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Conserved domains on  [gi|667331962|ref|XP_008591772|]
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PREDICTED: beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1 [Galeopterus variegatus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 565.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 137 AEALRCHLRDHVNVSMVESTDFPFNTSEWEGYLPKENIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 217 ANFQQDVGTKTTIRLMNSQLVTTDEH-FLKDSLYNEGILIVWDPSIYHSDIPKWYKTPDYSFFNNYKSYRKLHPDQPFYI 295
Cdd:cd23985   81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQRFFDIACTMGAYHPLLFE 375
Cdd:cd23985  161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                        250       260
                 ....*....|....*....|....*.
gi 667331962 376 KNLVKHLNKGTDEDIYLLGKATMPGF 401
Cdd:cd23985  241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 565.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 137 AEALRCHLRDHVNVSMVESTDFPFNTSEWEGYLPKENIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 217 ANFQQDVGTKTTIRLMNSQLVTTDEH-FLKDSLYNEGILIVWDPSIYHSDIPKWYKTPDYSFFNNYKSYRKLHPDQPFYI 295
Cdd:cd23985   81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQRFFDIACTMGAYHPLLFE 375
Cdd:cd23985  161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                        250       260
                 ....*....|....*....|....*.
gi 667331962 376 KNLVKHLNKGTDEDIYLLGKATMPGF 401
Cdd:cd23985  241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-384 7.95e-31

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 118.48  E-value: 7.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962  169 LPKENiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN--SQLVTTDEHFLKD 246
Cdd:pfam00777  32 LPKVS-PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962  247 SLYNEGILIVwdpSIYhsdipkwYKTPDY----SFFNNYK---SYRKLHPDQPFYIlkPQMPWEL----WDILQEI---- 311
Cdd:pfam00777 111 HPRDPFVEFV---LVP-------FKGRDLlwlpAFLTKGNvsrSLRVLYTLKEVKI--PVDPDKVlflhPDFLRYVanfw 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 667331962  312 --SPeEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYqrfFDIAC--TMGAY--HPLLFEKNLVKHLNK 384
Cdd:pfam00777 179 lrSH-GLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHY---YDNVLmkKGGFYgvHDMPFEFKLLQKLHK 253
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 565.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 137 AEALRCHLRDHVNVSMVESTDFPFNTSEWEGYLPKENIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 217 ANFQQDVGTKTTIRLMNSQLVTTDEH-FLKDSLYNEGILIVWDPSIYHSDIPKWYKTPDYSFFNNYKSYRKLHPDQPFYI 295
Cdd:cd23985   81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQRFFDIACTMGAYHPLLFE 375
Cdd:cd23985  161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                        250       260
                 ....*....|....*....|....*.
gi 667331962 376 KNLVKHLNKGTDEDIYLLGKATMPGF 401
Cdd:cd23985  241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 137-401 8.01e-145

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 412.05  E-value: 8.01e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 137 AEALRCHLRDHVNVSMVESTDFPFNTSEWEGYLPKENIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23968    1 SEDLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 217 ANFQQDVGTKTTIRLMNSQLVTTDE-HFLKDSLYNEGILIVWDPSIYHSDIPKWYKTPDYSFFNNYKSYRKLHPDQPFYI 295
Cdd:cd23968   81 KGFEKDVGSKTTLRLINSQILSKPEfNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQRFFDIACTMGAYHPLLFE 375
Cdd:cd23968  161 IDPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAE 240

                        250       260
                 ....*....|....*....|....*.
gi 667331962 376 KNLVKHLNKGTDEDIYLLGKATMPGF 401
Cdd:cd23968  241 KLLVRHLNVGSDDDIFRKGRATLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 134-401 2.49e-121

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 352.60  E-value: 2.49e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 134 KFSAEALRCHLRDHVNVSMVESTDFPFNTSEWEGYLPKENI-RTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFN 212
Cdd:cd23986    1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLsKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 213 GAPTANFQQDVGTKTTIRLMNSQLVTT-DEHFLKDSLYNEGILIVWDPSIYHSDIPKWYKTPDYSFFNNYKSYRKLHPDQ 291
Cdd:cd23986   81 SAPTRGYEKDVGNKTTIRIINSQILTNpNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 292 PFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQRFFDIACTMGAYHP 371
Cdd:cd23986  161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 667331962 372 LLFEKNLVKHLNKGTDEDIYLLGKATMPGF 401
Cdd:cd23986  241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 184-382 2.89e-53

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 175.63  E-value: 2.89e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV-----TTDEHFLKDSLYNEGILIVWD 258
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrGPRCGCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 259 PSIYhsdipkwyktpdysFFNNYKSYRKLHPDQPFYILK--PQMPWELWDILQEISPEEIQ-PNPPSSGMLGIIIMLTLC 335
Cdd:cd19952   81 AAAA--------------DFKRLKRRKKRHDNAVLLLTDpaPDLLSYVRKRLEKLGLKSFFgGNAPSSGLLAVLLALQLC 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 667331962 336 DQVDIYEF--LPSKRKTDVCYYYQRFFDIActMGAYHPLLFEKNLVKHL 382
Cdd:cd19952  147 DSVDLYGFgvDSGHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-384 7.95e-31

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 118.48  E-value: 7.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962  169 LPKENiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN--SQLVTTDEHFLKD 246
Cdd:pfam00777  32 LPKVS-PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962  247 SLYNEGILIVwdpSIYhsdipkwYKTPDY----SFFNNYK---SYRKLHPDQPFYIlkPQMPWEL----WDILQEI---- 311
Cdd:pfam00777 111 HPRDPFVEFV---LVP-------FKGRDLlwlpAFLTKGNvsrSLRVLYTLKEVKI--PVDPDKVlflhPDFLRYVanfw 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 667331962  312 --SPeEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYqrfFDIAC--TMGAY--HPLLFEKNLVKHLNK 384
Cdd:pfam00777 179 lrSH-GLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHY---YDNVLmkKGGFYgvHDMPFEFKLLQKLHK 253
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 182-370 2.41e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 100.01  E-value: 2.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 182 GRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM---NSQLVTTDEHFLKDSLYNEGILIVWD 258
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRLLRNAILLLAGTRAPTVVVFWG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 259 PSIYhsdipkwYKTPDYSFFNNYKSYRKLHPDQPFYILKPQMPWELWDILQ-------EISPEEIqpnppSSGMLGIIIM 331
Cdd:cd23965   82 PETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEketgksrIKSGTWL-----STGWFTMLLA 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 667331962 332 LTLCDQVDIYEFLPSK-----RKTDVCY-YYQRFFDIACTMGAYH 370
Cdd:cd23965  150 LDVCDEIKVYGMVPENycrehPNSKVPYhYYEPGGLKECTYYNYH 194
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 183-355 2.74e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 99.29  E-value: 2.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTD-EHFLKDSLYnegILIVWDPSI 261
Cdd:cd23967    4 RCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDpEEYDSDWLL---VLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 262 YH--SDIPKWYKTPDYSFFnnYKSYRKLHPDQP--FYILKPQMPWEL-WDILQEISPEEIQPNPPSSGMLGIIIMLTLCD 336
Cdd:cd23967   81 LLwlQAVIKGKKPNGKGGF--WKKIATSVPKPPkkIRILNPYILQEAaFDLIGLPMNGKQGKNVPTTGIIAIVMALHYCD 158

                        170       180
                 ....*....|....*....|.
gi 667331962 337 QVDI--YEFLPSKRKTDVCYY 355
Cdd:cd23967  159 EVDIagFGYDPSDPNAPLHYY 179
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 162-356 2.60e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 98.49  E-value: 2.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 162 TSEWEGYLPKENIrTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT--------TIRLMN 233
Cdd:cd23963   45 TKSLYELLPKTSP-FSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRY 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 234 SQLVTTD--EHFLKD-SLYNEGILivWdpsiYHSDIPKWYKTPdysFFNNYKSYRKLHPDQPFYILKPQMPWELWDILQE 310
Cdd:cd23963  124 NSLKKNRdrDKFLNRlKEYNGSIL--W----YPKFSFKSSTNL---LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKR 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 667331962 311 ISPEeiqpNPPSSGMLGIIIMLTLCDQVDIYEFLP---SKRKTDVCYYY 356
Cdd:cd23963  195 RGLE----KRPSTGLYLVSLALTFCDEIHLYGFWPfptDPNGRPVPYHY 239
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 183-384 2.11e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 87.70  E-value: 2.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTT--IRLMNSQLVTTDEHFL--KDSLYnegilivwd 258
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSfyTFFPESLHNSLLKHVPqdKDTKY--------- 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 259 psIYhsdIPkwYKTPDYSFFNNYKSYRKLhpdqPFYILKPQMPWELwdilqeiSPEEIQPN------P------------ 320
Cdd:cd23964  155 --LF---IP--FKIRDYDYLDAVLSGKPV----PDGCDKGKRPPPL-------FGPKLNATnvrllhPdfirylfnrwln 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 321 ------PSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVcYYYQRFFDIACTMGAyHPLLFEKNLVKHLNK 384
Cdd:cd23964  217 sstsyrPTTGALMLLTALHTCDQVSVYGFGYDPRFSLH-YYDKTFVKFTVFYAN-HDFTNERKLWRKLHE 284
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 183-382 4.10e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 84.72  E-value: 4.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM--NSQLVTTDEHFLKDSLYnegILIVWDPS 260
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypESAQFDPGIENDPDTLL---VLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 261 IYHsdipkWYktpdYSFFNNYKSYRKLHPDQP----------FYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIII 330
Cdd:cd23982   81 DFY-----WL----YEILSNEKRVRKGFWKQPpriwdanpkqIRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITL 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 667331962 331 MLTLCDQVDIYEF-LP-SKRKTDVCYYYQrffdiACTM----GAYHPLLFEKNLVKHL 382
Cdd:cd23982  152 ALHLCDEVHIAGFgYPdNGNSNQPIHYYN-----QITLksmaNSGHNLNAEAQAIQRL 204
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 182-370 1.45e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 81.06  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 182 GRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ----LVTTDEHFLK---DSLYnegil 254
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQqsrDTKY----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 255 IVWDPSiYHSDIPKWYKTpdysfFNNYKSYRKLHPDQPFYILKPQMPWELWDILQ-EISPEEIQPNP-PSSGMLGIIIML 332
Cdd:cd23977   77 VIWGPE-RNMDRDGGGKT-----YRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQnETGKNRMKSGSfLSTGWFTMILAL 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 667331962 333 TLCDQVDIY-----EFLPSKRKTDVCY-YYQRFFDIACTMGAYH 370
Cdd:cd23977  151 ELCEEILVYgmvsdSYCRNKNHSSVPYhYYEKGRLDECRMYLVH 194
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 183-343 1.84e-17

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 81.94  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTT---DEHFLkdsLYNEGIL-IVWD 258
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDldpGVHLV---LVPFKVLdLQWL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 259 PSIYHSDIPKWYKTPDYSFFNNYKSyrK---LHPDQPFYIlkpqmpWELWdilqeispEEIQPNPPSSGMLGIIIMLTLC 335
Cdd:cd23966  156 ISALTTGEITRTYTPVKRFIKADKD--KvlvINPAFIKYV------HDNW--------TEHHGRYPSTGFLALIFALHIC 219


                 ....*...
gi 667331962 336 DQVDIYEF 343
Cdd:cd23966  220 DEVSVFGF 227
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 153-384 2.57e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 81.79  E-value: 2.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 153 VESTDFPFNTSEWEGYLPKENirtkaGPWG--RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT--- 227
Cdd:cd23972   57 VASTLSLLNDSANAKLFFPRD-----TPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfy 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 228 --TIRLMNSQLVTTDEHFLKDSLYNEGILIVWDPS------IYHSDI--------------PKWYKTPDYSffnnYKSYR 285
Cdd:cd23972  132 gfTVNTMKNSLISYWNLGFTRTPQGQDLQYIFIPSdirdyvMLRSAIlgvpvpegldkgdrPHKYFGPEAS----AKKFK 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 286 KLHPDQPFYILKPQMPWELWDIlqeispEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQR------F 359
Cdd:cd23972  208 LLHPDFISYLTDRFLKSKLLNT------HYGHLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERkkkplvF 281

                        250       260
                 ....*....|....*....|....*
gi 667331962 360 FdiactmgAYHPLLFEKNLVKHLNK 384
Cdd:cd23972  282 Y-------ANHDMLLEAALWRRLHK 299
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 184-384 1.65e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 79.36  E-value: 1.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNS----------QLVTTDEHFLKDsLYNEGI 253
Cdd:cd23970   71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPsilekyynnlLTIQDRNNFFLS-LKKLDG 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 254 LIVWDPSI-YHSDIPKWYKTPDysFFNNYKSYRKLHPDQPFYIlkpqMPW--ELWDiLQEISPEEIqpnppSSGMLGIII 330
Cdd:cd23970  150 AILWIPAFfFHTSATVTRTLVD--FFVEHRGQLKVQLAWPGNI----MQHvnRYWK-TKHLSPKRL-----STGILMYTL 217

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 667331962 331 MLTLCDQVDIYEFLP---SKRKTDVCYYYQRFFDIACTMG--AYHPLLFEKNLVKHLNK 384
Cdd:cd23970  218 ASAICEEIHLYGFWPfgfDPTGTPLPYHYYDKKGTKFTTKwqESHQLPAEFVLLYKMHG 276
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 183-382 9.18e-16

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 75.55  E-value: 9.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTD-EHFLKDSLYnegILIVWDPSI 261
Cdd:cd23984    4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDpSHYDPNTTV---VLIPFKPHD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 262 YH--SDIPKWYKTPDYSFFNnyKSYRKL--HPDQ-----PFYILKpqMPWELWDiLQEISPEEIQPNPPSSGMLGIIIML 332
Cdd:cd23984   81 LRwlLDLLMGKKVSAKGFWK--KPALNLiyKPNQirilnPFILRI--AAYELLH-FPKRFPKEKKPKHPTTGIIAITLAL 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 667331962 333 TLCDQVDI----YEFLPSkrkTDVCYYYQRFFDIACTMGAYHPLLFEKNLVKHL 382
Cdd:cd23984  156 HICNEVHIagfkYDFSNL---NSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 184-376 1.43e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 75.67  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM---NSQLVTTDEHFLKDSLYNEgILIVWDPS 260
Cdd:cd23976   18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIahsSIQRILRNRNELLNVSQGT-VFIFWGPS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 261 IYHSDIPKWYktpdysFFNNYKSYRKLHPDQPFYILKPQMPWELWDIL-QEISPEEIQPNP-PSSGMLGIIIMLTLCDQV 338
Cdd:cd23976   97 NYMRRDGKGL------VYNNLQLMNQILPKLKVYTITRHKMLQFDELFkRETGKDRKISNTwLSTGWFTMIIALELCDRI 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 667331962 339 DIY-----EFLPSKRKTDVCY-YYQRFFDIACTM---------GAYHPLLFEK 376
Cdd:cd23976  171 NVYgmvppDFCRDPNHPSVPYhYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 183-343 5.19e-15

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 73.23  E-value: 5.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM--------------NSQLVTT-----DEHF 243
Cdd:cd23983    4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegapkseqeydpTSLFVAVlfksvDFAW 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 244 LKDSLYNEgILIVWDPSIYHSDIPKwyKTPdysffnnyksyrkLHPDQpFYILKPQMPWEL-WDILQEISPEEI----QP 318
Cdd:cd23983   84 LKAMVKKE-PLSFWSRLFFWKEVAD--SIP-------------LKPSQ-FRILNPLIIKETaLDILQYPEPQSRlwgwDK 146

                        170       180
                 ....*....|....*....|....*
gi 667331962 319 NPPSSGMLGIIIMLTLCDQVDIYEF 343
Cdd:cd23983  147 NVPTLGVTAVVLATHLCDEVSLAGF 171
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 184-356 1.92e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 72.83  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTD----------EHFLKD-SLYNEG 252
Cdd:cd23969   67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAygdlvnatdkEKFVERlRQLGDS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 253 ILivWDPSIyhsdIPKWYKtpDYSFFNNYKSyrkLHPDQPFYILKP-----QMPWELWdilqeiSPEEIQPNPPSSGMLG 327
Cdd:cd23969  147 IL--WIPAF----VSKGGE--EHVQWTNEII---LKHKLNVKTAYPplrlnHAIRGYW------LTTKFRIKRPSTGLLM 209

                        170       180       190
                 ....*....|....*....|....*....|..
gi 667331962 328 IIIMLTLCDQVDIYEFLPSK---RKTDVCYYY 356
Cdd:cd23969  210 YTLATRFCDEIHLYGFYPFSedgNGRAVKYHY 241
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 183-343 3.11e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 72.61  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTirlmnsqlvttdEHFLKDSLYNEGILIVwdpsiy 262
Cdd:cd23980   83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT------------HHFVYPESFRELAQNV------ 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 263 hSDIPKWYKTPDYSFFNNYKSY-----------RKLHPDQP-FYILKPQMPWELWD-ILQEispeeiQPNPPSSGMLGII 329
Cdd:cd23980  145 -SMILVPFKTLDLEWVISATTTgtishtyvpvpRKIKVKKEkILIYHPAFIKYVFDrWLQG------HGRYPSTGILSVI 217

                        170
                 ....*....|....
gi 667331962 330 IMLTLCDQVDIYEF 343
Cdd:cd23980  218 FSLHVCDEVDLYGF 231
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 175-377 6.99e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 71.71  E-value: 6.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 175 RTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT------TIRLMNS-------------Q 235
Cdd:cd23974   78 PNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTsfytfsTNTLMNSlrayagvgfngppQ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 236 LVTTDEHFLKDslYNEGILIVwDPSIYHSDI---PKWYKTPDYSFFNNYKS--YRKLHPDQPFY---------ILKPQMp 301
Cdd:cd23974  158 SKETRYIFLPD--HDRDYLLV-KAALTHTPIdrgRDKSKRPSKYFGKDVTAekFKIYHPDFIRYlrnrflwspILNTKQ- 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 667331962 302 welWDILQeispeeiqpnpPSSGMLGIIIMLTLCDQVDIYEFLpskrKTDVCYYYQRFFDiactmGAYHPLLFEKN 377
Cdd:cd23974  234 ---RDIYR-----------PSTGAVMLLAALHTCDQVSAYGFM----TPDYGKYSDHYYD-----KTYHKVVFYAN 286
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 169-345 9.42e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 70.75  E-value: 9.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 169 LPKENIrTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTaNFQQDVGTKTtirlmnsQLVTTDEHFLKD-- 246
Cdd:cd23971   53 LPKESP-FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKT-------NLVTANPSILREkf 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 247 -SLYNEGILIVWDPSIYHSdipKWYKTPDYSFFNNYK-SYRKLHPDQPF------------YILKPQMPWELWDiLQEIS 312
Cdd:cd23971  124 hNLKKRRRPFVERMKVYGN---ALLLLPAFSYTSNTEpSLRALYTLEDFgspqkvlffnpeYLRNLSRYWKSKG-LKARR 199

                        170       180       190
                 ....*....|....*....|....*....|...
gi 667331962 313 peeiqpnpPSSGMLGIIIMLTLCDQVDIYEFLP 345
Cdd:cd23971  200 --------LSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 183-384 3.45e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.78  E-value: 3.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTT----------------------- 239
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSslmilqkrgfknipqdkdikyil 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 240 ------DEHFLKDSLYNEGIlivwdPS-IYHSDIPKWYKTPDYsffnNYKSYRKLHPDQPFYI----LKP-QMPWELWDI 307
Cdd:cd23973  165 fpegprDYQWLEALLKNKTI-----PSgAYYGRRPRSYFSGDF----TEDKYLVLHPDFLRYVknrfLRSkTLKGKYWAI 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 308 LQeispeeiqpnpPSSGMLGIIIMLTLCDQVDIYEFLPSKRKTDVCYYYQR------FFdiactmgAYHPLLFEKNLVKH 381
Cdd:cd23973  236 YR-----------PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKkktklvFY-------INHDFRLEKKLWKR 297


                 ...
gi 667331962 382 LNK 384
Cdd:cd23973  298 LHD 300
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 170-356 5.09e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 68.83  E-value: 5.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 170 PKENIRTKAgpwgrCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------TT 239
Cdd:cd23988   58 PMKNRRFKT-----CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfrneSD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 240 DEHFLKD-SLYNEGILivWDPSIYHSDIPKWYKTPDYSFFNN-------YKSYRKLHPDQPFYIlkpqmpwelwdilqei 311
Cdd:cd23988  133 REKFVHRlSMLNDSVL--WIPAFMVKGGEKHVEWVNALILKNklkvrtaYPSLRLIHAVRGYWL---------------- 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 667331962 312 sPEEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLPSKRK---TDVCYYY 356
Cdd:cd23988  195 -TNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDangNPVKYHY 241
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 184-356 7.70e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 67.57  E-value: 7.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN----SQLVTTDEHFLkdSLYNEGILIVWDP 259
Cdd:cd23978    4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQEFL--NRTPETTLIFWGP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 260 siyHSDIPKWYKTPDYSFFNNYKSyrkLHPDQPFYILKPQMPWELWDILQEISPEEIQPNPP--SSGMLGIIIMLTLCDQ 337
Cdd:cd23978   82 ---PNKMQKDGKSNLFRIIQRASM---TFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAVELCDN 155

                        170       180
                 ....*....|....*....|....*
gi 667331962 338 VDIYEFLP----SKRKT--DVCYYY 356
Cdd:cd23978  156 VHVYGMVPpnycSKRPTpkKMPYHY 180
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 183-343 3.35e-12

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 65.33  E-value: 3.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ-LVTTDEHFLKDSLYnegILIVWDPSI 261
Cdd:cd23981    4 RCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgAIQKPEQYEKDSLF---VLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 262 YhsdipKWYKTPDYSFFNN-----YKSYRKLHPDQP--FYILKPQMpwelwdiLQEISPEEI----------QPNPPSSG 324
Cdd:cd23981   81 F-----KWLKYIVYKEKVSasdgfWKSVATRVPREPheIRILNPYF-------IQEAAFSFIglpfnnglmgRGNIPTLG 148

                        170
                 ....*....|....*....
gi 667331962 325 MLGIIIMLTLCDQVDIYEF 343
Cdd:cd23981  149 SVAITMALHNCDEVAVAGF 167
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 184-259 3.99e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 65.34  E-value: 3.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ----LVTTDEHFLKDSlyNEGILIVWDP 259
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKET--NETIYVIWGP 81
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 181-356 1.34e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 64.58  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 181 WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTDEHFLKDSLYNEGIL------ 254
Cdd:cd23987   64 FKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLqrlqsl 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 255 ---IVWDPSIYH---SDIPKWYKTPDYSFFNN----YKSYRKLHPDQPFYIlkpqmpwelwdilqeisPEEIQPNPPSSG 324
Cdd:cd23987  144 ngsILWIPAFMAkggEERVEWVNDLILKHHINvrtaYPSLRLLHAVRGYWL-----------------TNKVHIKRPTTG 206

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 667331962 325 MLGIIIMLTLCDQVDIYEFLPSKRKTD---VCYYY 356
Cdd:cd23987  207 LLMYTLATRFCNRIHLYGFWPFPRDQNqnpVKYHY 241
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 183-343 5.37e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 62.97  E-value: 5.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTDEHFLKDSLYNEGIL-IVWDPSI 261
Cdd:cd23979   82 RCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLdLLWITSA 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 262 YHSDIPKWYKTPDYSFFNNYKSyrKLHPDQPFYILKPQMPWelwdilqeispEEIQPNPPSSGMLGIIIMLTLCDQVDIY 341
Cdd:cd23979  162 LSTGQIRFTYAPVKQFLRVDKD--KVQIYNPAFFKYIHDRW-----------TEHHGRYPSTGMLVLFFALHVCDEVNVY 228


                 ..
gi 667331962 342 EF 343
Cdd:cd23979  229 GF 230
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 180-351 1.03e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 59.00  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 180 PWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT-ANFQQDVGTKTTIRLMNSQLVTTD--------EHFLKD-SLY 249
Cdd:cd23991   63 PYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTgGNISKDVGSKTNLVTANPSIISIKyaklnerrKPFLETvSVY 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 250 NEGILIVwdPSIYHSDipkwyktpdysffNNYKSYRKLHPDQPFYI-LKPQM--PWELWDILQEISPEEIQPNPPSSGML 326
Cdd:cd23991  143 GDAFLLL--PAFSYRS-------------NTALSFKVYYTLEDFKAkQKVIFfhPIYLKHLAQFWRSKGVQVYRLSTGLM 207

                        170       180
                 ....*....|....*....|....*
gi 667331962 327 GIIIMLTLCDQVDIYEFLPSKRKTD 351
Cdd:cd23991  208 ITSAALELCEEVKLYGFWPFSKNTE 232
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 183-343 1.52e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 58.31  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTAN-FQQDVGTKTTIRLMNSQLVTTDEHFLKD--SLYNEGILIVWDP 259
Cdd:cd23990   66 KCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIITERFHKLEKwrRPFYEVLQVYENA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 260 SIYhsdIPKWYKT--PDYSF-----FNNYKSYRKLHPDQPFYILKPQMPWelwdilqeiSPEEIQPNPPSSGMLGIIIML 332
Cdd:cd23990  146 SVV---LPAFYNTrnTDVSIrvkyvLDDFESQQAVYYFHPQYLLNVSRFW---------LRQGVRAKRISSGLMLVTAAL 213

                        170
                 ....*....|.
gi 667331962 333 TLCDQVDIYEF 343
Cdd:cd23990  214 ELCEEVHLYGF 224
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 180-345 3.47e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 57.15  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 180 PWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAP-TANFQQDVGTKTtirlmnsQLVTTdehflkdslynegilivwD 258
Cdd:cd23989   62 PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT-------QLVTA------------------N 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667331962 259 PSIyhsdIPKWYKTPDYS---FFNNYKSYRKLHPDQPFYILKPQMPWELW-------------------DILQEISP--- 313
Cdd:cd23989  117 PSI----IDKRFQNLLWSrksFVESMKVYGRSYIYMPAFSMKTGTDPSLRvyytladvganqtvlfanpNFLRNVGKfwk 192

                        170       180       190
                 ....*....|....*....|....*....|...
gi 667331962 314 -EEIQPNPPSSGMLGIIIMLTLCDQVDIYEFLP 345
Cdd:cd23989  193 sKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWP 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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