NCBI Conserved Domain Search

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 217.41 E-value: 1.21e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 207 WEDVMKGMKVEVLNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTI 286
Cdd:cd20121    1 WEDVMEGMKVEVLNTDAVLPSRVYWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTI 80

                         90       100
                 ....*....|....*....|..
gi 672059974 287 HAKFTDWKSYLMKRLVGSRTLP 308
Cdd:cd20121   81 HAKFTDWRGYLMKRLVGSRTIP 102

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 195.82 E-value: 1.26e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQP 507
Cdd:cd20127    1 FEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMIGIDGGPSTDGSDWFCYHASSHAIFPVGFCQKNDIELTPPKGYDAQT 80

                         90
                 ....*....|.
gi 672059974 508 FDWESYLEKTK 518
Cdd:cd20127   81 FNWENYLEKTK 91

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 188.12 E-value: 5.77e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 310 DFHIKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIK 389
Cdd:cd20124    1 DFHIKMAESMKYPFRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIK 80


                 ....
gi 672059974 390 MSER 393
Cdd:cd20124   81 MSDR 84

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 176.58 E-value: 1.74e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 207 WEDVMKGMKVEVLNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTI 286
Cdd:cd20120    1 WGDIAEGVRVEVPNTDCNLPTKVFWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTI 80

                         90       100
                 ....*....|....*....|..
gi 672059974 287 HAKFTDWKSYLMKRLVGSRTLP 308
Cdd:cd20120   81 QHKYTNWKAFLVKRLTGAKTLP 102

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 172.48 E-value: 4.55e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQP 507
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLVIGIDGPSADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESKP 80

                         90
                 ....*....|.
gi 672059974 508 FDWESYLEKTK 518
Cdd:cd20099   81 FDWEEYLEETG 91

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 167.85 E-value: 1.24e-49

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 168.25 E-value: 2.71e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 207 WEDVMKGMKVEVLNSDAVLP---SRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20097    1 WEKVKIGVKVEVANRDDDKPtdnVKVYWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPP 80

                         90       100
                 ....*....|....*....|....*
gi 672059974 284 RTIHAKFTDWKSYLMKRLVGSRTLP 308
Cdd:cd20097   81 KSIEDKENDWKEYIMKRLHGKRTIP 105

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 163.77 E-value: 1.06e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 207 WEDVMKGMKVEVLNSDAVL--PSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPR 284
Cdd:cd20119    1 WDNITVGMKVEVENTDTDLieDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPR 80

                         90       100
                 ....*....|....*....|....
gi 672059974 285 TIHAKFTDWKSYLMKRLVGSRTLP 308
Cdd:cd20119   81 TIEHKYSDWKEFLVKRLTGARTLP 104

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 160.93 E-value: 4.41e-47

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 531 CPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPV 605
Cdd:cd20130    1 CPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPV 75

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 159.57 E-value: 2.19e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYeTQP 507
Cdd:cd20126    1 FKEGMKLEAIDPLNLSTICVATVRKVLANGYLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGY-KKP 79

                         90
                 ....*....|.
gi 672059974 508 FDWESYLEKTK 518
Cdd:cd20126   80 FKWFDYLRETG 90

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 157.80 E-value: 1.01e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974   511 ESYLEKTKSKAAPARLFNM--DCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDI 588
Cdd:smart00561   1 EDYLEETGARAAPVELFKQpvDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDI 80

                           90
                   ....*....|....*.
gi 672059974   589 YPVGWCELTGYQLQPP 604
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 154.75 E-value: 8.16e-45

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20129    1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 146.24 E-value: 1.22e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 310 DFHIKMVESMKY-PFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDD-DFWCHMWSPLIHPVGWSRRVGHG 387
Cdd:cd20098    1 DFHEKVLESLKStPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDdDFWCHMKSPLIHPVGWSQAVGHK 80


                 ...
gi 672059974 388 IKM 390
Cdd:cd20098   81 IRA 83

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 144.99 E-value: 6.94e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDG-GPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20125    1 FKEGMKLEAVDPLNLSAICVATVMKVLRFGYLMIRIDSyEPDASGSDWFCYHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                         90       100
                 ....*....|....*....|....*..
gi 672059974 507 PFDWESYLEKTKSKAAPARLFNMDCPN 533
Cdd:cd20125   81 TFTWEGYLRQTGATAAPQHLFHRIIPD 107

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 135.08 E-value: 1.09e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 310 DFHIKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDG-DSDDDFWCHMWSPLIHPVGWSRRVGHGI 388
Cdd:cd20123    1 DFSQKVSESMQYPFKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEESeDGTDDFWCHMYSPLIHHIGWSRSIGHRF 80


                 ....
gi 672059974 389 KMSE 392
Cdd:cd20123   81 KRSD 84

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 125.05 E-value: 4.00e-34

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 533 NHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20102    1 PHGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPP 72

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 123.01 E-value: 1.03e-33

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974  540 MKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 123.51 E-value: 1.87e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974   294 KSYLmkRLVGSRTLPADFHIKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSP 373
Cdd:smart00561   1 EDYL--EETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSP 78

                           90
                   ....*....|....*..
gi 672059974   374 LIHPVGWSRRVGHGIKM 390
Cdd:smart00561  79 DIFPVGWCEKNGHPLQP 95

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 122.45 E-value: 2.58e-33

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20128    1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 117.76 E-value: 1.70e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 210 VMKGMKVEVLNSDavlPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAK 289
Cdd:cd20093    4 FKPGMKLEVPNKN---NPDTYWVATVVMTCGPLLRLRYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEK 80

                         90
                 ....*....|....
gi 672059974 290 FTDWKSYLMKRLVG 303
Cdd:cd20093   81 ELDWAEFLIKELTG 94

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 115.33 E-value: 9.40e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 310 DFHIKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDD-FWCHMWSPLIHPVGWSRRVGHGI 388
Cdd:cd20122    1 NFHNKVNESLRSRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDgFWCHEDSPLIHPVGWAQTVGHNL 80


                 ...
gi 672059974 389 KMS 391
Cdd:cd20122   81 AAS 83

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 113.14 E-value: 4.09e-30

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVV-HRLLsIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20103    1 PPHGFEVGMKLEAVDKRNPRLIRVATVADVEdYRVK-LHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 109.14 E-value: 1.15e-28

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPV 605
Cdd:cd20137    1 PPHGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPL 74

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 107.76 E-value: 6.28e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLNSDAVlpsRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20112    7 GMKLEVANKSNP---DTYWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEKYTD 83

                         90
                 ....*....|.
gi 672059974 293 WKSYLMKRLVG 303
Cdd:cd20112   84 WTEFLIHDLTG 94

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 105.81 E-value: 3.59e-27

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNT 611
Cdd:cd20101    4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSET 81

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 104.62 E-value: 5.52e-27

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPV 605
Cdd:cd20138    5 PPHGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQPPL 78

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 104.65 E-value: 7.35e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMI-CVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLVeIDDLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPPPGYPKS 80

                         90
                 ....*....|..
gi 672059974 507 PFDWESYLEKTK 518
Cdd:cd20095   81 EFDWDSYLKLCG 92

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 104.53 E-value: 8.44e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLNSDAvlpSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20111    7 GMKLEVAVRTD---PNTYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRDKLSD 83

                         90
                 ....*....|.
gi 672059974 293 WKSYLMKRLVG 303
Cdd:cd20111   84 WEEFLAQTLTG 94

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 102.05 E-value: 3.57e-26

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20092    6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 101.87 E-value: 5.33e-26

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAE 608
Cdd:cd20139    5 PPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVPLGAS 81

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 100.68 E-value: 1.80e-25

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20134    2 PPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP 74

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 99.25 E-value: 2.37e-25

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNE-YDQWVDCESPDIYPVGWCE 595
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSrYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 99.69 E-value: 3.73e-25

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20136    5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAP 73

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 98.46 E-value: 5.37e-25

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEY-DQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSpNIIVDVESTDIFPVGWCESNGYPLVTP 70

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 97.95 E-value: 1.79e-24

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 535 GFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20135    5 GFRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTP 74

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 95.39 E-value: 1.30e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLlDGYLMICVDGGpsTDGSDWFCyHASSHAIFPATFCQKNDIELTPPKGYETQP 507
Cdd:cd20102    4 FRVGMKLEAVDRKNPSLICVATVTDVI-GNRFLVHFDGW--DDSYDYWC-DPDSPYIHPVGWCEENGKTLQPPKGYSPGN 79

                         90
                 ....*....|.
gi 672059974 508 FDWESYLEKTK 518
Cdd:cd20102   80 FSWDKYLEETN 90

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 94.60 E-value: 2.89e-23

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20132    4 NGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 93.35 E-value: 3.08e-23

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974  432 MKLEAIDPLNLGNICVATICKVLlDGYLMICVDGgpsTDGSDWFCYHASSHAIFPATFCQKNDIELTPPK 501
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDG---WDDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 94.24 E-value: 3.62e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974   183 KFLKDHSYKAAPVGCFKHVPLyDQWEDVMKGMKVEVLNSDAvlpSRVYWIATVIQAAGYRVLLRYEGFenDASHDFWCNL 262
Cdd:smart00561   2 DYLEETGARAAPVELFKQPVD-SPPNGFKVGMKLEAVDPRN---PSLICVATVVEVKGYRLLLHFDGW--DDKYDFWCHA 75

                           90       100
                   ....*....|....*....|.
gi 672059974   263 GTVDVHPIGWCAINSKILVPP 283
Cdd:smart00561  76 DSPDIFPVGWCEKNGHPLQPP 96

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 93.49 E-value: 7.85e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVL-------LDGYLMiCVDggpstdgsdwFCYHASSHAIFPATFCQKNDIELTPP 500
Cdd:cd20101    6 FKVGMKLEGIDPKHPSLFCVLSVAEVRgyrlrlhFDGYSE-CYD----------FWVNADSPDIFPVGWCEKTGHKLQPP 74

                         90       100
                 ....*....|....*....|....*..
gi 672059974 501 KGYETQPFDWESYLEKTKSKAAPARLF 527
Cdd:cd20101   75 KGYTSETFSWSAYLKLTKAQAAPKHLF 101

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 93.32 E-value: 9.87e-23

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20133    4 NGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPP 74

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 91.36 E-value: 2.06e-22

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 535 GFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20110    5 LFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCARSGHPLQPP 74

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 91.48 E-value: 2.23e-22

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20109    2 PLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 91.54 E-value: 3.70e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974   408 CDAVPYLFKKVRAVYTEGgwFEEGMKLEAIDPLNLGNICVATICKVLlDGYLMICVDGGpstDGSDWFCYHASSHAIFPA 487
Cdd:smart00561  10 RAAPVELFKQPVDSPPNG--FKVGMKLEAVDPRNPSLICVATVVEVK-GYRLLLHFDGW---DDKYDFWCHADSPDIFPV 83

                           90
                   ....*....|...
gi 672059974   488 TFCQKNDIELTPP 500
Cdd:smart00561  84 GWCEKNGHPLQPP 96

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 89.49 E-value: 7.22e-22

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974  327 MRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGH 60

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 86.54 E-value: 1.13e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 533 NHgFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20108    4 NF-FKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 86.39 E-value: 1.69e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDG-GPSTDGSDWFCyHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20116    3 FTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDlRPEASENSMLC-HADSLGILPVQWCLKNGVNLTPPKGYSGQ 81

                         90
                 ....*....|.
gi 672059974 507 PFDWESYLEKT 517
Cdd:cd20116   82 DFDWADYQKQC 92

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 86.59 E-value: 4.57e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 508 FDWESYLEKTKSKAAPARLFNMDC--PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCES 585
Cdd:cd20105    2 FSWDKYLKETGAVPAPVHCFKQSYtpPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81

                         90       100
                 ....*....|....*....|
gi 672059974 586 PDIYPVGWCELTGYQLQPPV 605
Cdd:cd20105   82 SEIQPIGNCEKNGGMLQPPL 101

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 85.70 E-value: 5.18e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20131   12 NGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPP 82

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 85.05 E-value: 7.36e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPV 605
Cdd:cd20091    6 PVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPL 79

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 79.86 E-value: 1.66e-18

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974  214 MKVEVLNSDAvlpSRVYWIATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKILVPPR 284
Cdd:pfam02820   1 MKLEAVDPLN---PSLICVATVVKVLGGRLRLRFDGW--DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 79.87 E-value: 4.09e-18

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 535 GFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEY-DQWVDCESPDIYPVGWCELTGYQLQPPVSA 607
Cdd:cd20118    1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVpEYIVDVESMDIFPVGWCEANGYPLTPPHKA 74

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 77.98 E-value: 1.90e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDG-GPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20115    3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDlRPEEAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPPGYPGQ 82

                         90
                 ....*....|
gi 672059974 507 PFDWESYLEK 516
Cdd:cd20115   83 DFDWADYLKQ 92

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 74.98 E-value: 7.24e-17

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYED-GDSDDDFWCHMWSPLIHPVGWSR 382
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGwDPSRYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 75.60 E-value: 1.70e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLldGYLM-ICVDGGPStdgsdwfCY----HASSHAIFPATFCQKNDIELTPPKG 502
Cdd:cd20133    6 FKVGMRLEGIDPEHPSLFCVLSVAEVQ--GYRLrLHFDGYSE-------CYdfwvNADSPDIHPVGWCEKTGHKLLPPKG 76

                         90       100
                 ....*....|....*....|....*
gi 672059974 503 YETQPFDWESYLEKTKSKAAPARLF 527
Cdd:cd20133   77 YKDGEFNWSSYLKTCKAQAAPKNLF 101

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 75.80 E-value: 2.63e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 179 FDWGKFLKDHSYKAAPVGCFKH--VPLYDQWEdvmKGMKVEVLNSDAVLPSrvyWIATVIQAAGYRVLLRYEGFENdaSH 256
Cdd:cd20105    2 FSWDKYLKETGAVPAPVHCFKQsyTPPVNEFK---IGMKLEAQDPRNTTST---CIATVVGLTGARLRLRLDGSDN--KN 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 257 DFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPAD-FH 312
Cdd:cd20105   74 DFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRiFH 130

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 74.57 E-value: 3.34e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNT 611
Cdd:cd20106    6 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNA 85

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 73.06 E-value: 3.76e-16

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 213 GMKVEVLNSDAvlpSRVYWIATVIQAAGYRVLLRYEGFENDaSHDFWCNLGTVDVHPIGWCA 274
Cdd:cd20088    4 GMKLEAVDPLN---PSEICVATVVKVVGGRLLLHFDGWDPS-RYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 71.49 E-value: 3.91e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 532 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPV 605
Cdd:cd20107    6 PKNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPL 79

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 70.99 E-value: 4.78e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKvLLDGYLMICVDGgpSTDGSDWFCyHASSHAIFPATFCQKNDIELTPPKGY-ETQ 506
Cdd:cd20135    6 FRVGMKLEAVDKKNPSFICVATITD-MVDNRLLIHFDN--WDESYDYWC-DASSPYIHPVGYCQEHGRTLTTPPGYkDPK 81

                         90
                 ....*....|.
gi 672059974 507 PFDWESYLEKT 517
Cdd:cd20135   82 HFSWEKYLEET 92

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 70.79 E-value: 5.65e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVH-RLLSIHFDGWDNEYDQ-W--VDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVLRfGYLVIGIDGPSADDGSdWfcCHASSPFIFPVGFAEKNGIELTPP 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 70.34 E-value: 1.24e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLldGYLM-ICVDGGPstDGSDwFCYHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20132    6 FKVGMKLEGVDPEHQSMYCVLTVAEVC--GYRIrLHFDGYS--DCYD-FWVNADSPDIHPVGWCEKTGHKLHPPKGYKEE 80

                         90       100
                 ....*....|....*....|.
gi 672059974 507 PFDWESYLEKTKSKAAPARLF 527
Cdd:cd20132   81 EFNWQSYLKTCKAQAAPKSLF 101

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 69.99 E-value: 1.52e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 212 KGMKVEVLnsDAVLPSrVYWIATVIQAAGYRVLLRYEGFENDasHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFT 291
Cdd:cd20101    8 VGMKLEGI--DPKHPS-LFCVLSVAEVRGYRLRLHFDGYSEC--YDFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSETF 82


                 ....*...
gi 672059974 292 DWKSYLMK 299
Cdd:cd20101   83 SWSAYLKL 90

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 68.80 E-value: 1.64e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVlLDGYLMICVDGGPSTdgSDWFCYHASSHAIFPATFCQKNDIELTPPKGY 503
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKV-VGPLLWLHLDSEKKL--SPNIIVDVESTDIFPVGWCESNGYPLVTPRKY 73

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 68.32 E-value: 4.22e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLmicVDGGPSTDGSDWFCyHASSHAIFPATFCQKNDIELTPPKGY-ETQ 506
Cdd:cd20134    6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL---VHFDNWDDTYDYWC-DPSSPYIHPVGWCQKQGKPLTPPQDYpDPD 81

                         90
                 ....*....|..
gi 672059974 507 PFDWESYLEKTK 518
Cdd:cd20134   82 NFSWEKYLEETG 93

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 67.21 E-value: 8.96e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEY-DQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNTP 612
Cdd:cd20117    1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIpECIVHVESMDIFPVGWCETNGYPLLHPRKARVNKQ 80


                 .
gi 672059974 613 Q 613
Cdd:cd20117   81 R 81

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 66.90 E-value: 1.19e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVvhrlLSIHF--------DGWDNEYDQWV-DCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKV----FNEYYflveiddlRPEESEKITFVcHANSPGIFPVGWCAKNGLRLTPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 66.44 E-value: 2.99e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLldGY-LMICVDGgpSTDGSDwFCYHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20131   14 FKLGMKLEGIDPQHPSMYFILTVAEVC--GYrLRLHFDG--YSECHD-FWVNANSPDIHPAGWFEKTGHKLQPPKGYKEE 88

                         90       100
                 ....*....|....*....|.
gi 672059974 507 PFDWESYLEKTKSKAAPARLF 527
Cdd:cd20131   89 EFSWSQYLRSTRAQAAPKHLF 109

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 65.34 E-value: 4.12e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 212 KGMKVE---VLNSDAVLpsrvywIATVIQAAGYRVLLRYEGFENdaSHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHA 288
Cdd:cd20102    6 VGMKLEavdRKNPSLIC------VATVTDVIGNRFLVHFDGWDD--SYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSP 77


                 ....*....
gi 672059974 289 KFTDWKSYL 297
Cdd:cd20102   78 GNFSWDKYL 86

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 65.37 E-value: 4.16e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 535 GFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNE--YDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20093    3 GFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEDDrsADFWCDLSSGDVHPIGWCAQNGKPLQPP 74

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 65.33 E-value: 5.03e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 204 YDQwedVMKGMKVEVLNSDAVLpsrVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20094    1 ADR---IKVGMYLEVQDELNPY---SVWIAKVLENVGGRLLLRYDGPEDSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPP 74

                         90
                 ....*....|...
gi 672059974 284 RTIHAKFTD--WK 294
Cdd:cd20094   75 KSLEKLHATeeWK 87

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 64.63 E-value: 9.46e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVL-------LDGylmicvdggpsTDGSDWFCYHASSHAIFPATFCQKNDIELTPP 500
Cdd:cd20091   10 FKVGMKLEAQDPRNLTSTCIATVVGIQgprlrlrLDG-----------SDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPP 78

                         90
                 ....*....|....*..
gi 672059974 501 KGYETQPFDWESYLEKT 517
Cdd:cd20091   79 LGFRMNPSSWPMFLQKT 95

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 63.79 E-value: 2.33e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSrVYWIATVIQAAGYRVLLRYEGFENdaSHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20132    9 GMKLEGV--DPEHQS-MYCVLTVAEVCGYRIRLHFDGYSD--CYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEEEFN 83


                 ....*
gi 672059974 293 WKSYL 297
Cdd:cd20132   84 WQSYL 88

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 62.68 E-value: 2.77e-12

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20103    5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGH 68

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 63.27 E-value: 3.10e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSrVYWIATVIQAAGYRVLLRYEGFENdaSHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20133    9 GMRLEGI--DPEHPS-LFCVLSVAEVQGYRLRLHFDGYSE--CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDGEFN 83


                 ....*
gi 672059974 293 WKSYL 297
Cdd:cd20133   84 WSSYL 88

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 62.88 E-value: 3.32e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVV-HRLLSIHFDGWD--NEYDqWV--DCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20126    1 FKEGMKLEAIDPLNLSTICVATVRKVLaNGYLMIGIDGSEaaDGSD-WFcyHATSPSIFPVGFCEINMIELTPP 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 62.59 E-value: 6.40e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSrVYWIATVIQAAGYRVLLRYEGFENdaSHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20131   17 GMKLEGI--DPQHPS-MYFILTVAEVCGYRLRLHFDGYSE--CHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFS 91

                         90
                 ....*....|....*.
gi 672059974 293 WKSYLmkRLVGSRTLP 308
Cdd:cd20131   92 WSQYL--RSTRAQAAP 105

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 62.32 E-value: 6.83e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVlnSDAVLPSRVYwIATVIQAAGYRVLLRYEGfeNDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20091   13 GMKLEA--QDPRNLTSTC-IATVVGIQGPRLRLRLDG--SDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMNPSS 87


                 ....*....
gi 672059974 293 WKSYLMKRL 301
Cdd:cd20091   88 WPMFLQKTL 96

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 61.11 E-value: 1.09e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 529 MDCpnHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIH-FDGWDNEYDQWVDCESPDIYPVGWCELTGYQL 601
Cdd:cd20098   10 LKS--TPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVGWSQAVGHKI 81

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 61.56 E-value: 1.13e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDgYLMICVDGgpSTDGSDWFCyHASSHAIFPATFCQKNDIELTPPKGY-ETQ 506
Cdd:cd20136    5 FQVGMKLEAVDRKNPSLVCVATIADIVED-RLLVHFDN--WDDSYDYWC-DVNSPYIQPVGWCQENGRTLVAPQGYpNPE 80

                         90
                 ....*....|..
gi 672059974 507 PFDWESYLEKTK 518
Cdd:cd20136   81 KFSWTEYLEATQ 92

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 61.09 E-value: 1.27e-11

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDD--DFWCHMWSPLIHPVGW 380
Cdd:cd20094    4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSDspDFWLFYLSPRLHPLGW 63

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 60.79 E-value: 1.89e-11

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 319 MKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20136    1 MPKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGR 68

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 59.95 E-value: 3.87e-11

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 322 PFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLrLLYEDGDSDD-DFWCHMWSPLIHPVGW 380
Cdd:cd20102    3 GFRVGMKLEAVDRKNPSLICVATVTDVIGNRF-LVHFDGWDDSyDYWCDPDSPYIHPVGW 61

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 59.21 E-value: 4.47e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 212 KGMKVEVLnsDAVLPS--RVywiATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20103    7 VGMKLEAV--DKRNPRliRV---ATVADVEDYRVKLHFDGW--PDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 58.04 E-value: 6.55e-11

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVlLDGYLMICVDGgpSTDGSDWFCYHASSHAIFPATFCQ 491
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKV-VGGRLLLHFDG--WDPSRYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 59.62 E-value: 1.29e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKvLLDGYLMICVDGgpsTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQP 507
Cdd:cd20105   32 FKIGMKLEAQDPRNTTSTCIATVVG-LTGARLRLRLDG---SDNKNDFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNA 107

                         90       100
                 ....*....|....*....|...
gi 672059974 508 FDWESYLEKTKSKA--APARLFN 528
Cdd:cd20105  108 SSWPMFLLKTLNGAemAPVRIFH 130

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 58.40 E-value: 1.84e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVlLDGYLMICVDGGpstDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQP 507
Cdd:cd20107   10 FKIGMKLEALDPRNVTSTCIATVVGV-LGPRLRLRLDGS---DNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMNA 85

                         90
                 ....*....|....
gi 672059974 508 FDWESYLEKTKSKA 521
Cdd:cd20107   86 SSWPMFLLKTLNNA 99

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 58.01 E-value: 2.13e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLNSDAVLPSrvyWIATVIQAAGYRVLLRYEGfeNDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTD 292
Cdd:cd20107   13 GMKLEALDPRNVTST---CIATVVGVLGPRLRLRLDG--SDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMNASS 87


                 ....*....
gi 672059974 293 WKSYLMKRL 301
Cdd:cd20107   88 WPMFLLKTL 96

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 57.53 E-value: 2.59e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 535 GFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGW--DNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20111    3 GFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYgeDRRADFWCDIMTADLHPIGWCEQNGKTLRPP 74

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and similar domains; PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by MLL1/WDR5 complexes. It binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis. PHF20L1 also reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. PHF20L1 contains one MBT (malignant brain tumor) repeat. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the MBT repeat of PHF20L1 and similar domains that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439094 [Multi-domain] Cd Length: 60 Bit Score: 56.09 E-value: 3.15e-10

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 672059974 536 FKVGMKLEAVDLMepRLICVATVKRV--VHRLLSIHFDGWDNEYDQWVDCESPDIYPVG 592
Cdd:cd20104    1 FKVGDRVDALDGE--GKWYEAKIVEVdeEENKVLVHYDGWSSRYDEWIDRDSERLRPLH 57

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 56.86 E-value: 6.23e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEV---LNSDAVLpsrvywIATVIQAAGYRVLLRYEGfeNDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAK 289
Cdd:cd20106   13 GMKLEArdpRNATSVC------IATVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMN 84

                         90
                 ....*....|....
gi 672059974 290 FTDWKSYLMKRLVG 303
Cdd:cd20106   85 ASSWPMFLLRTLNG 98

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 56.35 E-value: 7.51e-10

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVG 385
Cdd:cd20135    6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHG 68

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 56.27 E-value: 8.77e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672059974 228 RVYWIATVIQAAGYRVLLRYEGFeNDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHA--KFTDWKSYLMKRL 301
Cdd:cd20114   19 FQYWIVRVIENVGGRLRLRYVGL-EDESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICDlkSASEWKEALEKSL 93

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 55.39 E-value: 1.47e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSRVyWIATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTI-HAKFT 291
Cdd:cd20136    8 GMKLEAV--DRKNPSLV-CVATIADIVEDRLLVHFDNW--DDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYpNPEKF 82


                 ....*.
gi 672059974 292 DWKSYL 297
Cdd:cd20136   83 SWTEYL 88

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 56.04 E-value: 1.52e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 320 KYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYeDGDSD-DDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20131   11 KNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHF-DGYSEcHDFWVNANSPDIHPAGWFEKTGH 77

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 55.32 E-value: 1.69e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVG 385
Cdd:cd20107   10 FKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNG 72

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 54.84 E-value: 2.15e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVG 385
Cdd:cd20134    6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQG 68

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 54.97 E-value: 2.48e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYE--DGDSDDDFWCHMWSPLIHPVGWSRR 383
Cdd:cd20093    4 FKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVgyEDDRSADFWCDLSSGDVHPIGWCAQ 66

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 54.93 E-value: 2.71e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 320 KYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYeDGDSDD-DFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20132    3 KNGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHF-DGYSDCyDFWVNADSPDIHPVGWCEKTGH 69

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 54.86 E-value: 3.19e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHR-LLSIHFDGW--DNEYDQWVdC---ESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20125    1 FKEGMKLEAVDPLNLSAICVATVMKVLRFgYLMIRIDSYepDASGSDWF-CyheSSPCIFPAGFCEVNNITLTPP 74

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 54.22 E-value: 3.64e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGW--DNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20112    4 FQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYgdDRRADFWCDVMTADLHPVGWCTQNNKVLMPP 74

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 54.16 E-value: 4.59e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVlLDGYLMICVDGgpsTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQP 507
Cdd:cd20106   10 FKVGMKLEARDPRNATSVCIATVIGI-TGARLRLRLDG---SDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNA 85

                         90
                 ....*....|
gi 672059974 508 FDWESYLEKT 517
Cdd:cd20106   86 SSWPMFLLRT 95

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 54.03 E-value: 5.48e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYeDGDSD-DDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20133    6 FKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHF-DGYSEcYDFWVNADSPDIHPVGWCEKTGH 69

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 53.01 E-value: 6.75e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20138    9 FQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGH 72

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 52.95 E-value: 8.29e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRCD 396
Cdd:cd20139    9 FQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVPLGASD 82

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 53.27 E-value: 8.52e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRL-LSIHFDGWDNEYDQ---WVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20116    1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHyFQVTVDDLRPEASEnsmLCHADSLGILPVQWCLKNGVNLTPP 75

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 53.07 E-value: 1.24e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGW 380
Cdd:cd20091   10 FKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGW 67

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 51.77 E-value: 1.93e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLNSDAVLPSRVywiATVIQAAGYRVLLRYEGFENDaSHDFWCNLGTVDVHPIGW 272
Cdd:cd20122   17 GLNLECVDKNRISQVRV---ATVTKIVGKRLHLRYEGSEPD-DDGFWCHEDSPLIHPVGW 72

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 52.14 E-value: 2.51e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGgRLRLLYEDGDSDD---DFWCHMWSPLIHPVGWSRRVGHGIKMSE 392
Cdd:cd20111    4 FSPGMKLEVAVRTDPNTYWVATIITTCG-QLLLLRYDGYGEDrraDFWCDIMTADLHPIGWCEQNGKTLRPPE 75

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 51.09 E-value: 3.25e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 213 GMKVEVLNSDAVLPSRVywiATVIQAAGYRVLLRYEGFENDAShDFWCNLGTVDVHPIGWC 273
Cdd:cd20098   18 GMRLEVVDKMCISRTRV---AVVEEVVGGRLRLQYVDSEDDDD-DFWCHMKSPLIHPVGWS 74

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 50.75 E-value: 3.80e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672059974 321 YPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGY 66

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 51.08 E-value: 4.20e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDN--EYDQWVDCESPDIYPVGWCELTGYQLQPPVS 606
Cdd:cd20094    4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDsdSPDFWLFYLSPRLHPLGWAKSNGYTYRPPKS 76

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 50.57 E-value: 8.11e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSRVyWIATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKILV-PPRTIHAKFT 291
Cdd:cd20135    9 GMKLEAV--DKKNPSFI-CVATITDMVDNRLLIHFDNW--DESYDYWCDASSPYIHPVGYCQEHGRTLTtPPGYKDPKHF 83


                 ....*.
gi 672059974 292 DWKSYL 297
Cdd:cd20135   84 SWEKYL 89

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 49.97 E-value: 1.25e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATIckVLLDG-YLMICVDGGPSTDGSDWFCyHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20093    4 FKPGMKLEVPNKNNPDTYWVATV--VMTCGpLLRLRYVGYEDDRSADFWC-DLSSGDVHPIGWCAQNGKPLQPPADIKEK 80

                         90
                 ....*....|...
gi 672059974 507 PFDWESYLEKTKS 519
Cdd:cd20093   81 ELDWAEFLIKELT 93

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 49.54 E-value: 1.35e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 212 KGMKVEVLNSDAVLPSRVywiATVIQAAGYRVLLRYEGFENDasHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20138   11 KNMKLEVVDKRNPMLIRV---ATVADTDDHRVKVHFDGWNNC--YDYWIDADSPDIHPAGWCAKTGHPLQPP 77

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 49.46 E-value: 1.44e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRVV-HRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20122   14 FRLGLNLECVDKNRISQVRVATVTKIVgKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNLAAS 83

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 49.28 E-value: 1.51e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIK 389
Cdd:cd20092    6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQ 72

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 48.67 E-value: 2.24e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20137    5 FQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGH 68

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 49.04 E-value: 2.72e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 326 GMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYE--DGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20113    7 GSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEglEGSDKSDTWLFYLDPFLHQVGWAAQHGY 69

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 48.83 E-value: 3.11e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGgRLRLLYEDGDSDD---DFWCHMWSPLIHPVGW 380
Cdd:cd20112    4 FQPGMKLEVANKSNPDTYWVATIITTCG-QLLLLRYCGYGDDrraDFWCDVMTADLHPVGW 63

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 48.67 E-value: 3.83e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVllDGYLM-ICVDG--GPSTDgsdwFCYHASSHAIFPATFCQKNDIELTPP 500
Cdd:cd20118    2 FTKNMKLEAVNPRNPAEICVASITSV--KGRLLwLHLEGlqNPVPE----YIVDVESMDIFPVGWCEANGYPLTPP 71

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 47.14 E-value: 1.04e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 528 NMDCPnhgFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20124    9 SMKYP---FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 47.23 E-value: 1.51e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVG 379
Cdd:cd20106   10 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIG 66

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 46.74 E-value: 1.56e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 536 FKVGMKLEAVDLMEPRLICVATVKRV-VHRLLSIHFDGwdNEYDQWVDC-----ESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20127    1 FEEGMKLEAIDPLNLGNICVATVCKVlLDGYLMIGIDG--GPSTDGSDWfcyhaSSHAIFPVGFCQKNDIELTPP 73

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 46.41 E-value: 1.93e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVlLDGYLMICVDGgpSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPK 501
Cdd:cd20117    3 FKENMKLEAVNPICPEEICVATVTKV-KGSYLWLQLEG--SKKPIPECIVHVESMDIFPVGWCETNGYPLLHPR 73

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 46.78 E-value: 1.93e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672059974 534 HGFKVGMKLEAVDLMEPRLICVATVKRVVH-RLLSIHFDGW--DNEYDQWVDC--ESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20115    1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNeKFFLVEMDDLrpEEAGAHSFVChrDSPGIFPVQWSLKNGLHLSPP 76

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 46.73 E-value: 2.06e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLNSDAVLpsrVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTI-HAKF- 290
Cdd:cd20113    7 GSRLELQDFQDSL---VAWIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIrHLKSe 83


                 ....*....
gi 672059974 291 TDWKSYLMK 299
Cdd:cd20113   84 AEWQEILKK 92

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 46.09 E-value: 2.06e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 213 GMKVEVL---NSDAVLPsrvywiATVIQAAGYRVLLRYEGFEndASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20108    9 GMKLEAVdrkNPHFICP------ATIGEVRGSEVLVTFDGWR--GAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 46.37 E-value: 2.19e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSRVyWIATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTI-HAKFT 291
Cdd:cd20134    9 GMKLEAV--DRMNPSLV-CVASVTDVVDSRFLVHFDNW--DDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYpDPDNF 83


                 ....*.
gi 672059974 292 DWKSYL 297
Cdd:cd20134   84 SWEKYL 89

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 45.24 E-value: 4.24e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 214 MKVEVLNSDAVLPSRVywiATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKIL-VPPRT 285
Cdd:cd20139   13 MKLEAVDKRNPILIRV---ATIVDKDDHRIKLHFDGW--DHNYDFWVDADSPDIHPVGWCDKTGHALqVPLGA 80

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 45.21 E-value: 4.29e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 212 KGMKVEVLNSDAVLPSRVYWIATVIqaaGYRVLLRYEGFENDAshDFWCNLGTVDVHPIGW 272
Cdd:cd20124   16 QGMRVEVVDKSQVSRTRMAVVDTVI---GGRLRLLYEDGDSDD--DFWCHMWSPLIHPVGW 71

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 46.53 E-value: 5.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 293 WKSYLMKrlVGSRTLPADFHIKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWS 372
Cdd:cd20105    4 WDKYLKE--TGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81


                 ....*..
gi 672059974 373 PLIHPVG 379
Cdd:cd20105   82 SEIQPIG 88

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 44.95 E-value: 5.82e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 212 KGMKVEVLNSDAVLPSRVywiATVIQAAGYRVLLRYEGFEnDASHDFWCNLGTVDVHPIGW 272
Cdd:cd20123   16 PCMRVEVVDKTHLCRTRV---AVVESVIGGRLRLVYEESE-DGTDDFWCHMYSPLIHHIGW 72

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 44.60 E-value: 7.00e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIK 389
Cdd:cd20130    6 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQ 72

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 43.88 E-value: 1.25e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 213 GMKVEvlnsdAVLPSRVYWI--ATVIQAAGYRVLLRYEGFENdaSHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20092    9 GMKLE-----AVDRKNPQLIcpATVGDVDGDEIHISFDGWRG--AFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 44.36 E-value: 1.63e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672059974 538 VGMKLEA----VDLME-PRLICVATVKRVVHRLLSIHFDGWDNE--YDQWVDCESPDIYPVGWCELTGYQLQPPVSAE 608
Cdd:cd20119    6 VGMKVEVentdTDLIEdPTSFWIATVLKIAGYKALMRYEGFGTDdsKDFWVNLCSEDVHPVGWCATRGKPLIPPRTIE 83

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 43.33 E-value: 2.09e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 213 GMKVEvlnsdAVLPSRVYWI--ATVIQAAGYRVLLRYEGFEndASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20109    9 GMKLE-----AIDKKNPYLIcpATIGDVKGDEVFITFDGWR--GAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 41.84 E-value: 4.79e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYE-DGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDsEKKLSPNIIVDVESTDIFPVGWCESNGY 65

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 42.29 E-value: 7.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 533 NHGFKVGMKLEAV----DLMEPRLIC--VATVKRVV-HRLLsIHFDGWDNE--YDQWVDCESPDIYPVGWCELTGYQLQP 603
Cdd:cd20097    1 WEKVKIGVKVEVAnrddDKPTDNVKVywFARIIKVAgYRVL-LRYEGYDEDssHDFWINLCSNEIHPIGYAAENGKILVP 79


                 ...
gi 672059974 604 PVS 606
Cdd:cd20097   80 PKS 82

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 41.28 E-value: 8.14e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
Cdd:cd20110    6 FKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCARSGH 69

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 41.12 E-value: 8.58e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 213 GMKVEVLNsdaVLPSRVYWIATVIQAAGYRVLLRYEGFENDasHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20129    6 GMKLEAVD---LMEPRLVCVATVTRIIHRLLRIHFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 71

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 41.12 E-value: 8.83e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 213 GMKVEvlnsdAVLPSRVYWI--ATVIQAAGYRVLLRYEGFENDasHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20100    6 GMKLE-----AVDLMEPRLIcvATVTRVVGRLLRVHFDGWDDE--FDQWVDCDSPDIYPVGWCELVGYPLQPP 71

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 41.12 E-value: 9.84e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIK 389
Cdd:cd20129    3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQ 69

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 41.35 E-value: 1.15e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 212 KGMKVEVLNSdaVLPSRVyWIATVIQAAGYRVLLRYEGFENdASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20118    4 KNMKLEAVNP--RNPAEI-CVASITSVKGRLLWLHLEGLQN-PVPEYIVDVESMDIFPVGWCEANGYPLTPP 71

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 40.79 E-value: 1.42e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 213 GMKVEVLNsdaVLPSRVYWIATVIQAAGYRVLLRYEGFENDasHDFWCNLGTVDVHPIGWCA-INSKILVPP 283
Cdd:cd20128    6 GMSLECAD---LMDPRLVCVATVARVVGRLLKVHFDGWTDE--YDQWLDCESADIYPVGWCVlVNHKLEGPP 72

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 40.58 E-value: 1.46e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 214 MKVEVLNSDAVLPSRVywiATVIQAAGYRVLLRYEGFENDasHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20137    9 MKLEAVDRRNPALIRV---ASVEDVEDHRIKIHFDGWSHG--YDFWIDADHPDIHPAGWCSKTGHPLQPP 73

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 40.36 E-value: 2.00e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 213 GMKVEVLNsdaVLPSRVYWIATVIQAAGYRVLLRYEGFenDASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20130    9 GMKLEAVD---LMEPRLICVATVKRVVHRLLSIHFDGW--DSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 39.53 E-value: 3.25e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672059974 212 KGMKVEVLNSDavLPSRVYwIATVIQAAGYRVLLRYEGFENDaSHDFWCNLGTVDVHPIGWCAINSKILVPPRTI 286
Cdd:cd20096    3 RGMKLEAVNPE--NPNQIC-VATITKVVGPLLWLHLDSEKKL-SPNIIVDVESTDIFPVGWCESNGYPLVTPRKY 73

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 40.09 E-value: 4.59e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 538 VGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNE-YDQWV---DCEspdIYPVGWCELTGYQLQPP 604
Cdd:cd20114    6 VGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLEDEsHDQWLfylDTR---LRPVGWCQENNLRMEPP 73

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 39.83 E-value: 6.35e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 538 VGMKLEAVDL---MEPRLICVATVKRVVHRLLSIHFDGWDNE--YDQWVDCESPDIYPVGWCELTGYQLQPPVS 606
Cdd:cd20120    6 EGVRVEVPNTdcnLPTKVFWIAGIVKLAGYKALLRYEGFENDssLDFWCNICGSDIHPVGWCATSGKPLVPPKT 79

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 39.20 E-value: 7.42e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLldGYLMICVDGGPSTD-GSDWFCyHASSHAIFPATFCQKNDIELTPPKGYETQ 506
Cdd:cd20112    4 FQPGMKLEVANKSNPDTYWVATIITTC--GQLLLLRYCGYGDDrRADFWC-DVMTADLHPVGWCTQNNKVLMPPDAIKEK 80


                 ....*...
gi 672059974 507 PFDWESYL 514
Cdd:cd20112   81 YTDWTEFL 88

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 38.59 E-value: 9.01e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 213 GMKVEVL---NSDAVLPsrvywiATVIQAAGYRVLLRYEGFEndASHDFWCNLGTVDVHPIGWCAINSKILVPP 283
Cdd:cd20110    9 GMKLEAVdrkNPHLICP------ATVGAVKDDQIFVTFDGWR--GAFDYWCRYDSRDIFPVGWCARSGHPLQPP 74

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 39.21 E-value: 9.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 429 EEGMKLEAI---DPLNLGNICV---ATICKVLldGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKG 502
Cdd:cd20097    5 KIGVKVEVAnrdDDKPTDNVKVywfARIIKVA--GYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPPKS 82

                         90
                 ....*....|....
gi 672059974 503 YETQPFDWESYLEK 516
Cdd:cd20097   83 IEDKENDWKEYIMK 96

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 38.78 E-value: 1.03e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRL-----LYEDGDSDDDFWCHMWSPLIHPVGWSRRvgHGIKMS 391
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLveiddLRPEESEKITFVCHANSPGIFPVGWCAK--NGLRLT 72

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 38.64 E-value: 1.52e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 539 GMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWD--NEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEP 609
Cdd:cd20113    7 GSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEgsDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRH 79

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 38.05 E-value: 2.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEVLnsDAVLPSRVYwIATVIQ--AAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKF 290
Cdd:cd20099    4 GMKLEAV--DPLNLSSIC-VATVRKvlRFGYLVIGIDGPSADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESKP 80


                 ....*....
gi 672059974 291 TDWKSYLMK 299
Cdd:cd20099   81 FDWEEYLEE 89

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 37.23 E-value: 2.34e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIK 389
Cdd:cd20108    6 FKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQ 72

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 37.55 E-value: 2.56e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672059974 214 MKVEVLNSdaVLPSRVYwIATVIQAAGYRVLLRYEGFENdASHDFWCNLGTVDVHPIGWCAINSKILVPPR 284
Cdd:cd20117    7 MKLEAVNP--ICPEEIC-VATVTKVKGSYLWLQLEGSKK-PIPECIVHVESMDIFPVGWCETNGYPLLHPR 73

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 37.62 E-value: 2.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 212 KGMKVEVLNsdavlPSRVYWI--ATVIQAAG---YRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCA-INSKILVPPRT 285
Cdd:cd20095    3 VGMKLEALH-----PKNPSTIcpATVTKVFNeyyFLVEIDDLRPEESEKITFVCHANSPGIFPVGWCAkNGLRLTPPPGY 77

                         90
                 ....*....|..
gi 672059974 286 IHAKFtDWKSYL 297
Cdd:cd20095   78 PKSEF-DWDSYL 88

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 36.79 E-value: 3.75e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVG 385
Cdd:cd20109    6 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTG 68

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 37.12 E-value: 3.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATI---CKVLLdgylMICVDGGPSTDGSDWFCYHASSHaIFPATFCQKNDIELTPPKGYE 504
Cdd:cd20111    4 FSPGMKLEVAVRTDPNTYWVATIittCGQLL----LLRYDGYGEDRRADFWCDIMTAD-LHPIGWCEQNGKTLRPPEGIR 78

                         90
                 ....*....|...
gi 672059974 505 TQPFDWESYLEKT 517
Cdd:cd20111   79 DKLSDWEEFLAQT 91

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 37.08 E-value: 4.16e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEV---LNSDAVLpsrvywIATVIQ--AAGYrVLLRYEGFENDASHDFWCNLGTV-DVHPIGWCAINSKILVPPRTI 286
Cdd:cd20126    4 GMKLEAidpLNLSTIC------VATVRKvlANGY-LMIGIDGSEAADGSDWFCYHATSpSIFPVGFCEINMIELTPPRGY 76

                         90
                 ....*....|...
gi 672059974 287 HAKFtDWKSYLMK 299
Cdd:cd20126   77 KKPF-KWFDYLRE 88

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 37.52 E-value: 4.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672059974 213 GMKVEV---LNSDAVLPsrvywiATVIQA--AGYrVLLRYEGFENDAS-HDFWC-NLGTVDVHPIGWCAINSKILVPPRT 285
Cdd:cd20125    4 GMKLEAvdpLNLSAICV------ATVMKVlrFGY-LMIRIDSYEPDASgSDWFCyHESSPCIFPAGFCEVNNITLTPPNG 76

                         90
                 ....*....|....
gi 672059974 286 IHAKFTDWKSYLMK 299
Cdd:cd20125   77 YDGRTFTWEGYLRQ 90

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 36.75 E-value: 6.31e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672059974 538 VGMKLEAVD---LMEPRLICVATVKRVVHRLLSIHFDGWDNE--YDQWVDCESPDIYPVGWCELTGYQLQPP 604
Cdd:cd20121    6 EGMKVEVLNtdaVLPSRVYWIASVIQLAGYKALLRYEGFENDssHDFWCNLGTVDVHPIGWCAINSKILVPP 77

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 36.44 E-value: 7.77e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVlLDGYLMICVDGGPSTDGSDWFCYHaSSHAIFPATFCQKNDIELTPPKGYE 504
Cdd:cd20094    4 IKVGMYLEVQDELNPYSVWIAKVLEN-VGGRLLLRYDGPEDSDSPDFWLFY-LSPRLHPLGWAKSNGYTYRPPKSLE 78

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 36.09 E-value: 8.38e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672059974 528 NMDCPnhgFKVGMKLEAVDLMEPRLICVATVKRVVH-RLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQ 602
Cdd:cd20123    9 SMQYP---FKPCMRVEVVDKTHLCRTRVAVVESVIGgRLRLVYEESEDGTDDFWCHMYSPLIHHIGWSRSIGHRFK 81

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 36.38 E-value: 8.45e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 323 FRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRL-----LYEDGDSDDDFWCHMWSPLIHPVGWSRRvgHGIKMS 391
Cdd:cd20115    3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLvemddLRPEEAGAHSFVCHRDSPGIFPVQWSLK--NGLHLS 74

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 36.07 E-value: 8.52e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672059974 428 FEEGMKLEAIDPLNLGNICVATICKVLLDGYLMICVDGGPSTDGsdwFCYHASSHAIFPATFCQ 491
Cdd:cd20098   15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDD---FWCHMKSPLIHPVGWSQ 75