFpkaiTVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILC 95
Cdd:cd17353 3 WLVLLGAVLmhlILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 96 SFGMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAG---SPVFLStlaPLNQFLFNAFG 172
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGfglGSLIFS---PLIAYLINTVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 173 WKGSFLILG-GLLLNCCVAGSLMRPVGPKTVPPVKKDVEKGTGDSALHKNNKKSFWQTmnkyldlslfkhRGFLIYLSgn 251
Cdd:cd17353 156 VPTTFLILGiIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTP------------TFWLLWLM-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 252 viMFIGFFAP---IVFLAPYAKHK-GIDEYSAAFLLSILAFVDMFARPSMGLVanSKFIRPKIQYFFSFAVfyNGVCHVM 327
Cdd:cd17353 222 --FFLNATAGlmlIGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWL--SDKIGRKNTLSIAFLI--QGVAMFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 328 CPLAT-NYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWlVDVTGEYQYMYFV 406
Cdd:cd17353 296 LPFIGsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFII 374
|
410
....*....|
gi 700380260 407 CGVIVIVASI 416
Cdd:cd17353 375 AAALSLVALA 384
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-421 |
4.76e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.65 E-value: 4.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGfsyafpkAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFG 98
Cdd:cd17325 2 SLALFLDMLGYG-------IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 99 MIASSFCNSVLELYLcIGVVGGLGLAFNLQPALTMIGKYF-YKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17325 75 TLLFAFATSYWQLLL-ARFLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGGLLLNCCVAGSLMRPVGPKTVPPVKKDVEKGTGDSALhknnkksfwqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL-------------------LLRDRRLLALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKHK-GIDEYSAAFLLSILAFVDMFARPSMGLVANsKFIRPKIqyfFSFAVFYNGVCHVMCPLATNYTG 336
Cdd:cd17325 215 FGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPL---ILIGLLLSAVALLLLPLATSFWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 337 LVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVASI 416
Cdd:cd17325 291 LLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAV 369
|
....*
gi 700380260 417 WLFIG 421
Cdd:cd17325 370 LFLLL 374
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
18-419 |
1.49e-21 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 96.02 E-value: 1.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIF-----HTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGG 92
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQedqkdQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 93 ILCSFGMIASSFCNSVLELYLCIGVVGGLGLAFNLQPALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFG 172
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 173 WKGSFLILGGLLLnccvagslmrpvgpktvppvkkdvekgtgdsalhknnkksfwqtMNKYLDLS--LFKHRGFLIYLSG 250
Cdd:cd17465 161 LAHTFQVLSLFMF--------------------------------------------IQIFLSLTykVFRRKTYRIWAFG 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 251 NVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQY-FFSFAVFynGVCHVMCP 329
Cdd:cd17465 197 IATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLIPGLKKIYLqVASFLLL--GIMSMMIP 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 330 LATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGV 409
Cdd:cd17465 275 LCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGV 354
|
410
....*....|
gi 700380260 410 IVIVASIWLF 419
Cdd:cd17465 355 PPIIGGTVLF 364
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-414 |
5.79e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.18 E-value: 5.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 60 ISSIMLAVMYAGgPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLeLYLCIGVVGGLGLAFNLQPALTMIGKYFY 139
Cdd:cd17489 37 VGLFTLAALLAR-PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 140 KKRpIANGLAMAGSPVFLSTL--APLNQFLFNAFGWKGSFLILGGLLLNCCVAGSLMrpvgpKTVPPVKKDVEKGTGDSA 217
Cdd:cd17489 115 PSR-RGEGIGYYGLATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV-----KDPPPVAAEEAEAGTRAF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 218 LHknnkksfwqtmnkyldlsLFKHRGFLIYLSGNViMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFvdMFARPSM 297
Cdd:cd17489 189 RR------------------LVEKKVLPPALILFL-ASIAYGAISTFLPLYAAERGISNAGLFFTVYAIAL--LLSRPFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 298 GLVANSKfiRPKIQYFFSFAVFYNGVchVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTI 377
Cdd:cd17489 248 GKLSDRK--GPKTVIIPGLLLLALGL--LLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFI 323
|
330 340 350
....*....|....*....|....*....|....*..
gi 700380260 378 VECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVA 414
Cdd:cd17489 324 FFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLA 359
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
43-420 |
1.19e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 78.38 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 43 FKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELyLCIGVVGGLG 122
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 123 LAFNLQPALTMIGKYF-YKKRP-------IANGLAMAGSPVFLSTLAplnqflfnAFGWKGSFLILGGLLLnccVAGSLM 194
Cdd:cd17474 101 AAGLGPLALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIP---VAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 195 RpvgpKTVPPVKKDVEKGTGDSALHKnnkksfwqtmnkyldLSLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHK-G 273
Cdd:cd17474 170 L----FLLPEPKEKAKSSSATKLRDL---------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 274 IDEYSAAFLLSILAFVDMFARPSMGLVaNSKFIRPKIQYFFSFAVFynGVCHVMCPLATNYTGLVIYAVFFGFAFGMVSS 353
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRL-LKKRFGARRILVIGLLLY--ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700380260 354 VLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVASIWLFI 420
Cdd:cd17474 308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLAL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
237-420 |
7.55e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.78 E-value: 7.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 237 SLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANsKFIRPKIqYFFSF 316
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD-RFGRRRV-LLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 317 AVFynGVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDV 396
Cdd:COG2814 83 LLF--ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....
gi 700380260 397 TGeYQYMYFVCGVIVIVASIWLFI 420
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-420 |
7.61e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.07 E-value: 7.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 72 GPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIGVVGgLGLAFNLQPALTMIGKYFY-KKRPIANGLAM 150
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG-IGVAGIMTLATALIGDYFEgEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 151 AGSPVFLSTLAPLNQFLfNAFGWKGSFLI-LGGLLLNCCVAGSLMRPVGPKTVPPVKKDVEKGTgdsalhknnkksfwqt 229
Cdd:cd17473 131 AAMSLGGVVFLLLGGAL-AEIGWRAPFLVyLLALPVLILVLLFLPEPARKSKSAASPGAATAAA---------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 230 mnkyldlslFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHKGI-DEYSAAFLLSILAFVDMFARPSMGLVanSKFIRP 308
Cdd:cd17473 194 ---------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRL--KRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 309 KIQYFFSFAVFynGVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVeccpVLIG-- 386
Cdd:cd17473 263 RRLLAIGFALM--ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA----FFLGqf 336
|
330 340 350
....*....|....*....|....*....|....*.
gi 700380260 387 --PPLGGWLVDVTGEYQYMYFVCGVIVIVASIWLFI 420
Cdd:cd17473 337 lsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-420 |
1.58e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.91 E-value: 1.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFG 98
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 99 MIASSFCNSVLELYLCIGVVgGLGLAFNLQPALTMIGKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 178 LILGglllnccVAGSLMRPVgpktvppvkkdvekgtgdsalhknnkksfWqtmnkyldlsLFKHRGFLIYLSGNVIMFIG 257
Cdd:cd17319 161 IIEG-------LLGLLLAVL-----------------------------W----------WFYLRQVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 258 FFAPIVFLAPYAKH-KGIDEYSAAFLLSI---LAFVDMFArpsmGLVANSKFI---RPKIQyFFSFAVFynGVCHVMCPL 330
Cdd:cd17319 195 LYGLLTWLPTYLKQaRGFSLKQVGLLAAIpflAGAIGMIL----GGRLSDRLLrgaRRLVI-IIGLLLA--AVGLLLAYL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 331 ATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVI 410
Cdd:cd17319 268 TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAV 347
|
410
....*....|
gi 700380260 411 VIVASIWLFI 420
Cdd:cd17319 348 ALLAALLVLL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
45-419 |
1.69e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.89 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 45 EIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSvLELYLCIGVVGGLGLA 124
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 125 FNLQPALTMIGKYF-YKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSFLILGGLLLnccVAGSLMRPVGPKTVP 203
Cdd:cd17324 103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL---LAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 204 PVKKdvekgtgdsalHKNNKKSFWqtmnkyldlSLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHK-GIDEYSAAFL 282
Cdd:cd17324 180 KKPG-----------SLGLLSSLL---------LLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 283 LSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVfyngVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDL 362
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA----ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 700380260 363 VGAARfSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVASIWLF 419
Cdd:cd17324 316 APEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-418 |
2.01e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.89 E-value: 2.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 20 VVVFGAFISIGFSYAfpkAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGM 99
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 100 IASSFCNSVLELYLCIGVVgGLGLAFnLQPALTMIGKYFYKKRP--------IANGLAMAGSPVFLSTLAplnqFLFNAF 171
Cdd:COG0738 88 LLFALAPSYPLLLLALFLL-GLGLGL-LDVAANPYVAALGPETAasrlnllhAFFSLGALLGPLLGGLLI----LLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 172 GWKGSFLILGGLLLNCCVAGSLMRpvgpktVPPVKKDVEKGTGDSALHKnnkksfwqtmnkyldlSLFKHRGFLIYLsgn 251
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSK------LPEIEEEEEEAAGSAASLK----------------SLLKNPRLLLGG--- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 252 VIMFIGFFA---PIVFLAPYAK-HKGIDEYSAAFLLSILAFVDMFARPSMGLVAnsKFIRPKIQYFFSFAVfyNGVCHVM 327
Cdd:COG0738 217 LAIFLYVGAegaIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLL--KRFGPVRLLRLSALL--AAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 328 CPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARfSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYF-- 405
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVpl 371
|
410
....*....|...
gi 700380260 406 VCGVIVIVASIWL 418
Cdd:COG0738 372 VCYLLILLLALAL 384
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-418 |
3.60e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 73.81 E-value: 3.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 46 IQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIgVVGGLGLAF 125
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 126 NLQPALTMIGKYFYKKRpiaNGLAM----AGSPVFLSTLAPLNQFLFNAFGWKGSFLILGGLLLNCCVAGSLM--RPVGP 199
Cdd:cd17475 101 VQPGGGRAIMRWFPPRE---RGLAMgirqTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyrEPPAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 200 KTVPPVKKDVEKGTGDSALHKNnkksFWqtmnkyldlslfkhrgfLIYLSGNVIMFIGfFAPIVFLAPYAK-HKGIDEYS 278
Cdd:cd17475 178 SAATESASTLLRSLKEVLRNRD----VW-----------------LIAIAGALLVAPQ-FALLTFLLLFLHdHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 279 AAFLLSILAFVDMFARPSMGLVANSKFI--RPKIQYFFSFAVFYNGVCHVMCPLATNYTGLVIYAVFFG-FAFGMVsSVL 355
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGgrRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGlFAIGWN-GLY 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 700380260 356 FETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIWL 418
Cdd:cd17475 315 LTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
248-420 |
1.81e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.47 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 248 LSGNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFynGVCHVM 327
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 328 CPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVC 407
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
170
....*....|...
gi 700380260 408 GVIVIVASIWLFI 420
Cdd:cd17489 157 AVLALLALLLVFL 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-441 |
1.70e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 58 AWISSIMLAVMYAGG---PISSILVNKYGSR-----PVMIAGGILCSFGMI----ASSFCNSVLELYLCIGVVG-GLGLA 124
Cdd:COG2211 46 ALVGLILLVARLWDAitdPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVllftAPDLSPTGKLIYALVTYLLlGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 125 FNLQPALTMIGKYF--YKKRPIANG----LAMAGSPVFLSTLAPLNQFLF--NAFGWKGSFLILGGLLLnCCVAGSLMrp 196
Cdd:COG2211 126 LVNIPYSALGAELTpdYEERTRLSSwrfaFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGL-LAFLLTFF-- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 197 vgpktvppvkkdvekGTGDSALHKNNKKSFWQTMnkyldLSLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHK-GID 275
Cdd:COG2211 203 ---------------GTKERPVPEEEKVSLKESL-----KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 276 EYSAAFLLSILAFVDMFARPSMGLVANsKFIRPKIqYFFSFAVFynGVCHVMCPLA--TNYTGLVIYAVFFGFAFGMVSS 353
Cdd:COG2211 263 AALVGLLLALYFLAALLGAPLWPRLAK-RFGKKKA-FIIGLLLA--ALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 354 VLFETLMDLV-------GAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTG-------------EYQYMYFVCGVIVIV 413
Cdd:COG2211 339 LPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLL 418
|
410 420
....*....|....*....|....*....
gi 700380260 414 ASIWLFIGNAINYRLLAK-EKKLEDEKQK 441
Cdd:COG2211 419 LAALLLLFYPLTRERHAEiRAELAARRAA 447
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-185 |
1.91e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.75 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 5 TVAPQYPPPDGGWGWVVVFGAFISIGFSYAfpkAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGS 84
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 85 RPVMIAGGILCSFGMIASSFCNSVLELYLCIgVVGGLGLAFNLQPALTMIGKYF-YKKRPIANGLAMAGSPVFLSTLAPL 163
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLL 157
|
170 180
....*....|....*....|..
gi 700380260 164 NQFLFNAFGWKGSFLILGGLLL 185
Cdd:COG0477 158 GGLLVAALGWRWIFLINAPLGL 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
248-420 |
1.86e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.97 E-value: 1.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 248 LSGNVIMFIGFFAPIVFLAPY-AKHKGIDEYSAAFLLSILAFVDMFARPSMGLVanSKFIRPKIQYFFSFAVFynGVCHV 326
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL--SDRFGRRRVLLIGLLLF--ALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 327 MCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFV 406
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 700380260 407 CGVIVIVASIWLFI 420
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
53-414 |
1.97e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 59.24 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 53 SYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELyLCIGVVGGLGLAFNLQPALT 132
Cdd:cd06180 32 SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAAL-LALRFLAGAASAFVFVFGSN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 133 MIGKYFYKKR---PIANGLAMAGSPVFLSTLAPLnQFLFNAFGWKGSFLILGGLLLNCCVAGSLMRPVGPKTVPPVKkdv 209
Cdd:cd06180 111 LVLHHATAAGrghLIGLLFAGVGLGIALSGLLVP-AGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 210 ekgTGDSALHKNnkKSFWQTMNKYLdlsLFkhrGFliylsgnvimfiGFFAPIVFLAPYAKHKGIDEYSAAFLLSIlafV 289
Cdd:cd06180 187 ---AAESAPGLN--RPLWRLALAYG---LF---GF------------GYIITATFLPLIARETGAGSLLAGLLWSL---F 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 290 DMFARPSMGLV-ANSKFIRPKIQYFFSFAVfyNGVCHVMCPLATNYTGLVIYAVFFGFAF-GMVSSVLFETLMdlVGAAR 367
Cdd:cd06180 241 GLAAVPSCFLWgALSDRWGTRRALAANLLV--QAVGVLLPLLSPGPAGLVLSAVLFGGTFmAITALVMALARE--LAPPA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 700380260 368 FSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVA 414
Cdd:cd06180 317 APRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVA 363
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-420 |
2.15e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.16 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFI-SIGFSYAFPkAITVFFKEIQEIfhtSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17329 2 WVLLIGSFLnRLGFFMVWP-FMAIYLHQQLGL---SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLElyLCIGVVG-GLGLAFNLQPALTMIG--------KYFYKKRPIANGLAMAGSPVFlstlaplnqflf 168
Cdd:cd17329 78 GFALLGFAHSPWL--FAIALVLtGFGGGLFEPASEAMIAdvttpenrTRAFSLLYWAINLGVAIGPLL------------ 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 169 nafgwkGSFLILGGLLLNCCVAGSLMrpVGPKTVPPVKKDVEKGTGDSALHKNNKKSFWQtmnkyldlsLFKHRGFLIYL 248
Cdd:cd17329 144 ------GGLLLLYSFRLLFLAAAVLF--LLAALVLLFLLPETRPKRRAAEKTEILRGYKI---------VLRDRAFLLFL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 249 SGNVIMFIGFFAPIVFLAPYAKHKGIDEYSA-AFLLSILAFVDMFARPSMGLVANskfiRPKIQYFFSFAVFYNGVCHVM 327
Cdd:cd17329 207 LASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVE----RFRLRKILMIGILLFAIGFAV 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 328 CPLATNYTGLVIYAVFFGFAFGMVS---SVLFETLMDLVGAARFSSAVGLVTIVEccpVLIGPPLGGWLVDVTGeYQYMY 404
Cdd:cd17329 283 LAFANTLAVLILAMIVLTLGEMLVFpavQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGLLLDLLG-PGLPW 358
|
410
....*....|....*.
gi 700380260 405 FVCGVIVIVASIWLFI 420
Cdd:cd17329 359 LILAALGLIAAALLLG 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
43-418 |
3.25e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 58.74 E-value: 3.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 43 FKEIQEIFHTSYSEIAWISSIMLAVMYAG----GPISSilvnKYGSRPVMIAGGILCSFGMIASSFCNSVlELYLCIGVV 118
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSD----RFGRRPVLLAGLLLFILASLLCALASSI-EQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 119 GGLGLAFNLQPALTMI-GKYFYKKRPIANGLAMAG---SPVflstLAP-LNQFLFNAFGWKGSFLILGGLLLnCCVAGSL 193
Cdd:cd17320 97 QGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIlaiAPA----LAPlLGGLLLLFFGWRAIFVFLALLGL-LLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 194 MRPvgPKTVPPvkkdvekgtgdsalhKNNKKSFWQTMNKYLdlSLFKHRGFLIYLSGNVIMFIGFF-----APIVFLAPY 268
Cdd:cd17320 172 LFL--PETLPE---------------EKRKPLLSSLLRAYK--RVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 269 akHKGIDEYSAAFLLSILAFVdmfarpsMGLVANSKFI-RPKIQYFFSFAVFYNGVCHVMCPLAT-----NYTGLVIYAV 342
Cdd:cd17320 233 --GLSPAQFGLLFALNAIALI-------LGSLLNGRLVrRFGPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 343 FFGFAFGMVSSVLFETLMDLVG--AARFSSAVGLVTIVECCPV--LIGPPLGGWLVDVTGeyqyMYFVCGVIVIVASIWL 418
Cdd:cd17320 304 LIFFGFGLIFPNATSLALEPFPhvAGTASALLGFLQFLIGALAgaLVGLLPNGTALPMGL----LILVLGLLALLLLILL 379
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
253-419 |
3.96e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.33 E-value: 3.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 253 IMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSKFIRPKIqyFFSFAVFynGVCHVMCPLAT 332
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--LVLLLLF--ILGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 333 NYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVI 412
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLAL 164
|
....*..
gi 700380260 413 VASIWLF 419
Cdd:cd17324 165 LAALLLW 171
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
46-419 |
2.55e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.79 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 46 IQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSvLELYLCIGVVGGLGLAF 125
Cdd:cd17333 22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPS-IYLFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 126 NLQPALTMIGKYFYKKRPIANGLaMAGSPVFLSTLAPL--NQFLFNAFGWKGSFLILGGLLLnccvagslmrPVGPKTVP 203
Cdd:cd17333 101 LDTGANTFVGALFEESSATRLNV-LHGFFGLGALIGPLiaTSLLTSELSWSWAYLIIGLIYL----------LLAILILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 204 PVKKDvekgTGDSALHKNNKKSFWQTMNKYLdlslfkhRGFLIYLSGNVIMF--IGFFAPIVFLAPYAKHK-GIDEYSAA 280
Cdd:cd17333 170 TLFPE----LPSARNPQQSVGAFSASASRLL-------RNPSIILGALALFLyvGAETAFSSWVPSYLVEKkHVSDGLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 281 FLLSILAFVDMFARPSMGLVANskFIRPKIQYFFSFAvfynGVCHVMCPLATNYTGLVIYAVFFGFAFGMvsSVLFETLM 360
Cdd:cd17333 239 YLLSGFWVGITIGRLLGGPISR--RIKPHTLLVLSGS----GALLGLLILLLAPTLVVGLVATALLGLFM--AALFPTIL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 700380260 361 DLvGAARF----SSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIWLF 419
Cdd:cd17333 311 SL-GISNLpyakGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
250-424 |
2.61e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.65 E-value: 2.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 250 GNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFynGVCHVMCP 329
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR--FGRRRVLAIGLLLW--GLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 330 LATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGV 409
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGL 172
|
170
....*....|....*
gi 700380260 410 IVIVASIWLFIGNAI 424
Cdd:COG2271 173 PGLLLALLRFWLLAL 187
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-196 |
8.45e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 8.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGFSYAFpkaITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSR--PVMIAGGILCS 96
Cdd:COG2271 183 WLLALAYFLVYFALYGF---LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 97 FGMIASSFCNSVLELYLCIGVVGGLGLAFnlQPALTMIGKYFY--KKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWK 174
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGA--FGLLWALAAELFpkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|..
gi 700380260 175 GSFLILGGLLLNCCVAGSLMRP 196
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLR 359
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
282-420 |
2.38e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 49.96 E-value: 2.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 282 LLSILAFVDMFARPsMGLVANSKFIRpKIQYFFSFAVFYngVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMD 361
Cdd:TIGR00880 3 LLAGYALGQLIYSP-LSGLLTDRFGR-KPVLLVGLFIFV--LSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 700380260 362 LVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVASIWLFI 420
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG-WRAPFLFLAILALAAFILLAF 136
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-420 |
6.75e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 6.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 57 IAWISSIMLAVMYAGGPISSILVNKYGSRPVMIA-----GGILCSFGMIASSFCNSVLELYLCIGVVGGLGLAFnlQPAL 131
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFF--GPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 132 T-----MIGKYFYKKrpiANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSFLILGGLLLNCCVAGSLMRPVGPKTVPPvk 206
Cdd:cd06173 114 QallpeLVPKEQLVR---ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGE-- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 207 kdvekgtgdsalhknnkKSFWQTMNKYLDLSLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPY--AKHKGIDEYSAAFLLS 284
Cdd:cd06173 189 -----------------SSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLlaKEVLGGGAAGYGLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 285 ILAfVDMFArpsMGLVANSKFIRPKIQYFFSFAVFYNGVCHVMCPLATNYTGLVIYAVFFGFAfGMVSSVLFETLMDLVG 364
Cdd:cd06173 252 AFG-VGALL---GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLA-GGLFNVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 700380260 365 AARFSSAV-GLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVASIWLFI 420
Cdd:cd06173 327 PDELRGRVfSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
166-416 |
7.06e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.07 E-value: 7.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 166 FLFNAFGWKGSFL--ILGGLLlnccvAGSLMRPVGPKTVPpvkkdvekgtgdsalhKNNKKSFWQTMnkyldLSLFKHRg 243
Cdd:cd17490 142 LIAEHFGMRAPFLlaALAGVL-----GFILSLFIKEERRE----------------KKPVLTELKEL-----LSVLKDK- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 244 FLIYLS--GNVIMFIGFFAPIVFLAPYAKHKGideySAAFLLSILAFVDMFARPSMGLVANSKFIRPKIQYFFSFAVFY- 320
Cdd:cd17490 195 KLLFFSllAILQQMITFSTTFGFTPLIAKQLG----ASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLl 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 321 NGVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeY 400
Cdd:cd17490 271 LGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-L 349
|
250
....*....|....*.
gi 700380260 401 QYMYFVCGVIVIVASI 416
Cdd:cd17490 350 QTGFFVIGVIALLAAI 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-195 |
7.23e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 7.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 20 VVVFGAFISIGFSYAFpkaITVFFkeiQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGM 99
Cdd:cd17325 206 LAIFVLAFAFGALEPF---LPLYA---AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 100 IASSFCNSVLELYLCIgVVGGLGLAFNLQPALTMIGKYFykkRPIANGLAMAGSPVFLS---TLAPL-NQFLFNAFGWKG 175
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIV---PPEGRGTAMGLFNTAFSlgmVLGPLlGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 700380260 176 SFLILGGLLLNCCVAGSLMR 195
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
72-181 |
7.53e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 48.41 E-value: 7.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 72 GPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCiGVVGGLGLAFNLQPALTMIGKYF-YKKRPIANGLAM 150
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYpPEERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|.
gi 700380260 151 AGSPVFLSTLAPLNQFLFNAFGWKGSFLILG 181
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-378 |
9.63e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 50.65 E-value: 9.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 38 AITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYL---C 114
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIfriL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 115 IGVVGGLglafnLQP-ALTMIGKYfYKKRPIANGLAMAGSPVFLS-TLAP-LNQFLFNAFGWKGSFLIlgglLLNCCVAG 191
Cdd:cd17503 94 QGFGGGV-----LIPlAQTILLRI-YPPEKRGAAMGLVGLVILLApAIGPtLGGWLTDNLSWRWIFYI----NLPIGILA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 192 SLMRPVgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyLDLSLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKH 271
Cdd:cd17503 164 LLLAPL------------------------------------LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 272 -KGIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFYnGVCHVMCPL--ATNYTGLVIYAVFFGFAF 348
Cdd:cd17503 208 vLGYSAFESGLVLAPGGLASAILSPLVGRLLDK--FGPRLLLLAGLLLLA-LGTLLLAFLtpDTSLWLIILPLFIRGLGM 284
|
330 340 350
....*....|....*....|....*....|
gi 700380260 349 GMVSSVLFETLMDLVGAARFSSAVGLVTIV 378
Cdd:cd17503 285 GLVFMPLNTLALNSLPPEQIGDATALFNTI 314
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
19-185 |
1.81e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.96 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAvMYAGGP-ISSILVNKYGSRPVMIAGGILCSF 97
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLI-AYAVGKfISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELYLCIGVVG---GLGLAfnlqPALTMIGKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLFNAFGW 173
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGlfqSMGWP----PCVKLLGNWFSKKeRGTVYGIWSTSHNFGGILAPILAASLASYYGW 156
|
170
....*....|..
gi 700380260 174 KGSFLILGGLLL 185
Cdd:cd17312 157 RAAFLVPGIVGL 168
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-125 |
5.19e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 5.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGFSYAFPKAITVFFkeIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFG 98
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100
....*....|....*....|....*...
gi 700380260 99 MIASSFCNSV-LELYLCIGVVGGLGLAF 125
Cdd:COG2211 308 LLLLFFLGPGnLWLLLVLAALAGIGLGA 335
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
55-194 |
5.70e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.35 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 55 SEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLcIGVVGGLGLAFNLQPALTMI 134
Cdd:cd17365 34 AQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 700380260 135 GKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSFLILGGLLLNC--CVAGSLM 194
Cdd:cd17365 113 SEYAPARrRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILlpLLRGTLL 175
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-134 |
5.75e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.32 E-value: 5.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 46 IQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIG--VVGGLGL 123
Cdd:cd17321 195 LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPglVLLGLGL 274
|
90
....*....|.
gi 700380260 124 AFNLQPALTMI 134
Cdd:cd17321 275 GLFATPLTNAA 285
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-181 |
7.41e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.12 E-value: 7.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 18 GWVVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSF 97
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 98 GMIASSFCNSVLELyLCIGVVGGLGLAFNLQPALTMIGKYFYKK-RPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGS 176
Cdd:TIGR00895 95 FTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
....*
gi 700380260 177 FLILG 181
Cdd:TIGR00895 174 FYVGG 178
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-419 |
1.35e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 46 IQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIgVVGGLGLAF 125
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 126 NLQPALTMIGKYFYKKRPIANGLAMAG-------SPVFLStlaplnqFLFNAFGWKGSFLILGGLLLnccVAGSLMRPVG 198
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGL---AVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 199 PKTVPPVKKDVEKGTGDSALHKNNkksfwqtmnkyldlslfkhRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHKGIDEYS 278
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVW-------------------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 279 AAFLLSILAFVDMFARPSMGLVANsKFIRPKIqYFFSFAVFynGVCHVMCPLaTNYTGLVIYAVFFGFAFGMVSSVLFET 358
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSD-RFGRRRV-IIASLLLA--APFLLLFLL-TPGIWSYILLVLAGFLLFASFPVTVVL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 700380260 359 LMDLVgAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVIVASIWLF 419
Cdd:cd17478 307 AQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGALLAF 365
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
43-260 |
3.27e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 46.04 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 43 FKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLC--IGVVGG 120
Cdd:PRK11043 29 FKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLrfVQAVGV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 121 LGLAFNLQpALtMIGKYFYKKrpiANGLAMAGSP-VFLS-TLAP-LNQFLFNAFGWKGSFLILgglllnCCVAGSLMRPV 197
Cdd:PRK11043 109 CSAAVIWQ-AL-VIDRYPAQK---ANRVFATIMPlVALSpALAPlLGAWLLNHFGWQAIFATL------FAITLLLILPT 177
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700380260 198 gPKTVPPVKKDVekgtgdsalHKNNKKSFWQtmnkyldlsLFKHRGFliylSGNVIMF----IGFFA 260
Cdd:PRK11043 178 -LRLKPSKKARK---------QSQDALTFKQ---------LLKSKTY----LGNVLIFaacsAAFFA 221
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
20-194 |
5.94e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 45.33 E-value: 5.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 20 VVVFGAFISIGFSYAFPKAITVFFKE-IQEIFHTSY------SEIAWISSIMLAVMYAGG----PISSILVNKYGSRPVM 88
Cdd:cd17357 3 IVAFGGSFQFGYNIGVVNAPQEVFKEfINDTLVDRYglnlsdSELDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 89 IAGGILCSFGMIASSFCNSvleLYLCIgvvgglglafnlqpaLTMIGKYFYKkrpIANGLAMAGSPVFLSTLAPLNqflf 168
Cdd:cd17357 83 LISNALLVVSSLLMFLSKS---AKSPE---------------LLIFGRFLVG---IACGLSTGFVPMYLQEISPSE---- 137
|
170 180
....*....|....*....|....*..
gi 700380260 169 nafgWKGSFLILGGLLLNC-CVAGSLM 194
Cdd:cd17357 138 ----LRGALGSLTQIGVTLgILLGQVF 160
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
242-419 |
6.77e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.80 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 242 RGFLIYLSGNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANsKFIRPKIqYFFSFAVFyn 321
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD-RYGRKRV-LLIGLLLF-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 322 GVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQ 401
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WR 168
|
170
....*....|....*...
gi 700380260 402 YMYFVCGVIVIVASIWLF 419
Cdd:COG0477 169 WIFLINAPLGLLALVLRL 186
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
250-440 |
7.78e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.87 E-value: 7.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 250 GNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFynGVCHVMCP 329
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDR--FGPRRVLLIGLLLL--GIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 330 LATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGV 409
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLILGI 167
|
170 180 190
....*....|....*....|....*....|...
gi 700380260 410 IVIVASI--WLFIGNAINYRLLAKEKKLEDEKQ 440
Cdd:COG2223 168 LLLVVAVlaWLFLRDPPAGAAAAAKASLRDQLE 200
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
19-421 |
1.02e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFgaFISIGFSYAFPkAITVFfkeIQEIFHTSYSEIAWISSIMLA----VMYAGGPISSILVNKYGSRPVMIAGGIL 94
Cdd:cd17391 2 WLGNF--FTGIGFSLIAP-FLPLY---IEQLGVTSGGLVELWSGLAFSstflVSAIFSPIWGRLADRYGRKPMLLRASLG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 95 CSFGMIASSFCNSVLELY---LCIGVVGGLGLAfnlqpALTMIGKYFYKKRP-IANGLAMAGSpVFLSTLAPL-NQFLFN 169
Cdd:cd17391 76 MAIVIGLMAFVTNVWQLLilrLLQGVFSGYVPN-----ATALIASQTPKEKSgWALGTLSTGV-VAGTLIGPLlGGFLAD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 170 AFGWKGSFLILGGLLLNCCVAGSLMrpVGPKTVPPVKKDVEKGtgdsalhknnkKSFWQTM-NKYLDLSLFKHRgFLIYL 248
Cdd:cd17391 150 LFGIRNVFFITGGLLFLAFLLTLFF--VKEDFKPVEKKKMVST-----------KEVWNSVpNPSLLISLFVTT-FIIQL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 249 SGNVImfigffAPIvfLAPYAKHKGIDEYSAAFL----LSILAFVDMFARPSMGLVANsKFIRPKIQYFFSFAVFyngVC 324
Cdd:cd17391 216 ANQSI------EPI--LTLYIRQLMGDASNLAFIsglvFSATGVSSLLSAPRLGKLGD-RIGHHRILLGALLASA---LL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 325 HVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGwLVDVTGEYQYMY 404
Cdd:cd17391 284 YIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGS-AIAAHFGYRAVF 362
|
410
....*....|....*..
gi 700380260 405 FVCGVIVIVASIWLFIG 421
Cdd:cd17391 363 VVTALLVLLNAIWSFIF 379
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-376 |
1.04e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 45 EIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELyLCIGVVGGLGLA 124
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 125 FnLQPALTMIGKYFY--KKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSFLILGGLLLnccvagslmrpvgpktv 202
Cdd:cd17321 100 A-IMPASLALIAATFpgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL----------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 203 ppvkkdvekgtgdsalhknnkksfwqtmnkyldLSLFKHRGFLIYLSGNVIMFIGFFAPIVFLAPYAKH-KGIDEYSAAF 281
Cdd:cd17321 162 ---------------------------------VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 282 LLSILAFVDMFARPSMGLVANSKFIRPKIqyFFSFAVFYNGV-CHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLM 360
Cdd:cd17321 209 ALLPLALAMLVAAPLAGRLADRFGPRLVL--VAGLLLTAVGLlLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330
....*....|....*.
gi 700380260 361 DLVGAARFSSAVGLVT 376
Cdd:cd17321 287 SSVPKEKAGAASGILN 302
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
312-430 |
1.07e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 312 YFFSFAVFynGVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGG 391
Cdd:cd17503 64 FLTALALF--TLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGG 141
|
90 100 110
....*....|....*....|....*....|....*....
gi 700380260 392 WLVDVTGeYQYMYFVCGVIVIVAsiwLFIGNAINYRLLA 430
Cdd:cd17503 142 WLTDNLS-WRWIFYINLPIGILA---LLLAPLLDLRLFK 176
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
322-419 |
1.09e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 44.49 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 322 GVCHVMCPLATNYTGLVIYAVFFGFAFGMVSSVLFE---TLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTG 398
Cdd:cd17384 271 GISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPllaYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIG 350
|
90 100
....*....|....*....|.
gi 700380260 399 eYQYMYFVCGVIVIVASIWLF 419
Cdd:cd17384 351 -FPWLMRIIGIINILYAPLLF 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
55-417 |
1.12e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 55 SEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVlELYLCIGVVGGLGLAFNL---QPAL 131
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP-WVWFLLRFVMGIGLAGLFvvsESWL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 132 ----------TMIGKYFykkrpIANGLAMAGSPVFLSTLAPLNQFLFnafgwkgsfLILGGLLLNCCVAGSLMRPVGPkt 201
Cdd:cd17477 110 nalatnenrgRVLGLYS-----TVLGLGFALGPLLLALVGTAGALPF---------LIAAVLLLLALVPLLLTRRAAP-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 202 vppvkkdvekgtgdsALHKNNKKSFWQTMnkyldlslfkhRGFLIYLSGNVIMFIGFFAPIVFLAPYAKHKGIDEYSAAF 281
Cdd:cd17477 174 ---------------EIEEAESISLRRLL-----------RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 282 LLSILAFVDMFARPSMGLVANsKFIRPKIQYFFSFAVFyngVCHVMCPLATNYTGLVIyavFFGFAFGMVSSVLFETLM- 360
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLAD-RFDRRRVLLGCALLGA---LAALLLPLVPGLPLALL---VLLFLWGGAAGPLYTLALa 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 361 ---DLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17477 301 lagDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
66-125 |
1.31e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.11 E-value: 1.31e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 66 AVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIGVVGGLGLAF 125
Cdd:cd17504 228 LVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGL 287
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-416 |
1.99e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 15 GGWGWVVVFGAFISIGFSYAFPKAItvffkeiqEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGIL 94
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAE--------FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 95 CSFGMIASSFCNSVLELYLCIGVVgGLGLAFNLQPALTMIGKYFYKKRP-----IANGLAMAGSPVFLSTLAPLNQFLFN 169
Cdd:cd17316 76 FGLATLLIGLLPTPILLLVLRFLQ-GIGIGGEYPGASTYVAEFAPSKRRgfalgLLQSGWALGALLAALVASLLIPLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 170 AFGWKGSFLILGGLLLnccvagslmrpvgpktvppvkkdvekgtgdsalhknnkksfwqtmnkyldLSLFKHRGFLIYLS 249
Cdd:cd17316 155 DWGWRILFLIGALPAL--------------------------------------------------LALLLRRRTLLLIL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 250 GNVIMFIGFFAPIVFLAPY-AKHKGIDEYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFYNGVCHVMC 328
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR--IGRKKTLVIGLILSGILALPLFY 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 329 PLATNYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGEYQYMYFVCG 408
Cdd:cd17316 263 LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILA 342
|
....*...
gi 700380260 409 VIVIVASI 416
Cdd:cd17316 343 LLAIVALI 350
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-131 |
2.12e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.80 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 20 VVVFGAFI---SIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSI----LVNKYGSRPVMIAGG 92
Cdd:pfam00083 4 VAALGGFLfgyDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLfagkLGDRFGRKKSLLIAN 83
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 700380260 93 ILC---SFGMIASSFCNSVLELYLCIGVVG-GLGLAFNLQPAL 131
Cdd:pfam00083 84 VLFvigAVLQGAAKGKWSVYQLIVGRVLVGiGVGGASVLAPMY 126
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
45-419 |
3.15e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.01 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 45 EIQEIFHTSYSEIAWissiMLAVMYAGGPIS----SILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCIGVVGG 120
Cdd:cd17341 24 VIRDDLGLSTSQIGL----LVAIPVLAGALLrlpyGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 121 LGLAfNLQPALTMIGKYFYKKRP-----IANGLAMAGSPV---FLSTLAPLNQFLFNAFGWKGSFLILGGLLLNCCVAGS 192
Cdd:cd17341 100 FAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVsqlLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 193 LMR---PVGPKTVPPVKKDVEKGTGDSALhknnkksfWQTMnkyldlslfkhrgfLIYlsgnVIMFIGFFAPIVFLAPYA 269
Cdd:cd17341 179 LFGddlPTGKASALEFLKVQLAVLKNYRT--------WILS--------------LLY----GVTFGSFVGFSNVLPTYF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 270 K-HKGIDEYSAAFLLSILAFVDMFARPSMGLVANskFIRPKIQYFFSFAVFynGVCHVMC---------PLATNYTGLVI 339
Cdd:cd17341 233 KtRFGLPLVTAGILAALFPLAGALARPAGGWLSD--RFGGRRRLWWLFIVM--TIGAALLslslptsgtNLVLFLALFVA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 340 YAVFFGFAFGMVSSVL-FETLMDLVGAARFSSAVGLVTIVeccpvliGPPLG-GWLVDVTGEYQYMYFVCGVIVIVASIW 417
Cdd:cd17341 309 LGLGAGAGNGSVFRMVpFIFRRELGAVTGLVGAIGGLGGF-------FLPLLfGSSALMTGSGVGAFSLFGVLAVACTLL 381
|
..
gi 700380260 418 LF 419
Cdd:cd17341 382 VW 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-416 |
8.40e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 8.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 46 IQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFGMIASSFCNSVLELYLCiGVVGGLGLAF 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG-RALQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 126 nLQPALTMIGKYFYKKR-PIANGL--AMAGSPVFLSTL--APLNQFLfnafGWKGSFLILGGLllncCVAGSLMRPVgpk 200
Cdd:cd17504 101 -FPLAFALVREEFPPERvPVAQGIlsATFGIGAGIGLPlgGWIVQHL----GWRWIFWTAAPV----AVLLAALVPL--- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 201 tvppvkkdvekgtgdsalhknnkksfwqtmnkyLDLSLFKHRGFLIYLSGNVIMFIGFFA-----PIVFLAPYAKHKGID 275
Cdd:cd17504 169 ---------------------------------IDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 276 EYSAAFLLSILAFVDMFARPSMGLVANSkfIRPKIQYFFSFAVFynGVCHVMcpLATNYTGL---VIYAVFFGFAFGMVS 352
Cdd:cd17504 216 ITEAGLLLLPGALVMLIAGPLAGRLIAR--VGPRRVLLIGLVIS--AVGLLL--LALLHSSLwalVVALLLIGIGLGLAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 700380260 353 SVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGG------------WLVDVTGEYQYMYFVCGVIVIVASI 416
Cdd:cd17504 290 ASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGailttytvsitsGGVPTEGAYVLAFLIGAALALAALL 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-185 |
4.14e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 19 WVVVFGAFISIGFSYAFPKAITVFFKEIqeiFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGILCSFG 98
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDV---LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 99 MIASSFCNSVLELYLCIGVVG-GLGLAFNLqpALTMIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNAFGWKGSF 177
Cdd:COG0738 290 LLLALLAPGPWLALIGLALVGlGLSLMFPT--IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
|
....*...
gi 700380260 178 LILGGLLL 185
Cdd:COG0738 368 LVPLVCYL 375
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
259-418 |
8.17e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 38.36 E-value: 8.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 259 FAPIVFLAPYAKHKGIDEYSAAFLLSILAFVDMFArpsmglvanSKFIRPKIQ------YFFSFAVFYNGVChVMCPLAT 332
Cdd:PRK10213 37 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFA---------SLFITQTIQatdrryVVILFAVLLTLSC-LLVSFAN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700380260 333 NYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAARFSSAVGLVTIVECCPVLIGPPLGGWLVDVTGeYQYMYFVCGVIVI 412
Cdd:PRK10213 107 SFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIG-WRNVFNAAAVMGV 185
|
....*.
gi 700380260 413 VASIWL 418
Cdd:PRK10213 186 LCIFWI 191
|
|
| |
