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Conserved domains on  [gi|677975712|ref|XP_009072118|]
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PREDICTED: alpha-1,4-N-acetylglucosaminyltransferase [Acanthisitta chloris]

Protein Classification

Gly_transf_sug and Gb3_synth domain-containing protein( domain architecture ID 10376080)

Gly_transf_sug and Gb3_synth domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 249-374 3.17e-55

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


:

Pssm-ID: 428017  Cd Length: 130  Bit Score: 178.21  E-value: 3.17e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677975712  249 GFPAHHQFLWDCMENFVLKYNGNIWGNQGPFLMTRMLKSICNLTDFKGTEDHSCHNISFLNPQRFYPIPYPAWSRYYQVW 328
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 677975712  329 DKSPNFT---HSYALHLWNFMNHNRKVVVaGSNTLAEKLYKAYCPTTYE 374
Cdd:pfam04572  81 DLEETMKltkDSYAVHLWNKLSKGEPLKV-GSNSLYARLARKHCPRTYA 128
Gly_transf_sug super family cl19952
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 117-235 3.48e-12

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


The actual alignment was detected with superfamily member pfam04488:

Pssm-ID: 418730 [Multi-domain]  Cd Length: 93  Bit Score: 61.97  E-value: 3.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677975712  117 SPLVSCSVESAARIYQDRPIILFMKGLtnetaldlnssyaafsllssmknvfIFPLQMETVFQETPllqWYNQVvpeQEK 196
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDL-------------------------DFALDINFLKSDTP---WFLEA---YSL 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 677975712  197 NWVHI-SSDASRLALIWKYGGIYMDTDVISIRPI----PEESFL 235
Cdd:pfam04488  50 LPLFIaKSDLLRYAILYKYGGIYLDTDVIPLKSLnsigAQERFL 93
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 249-374 3.17e-55

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 178.21  E-value: 3.17e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677975712  249 GFPAHHQFLWDCMENFVLKYNGNIWGNQGPFLMTRMLKSICNLTDFKGTEDHSCHNISFLNPQRFYPIPYPAWSRYYQVW 328
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 677975712  329 DKSPNFT---HSYALHLWNFMNHNRKVVVaGSNTLAEKLYKAYCPTTYE 374
Cdd:pfam04572  81 DLEETMKltkDSYAVHLWNKLSKGEPLKV-GSNSLYARLARKHCPRTYA 128
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 117-235 3.48e-12

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 61.97  E-value: 3.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677975712  117 SPLVSCSVESAARIYQDRPIILFMKGLtnetaldlnssyaafsllssmknvfIFPLQMETVFQETPllqWYNQVvpeQEK 196
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDL-------------------------DFALDINFLKSDTP---WFLEA---YSL 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 677975712  197 NWVHI-SSDASRLALIWKYGGIYMDTDVISIRPI----PEESFL 235
Cdd:pfam04488  50 LPLFIaKSDLLRYAILYKYGGIYLDTDVIPLKSLnsigAQERFL 93
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
196-262 8.06e-10

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 56.44  E-value: 8.06e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 677975712 196 KNWVHISsDASRLALIWKYGGIYMDTDVISIRPI-----PEESFLAAQKSRFS--SNGIFGFPAHHQFLWDCME 262
Cdd:COG3774   64 KKGAARA-DLFRLLLLYKYGGIYLDIDVECLKPLdplldGDDLFLGYEDPPPGiiSNGFIAAEPGHPFLKKALE 136
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 249-374 3.17e-55

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 178.21  E-value: 3.17e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677975712  249 GFPAHHQFLWDCMENFVLKYNGNIWGNQGPFLMTRMLKSICNLTDFKGTEDHSCHNISFLNPQRFYPIPYPAWSRYYQVW 328
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 677975712  329 DKSPNFT---HSYALHLWNFMNHNRKVVVaGSNTLAEKLYKAYCPTTYE 374
Cdd:pfam04572  81 DLEETMKltkDSYAVHLWNKLSKGEPLKV-GSNSLYARLARKHCPRTYA 128
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 117-235 3.48e-12

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 61.97  E-value: 3.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677975712  117 SPLVSCSVESAARIYQDRPIILFMKGLtnetaldlnssyaafsllssmknvfIFPLQMETVFQETPllqWYNQVvpeQEK 196
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDL-------------------------DFALDINFLKSDTP---WFLEA---YSL 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 677975712  197 NWVHI-SSDASRLALIWKYGGIYMDTDVISIRPI----PEESFL 235
Cdd:pfam04488  50 LPLFIaKSDLLRYAILYKYGGIYLDTDVIPLKSLnsigAQERFL 93
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
196-262 8.06e-10

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 56.44  E-value: 8.06e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 677975712 196 KNWVHISsDASRLALIWKYGGIYMDTDVISIRPI-----PEESFLAAQKSRFS--SNGIFGFPAHHQFLWDCME 262
Cdd:COG3774   64 KKGAARA-DLFRLLLLYKYGGIYLDIDVECLKPLdplldGDDLFLGYEDPPPGiiSNGFIAAEPGHPFLKKALE 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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