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Conserved domains on  [gi|637322026|ref|XP_008112964|]
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nuclear receptor-binding factor 2 isoform X1 [Anolis carolinensis]

Protein Classification

NRBF2_MIT and NRBF2 domain-containing protein( domain architecture ID 11977866)

NRBF2_MIT and NRBF2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRBF2 pfam08961
Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in ...
 126-326 6.94e-119

Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


:

Pssm-ID: 430345  Cd Length: 200  Bit Score: 340.75  E-value: 6.94e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322026  126 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 205
Cdd:pfam08961   1 VTDRDAAAHLQASPKPSAEEADGQSVLGPASQKYSPSPEKYLQEIQSVFDRDPDTLLFLLQKRKEPTETCIGSKAPKDDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322026  206 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPLEKELDVDADFVEKSELWGLQQHSETaAATSASSW 285
Cdd:pfam08961  81 TKIEEQATKIAELKRHVEFLLAENERLRKENKQLKAEKARLQKNPIEKELDVDADFVEKSELWGLQQHSES-AATAASTW 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 637322026  286 QKFTSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 326
Cdd:pfam08961 160 QKFTANAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGL 200
NRBF2_MIT super family cl28842
MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule ...
 76-122 9.60e-20

MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


The actual alignment was detected with superfamily member pfam17169:

Pssm-ID: 465368  Cd Length: 83  Bit Score: 82.06  E-value: 9.60e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 637322026   76 AYLSDAMKLTQSDQAQLSLQLQKESHLKQILLIQERWKRAKREERLK 122
Cdd:pfam17169  36 AYLSEAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLK 82
 
Name Accession Description Interval E-value
NRBF2 pfam08961
Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in ...
 126-326 6.94e-119

Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 430345  Cd Length: 200  Bit Score: 340.75  E-value: 6.94e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322026  126 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 205
Cdd:pfam08961   1 VTDRDAAAHLQASPKPSAEEADGQSVLGPASQKYSPSPEKYLQEIQSVFDRDPDTLLFLLQKRKEPTETCIGSKAPKDDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322026  206 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPLEKELDVDADFVEKSELWGLQQHSETaAATSASSW 285
Cdd:pfam08961  81 TKIEEQATKIAELKRHVEFLLAENERLRKENKQLKAEKARLQKNPIEKELDVDADFVEKSELWGLQQHSES-AATAASTW 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 637322026  286 QKFTSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 326
Cdd:pfam08961 160 QKFTANAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGL 200
NRBF2_MIT pfam17169
MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule ...
 76-122 9.60e-20

MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 465368  Cd Length: 83  Bit Score: 82.06  E-value: 9.60e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 637322026   76 AYLSDAMKLTQSDQAQLSLQLQKESHLKQILLIQERWKRAKREERLK 122
Cdd:pfam17169  36 AYLSEAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLK 82
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 197-251 6.97e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 40.97  E-value: 6.97e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 637322026 197 RSKTPKDDKTKMEEQatkIALLERHVEVLLAENERLRQENKQLKAERARLLKSPL 251
Cdd:PRK03992   2 RLEALEERNSELEEQ---IRQLELKLRDLEAENEKLERELERLKSELEKLKSPPL 53
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
218-246 2.39e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 36.78  E-value: 2.39e-03
                         10        20
                 ....*....|....*....|....*....
gi 637322026 218 LERHVEVLLAENERLRQENKQLKAERARL 246
Cdd:COG2919   34 LRQEIAELEAENAKLKARNAELEAEVADL 62
 
Name Accession Description Interval E-value
NRBF2 pfam08961
Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in ...
 126-326 6.94e-119

Nuclear receptor-binding factor 2, autophagy regulator; NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 430345  Cd Length: 200  Bit Score: 340.75  E-value: 6.94e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322026  126 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 205
Cdd:pfam08961   1 VTDRDAAAHLQASPKPSAEEADGQSVLGPASQKYSPSPEKYLQEIQSVFDRDPDTLLFLLQKRKEPTETCIGSKAPKDDK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637322026  206 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPLEKELDVDADFVEKSELWGLQQHSETaAATSASSW 285
Cdd:pfam08961  81 TKIEEQATKIAELKRHVEFLLAENERLRKENKQLKAEKARLQKNPIEKELDVDADFVEKSELWGLQQHSES-AATAASTW 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 637322026  286 QKFTSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 326
Cdd:pfam08961 160 QKFTANAGKAKDIPIPNLPPLDIPSPELPLLELSEDILKGL 200
NRBF2_MIT pfam17169
MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule ...
 76-122 9.60e-20

MIT domain of nuclear receptor-binding factor 2; This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.


Pssm-ID: 465368  Cd Length: 83  Bit Score: 82.06  E-value: 9.60e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 637322026   76 AYLSDAMKLTQSDQAQLSLQLQKESHLKQILLIQERWKRAKREERLK 122
Cdd:pfam17169  36 AYLSEAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLK 82
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 197-251 6.97e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 40.97  E-value: 6.97e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 637322026 197 RSKTPKDDKTKMEEQatkIALLERHVEVLLAENERLRQENKQLKAERARLLKSPL 251
Cdd:PRK03992   2 RLEALEERNSELEEQ---IRQLELKLRDLEAENEKLERELERLKSELEKLKSPPL 53
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
218-246 2.39e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 36.78  E-value: 2.39e-03
                         10        20
                 ....*....|....*....|....*....
gi 637322026 218 LERHVEVLLAENERLRQENKQLKAERARL 246
Cdd:COG2919   34 LRQEIAELEAENAKLKARNAELEAEVADL 62
bZIP_2 pfam07716
Basic region leucine zipper;
186-242 6.98e-03

Basic region leucine zipper;


Pssm-ID: 462244 [Multi-domain]  Cd Length: 51  Bit Score: 34.11  E-value: 6.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 637322026  186 QKRKEPQEACVRSKtpkdDKTKMEEQAtkialLERHVEVLLAENERLRQENKQLKAE 242
Cdd:pfam07716   4 DRRRKNNEAAKRSR----EKKKQKEEE-----LEERVKELERENAQLRQKVEQLEKE 51
PRK10265 PRK10265
chaperone modulator CbpM;
225-250 7.90e-03

chaperone modulator CbpM;


Pssm-ID: 182346  Cd Length: 101  Bit Score: 35.48  E-value: 7.90e-03
                         10        20
                 ....*....|....*....|....*.
gi 637322026 225 LLAENERLRQENKQLKAERARLLKSP 250
Cdd:PRK10265  76 LLDEIAHLKQENRLLRQRLSRFVAHP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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