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Conserved domains on  [gi|677981116|ref|XP_009073174|]
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PREDICTED: annexin A7 isoform X2 [Acanthisitta chloris]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 160-225 4.93e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.03  E-value: 4.93e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  160 RDAEILRKAMKGFGTDEQAIIDVVANRSNEQRQNIKAAFKTMYGKDLIKDLKSELNGNVEELILAL 225
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 391-456 1.18e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 104.48  E-value: 1.18e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  391 FFAEKLYHSMKGAGTDDSTLIRIIVTRSEIDLVQIKQMFTQMYQKTLATMIASDTSGDYRRLLLAI 456
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 232-297 1.24e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 101.78  E-value: 1.24e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  232 YDAWSLRHAMKGIGTQESVLIEILCTRTNQEIREIVNCYNSEFGRDIEQDIRADTSGHFERLLISM 297
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 316-381 2.70e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 75.97  E-value: 2.70e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  316 DAQRLYQAgEGKLGTDESCFNMVLATRSFPQLKATVEAYSRVANRDLLSSIGREFSGNVEHGLKAI 381
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 160-225 4.93e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.03  E-value: 4.93e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  160 RDAEILRKAMKGFGTDEQAIIDVVANRSNEQRQNIKAAFKTMYGKDLIKDLKSELNGNVEELILAL 225
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 391-456 1.18e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 104.48  E-value: 1.18e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  391 FFAEKLYHSMKGAGTDDSTLIRIIVTRSEIDLVQIKQMFTQMYQKTLATMIASDTSGDYRRLLLAI 456
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 232-297 1.24e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 101.78  E-value: 1.24e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  232 YDAWSLRHAMKGIGTQESVLIEILCTRTNQEIREIVNCYNSEFGRDIEQDIRADTSGHFERLLISM 297
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
173-225 8.72e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 90.93  E-value: 8.72e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   173 GTDEQAIIDVVANRSNEQRQNIKAAFKTMYGKDLIKDLKSELNGNVEELILAL 225
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
404-456 3.97e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 89.00  E-value: 3.97e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   404 GTDDSTLIRIIVTRSEIDLVQIKQMFTQMYQKTLATMIASDTSGDYRRLLLAI 456
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
245-297 2.62e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 80.91  E-value: 2.62e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   245 GTQESVLIEILCTRTNQEIREIVNCYNSEFGRDIEQDIRADTSGHFERLLISM 297
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 316-381 2.70e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 75.97  E-value: 2.70e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  316 DAQRLYQAgEGKLGTDESCFNMVLATRSFPQLKATVEAYSRVANRDLLSSIGREFSGNVEHGLKAI 381
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
329-381 1.13e-10

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 56.65  E-value: 1.13e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   329 GTDESCFNMVLATRSFPQLKATVEAYSRVANRDLLSSIGREFSGNVEHGLKAI 381
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 160-225 4.93e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.03  E-value: 4.93e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  160 RDAEILRKAMKGFGTDEQAIIDVVANRSNEQRQNIKAAFKTMYGKDLIKDLKSELNGNVEELILAL 225
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 391-456 1.18e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 104.48  E-value: 1.18e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  391 FFAEKLYHSMKGAGTDDSTLIRIIVTRSEIDLVQIKQMFTQMYQKTLATMIASDTSGDYRRLLLAI 456
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 232-297 1.24e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 101.78  E-value: 1.24e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  232 YDAWSLRHAMKGIGTQESVLIEILCTRTNQEIREIVNCYNSEFGRDIEQDIRADTSGHFERLLISM 297
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
173-225 8.72e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 90.93  E-value: 8.72e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   173 GTDEQAIIDVVANRSNEQRQNIKAAFKTMYGKDLIKDLKSELNGNVEELILAL 225
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
404-456 3.97e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 89.00  E-value: 3.97e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   404 GTDDSTLIRIIVTRSEIDLVQIKQMFTQMYQKTLATMIASDTSGDYRRLLLAI 456
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
245-297 2.62e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 80.91  E-value: 2.62e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   245 GTQESVLIEILCTRTNQEIREIVNCYNSEFGRDIEQDIRADTSGHFERLLISM 297
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 316-381 2.70e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 75.97  E-value: 2.70e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 677981116  316 DAQRLYQAgEGKLGTDESCFNMVLATRSFPQLKATVEAYSRVANRDLLSSIGREFSGNVEHGLKAI 381
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
329-381 1.13e-10

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 56.65  E-value: 1.13e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 677981116   329 GTDESCFNMVLATRSFPQLKATVEAYSRVANRDLLSSIGREFSGNVEHGLKAI 381
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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