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Conserved domains on  [gi|699702926|ref|XP_009891604|]
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PREDICTED: toll-like receptor 2 type-2, partial [Charadrius vociferus]

Protein Classification

toll-like receptor( domain architecture ID 18785053)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
627-751 1.05e-33

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.05e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926   627 CYDAFVSYSENDsdWVENIMVRELEQACPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELDF 706
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 699702926   707 SHFRLFDENNDAAILVLLEPIQSKaIPKRFCKLRKIMnTKTYLEW 751
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKW 121
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
231-532 5.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 5.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 231 LLRVLSLSFAQKISLKEALLTDATVPEIVSILEDMPKLVEVEMIDCRLMGTGQWQIQIQANQSQTLRVLTIEKLSIEEFY 310
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 311 LFTDLQAVEGLLSL--LTKVTVRNTKVFLVPCSLSRrLLSLEYLDLSANLLGDQSLEhsacQGGWPSLQALNLSQNSLSD 388
Cdd:COG4886   99 TELDLSGNEELSNLtnLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP----LGNLTNLKSLDLSNNQLTD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 389 LemtGKSLSRLRQLILLDISQNNFGEIPDVCEWPKHLKYLNLSSTQIPKLTTCIP-LT-LEVLDVSANNLKEFG--LQLP 464
Cdd:COG4886  174 L---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnLTnLETLDLSNNQLTDLPelGNLT 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 699702926 465 FLKELYLAKNQLKTLPGAAPIPNLVAMSIRRNKLNSFSREEFEAFKKMELLDASDNNFICSCEFVSFI 532
Cdd:COG4886  251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-190 1.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  27 NCSSMDLDFIPAGLTD--KITTLNLSHNRIKHIRSqDLQQTVNLRVLLLQSNNISSIDEdSFRSLGKLELLDLSNNSLAH 104
Cdd:COG4886  119 DLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 105 VsPAWFGHLFSLQHLHLQGNAYRDLGEssPFSSLRNLSSLHLGNRRFSTIRrgNFEGIELLDKLWIDGGNLRQYEP-GSF 183
Cdd:COG4886  197 L-PEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPlANL 271


                 ....*..
gi 699702926 184 KSIKKVN 190
Cdd:COG4886  272 TNLKTLD 278
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
520-573 1.85e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 699702926   520 NNFICSCEFVSFIQHQagMAQVLVGWPDKYICDSPLAVRGtQVGAVHPSLMECH 573
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
627-751 1.05e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.05e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926   627 CYDAFVSYSENDsdWVENIMVRELEQACPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELDF 706
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 699702926   707 SHFRLFDENNDAAILVLLEPIQSKaIPKRFCKLRKIMnTKTYLEW 751
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKW 121
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
231-532 5.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 5.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 231 LLRVLSLSFAQKISLKEALLTDATVPEIVSILEDMPKLVEVEMIDCRLMGTGQWQIQIQANQSQTLRVLTIEKLSIEEFY 310
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 311 LFTDLQAVEGLLSL--LTKVTVRNTKVFLVPCSLSRrLLSLEYLDLSANLLGDQSLEhsacQGGWPSLQALNLSQNSLSD 388
Cdd:COG4886   99 TELDLSGNEELSNLtnLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP----LGNLTNLKSLDLSNNQLTD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 389 LemtGKSLSRLRQLILLDISQNNFGEIPDVCEWPKHLKYLNLSSTQIPKLTTCIP-LT-LEVLDVSANNLKEFG--LQLP 464
Cdd:COG4886  174 L---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnLTnLETLDLSNNQLTDLPelGNLT 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 699702926 465 FLKELYLAKNQLKTLPGAAPIPNLVAMSIRRNKLNSFSREEFEAFKKMELLDASDNNFICSCEFVSFI 532
Cdd:COG4886  251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 628-751 4.88e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 87.81  E-value: 4.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  628 YDAFVSYSENDS-DWVENIMVRELEQacPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELDF 706
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQ--KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 699702926  707 S-HFRLfdENNDAAILVLLEPI------QSKAIPKRFCKLRKIMNTKTYLEW 751
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDpsdvrkQTGSFGKAFKKHKKVLTEEKVLKW 128
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-190 1.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  27 NCSSMDLDFIPAGLTD--KITTLNLSHNRIKHIRSqDLQQTVNLRVLLLQSNNISSIDEdSFRSLGKLELLDLSNNSLAH 104
Cdd:COG4886  119 DLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 105 VsPAWFGHLFSLQHLHLQGNAYRDLGEssPFSSLRNLSSLHLGNRRFSTIRrgNFEGIELLDKLWIDGGNLRQYEP-GSF 183
Cdd:COG4886  197 L-PEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPlANL 271


                 ....*..
gi 699702926 184 KSIKKVN 190
Cdd:COG4886  272 TNLKTLD 278
LRR_8 pfam13855
Leucine rich repeat;
67-124 1.68e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.68e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 699702926   67 NLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSLAHVSPAWFGHLFSLQHLHLQGN 124
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-168 3.66e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  43 KITTLNLSHNRIKHIrsQDLQQTVNLRVLLLQSNNISSIDedsfrslgklellDLSNNSlahvspawfghlfSLQHLHLQ 122
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-------------NLEFLT-------------NLTHLYLQ 54

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 699702926 123 GNayrDLGESSPFSSLRNLSSLHLGNRRFSTIrrgnfEGIELLDKL 168
Cdd:cd21340   55 NN---QIEKIENLENLVNLKKLYLGGNRISVV-----EGLENLTNL 92
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-522 5.50e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  44 ITTLNLSHNRIKHIRSQDLQQTV-NLRVLLLQSNNISSIDEDSFRSLgkLELLDLSNNSLAHVSPAWFGHLFSLQHLHLQ 122
Cdd:PLN00113  95 IQTINLSNNQLSGPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSGEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 123 GNAYrdLGESSPfsSLRNLSSLhlgnrRFSTIRRGNFEG---IEL-----LDKLWIDGGNLRQYEPGSFKSIKKVNHMiv 194
Cdd:PLN00113 173 GNVL--VGKIPN--SLTNLTSL-----EFLTLASNQLVGqipRELgqmksLKWIYLGYNNLSGEIPYEIGGLTSLNHL-- 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 195 dirsinvfsaivrDLLHSvtwlelrKIPFSIPAEMQLLRVLSLSFaqkisLKEALLTDATVPEIVSiledMPKLVEVEMI 274
Cdd:PLN00113 242 -------------DLVYN-------NLTGPIPSSLGNLKNLQYLF-----LYQNKLSGPIPPSIFS----LQKLISLDLS 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 275 DCRLMGtgqwQIQIQANQSQTLRVLtieklsieefYLFTD--LQAVEGLLSLLTKVTV----RNTKVFLVPCSLSRRLlS 348
Cdd:PLN00113 293 DNSLSG----EIPELVIQLQNLEIL----------HLFSNnfTGKIPVALTSLPRLQVlqlwSNKFSGEIPKNLGKHN-N 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 349 LEYLDLSANLLGDQsLEHSACQGGwpSLQALNLSQNSLSDleMTGKSLSRLRQLILLDISQNNF-GEIPDVCEWPKHLKY 427
Cdd:PLN00113 358 LTVLDLSTNNLTGE-IPEGLCSSG--NLFKLILFSNSLEG--EIPKSLGACRSLRRVRLQDNSFsGELPSEFTKLPLVYF 432

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 428 LNLSSTQIP-KLTTC---IPlTLEVLDVSANNLkeFGlQLP------FLKELYLAKNQLKtlpGAAP-----IPNLVAMS 492
Cdd:PLN00113 433 LDISNNNLQgRINSRkwdMP-SLQMLSLARNKF--FG-GLPdsfgskRLENLDLSRNQFS---GAVPrklgsLSELMQLK 505

                        490       500       510
                 ....*....|....*....|....*....|
gi 699702926 493 IRRNKLNSFSREEFEAFKKMELLDASDNNF 522
Cdd:PLN00113 506 LSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
348-412 3.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 699702926  348 SLEYLDLSANLLgdQSLEHSACQGgWPSLQALNLSQNSLSDLEmtGKSLSRLRQLILLDISQNNF 412
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKG-LSNLKVLDLSNNLLTTLS--PGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 374-450 3.64e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 374 PSLQALNLSQNSLSDLEmtgkSLSRLRQLILLDISQNNFGEIPDVCE----WPkHLKYLNLSS---TQIPK-----LTTC 441
Cdd:cd21340  120 NSLRVLNISGNNIDSLE----PLAPLRNLEQLDASNNQISDLEELLDllssWP-SLRELDLTGnpvCKKPKyrdkiILAS 194


                 ....*....
gi 699702926 442 ipLTLEVLD 450
Cdd:cd21340  195 --KSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 44-124 1.39e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.19  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  44 ITTLNLSHNRIKHIRSQDLQQTVNLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSLAHVSPAWFGHLFSLQHLHLQG 123
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 .
gi 699702926 124 N 124
Cdd:PLN03150 500 N 500
LRRCT smart00082
Leucine rich repeat C-terminal domain;
520-573 1.85e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 699702926   520 NNFICSCEFVSFIQHQagMAQVLVGWPDKYICDSPLAVRGtQVGAVHPSLMECH 573
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
627-751 1.05e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.05e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926   627 CYDAFVSYSENDsdWVENIMVRELEQACPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELDF 706
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 699702926   707 SHFRLFDENNDAAILVLLEPIQSKaIPKRFCKLRKIMnTKTYLEW 751
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKW 121
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
231-532 5.31e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 5.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 231 LLRVLSLSFAQKISLKEALLTDATVPEIVSILEDMPKLVEVEMIDCRLMGTGQWQIQIQANQSQTLRVLTIEKLSIEEFY 310
Cdd:COG4886   19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 311 LFTDLQAVEGLLSL--LTKVTVRNTKVFLVPCSLSRrLLSLEYLDLSANLLGDQSLEhsacQGGWPSLQALNLSQNSLSD 388
Cdd:COG4886   99 TELDLSGNEELSNLtnLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP----LGNLTNLKSLDLSNNQLTD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 389 LemtGKSLSRLRQLILLDISQNNFGEIPDVCEWPKHLKYLNLSSTQIPKLTTCIP-LT-LEVLDVSANNLKEFG--LQLP 464
Cdd:COG4886  174 L---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnLTnLETLDLSNNQLTDLPelGNLT 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 699702926 465 FLKELYLAKNQLKTLPGAAPIPNLVAMSIRRNKLNSFSREEFEAFKKMELLDASDNNFICSCEFVSFI 532
Cdd:COG4886  251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 628-751 4.88e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 87.81  E-value: 4.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  628 YDAFVSYSENDS-DWVENIMVRELEQacPPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELDF 706
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQ--KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 699702926  707 S-HFRLfdENNDAAILVLLEPI------QSKAIPKRFCKLRKIMNTKTYLEW 751
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDpsdvrkQTGSFGKAFKKHKKVLTEEKVLKW 128
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 631-705 1.63e-15

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 73.12  E-value: 1.63e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 699702926  631 FVSYSENDSDWVENImVRELEQAcpPFRLCLHKRDFVPGKWIVDNIIDSIEKSHKTLFVLSEHFVQSEWCKYELD 705
Cdd:pfam13676   2 FISYAGEDRAWAEWL-ADALEAA--GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
322-523 4.34e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 322 LSLLTKVTVRNTKVFLVPCSLSRrLLSLEYLDLSANLLgdQSLEHSAcqGGWPSLQALNLSQNSLSDLemtGKSLSRLRQ 401
Cdd:COG4886  135 LTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQL--TDLPEEL--GNLTNLKELDLSNNQITDL---PEPLGNLTN 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 402 LILLDISQNNFGEIPDVCEWPKHLKYLNLSSTQI---PKLTTCIplTLEVLDVSANNLKEFG--LQLPFLKELYLAKNQL 476
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLtdlPELGNLT--NLEELDLSNNQLTDLPplANLTNLKTLDLSNNQL 284

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 699702926 477 KTLPGAAPIPNLVAMSIRRNKLNSFSREEFEAFKKMELLDASDNNFI 523
Cdd:COG4886  285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-190 1.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  27 NCSSMDLDFIPAGLTD--KITTLNLSHNRIKHIRSqDLQQTVNLRVLLLQSNNISSIDEdSFRSLGKLELLDLSNNSLAH 104
Cdd:COG4886  119 DLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 105 VsPAWFGHLFSLQHLHLQGNAYRDLGEssPFSSLRNLSSLHLGNRRFSTIRrgNFEGIELLDKLWIDGGNLRQYEP-GSF 183
Cdd:COG4886  197 L-PEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPlANL 271


                 ....*..
gi 699702926 184 KSIKKVN 190
Cdd:COG4886  272 TNLKTLD 278
LRR_8 pfam13855
Leucine rich repeat;
67-124 1.68e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.68e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 699702926   67 NLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSLAHVSPAWFGHLFSLQHLHLQGN 124
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-168 4.66e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 4.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  27 NCSSMDLDFIPAGLTD--KITTLNLSHNRIKHIrSQDLQQTVNLRVLLLQSNNISSIDEdSFRSLGKLELLDLSNNSLAH 104
Cdd:COG4886  165 DLSNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 699702926 105 VSpaWFGHLFSLQHLHLQGNAYRDLgesSPFSSLRNLSSLHLGNRRFSTIRRGNFEGIELLDKL 168
Cdd:COG4886  243 LP--ELGNLTNLEELDLSNNQLTDL---PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-168 3.66e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  43 KITTLNLSHNRIKHIrsQDLQQTVNLRVLLLQSNNISSIDedsfrslgklellDLSNNSlahvspawfghlfSLQHLHLQ 122
Cdd:cd21340    3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE-------------NLEFLT-------------NLTHLYLQ 54

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 699702926 123 GNayrDLGESSPFSSLRNLSSLHLGNRRFSTIrrgnfEGIELLDKL 168
Cdd:cd21340   55 NN---QIEKIENLENLVNLKKLYLGGNRISVV-----EGLENLTNL 92
LRR_8 pfam13855
Leucine rich repeat;
43-102 4.22e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 4.22e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926   43 KITTLNLSHNRIKHIRSQDLQQTVNLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSL 102
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-522 5.50e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  44 ITTLNLSHNRIKHIRSQDLQQTV-NLRVLLLQSNNISSIDEDSFRSLgkLELLDLSNNSLAHVSPAWFGHLFSLQHLHLQ 122
Cdd:PLN00113  95 IQTINLSNNQLSGPIPDDIFTTSsSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSGEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 123 GNAYrdLGESSPfsSLRNLSSLhlgnrRFSTIRRGNFEG---IEL-----LDKLWIDGGNLRQYEPGSFKSIKKVNHMiv 194
Cdd:PLN00113 173 GNVL--VGKIPN--SLTNLTSL-----EFLTLASNQLVGqipRELgqmksLKWIYLGYNNLSGEIPYEIGGLTSLNHL-- 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 195 dirsinvfsaivrDLLHSvtwlelrKIPFSIPAEMQLLRVLSLSFaqkisLKEALLTDATVPEIVSiledMPKLVEVEMI 274
Cdd:PLN00113 242 -------------DLVYN-------NLTGPIPSSLGNLKNLQYLF-----LYQNKLSGPIPPSIFS----LQKLISLDLS 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 275 DCRLMGtgqwQIQIQANQSQTLRVLtieklsieefYLFTD--LQAVEGLLSLLTKVTV----RNTKVFLVPCSLSRRLlS 348
Cdd:PLN00113 293 DNSLSG----EIPELVIQLQNLEIL----------HLFSNnfTGKIPVALTSLPRLQVlqlwSNKFSGEIPKNLGKHN-N 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 349 LEYLDLSANLLGDQsLEHSACQGGwpSLQALNLSQNSLSDleMTGKSLSRLRQLILLDISQNNF-GEIPDVCEWPKHLKY 427
Cdd:PLN00113 358 LTVLDLSTNNLTGE-IPEGLCSSG--NLFKLILFSNSLEG--EIPKSLGACRSLRRVRLQDNSFsGELPSEFTKLPLVYF 432

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 428 LNLSSTQIP-KLTTC---IPlTLEVLDVSANNLkeFGlQLP------FLKELYLAKNQLKtlpGAAP-----IPNLVAMS 492
Cdd:PLN00113 433 LDISNNNLQgRINSRkwdMP-SLQMLSLARNKF--FG-GLPdsfgskRLENLDLSRNQFS---GAVPrklgsLSELMQLK 505

                        490       500       510
                 ....*....|....*....|....*....|
gi 699702926 493 IRRNKLNSFSREEFEAFKKMELLDASDNNF 522
Cdd:PLN00113 506 LSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-499 2.12e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  29 SSMDLDFIPAGLTDKITTLNLSHNRIKHIRSQDLQQTVNLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSLahvspa 108
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 109 wFGHLFSLQHLHLQGNAYRDLGESspFSSLRNLSSLHLGNRRFSTIrrgnfegielldklwidggnlrqyePGSFKSIKK 188
Cdd:COG4886  109 -LSNLTNLESLDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDL-------------------------PEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 189 vnhmivdirsinvfsaivrdllhsvtwlelrkipfsipaemqlLRVLSLSFAQkislkealltdatvpeivsiLEDMPKl 268
Cdd:COG4886  161 -------------------------------------------LKSLDLSNNQ--------------------LTDLPE- 176

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 269 vevemidcrlmgtgqwqiqiqanqsqtlrvlTIEKLSieefylftdlqavegllslltkvtvrntkvflvpcslsrrllS 348
Cdd:COG4886  177 -------------------------------ELGNLT------------------------------------------N 183

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 349 LEYLDLSANLLGD--QSLehsacqGGWPSLQALNLSQNSLSDLemtGKSLSRLRQLILLDISQNNFGEIPDVCEWPKhLK 426
Cdd:COG4886  184 LKELDLSNNQITDlpEPL------GNLTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPELGNLTN-LE 253

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 699702926 427 YLNLSSTQIPKLTTCIPLT-LEVLDVSANNLKEFGLQ-LPFLKELYLAKNQLKTLPGAAPIPNLVAMSIRRNKLN 499
Cdd:COG4886  254 ELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-525 5.86e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 5.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  36 IPAGLTDKITTLNLSHNRIKHIRSQDLQQTVNLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSLAHVSPAWFGHLFS 115
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 116 LQHLHLqgnAYRDLGESSPFS--SLRNLSSLHLGNRRFSTIRRGNFEGIELLDKLWIDGGNLRQYEPGSFKSIKKVnhMI 193
Cdd:PLN00113 214 LKWIYL---GYNNLSGEIPYEigGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKL--IS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 194 VDIrSINVFSAIVRDLLHSVTWLELR---------KIPF---SIPaEMQLLRVLSLSFAQKISLKEA---------LLTD 252
Cdd:PLN00113 289 LDL-SDNSLSGEIPELVIQLQNLEILhlfsnnftgKIPValtSLP-RLQVLQLWSNKFSGEIPKNLGkhnnltvldLSTN 366

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 253 ATVPEIVSILEDMPKLVEVEMIDCRLMGtgqwQIQIQANQSQTLRVLTIEK--LSIEEFYLFTDLQAVEGLLSLLTKVTV 330
Cdd:PLN00113 367 NLTGEIPEGLCSSGNLFKLILFSNSLEG----EIPKSLGACRSLRRVRLQDnsFSGELPSEFTKLPLVYFLDISNNNLQG 442

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 331 R-NTKVFLVPcslsrrllSLEYLDLSANLLgdqslehsacQGGWP------SLQALNLSQNSLSdlEMTGKSLSRLRQLI 403
Cdd:PLN00113 443 RiNSRKWDMP--------SLQMLSLARNKF----------FGGLPdsfgskRLENLDLSRNQFS--GAVPRKLGSLSELM 502

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 404 LLDISQNNF-GEIPDVCEWPKHLKYLNLSSTQipkLTTCIPLTLEvldvsannlkefglQLPFLKELYLAKNQL--KTLP 480
Cdd:PLN00113 503 QLKLSENKLsGEIPDELSSCKKLVSLDLSHNQ---LSGQIPASFS--------------EMPVLSQLDLSQNQLsgEIPK 565

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 699702926 481 GAAPIPNLVAMSIRRNKLNSfSREEFEAFKKMELLDASDNNFICS 525
Cdd:PLN00113 566 NLGNVESLVQVNISHNHLHG-SLPSTGAFLAINASAVAGNIDLCG 609
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-489 7.10e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 7.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  24 QLCNCSSMDLDFIP--AGLTDkITTLNLSHNRIKHIrSQDLQQTVNLRVLLLQSNNISSIDEdSFRSLGKLELLDLSNNS 101
Cdd:COG4886   94 DLTNLTELDLSGNEelSNLTN-LESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 102 LAHVsPAWFGHLFSLQHLHLQGNAYRDLgeSSPFSSLRNLSSLHLGNRRFSTIrrgnfegielldklwidggnlrqyePG 181
Cdd:COG4886  171 LTDL-PEELGNLTNLKELDLSNNQITDL--PEPLGNLTNLEELDLSGNQLTDL-------------------------PE 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 182 SFKSIKKvnhmivdirsinvfsaivrdllhsvtwlelrkipfsipaemqlLRVLSLSFAQkislkealltdatvpeivsi 261
Cdd:COG4886  223 PLANLTN-------------------------------------------LETLDLSNNQ-------------------- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 262 LEDMPKLvevemidcrlmgtgqwqiqiqanqsqtlrvltieklsieefylftdlqaveGLLSLLTKVTVRNTKVFLVPCS 341
Cdd:COG4886  240 LTDLPEL---------------------------------------------------GNLTNLEELDLSNNQLTDLPPL 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 342 LSrrLLSLEYLDLSANLLGDQSLEHSACQGGWPSLQALNLSQNSLSDLEMTGKSLSRLRQLILLDISQNNFGEIPDVCEW 421
Cdd:COG4886  269 AN--LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 699702926 422 PKHLKYLNLSSTQIPKLTTCIPLTLEVLDVSANNLKEFGLQLPFLKELYLAKNQLKTLPGAAPIPNLV 489
Cdd:COG4886  347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
380-501 8.00e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 8.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 380 NLSQNSLSDLEMTGKSLSRLRQLILLDISQNNFGEIPDVCEwpKHLKYLNLSSTQIPKLTTCIPLTLEVLDVSANNLKEF 459
Cdd:PRK15370 179 NKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL 256

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 699702926 460 GLQLP-FLKELYLAKNQLKTLPGAAPiPNLVAMSIRRNKLNSF 501
Cdd:PRK15370 257 PERLPsALQSLDLFHNKISCLPENLP-EELRYLSVYDNSIRTL 298
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-106 1.09e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.09e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699702926  38 AGLTDKITTLNLSHNRIKHIrsQDLQQTVNLRVLLLQSNNISSIDE--DSFRSLGKLELLDLSNNSLAHVS 106
Cdd:cd21340  116 AALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
287-484 1.12e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 287 QIQANQSQTLRVLTIEKLSIEEFYLFTD--LQAVEGLLSLLTKVTVRNTKVFLVPCSLSRrllSLEYLDLSANLLgdqsl 364
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINriTELPERLPSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSI----- 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 365 ehSACQGGWPS-LQALNLSQNSLSDLEMTGKSlsrlrQLILLDISQNNFGEIPDvcEWPKHLKYLNLSSTQIPKLTTCIP 443
Cdd:PRK15370 296 --RTLPAHLPSgITHLNVQSNSLTALPETLPP-----GLKTLEAGENALTSLPA--SLPPELQVLDVSKNQITVLPETLP 366

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 699702926 444 LTLEVLDVSANNLKEFGLQLP-FLKELYLAKNQLKTLPGAAP 484
Cdd:PRK15370 367 PTITTLDVSRNALTNLPENLPaALQIMQASRNNLVRLPESLP 408
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
326-498 1.19e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 326 TKVTVRNTKVFLVPCSLSRRLLSL-----EYLDLSANLLGD------QSLEHSACQGGWP-SLQALNLSQNSLSDLEmtg 393
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLildnnELKSLPENLQGNiktlyaNSNQLTSIPATLPdTIQEMELSINRITELP--- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 394 kslSRL-RQLILLDISQNNFGEIPDvcEWPKHLKYLNLSSTQIPKLTTCIPLTLEVLDVSANNLKEFGLQLPF-LKELYL 471
Cdd:PRK15370 258 ---ERLpSALQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPgLKTLEA 332

                        170       180
                 ....*....|....*....|....*..
gi 699702926 472 AKNQLKTLPGAAPiPNLVAMSIRRNKL 498
Cdd:PRK15370 333 GENALTSLPASLP-PELQVLDVSKNQI 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-128 1.33e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  43 KITTLNLSHNRIK--------------HIRSQDLQQTV--------------NLRVLLLQSNNISSIDEdsFRSLGKLEL 94
Cdd:cd21340   69 NLKKLYLGGNRISvveglenltnleelHIENQRLPPGEkltfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQ 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 699702926  95 LDLSNNSLAHVSP--AWFGHLFSLQHLHLQGNA------YRD 128
Cdd:cd21340  147 LDASNNQISDLEEllDLLSSWPSLRELDLTGNPvckkpkYRD 188
LRR_8 pfam13855
Leucine rich repeat;
348-412 3.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 699702926  348 SLEYLDLSANLLgdQSLEHSACQGgWPSLQALNLSQNSLSDLEmtGKSLSRLRQLILLDISQNNF 412
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKG-LSNLKVLDLSNNLLTTLS--PGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 374-450 3.64e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 374 PSLQALNLSQNSLSDLEmtgkSLSRLRQLILLDISQNNFGEIPDVCE----WPkHLKYLNLSS---TQIPK-----LTTC 441
Cdd:cd21340  120 NSLRVLNISGNNIDSLE----PLAPLRNLEQLDASNNQISDLEELLDllssWP-SLRELDLTGnpvCKKPKyrdkiILAS 194


                 ....*....
gi 699702926 442 ipLTLEVLD 450
Cdd:cd21340  195 --KSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 44-124 1.39e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.19  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  44 ITTLNLSHNRIKHIRSQDLQQTVNLRVLLLQSNNISSIDEDSFRSLGKLELLDLSNNSLAHVSPAWFGHLFSLQHLHLQG 123
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNG 499


                 .
gi 699702926 124 N 124
Cdd:PLN03150 500 N 500
LRRCT smart00082
Leucine rich repeat C-terminal domain;
520-573 1.85e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 699702926   520 NNFICSCEFVSFIQHQagMAQVLVGWPDKYICDSPLAVRGtQVGAVHPSLMECH 573
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
374-435 2.63e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 699702926  374 PSLQALNLSQNSLSDLEmtGKSLSRLRQLILLDISQNNFGEI-PDVCEWPKHLKYLNLSSTQI 435
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 374-474 5.96e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 5.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 374 PSLQALNLSQNSLSDLEmtgkSLSRLRQLILLDISQNNFGE----IPD---VCEWPKHLKYLNLSSTQIPKLTTCIPLT- 445
Cdd:cd21340   68 VNLKKLYLGGNRISVVE----GLENLTNLEELHIENQRLPPgeklTFDprsLAALSNSLRVLNISGNNIDSLEPLAPLRn 143

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 699702926 446 LEVLDVSANNLKEFG------LQLPFLKELYLAKN 474
Cdd:cd21340  144 LEQLDASNNQISDLEelldllSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 230-478 6.77e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 6.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 230 QLLRVLSLsfAQKISLKEALLTDATVPEIVSILEDMPKLVEVEMidcRLMGTG----QWQIQIQANQSQTLrvltIEKLS 305
Cdd:cd00116   17 ELLPKLLC--LQVLRLEGNTLGEEAAKALASALRPQPSLKELCL---SLNETGriprGLQSLLQGLTKGCG----LQELD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 306 IEEFYLFTDLQAVegLLSLLTKVTVRNTK----------VFLVPCSLSRRLLSLEYLDLSANLLGDQSLEHSACQ-GGWP 374
Cdd:cd00116   88 LSDNALGPDGCGV--LESLLRSSSLQELKlnnnglgdrgLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKAlRANR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 375 SLQALNLSQNSLSD--LEMTGKSLSRLRQLILLDISQNNFGE--IPDVCEWPKHLKYL--------NLSSTQIPKLTTCI 442
Cdd:cd00116  166 DLKELNLANNGIGDagIRALAEGLKANCNLEVLDLNNNGLTDegASALAETLASLKSLevlnlgdnNLTDAGAAALASAL 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 699702926 443 PL---TLEVLDVSANNLKEFGL--------QLPFLKELYLAKNQLKT 478
Cdd:cd00116  246 LSpniSLLTLSLSCNDITDDGAkdlaevlaEKESLLELDLRGNKFGE 292
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
374-498 7.03e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 7.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 374 PSLQALNLSQNSLSDLEMTGKSLSRL--------------RQLILLDISQNNFGEIPDVCEWPKHLKYLNLSSTQIPKLt 439
Cdd:PRK15387 302 PGLQELSVSDNQLASLPALPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPAL- 380

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 440 tciPLTLEVLDVSANNLKEFGLQLPFLKELYLAKNQLKTLPgaaPIPN-LVAMSIRRNKL 498
Cdd:PRK15387 381 ---PSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLP---MLPSgLLSLSVYRNQL 434
LRR_8 pfam13855
Leucine rich repeat;
466-522 1.14e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 699702926  466 LKELYLAKNQLKTLPGAAPI--PNLVAMSIRRNKLNSFSREEFEAFKKMELLDASDNNF 522
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 348-476 3.37e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926 348 SLEYLDLSANLLGDQSLEH--SACQGGwPSLQALNLSQNSLSD--LEMTGKSLSRLRQLILLDISQNNFGE-----IPDV 418
Cdd:COG5238  237 SLTTLDLSNNQIGDEGVIAlaEALKNN-TTVETLYLSGNQIGAegAIALAKALQGNTTLTSLDLSVNRIGDegaiaLAEG 315

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 699702926 419 CEWPKHLKYLNLSSTQIPKlTTCIPL--------TLEVLDVSANNLKEFG-------LQL-PFLKELYLAKNQL 476
Cdd:COG5238  316 LQGNKTLHTLNLAYNGIGA-QGAIALakalqentTLHSLDLSDNQIGDEGaialakyLEGnTTLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-148 3.69e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699702926  67 NLRVLLLQSNNISSIDEDS----FRSLGKLELLDLSNNSL-----AHVSPAwFGHLFSLQHLHLQGNAYRDLGESS---P 134
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIgdagiRALAEG-LKANCNLEVLDLNNNGLTDEGASAlaeT 216

                         90
                 ....*....|....
gi 699702926 135 FSSLRNLSSLHLGN 148
Cdd:cd00116  217 LASLKSLEVLNLGD 230
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 67-100 5.04e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 699702926   67 NLRVLLLQSNNISSIdeDSFRSLGKLELLDLSNN 100
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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