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Conserved domains on  [gi|1849200560|ref|XP_008960582|]
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coagulation factor VIII isoform X2 [Pan paniscus]

Protein Classification

discoidin domain-containing protein; discoidin domain-containing protein kinase; discoidin domain-containing protein; discoidin domain-containing protein kinase( domain architecture ID 11736611)

discoidin domain-containing protein kinase is a receptor protein-tyrosine kinase, similar to discoidin domain-containing receptors 1 (DDR1) and 2 (DDR2); discoidin domain-containing protein kinase is a receptor protein-tyrosine kinase, similar to discoidin domain-containing receptors 1 (DDR1) and 2 (DDR2); discoidin domain-containing protein similar to human retinoschisin (aka X-linked juvenile retinoschisis protein) that plays a crucial role in the cellular organization of the retina; discoidin domain-containing protein similar to human retinoschisin (aka X-linked juvenile retinoschisis protein) that plays a crucial role in the cellular organization of the retina

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 133-282 1.27e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 196.80  E-value: 1.27e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 133 MPLGMESKAiSDAQITASSYFTnmfATWSPSKARLHlqgRSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSLLTSM 212
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYS---SGWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 213 YVKEFLISSSQDGHHWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLG 282
Cdd:cd00057    74 WVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C super family cl25480
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 75-125 4.28e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


The actual alignment was detected with superfamily member cd00057:

Pssm-ID: 330301 [Multi-domain]  Cd Length: 143  Bit Score: 78.93  E-value: 4.28e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1849200560  75 RSQDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMG 125
Cdd:cd00057    93 KDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 133-282 1.27e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 196.80  E-value: 1.27e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 133 MPLGMESKAiSDAQITASSYFTnmfATWSPSKARLHlqgRSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSLLTSM 212
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYS---SGWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 213 YVKEFLISSSQDGHHWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLG 282
Cdd:cd00057    74 WVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 130-283 5.25e-36

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 125.70  E-value: 5.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560  130 SCSMPLGMESkaisDAQITASSyftnmfATWSPSKARLHlQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSLL 209
Cdd:smart00231   1 PCNEPLGLES----DSQITASS------SYWAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNG 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1849200560  210 TsmYVKEFLISSSqDGHHWTlFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGC 283
Cdd:smart00231  70 D--WVTYKLEYSD-DGVNWT-TYKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 146-280 1.05e-32

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 116.78  E-value: 1.05e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 146 QITASSYFTNmfaTWSPSKArlhLQG-RSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSlLTSMYVKEFLISSSQD 224
Cdd:pfam00754   1 QITASSSYSG---EGPAAAA---LDGdPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSLD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1849200560 225 GHHWTLFFQNGkvkvFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQ--IALRMEV 280
Cdd:pfam00754  74 GENWTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 75-125 4.28e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 78.93  E-value: 4.28e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1849200560  75 RSQDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMG 125
Cdd:cd00057    93 KDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 80-126 3.86e-16

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 73.31  E-value: 3.86e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1849200560   80 GKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 126
Cdd:smart00231  93 SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 85-123 7.93e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 50.14  E-value: 7.93e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1849200560  85 GNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS--TLRMEL 123
Cdd:pfam00754  87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNgiALRAEL 127
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 133-282 1.27e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 196.80  E-value: 1.27e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 133 MPLGMESKAiSDAQITASSYFTnmfATWSPSKARLHlqgRSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSLLTSM 212
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYS---SGWEASRARLN---SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 213 YVKEFLISSSQDGHHWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLG 282
Cdd:cd00057    74 WVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 130-283 5.25e-36

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 125.70  E-value: 5.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560  130 SCSMPLGMESkaisDAQITASSyftnmfATWSPSKARLHlQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSLL 209
Cdd:smart00231   1 PCNEPLGLES----DSQITASS------SYWAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNG 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1849200560  210 TsmYVKEFLISSSqDGHHWTlFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGC 283
Cdd:smart00231  70 D--WVTYKLEYSD-DGVNWT-TYKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 146-280 1.05e-32

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 116.78  E-value: 1.05e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1849200560 146 QITASSYFTNmfaTWSPSKArlhLQG-RSNAWRPQVNNPKEWLQVDFQKTMKVTGITTQGVKSlLTSMYVKEFLISSSQD 224
Cdd:pfam00754   1 QITASSSYSG---EGPAAAA---LDGdPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSLD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1849200560 225 GHHWTLFFQNGkvkvFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQ--IALRMEV 280
Cdd:pfam00754  74 GENWTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 75-125 4.28e-18

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 78.93  E-value: 4.28e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1849200560  75 RSQDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMG 125
Cdd:cd00057    93 KDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 80-126 3.86e-16

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 73.31  E-value: 3.86e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1849200560   80 GKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 126
Cdd:smart00231  93 SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 85-123 7.93e-08

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 50.14  E-value: 7.93e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1849200560  85 GNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS--TLRMEL 123
Cdd:pfam00754  87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNgiALRAEL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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