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Conserved domains on  [gi|686602838|ref|XP_009277767|]
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PREDICTED: methyltransferase-like protein 23 [Aptenodytes forsteri]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1904217)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnt1 super family cl43977
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 9-93 8.72e-10

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3897:

Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 55.28  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686602838   9 IGAGVSLPGVVAAKCGA-EVILSDSEelPQCLRNCRRSCLMNDLPhVPVIGLSWGRVSPEllslAPVDVILGSDVFFDPK 87
Cdd:COG3897   77 LGCGLGLVGIAAAKAGAaDVTATDYD--PEALAALRLNAALNGVA-ITTRLGDWRDPPAA----GGFDLILGGDVLYERD 149


                 ....*.
gi 686602838  88 DFEDIL 93
Cdd:COG3897  150 LAEPLL 155
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 9-93 8.72e-10

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 55.28  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686602838   9 IGAGVSLPGVVAAKCGA-EVILSDSEelPQCLRNCRRSCLMNDLPhVPVIGLSWGRVSPEllslAPVDVILGSDVFFDPK 87
Cdd:COG3897   77 LGCGLGLVGIAAAKAGAaDVTATDYD--PEALAALRLNAALNGVA-ITTRLGDWRDPPAA----GGFDLILGGDVLYERD 149


                 ....*.
gi 686602838  88 DFEDIL 93
Cdd:COG3897  150 LAEPLL 155
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 9-104 5.97e-08

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 49.64  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686602838    9 IGAGVSLPGVVAAK--CGAEVILSDSEELPQCLRncrRSCLMNDL-PHVPVIGLSWG-RVSPELLSLAPVDVILGSDVFF 84
Cdd:pfam10294  53 LGSGTGLVGIAVALllPGASVTITDLEEALELLK---KNIELNALsSKVVVKVLDWGeNLPPDLFDGHPVDLILAADCVY 129

                          90       100
                  ....*....|....*....|
gi 686602838   85 DPKDFEDILTTVYFLLEKNP 104
Cdd:pfam10294 130 NEDSFPLLEKTLKDLLGKES 149
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 9-93 8.72e-10

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 55.28  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686602838   9 IGAGVSLPGVVAAKCGA-EVILSDSEelPQCLRNCRRSCLMNDLPhVPVIGLSWGRVSPEllslAPVDVILGSDVFFDPK 87
Cdd:COG3897   77 LGCGLGLVGIAAAKAGAaDVTATDYD--PEALAALRLNAALNGVA-ITTRLGDWRDPPAA----GGFDLILGGDVLYERD 149


                 ....*.
gi 686602838  88 DFEDIL 93
Cdd:COG3897  150 LAEPLL 155
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 9-104 5.97e-08

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 49.64  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686602838    9 IGAGVSLPGVVAAK--CGAEVILSDSEELPQCLRncrRSCLMNDL-PHVPVIGLSWG-RVSPELLSLAPVDVILGSDVFF 84
Cdd:pfam10294  53 LGSGTGLVGIAVALllPGASVTITDLEEALELLK---KNIELNALsSKVVVKVLDWGeNLPPDLFDGHPVDLILAADCVY 129

                          90       100
                  ....*....|....*....|
gi 686602838   85 DPKDFEDILTTVYFLLEKNP 104
Cdd:pfam10294 130 NEDSFPLLEKTLKDLLGKES 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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