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Conserved domains on  [gi|698435326|ref|XP_009698003|]
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PREDICTED: N-acetylgalactosamine kinase [Cariama cristata]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 2-431 1.86e-157

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 454.17  E-value: 1.86e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQ-VVQLANTNSLYL--DFSTNVNNiQINK 78
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTtcTFPADPDQ-EVDL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  79 TKPQWHNYFLCGLKGIQEHFGLNN-----PTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTK 153
Cdd:PLN02521 118 ANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 154 SERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLPSGAAFVIANSCVEMNKAATSH--YNIRVMECRLATKLLS 231
Cdd:PLN02521 198 CERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLA 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 232 KSKGLDWKKMLR----LHDVQtKLGVSLEE------MLTIVEEVLHPEPYSTEEICKCLEISLEELRSQilSQNTQDV-- 299
Cdd:PLN02521 278 VKLGMSAEEAISkvktLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVlk 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 300 --STFKLYQRAKHVYSEAARVLEFKKIC--NEAPANAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRFGAIGSRL 375
Cdd:PLN02521 355 aaKHFKLHQRAVHVYSEAKRVHAFRDTVssSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARL 434

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 376 TGAGWGGCTVSMVPTDKLNTFLKNVQKAYYQTDVQR-LASENN---SLFATKPGRGALVF 431
Cdd:PLN02521 435 TGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKgVIKEEDlglYVFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-431 1.86e-157

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 454.17  E-value: 1.86e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQ-VVQLANTNSLYL--DFSTNVNNiQINK 78
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTtcTFPADPDQ-EVDL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  79 TKPQWHNYFLCGLKGIQEHFGLNN-----PTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTK 153
Cdd:PLN02521 118 ANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 154 SERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLPSGAAFVIANSCVEMNKAATSH--YNIRVMECRLATKLLS 231
Cdd:PLN02521 198 CERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLA 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 232 KSKGLDWKKMLR----LHDVQtKLGVSLEE------MLTIVEEVLHPEPYSTEEICKCLEISLEELRSQilSQNTQDV-- 299
Cdd:PLN02521 278 VKLGMSAEEAISkvktLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVlk 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 300 --STFKLYQRAKHVYSEAARVLEFKKIC--NEAPANAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRFGAIGSRL 375
Cdd:PLN02521 355 aaKHFKLHQRAVHVYSEAKRVHAFRDTVssSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARL 434

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 376 TGAGWGGCTVSMVPTDKLNTFLKNVQKAYYQTDVQR-LASENN---SLFATKPGRGALVF 431
Cdd:PLN02521 435 TGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKgVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-406 1.17e-84

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 263.94  E-value: 1.17e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQLAntnSLYLD--FSTNVNNIQINKt 79
Cdd:COG0153    9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVY---SADFDeeVEFDLDDLEPGE- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  80 KPQWHNYFLcG-LKGIQEHfGLnNPTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTKSE-RY 157
Cdd:COG0153   85 EDGWANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLP-SGAAFVIANSCVEMNkAATSHYNIRVMECRLATKLLSKSkgl 236
Cdd:COG0153  162 VGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGVK--- 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 237 dwkkmlRLHDvqtklgVSLEEmltiveevlhpepysteeickcleisLEELRSQILSQntqdvstfKLYQRAKHVYSEAA 316
Cdd:COG0153  238 ------SLRD------VTLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQ 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 317 RVLEFKKICNeapANAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRF-GAIGSRLTGAGWGGCTVSMVPTDKLNT 395
Cdd:COG0153  272 RVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDE 348

                        410
                 ....*....|.
gi 698435326 396 FLKNVQKAYYQ 406
Cdd:COG0153  349 FIEAVAEAYAE 359
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-429 9.94e-79

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 248.97  E-value: 9.94e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326    2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQ--LANTNSLYLDFSTNVnnIQINKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRiyLANADNKFAERSLDL--PLDGSE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   80 KPQWHNYFLCGLKGIQEHFGlNNPTGMNCLLDGTIPPSSGLSSSSALVCCAGlVTLRANGKT-LSKVELAEICTKSE-RY 157
Cdd:TIGR00131  86 VSDWANYFKGVLHVAQERFN-SFPLGADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLpLDSKQILLRIQVAEnHF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLP-SGAAFVIANSCVEMNkAATSHYNIRVMECRLATKLLSKskgl 236
Cdd:TIGR00131 164 VGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA---- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  237 dwKKMLRLHDVQ----TKLGVSLEEMLTIVEEvlhpepysteeickcleisleelrsqilsqntqdvstfklyqRAKHVY 312
Cdd:TIGR00131 239 --TDKGALRDFMneyfARYIARLTKMLPLVEE------------------------------------------RAKHVV 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  313 SEAARVLEFKKICNEapaNAIQLLGDLMNQSYISCREMYECSCPELDRLVD-ICLRFGAIGSRLTGAGWGGCTVSMVPTD 391
Cdd:TIGR00131 275 SENLRVLKAVKAMKD---NDFKQFGALMNESHASCDDDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVPNE 351

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 698435326  392 KLNTFLKNVQKAYYQ-TDVQrlasENNSLFATKPGRGAL 429
Cdd:TIGR00131 352 NVDKVRQAVADKYPKkTGLE----LTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 5.23e-23

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 90.97  E-value: 5.23e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 698435326    2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-431 1.86e-157

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 454.17  E-value: 1.86e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQ-VVQLANTNSLYL--DFSTNVNNiQINK 78
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTtcTFPADPDQ-EVDL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  79 TKPQWHNYFLCGLKGIQEHFGLNN-----PTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTK 153
Cdd:PLN02521 118 ANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 154 SERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLPSGAAFVIANSCVEMNKAATSH--YNIRVMECRLATKLLS 231
Cdd:PLN02521 198 CERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLA 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 232 KSKGLDWKKMLR----LHDVQtKLGVSLEE------MLTIVEEVLHPEPYSTEEICKCLEISLEELRSQilSQNTQDV-- 299
Cdd:PLN02521 278 VKLGMSAEEAISkvktLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVlk 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 300 --STFKLYQRAKHVYSEAARVLEFKKIC--NEAPANAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRFGAIGSRL 375
Cdd:PLN02521 355 aaKHFKLHQRAVHVYSEAKRVHAFRDTVssSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARL 434

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 376 TGAGWGGCTVSMVPTDKLNTFLKNVQKAYYQTDVQR-LASENN---SLFATKPGRGALVF 431
Cdd:PLN02521 435 TGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKgVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-406 1.17e-84

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 263.94  E-value: 1.17e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQLAntnSLYLD--FSTNVNNIQINKt 79
Cdd:COG0153    9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVY---SADFDeeVEFDLDDLEPGE- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  80 KPQWHNYFLcG-LKGIQEHfGLnNPTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTKSE-RY 157
Cdd:COG0153   85 EDGWANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLP-SGAAFVIANSCVEMNkAATSHYNIRVMECRLATKLLSKSkgl 236
Cdd:COG0153  162 VGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGVK--- 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 237 dwkkmlRLHDvqtklgVSLEEmltiveevlhpepysteeickcleisLEELRSQILSQntqdvstfKLYQRAKHVYSEAA 316
Cdd:COG0153  238 ------SLRD------VTLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQ 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 317 RVLEFKKICNeapANAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRF-GAIGSRLTGAGWGGCTVSMVPTDKLNT 395
Cdd:COG0153  272 RVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDE 348

                        410
                 ....*....|.
gi 698435326 396 FLKNVQKAYYQ 406
Cdd:COG0153  349 FIEAVAEAYAE 359
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-429 9.94e-79

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 248.97  E-value: 9.94e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326    2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQ--LANTNSLYLDFSTNVnnIQINKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRiyLANADNKFAERSLDL--PLDGSE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   80 KPQWHNYFLCGLKGIQEHFGlNNPTGMNCLLDGTIPPSSGLSSSSALVCCAGlVTLRANGKT-LSKVELAEICTKSE-RY 157
Cdd:TIGR00131  86 VSDWANYFKGVLHVAQERFN-SFPLGADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLpLDSKQILLRIQVAEnHF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  158 IGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLP-SGAAFVIANSCVEMNkAATSHYNIRVMECRLATKLLSKskgl 236
Cdd:TIGR00131 164 VGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA---- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  237 dwKKMLRLHDVQ----TKLGVSLEEMLTIVEEvlhpepysteeickcleisleelrsqilsqntqdvstfklyqRAKHVY 312
Cdd:TIGR00131 239 --TDKGALRDFMneyfARYIARLTKMLPLVEE------------------------------------------RAKHVV 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  313 SEAARVLEFKKICNEapaNAIQLLGDLMNQSYISCREMYECSCPELDRLVD-ICLRFGAIGSRLTGAGWGGCTVSMVPTD 391
Cdd:TIGR00131 275 SENLRVLKAVKAMKD---NDFKQFGALMNESHASCDDDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVPNE 351

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 698435326  392 KLNTFLKNVQKAYYQ-TDVQrlasENNSLFATKPGRGAL 429
Cdd:TIGR00131 352 NVDKVRQAVADKYPKkTGLE----LTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 2-404 7.00e-52

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 178.90  E-value: 7.00e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   2 FISKFGSAP--RFYvrAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQLANTNSLYLD-FSTNVNNIQINK 78
Cdd:PRK05322  10 FAEVFGEEAedVFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGiIEFDLDDLSFDK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  79 tKPQWHNYFLCGLKGIQEHfGLNNPTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTKSE-RY 157
Cdd:PRK05322  88 -EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTEnEF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 158 IGTEGGGMDQSISFLAEEGTAKLI-------EFSPLRATDVRLpsgaafVIANScvemNKA---ATSHYNIRVMECRLAT 227
Cdd:PRK05322 166 IGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERRAECEKAL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 228 KLLskskgldwkkmlrlhdvQTKLGVSleemltiveevlhpepysteeickcleiSLEELRSQILSQNTQDVSTFKLYQR 307
Cdd:PRK05322 236 EEL-----------------QKKLDIK----------------------------SLGELTEEEFDEYSYLIKDETLLKR 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 308 AKHVYSEAARVLEFKKICNEapaNAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRF-GAIGSRLTGAGWGGCTVS 386
Cdd:PRK05322 271 ARHAVTENQRTLKAVKALKA---GDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGCAIA 347

                        410
                 ....*....|....*...
gi 698435326 387 MVPTDKLNTFLKNVQKAY 404
Cdd:PRK05322 348 IVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 1-406 2.52e-44

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 158.55  E-value: 2.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326   1 MFISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQL--ANTNSLYLDFSTNvNNIQINK 78
Cdd:PRK05101  10 LFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViaADYDNQQDEFSLD-APIVPHP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  79 TKpQWHNYFLCGLKGIQEH---FGlnnptGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTKSE 155
Cdd:PRK05101  89 EQ-QWANYVRGVVKHLQERnpdFG-----GADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 156 -RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVRLPSGAAFVIANSCVEMNkAATSHYNIRVMECRLATKLLSksk 234
Cdd:PRK05101 163 nQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFFG--- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 235 gldwKKMLRlhDvqtklgVSLEEMLTIVEEvlhpepysteeickcleisLEELrsqilsqntqdvstfkLYQRAKHVYSE 314
Cdd:PRK05101 239 ----VKALR--D------VTLEQFNAVAAE-------------------LDPV----------------VAKRARHVITE 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 315 AARVLEFKKICNeapANAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLrfGAIGS----RLTGAGWGGCTVSMVPT 390
Cdd:PRK05101 272 NARTLEAASALA---AGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK--AVIGDqggvRMTGGGFGGCIVALVPE 346

                        410
                 ....*....|....*.
gi 698435326 391 DKLNTFLKNVQKAYYQ 406
Cdd:PRK05101 347 ELVEAVRQAVAEQYEA 362
PRK03817 PRK03817
galactokinase; Provisional
 14-407 5.70e-40

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 146.29  E-value: 5.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  14 VRAPGRVNLIGEHIDYC-GYaVLPMAIEQDILIAVEPVKTQVVqlantnslyldFSTNVN---NIQINKTKP--QWHNYF 87
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFIF-----------YSENFNeekTFELDKLEKlnSWADYI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  88 LCGLKGIQEHFGlnNPTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTKSER-YIGTEGGGMD 166
Cdd:PRK03817  71 KGVIWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 167 QSISFLAEEGTAKLIEFSPLRATDVRLPSGAAFVIANSCVEmNKAATSHYNIRVMECRLATKLLSKSkgldwkkmlrlhd 246
Cdd:PRK03817 149 QFAVAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKK------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 247 vqtklgvSLEEmltIVEEVLHpepysteeickcleiSLEELrsqilsqntqdvstfkLYQRAKHVYSEAARVLEFKKICN 326
Cdd:PRK03817 215 -------SSKE---VTEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALK 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 327 EapaNAIQLLGDLMNQSYISCREMYECSCPELDRLVDICLRFGAIGSRLTGAGWGGCTVSMVPTDKLNTFLKNVQKAYYQ 406
Cdd:PRK03817 254 E---GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKK 330


                 .
gi 698435326 407 T 407
Cdd:PRK03817 331 R 331
PRK00555 PRK00555
galactokinase; Provisional
 16-403 5.28e-28

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 113.80  E-value: 5.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  16 APGRVNLIGEHIDY-CGYAvLPMAIEQDILIAVEPVKTQVVQLANtnslylDFSTNVNNIQINKTKPQ---WHNYFLCGL 91
Cdd:PRK00555   7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLDTTPGQvtgWAAYAAGVI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  92 KGIQEHfGLNNPTG-MNCLLDgtIPPSSGLSSSSALVCCAGLVTLRANGKTLSKVELAEICTKSER-YIGTEGGGMDQSI 169
Cdd:PRK00555  80 WALRGA-GHPVPGGaMSITSD--VEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 170 SFLAEEGTAKLIEFSPLRATDVRLPSGAAFV--IANSCVEMNKAATSHYNIRVMECRLATKLLSKSKgldwkkmlrLHDV 247
Cdd:PRK00555 157 ALFGAPKTALLIDFRDLTVRPVAFDPDAAGVvlLLMDSRARHRHAGGEYAARRASCERAAADLGVSS---------LRAV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 248 QTKLGVSLEEmltiveevlhpepysteeickcleisleelrsqilsqnTQDVSTFKlyqRAKHVYSEAARVLEFKKICNE 327
Cdd:PRK00555 228 QDRGLAALGA--------------------------------------IADPIDAR---RARHVLTENQRVLDFAAALAD 266

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 698435326 328 APANAiqlLGDLMNQSYISCREMYECSCPELDRLVDICLRFGAIGSRLTGAGWGGCTVSMVPTDKLNTFLKNVQKA 403
Cdd:PRK00555 267 SDFTA---AGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRA 339
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 5.23e-23

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 90.97  E-value: 5.23e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 698435326    2 FISKFGSAPRFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PLN02865 PLN02865
galactokinase
 14-430 1.80e-21

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 96.02  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  14 VRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVKTQVVQLANTN-SLYLDFSTNV--NNIQINKTKP----QWHNY 86
Cdd:PLN02865  33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQfEGEVRFRVDEiqHPIANVSSDSkeesNWGDY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  87 FLCGLKGIQEhFGLNNPTGMNCLLDGTIPPSSGLSSSSALVCCAGLVTLR-ANGKTLSKVELAEICTKSE-RYIGTEGGG 164
Cdd:PLN02865 113 ARGAVYALQS-RGHALSQGITGYISGSEGLDSSGLSSSAAVGVAYLLALEnANNLTVSPEDNIELDRLIEnEYLGLRNGI 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 165 MDQSISFLAEEGTAKLIEFSPLRATDVRLPSGA-------AFVIANSCVEMNKAATSHYNIRVMECRLATKLLSKSKGLD 237
Cdd:PLN02865 192 LDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpfKILLAFSGLRHALTNKPGYNLRVSECQEAARFLLEASGND 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 238 wkkmlrlhdvqtklgvSLEEMLTIVEevlhPEPYsteEICKCleiSLEELrsqilsqntqdvstfkLYQRAKHVYSEAAR 317
Cdd:PLN02865 272 ----------------ELEPLLCNVE----PEVY---EAHKC---KLEAV----------------LARRAEHYFSENMR 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 318 VLEFKkicnEAPANA-IQLLGDLMNQSYISCREMYECSCPELDRLVDICLRF-GAIGSRLTGAGWGGCTVSMVPTDKLNT 395
Cdd:PLN02865 310 VIKGV----EAWASGnLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEE 385

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 698435326 396 FLKNVQKAYYQTDVQrLASENNS---LFATKPGRGALV 430
Cdd:PLN02865 386 AASFVRDEYEKAQPE-LASNINGdkpVLICEAGDCARV 422
PTZ00290 PTZ00290
galactokinase; Provisional
 11-430 5.06e-17

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 82.95  E-value: 5.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  11 RFYVRAPGRVNLIGEHIDYCGYAVLPMAIEQDILIAVEPVK---TQVVQLANTNSLYLDfstnVNNIQINKTKPQWHNyF 87
Cdd:PTZ00290  37 LLFTFAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKhfcDHKLRFATETDEHFV----LDHLGGAKHNKAWTT-F 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  88 LCGLKGIQ-EHFG--LNNPT--GMNCLLDGTIPPSSGLSSSSA-----LVCCAGLVTLRANGK------------TLSKV 145
Cdd:PTZ00290 112 VRGAATLRlNRLGvaIDAPSlqGVCMVVHGTLPMGAGMSASASfgvalLNAINTVVTRRYKGCptspgrrysilpPMSKE 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 146 ELAEIcTKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvrLPSGAAFVIANSCV--EM 208
Cdd:PTZ00290 192 ELIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIkhDL 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 209 NKAATSHYNIRVMECRLATKLLSKskgldwkkmlrlHDVQTKlgvsleeMLTIVEEVLHPEPYSTEeicKCLEISLEELR 288
Cdd:PTZ00290 265 LGGTAGMYNTVRSDQEGAQKKIGK------------HRYRGK-------PFTFSDLVRNPKKYTFD---GDVVAFMESCK 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 289 SQIlsqntqdvsTFKLYQRAKHVYSEAARVLEFKKICNEAPA----NAIQLLGDLMNQSYISCREMYECSCPELDRLVD- 363
Cdd:PTZ00290 323 PLM---------TPGEFERGTYNIMEQIRTLEFIKLNDPELPlsreERFRKAGEILNAGHQGMRDLMKITTPELDFIHEl 393

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 698435326 364 ICLRFGAIGSRLTGAGWGGCTVSMVPTDKLNTFLKNVQKAYYqtdvQRLASEnNSLFATKPGRGALV 430
Cdd:PTZ00290 394 INEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFK----ARFGVE-NDVYPVVAGDGAFV 455
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 16-383 2.84e-12

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 66.79  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  16 APGRVNLIGEHID-YcGYAVLPMAIEQDILIAVEPVKTQVVQLantNSLYLDFSTNVNNIQinktKPQWHnYFLCGLKGI 94
Cdd:COG1577    1 APGKLILFGEHAVvY-GQPAIAVAVDRRATVTVEPSDDDKLRI---ESPDLGGTLDLDPLA----DAALR-YIKAAIEAA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  95 QEHFGLNNPtGMNCLLDGTIPPSsglssssalvccAGL-----VT-------LRANGKTLSKVELAEICTKSERYIGTEG 162
Cdd:COG1577   72 LEYLGLPLK-GFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 163 GGMDQSISFLaeEGtakLIEF-SPLRATDVRLPSGAAFVIANSCVemnKAATSHynirvmecrlatkllskskgldwkkm 241
Cdd:COG1577  139 SGLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKE-------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 242 lrlhdvqtklgvsleemltIVEEVlhpepysteeickcleisleelrSQILSQNTQDVSTFklYQRAKHVYSEAARVLEf 321
Cdd:COG1577  185 -------------------LVAKV-----------------------RKLKERNPELYEAF--LEEIGDLVEEAIEALE- 219

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 698435326 322 kkicneapANAIQLLGDLMNQsyisCREMYE---CSCPELDRLVDICLRFGAIGSRLTGAGWGGC 383
Cdd:COG1577  220 --------EGDLEALGELMNE----NHGLLRalgVSTPELDRLVEAARKAGALGAKLTGAGGGGC 272
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 303-387 3.70e-09

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 57.94  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 303 KLYQRAKHVYSEAARVLEfkkicneapANAIQLLGDLMNQSYISCREMyECSCPELDRLVDICLRFGAIGSRLTGAGWGG 382
Cdd:PTZ00298 218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                 ....*
gi 698435326 383 CTVSM 387
Cdd:PTZ00298 288 LVVAL 292
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 327-406 2.22e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 2.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326  327 EAPANAIQLLGDLMNQSYISCREM--YECSCPELDRLVDICLRFGaIGSRLTGAGWGGCTVSMVPT-DKLNTFLKNVQKA 403
Cdd:pfam08544   4 ALLRGDLEELGKLLTESAESLEPLlvVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKDeDDAEEVARALREA 82


                  ...
gi 698435326  404 YYQ 406
Cdd:pfam08544  83 GKK 85
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 336-385 1.54e-06

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 49.60  E-value: 1.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 698435326  336 LGDLMNQSYiSCREMYECSCPELDRLVDICLRFGAIGSRLTGAGWGGCTV 385
Cdd:TIGR00549 223 LGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
PRK03926 PRK03926
mevalonate kinase; Provisional
 336-392 5.07e-05

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 45.04  E-value: 5.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 698435326 336 LGDLM--NQSYIscrEMYECSCPELDRLVDICLRFGAIGSRLTGAGWGGCTVSMVPTDK 392
Cdd:PRK03926 216 LGELMniNQGLL---DALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 287-406 5.30e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 44.78  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698435326 287 LRSQILSQNTQDVSTFKLYQRAKHVYSEAARVLEfkkicneapANAIQLLGDLMNQSYISCREMYE-CSCPELDRLVDIC 365
Cdd:COG2605  202 LKEQVKNVEDGDEATLEALHEMKELALEMKEALL---------KGDLDEFGELLNEGWELKKRLASgISNPAIDEIYELA 272

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 698435326 366 LRFGAIGSRLTGAGWGGCTVSMVPTDKLNTFLKNVQKAYYQ 406
Cdd:COG2605  273 RKAGALGGKLLGAGGGGFLLFYAPPERREAVREALSKAGLR 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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