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Conserved domains on  [gi|672087333|ref|XP_008771388|]
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ankyrin repeat and SOCS box protein 11 isoform X2 [Rattus norvegicus]

Protein Classification

ankyrin repeat and SOCS box protein( domain architecture ID 1562964)

ankyrin repeat and SOCS box protein (ASB) may be a substrate-recognition component of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Ontology:  GO:0016567|GO:0005515
PubMed:  17176038|18948053|12076535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-242 3.56e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 3.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  12 LLRLLLTPNTQDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTV 91
Cdd:COG0666   39 LLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  92 HGATPLFNACCSGSAACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQR 170
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672087333 171 VDCVKKLLELGASVDH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 242
Cdd:COG0666  199 LEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 244-285 5.58e-16

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 70.20  E-value: 5.58e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672087333 244 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-242 3.56e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 3.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  12 LLRLLLTPNTQDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTV 91
Cdd:COG0666   39 LLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  92 HGATPLFNACCSGSAACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQR 170
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672087333 171 VDCVKKLLELGASVDH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 242
Cdd:COG0666  199 LEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 24-246 3.25e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  24 CWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGLTVHGATPLF 98
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  99 NA--CCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHR--ECMEILLANNVNIEqeipqlgtplyvACTyqRVDC 173
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RVNY 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672087333 174 vkkLLELGASVD----HGrwlDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVE-QALLLHEGP 246
Cdd:PHA03100 178 ---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 244-285 5.58e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 70.20  E-value: 5.58e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672087333 244 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-151 6.35e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 6.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333   64 LHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVYLASPIHEAVKRGHRECMEI 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*...
gi 672087333  144 LLANNVNI 151
Cdd:pfam12796  80 LLEKGADI 87
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 245-283 8.70e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 50.24  E-value: 8.70e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 672087333  245 GPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLL 283
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 27-231 1.53e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333   27 DRSPLHEAAAQGRLLALKTLiaqginvnLVTINRVSSLHEACLggHvacaKALLENGAHVNGLTVHgatPLFNACCSGSA 106
Cdd:TIGR00870  52 GRSALFVAAIENENLELTEL--------LLNLSCRGAVGDTLL--H----AISLEYVDAVEAILLH---LLAAFRKSGPL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  107 ACVNvllefgAKAQLEVYLA-SPIHEAVKRGHRECMEILLANNVNIEqeipqlgtplyVACTYqrVDCVKKllELGASVD 185
Cdd:TIGR00870 115 ELAN------DQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGASVP-----------ARACG--DFFVKS--QGVDSFY 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 672087333  186 HGRwldTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAA 231
Cdd:TIGR00870 174 HGE---SPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLV 216
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 95-227 3.85e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  95 TPLFNACCSGSAACVNVLLEF--------GAKAQlevylaSPIHEAVKRGHRECMEILLAN-----NVNIEQEIPQLGTP 161
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpscdlfqrGALGE------TALHVAALYDNLEAAVVLMEAapelvNEPMTSDLYQGETA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 162 LYVACTYQRVDCVKKLLELGASVDHGRWLDT---------------PLHAAARQSSVEVINLLTEYGANLKLRNSQGKSA 226
Cdd:cd22192   93 LHIAVVNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172


                 .
gi 672087333 227 L 227
Cdd:cd22192  173 L 173
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 247-285 2.18e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 37.77  E-value: 2.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 672087333   247 PALSQLCRLCVRKCLGrtchqAIYALGLPEPLEKFLLYQ 285
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 160-185 7.93e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.93e-03
                           10        20
                   ....*....|....*....|....*.
gi 672087333   160 TPLYVACTYQRVDCVKKLLELGASVD 185
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-242 3.56e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 3.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  12 LLRLLLTPNTQDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTV 91
Cdd:COG0666   39 LLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  92 HGATPLFNACCSGSAACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQR 170
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672087333 171 VDCVKKLLELGASVDH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 242
Cdd:COG0666  199 LEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
26-244 9.26e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 119.29  E-value: 9.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  26 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGS 105
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 106 AACVNVLLEFGAK-AQLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV 184
Cdd:COG0666  100 LEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672087333 185 DH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHE 244
Cdd:COG0666  180 NArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-182 1.61e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 1.61e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  12 LLRLLLTPNTQDcWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTV 91
Cdd:COG0666  106 LLEAGADVNARD-KDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  92 HGATPLFNACCSGSAACVNVLLEFGAKAQLEV-YLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQR 170
Cdd:COG0666  185 DGETPLHLAAENGHLEIVKLLLEAGADVNAKDnDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264

                        170
                 ....*....|..
gi 672087333 171 VDCVKKLLELGA 182
Cdd:COG0666  265 ALIVKLLLLALL 276
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 24-246 3.25e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  24 CWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGLTVHGATPLF 98
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  99 NA--CCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHR--ECMEILLANNVNIEqeipqlgtplyvACTyqRVDC 173
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RVNY 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672087333 174 vkkLLELGASVD----HGrwlDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVE-QALLLHEGP 246
Cdd:PHA03100 178 ---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 244-285 5.58e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 70.20  E-value: 5.58e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672087333 244 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-230 7.96e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 77.41  E-value: 7.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  20 NTQDCWAdRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLEN----------------- 82
Cdd:PHA02876 172 NAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairn 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  83 ------------GAHVNGLTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VYLASPIHEAVKRGH-RECMEILLAN 147
Cdd:PHA02876 251 edletslllydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGYdTENIRTLIML 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 148 NVNIEQEIPQLGTPLYVACTYQRV-DCVKKLLELGASVDHGRWLD-TPLHAAARQSSVEVINLLTEYGANLKLRNSQGKS 225
Cdd:PHA02876 331 GADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGT 410


                 ....*
gi 672087333 226 ALELA 230
Cdd:PHA02876 411 ALHFA 415
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 43-230 1.65e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.16  E-value: 1.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  43 LKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 121
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 122 EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRvdCVKKLLELGASVD----HGRwldTPLHAA 197
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASINdqdiDGS---TPLHHA 261

                        170       180       190
                 ....*....|....*....|....*....|....
gi 672087333 198 AR-QSSVEVINLLTEYGANLKLRNSQGKSALELA 230
Cdd:PHA02874 262 INpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-151 6.35e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 6.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333   64 LHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVYLASPIHEAVKRGHRECMEI 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*...
gi 672087333  144 LLANNVNI 151
Cdd:pfam12796  80 LLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-220 2.06e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 2.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  129 IHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLElGASVDHGRWLDTPLHAAARQSSVEVINL 208
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 672087333  209 LTEYGANLKLRN 220
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-118 3.50e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333   31 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgLTVHGATPLFNACCSGSAACVN 110
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 672087333  111 VLLEFGAK 118
Cdd:pfam12796  79 LLLEKGAD 86
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 77-235 4.84e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 4.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  77 KALLENGAHVNGLTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVYLASPIHEAVKRGHRECMEILLANNVNIEQE 154
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 155 IPQLGTPLYVACTY-QRVDCVKKLLELGASVDHGRWLD--TPLHAAARqsSVEVINLLTEYGANLKLRNSQGKSALELAA 231
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 672087333 232 PKSS 235
Cdd:PHA02878 309 KQYL 312
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 244-285 5.01e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 62.13  E-value: 5.01e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672087333 244 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 29-245 6.37e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 6.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  29 SPLHEAAAQGRLLAL-KTLIAQGINVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGLTVHGATPLFNACC-SGS 105
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 106 AACVNVLLEFGAKAQLEVYL-ASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVA-CTYQRVDCVKKLLELGAS 183
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672087333 184 VD-HGRWLDTPLHAAARQS-SVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQaLLLHEG 245
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVN-ILLHYG 497
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 63-237 3.06e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.09  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  63 SLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVY-LASPIHEAVKRGHRECM 141
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPdIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 142 EILLANNVNIEQEIPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGRwLD--TPLHAAARQSSVEVINLLTEYGANLKL 218
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 672087333 219 RNSQGKSALELAAPKSSVE 237
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 246-285 1.14e-10

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 55.55  E-value: 1.14e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-231 2.48e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.36  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  38 GRLLALKTLIAQGIN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFG 116
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 117 AKAQLevyLASPIHEavkrghRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV----DHGRWldt 192
Cdd:PHA02874  92 VDTSI---LPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVniedDNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 672087333 193 PLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAA 231
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA03095 PHA03095
ankyrin-like protein; Provisional
 27-231 3.07e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.34  E-value: 3.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  27 DRSPLH---EAAAQGRLLALKTLIAQGINVNLVTINRVSSLH-EACLGGHVACAKALLENGAHVNGLTVHGATPLfNACC 102
Cdd:PHA03095  47 GKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-HVYL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 103 SG---SAACVNVLLEFGAKAQ-LEVYLASPIHEAVKRgHRECMEIL---------LANNVNIEQeipqlgTPLYVACTY- 168
Cdd:PHA03095 126 SGfniNPKVIRLLLRKGADVNaLDLYGMTPLAVLLKS-RNANVELLrllidagadVYAVDDRFR------SLLHHHLQSf 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672087333 169 -QRVDCVKKLLELGASVDHGRWLD-TPLHAAARQSSVEVINL--LTEYGANLKLRNSQGKSALELAA 231
Cdd:PHA03095 199 kPRARIVRELIRAGCDPAATDMLGnTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAA 265
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 95-244 4.89e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.51  E-value: 4.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  95 TPLFNACCSGSAACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIeqeipqlgTPLYVACTYQrvDC 173
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT--------SILPIPCIEK--DM 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672087333 174 VKKLLELGASVD-HGRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHE 244
Cdd:PHA02874 107 IKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 245-283 8.70e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 50.24  E-value: 8.70e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 672087333  245 GPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLL 283
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 29-158 1.05e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  29 SPLHEAAAQ--GRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHV--ACAKALLENGAHVNGLT-------------- 90
Cdd:PHA03100 108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNrvnyllsygvpini 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672087333  91 --VHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQL 158
Cdd:PHA03100 188 kdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLvNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 29-215 1.18e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.38  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  29 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVH-GATPLFNACCSGSAA 107
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 108 CVNVLLEFGAKAQL-EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDH 186
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 672087333 187 -GRWLD-TPLHAAARQSSVEVINLLTEYGAN 215
Cdd:PHA02875 197 fGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 34-186 1.28e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  34 AAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLL 113
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 114 EFGAkaqlevylASPIH-------EAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDH 186
Cdd:PLN03192 612 HFAS--------ISDPHaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 29-195 2.73e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 2.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  29 SPLHEAAAQGRLL-ALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPL-FNACCSGSA 106
Cdd:PHA02876 343 TPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPY 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 107 ACVNVLLEFGAKAQLE-VYLASPIHEAVKRGHR-ECMEILLANNVNIEQEIPQLGTPLYVACTYQRVdcVKKLLELGASV 184
Cdd:PHA02876 423 MSVKTLIDRGANVNSKnKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILLHYGAEL 500

                        170
                 ....*....|.
gi 672087333 185 DHGRWLDTPLH 195
Cdd:PHA02876 501 RDSRVLHKSLN 511
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 97-242 3.88e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  97 LFNACCSGSAACVNVLLEFGAKAQLEVYLA-SPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVK 175
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672087333 176 KLLELGASVDHGRWLD--TPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 242
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-228 3.97e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 3.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  33 EAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGLTVHGATPLFnaCCSGSAACV 109
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLH--LYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 110 NVllefgakaqlevylaspiheavkrghrecMEILLANNVNIEQEIPQLGTPLYVACTYQRVD--CVKKLLELGASV--- 184
Cdd:PHA03095  98 DV-----------------------------IKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVnal 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 672087333 185 -DHGRwldTPLHAAARQS--SVEVINLLTEYGANLKLRNSQGKSALE 228
Cdd:PHA03095 149 dLYGM---TPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 12-178 6.80e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.35  E-value: 6.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  12 LLRLLLT----PNTQDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVN 87
Cdd:PHA02878 149 ITKLLLSygadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  88 GLTVHGATPLFNAccsgSAACVN-----VLLEFGAKAQLEVYLA--SPIHEAVKRGHRecMEILL-----ANNVNIEQEi 155
Cdd:PHA02878 229 ARDKCGNTPLHIS----VGYCKDydilkLLLEHGVDVNAKSYILglTALHSSIKSERK--LKLLLeygadINSLNSYKL- 301

                        170       180
                 ....*....|....*....|....
gi 672087333 156 pqlgTPLYVAC-TYQRVDCVKKLL 178
Cdd:PHA02878 302 ----TPLSSAVkQYLCINIGRILI 321
Ank_4 pfam13637
Ankyrin repeats (many copies);
28-80 3.11e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 3.11e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672087333   28 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALL 80
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
6-87 3.80e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 3.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333    6 PSFCQPLLRLLLTPNTQDCWaDRSPLHEAAAQGRLLALKTLIAQgINVNLVTINRvSSLHEACLGGHVACAKALLENGAH 85
Cdd:pfam12796  10 LELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGAD 86


                  ..
gi 672087333   86 VN 87
Cdd:pfam12796  87 IN 88
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-231 4.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 4.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  46 LIAQGINVNLVTINRVS-------SLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAK 118
Cdd:PHA02876 124 ILKEAISGNDIHYDKINesieymkLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGAD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 119 AQLEVYLASPIHE-AVKRGHRECMEILLANNVNIEQEipqlGTPLYVACTYQRVDCVKKLLELGASVDH-GRWLDTPLHA 196
Cdd:PHA02876 204 VNIIALDDLSVLEcAVDSKNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHH 279

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 672087333 197 AARQSSV-EVINLLTEYGANLKLRNSQGKSALELAA 231
Cdd:PHA02876 280 ASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMA 315
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 76-145 1.88e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.74  E-value: 1.88e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672087333  76 AKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVYLASPIHEAVKRGHRECMEILL 145
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 30-176 2.35e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  30 PLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAAcV 109
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-I 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672087333 110 NVLLEFGAKAQLEVYLASPIHEAVKRG-HRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKK 176
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK 306
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 64-245 3.78e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  64 LHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNAC-----------------CSGS--------------------- 105
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 106 --------------------------AACVNVLLEFGAKAQL--EVYLASPIHEAVKRGHRECMEILLANNVNIeqEIPQ 157
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANV--NIPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 158 LG--TPLYVACTYQRVDCVKKLLELGASVDH-GRWLDTPLH-AAARQSSVEVINLLTEYGANLKLRNS-QGKSALELAAp 232
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI- 277

                        250
                 ....*....|...
gi 672087333 233 KSSVEQALLLHEG 245
Cdd:PHA02878 278 KSERKLKLLLEYG 290
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 246-285 6.07e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 42.29  E-value: 6.07e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 28-182 1.15e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  28 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINR-VSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSA 106
Cdd:PHA02875  69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672087333 107 ACVNVLLEFGAKAQLE-VYLASPIHEAVKRGHRECMEILLANNVNIE--QEIPQLgTPLYVACTYQRVDCVKKLLELGA 182
Cdd:PHA02875 149 KGIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGANIDyfGKNGCV-AALCYAIENNKIDIVRLFIKRGA 226
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 27-231 1.53e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333   27 DRSPLHEAAAQGRLLALKTLiaqginvnLVTINRVSSLHEACLggHvacaKALLENGAHVNGLTVHgatPLFNACCSGSA 106
Cdd:TIGR00870  52 GRSALFVAAIENENLELTEL--------LLNLSCRGAVGDTLL--H----AISLEYVDAVEAILLH---LLAAFRKSGPL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  107 ACVNvllefgAKAQLEVYLA-SPIHEAVKRGHRECMEILLANNVNIEqeipqlgtplyVACTYqrVDCVKKllELGASVD 185
Cdd:TIGR00870 115 ELAN------DQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGASVP-----------ARACG--DFFVKS--QGVDSFY 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 672087333  186 HGRwldTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAA 231
Cdd:TIGR00870 174 HGE---SPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLV 216
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 246-285 2.12e-05

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 41.02  E-value: 2.12e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 31-119 3.84e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  31 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVN 110
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 672087333 111 VLL-------EFGAKA 119
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 95-227 3.85e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  95 TPLFNACCSGSAACVNVLLEF--------GAKAQlevylaSPIHEAVKRGHRECMEILLAN-----NVNIEQEIPQLGTP 161
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpscdlfqrGALGE------TALHVAALYDNLEAAVVLMEAapelvNEPMTSDLYQGETA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 162 LYVACTYQRVDCVKKLLELGASVDHGRWLDT---------------PLHAAARQSSVEVINLLTEYGANLKLRNSQGKSA 226
Cdd:cd22192   93 LHIAVVNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172


                 .
gi 672087333 227 L 227
Cdd:cd22192  173 L 173
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 30-230 3.87e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 3.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  30 PLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLengahvnglTVHGATPLFNACCSGSAACV 109
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---------RSINKCSVFYTLVAIKDAFN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 110 N--------VLLEFGAKAQL--EVYLASPIHEAVKRGhrECMEILLAN--NVNIEQEiPQLGTPLYVACTYQRVDCVKKL 177
Cdd:PHA02878 111 NrnveifkiILTNRYKNIQTidLVYIDKKSKDDIIEA--EITKLLLSYgaDINMKDR-HKGNTALHYATENKDQRLTELL 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672087333 178 LELGASVDH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELA 230
Cdd:PHA02878 188 LSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 82-242 6.22e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 6.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333  82 NGAHVNgltVHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGT 160
Cdd:PLN03192 517 GGEHDD---PNMASNLLTVASTGNAALLEELLKAKLDPDIgDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 161 PLYVACTYQRVDCVKKLLELGASVDHGRWLDTpLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQAL 240
Cdd:PLN03192 594 ALWNAISAKHHKIFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVR 672


                 ..
gi 672087333 241 LL 242
Cdd:PLN03192 673 LL 674
Ank_4 pfam13637
Ankyrin repeats (many copies);
60-113 6.33e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 6.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 672087333   60 RVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLL 113
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
160-209 7.49e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 7.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672087333  160 TPLYVACTYQRVDCVKKLLELGASVDH-GRWLDTPLHAAARQSSVEVINLL 209
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvDGNGETALHFAASNGNVEVLKLL 53
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 246-283 1.22e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.96  E-value: 1.22e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLL 283
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 247-285 2.18e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 37.77  E-value: 2.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 672087333   247 PALSQLCRLCVRKCLGrtchqAIYALGLPEPLEKFLLYQ 285
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 244-285 2.74e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 37.69  E-value: 2.74e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672087333 244 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 246-285 2.90e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 37.78  E-value: 2.90e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
188-230 2.93e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 2.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 672087333  188 RWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELA 230
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 174-243 3.00e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 3.00e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672087333 174 VKKLLELGASVD----HGRwldTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKS--SVEQALLLH 243
Cdd:PTZ00322  98 ARILLTGGADPNcrdyDGR---TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGfrEVVQLLSRH 170
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 246-284 5.84e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 36.69  E-value: 5.84e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLY 284
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 29-100 6.06e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 6.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672087333  29 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLggHVACAKALLENGAHVNGLTVHGATPLFNA 100
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHA 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 160-235 6.44e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 6.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672087333 160 TPLYVACTYQRVDCVKKLLELGASVDhgrWLD----TPLHAAARQSSVEVINLLTEY-------GANLKLRNSQGKSALE 228
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPT---LLDkdgkTPLELAEENGFREVVQLLSRHsqchfelGANAKPDSFTGKPPSL 193


                 ....*..
gi 672087333 229 LAAPKSS 235
Cdd:PTZ00322 194 EDSPISS 200
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 244-285 8.40e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 36.38  E-value: 8.40e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 672087333 244 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 246-285 8.48e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 36.47  E-value: 8.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 244-285 1.85e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 35.98  E-value: 1.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 672087333 244 EGPPALSQLCRLCVRKCLGR---TCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 246-285 2.13e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 35.34  E-value: 2.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 672087333 246 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 285
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
46-97 2.61e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 2.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672087333   46 LIAQG-INVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPL 97
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
192-243 4.21e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 4.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672087333  192 TPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLH 243
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 160-185 7.93e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.93e-03
                           10        20
                   ....*....|....*....|....*.
gi 672087333   160 TPLYVACTYQRVDCVKKLLELGASVD 185
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 177-237 8.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.35  E-value: 8.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672087333 177 LLELGASVDHGR-WLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVE 237
Cdd:PHA02876 164 LLEGGADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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