|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
73-457 |
4.64e-163 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 464.72 E-value: 4.64e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLFIYvgsAH 152
Cdd:cd17380 12 YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY---SS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 153 LVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLW 232
Cdd:cd17380 89 LPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 233 VYCMCKYLLnekeiiipledlvkglslskqtkvpwkqifkkaPVWAVIVAQLCAASTFFTLLSWLPTFFTETF-PDSKGW 311
Cdd:cd17380 169 ALVWLIYLP---------------------------------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVLvPLAKGW 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 312 IFNVVPWLVAIPTSLFSGFLSDQCINQGYKPITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGI 391
Cdd:cd17380 216 VFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGV 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 637298370 392 SVNIQDLAPSCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFLIFG 457
Cdd:cd17380 296 LVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
73-457 |
5.91e-105 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 317.64 E-value: 5.91e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAH----------------------FGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLL 130
Cdd:cd17318 12 YAMRVNLSVAIVAMVNStathdnnntstdkdtlpveapeFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 131 SATAWGCITAITPLFIYvgsAHLVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGS 210
Cdd:cd17318 92 SILITALLTLLTPLAAR---GGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 211 LLLDWYGWETVFYFSGLLTLLWvyCMCKYLLnekeiiipledlvkglslskqtkVPwkqifkkaPVWAVIVAQLCAASTF 290
Cdd:cd17318 169 FLCESLGWPSIFYIFGGLGLLW--CLLWFFL-----------------------VL--------PVWAIVVAHFGHNWGF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 291 FTLLSWLPTFFTET--FPDSKGWIFNVVPWLVAIPTSLFSGFLSDQCINQG-YKPITIRKFMQIVGLGISSIFALGIGY- 366
Cdd:cd17318 216 YTLLTELPTYMSDVlhFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGPGVFLIALGYl 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 367 TSSFCQAVVFASACIGFQTFNHSGISVNIQDLAPSCAGLLFGVANTGGALLGVVCVYLAGHLI---ESTGSWVSVFNLVA 443
Cdd:cd17318 296 GSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQTIGQWRIVFFISA 375
|
410
....*....|....
gi 637298370 444 TVNAVGLCTFLIFG 457
Cdd:cd17318 376 AIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
90-457 |
5.16e-46 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 164.57 E-value: 5.16e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 90 FGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLFIYVGSAHLVLMtfsRFFMGLFQGV 169
Cdd:cd17381 60 YDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAV---RALEGLGEGV 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 170 HFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMCKYLLnekeiiip 249
Cdd:cd17381 137 TFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM-------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 250 ledlvkglslskqtkvpwkqifkkaPVWAVIVAQLCAASTFFTLLSWLPTFFTET--FPDSKGWIFNVVPWLVAIPTSLF 327
Cdd:cd17381 209 -------------------------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEIlrFDIQENGFLSALPYLGCWLFMIL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 328 SGFLSDQCI-NQGYKPITIRKFMQIVGLGISSIFALGIGYTS-SFCQAVVFASACIGFQTFNHSGISVNIQDLAPSCAGL 405
Cdd:cd17381 264 SGQIADNLReKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGI 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 637298370 406 LFGVANTGGALLGVVCVYLAGHLIE--STGSWVSVFNLVATVNAVGLCTFLIFG 457
Cdd:cd17381 344 LLGITNTFATIPGMVGPVIAKSLTHnnTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
83-457 |
5.94e-45 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 161.35 E-value: 5.94e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 83 VVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLFIYVgsaHLVLMTFSRFF 162
Cdd:cd17382 37 VIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARV---HYGCVIFVRIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 163 MGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWvYCMckylln 242
Cdd:cd17382 114 QGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIW-YMF------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 243 ekeiiipledlvkglslskqtkvpWkqIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETF--PDSKGWIFNVVPWLV 320
Cdd:cd17382 187 ------------------------W--MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFgfDISKVGILSALPHLV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 321 AIPTSLFSGFLSDQCINQGYKPIT-IRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGISVNIQDLA 399
Cdd:cd17382 241 MTIIVPIGGQLADYLRSRGILSTTaVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIA 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 400 PSCAGLLFGVANTGGALLGVVCVYLAGHLI--ESTGSWVSVFNLVATVNAVGLCTFLIFG 457
Cdd:cd17382 321 PRYASILMGISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
76-461 |
1.89e-44 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 159.27 E-value: 1.89e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 76 RVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAitpLFIYVGSahLVL 155
Cdd:COG2271 26 RSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL---LFGFATS--FWQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 156 MTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYc 235
Cdd:COG2271 101 LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 236 mckyllnekeiiipledlvkglslskqtkvpwkqifkkAPVWAVIVAQLCAASTFFTLLSWLPTFFTET--FPDSKGWIF 313
Cdd:COG2271 180 --------------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVrgLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 314 NVVPWLVAIPTSLFSGFLSDqcinqgyKPITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGISV 393
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSD-------RLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 637298370 394 NIQDLAP-SCAGLLFGVANTGGALLGVVCVYLAGHLIESTGsWVSVFNLVATVNAVGLCTFLIFGKAHR 461
Cdd:COG2271 295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
73-455 |
1.03e-42 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 154.65 E-value: 1.03e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyVGSah 152
Cdd:cd17319 16 YLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF---ATS-- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 153 LVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLW 232
Cdd:cd17319 91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 233 VycmckyllnekeiiipledlvkglslskqtkVPWKQIFKKapVWAVIVAQLCAASTFFTLLSWLPTFFTETF---PDSK 309
Cdd:cd17319 171 A-------------------------------VLWWFYLRQ--VWGLALGYFGINYALYGLLTWLPTYLKQARgfsLKQV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 310 GWIfNVVPWLVAIPTSLFSGFLSDQCINQGykpitiRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHS 389
Cdd:cd17319 218 GLL-AAIPFLAGAIGMILGGRLSDRLLRGA------RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASP 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 637298370 390 GISVNIQDLAP-SCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFLI 455
Cdd:cd17319 291 VFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
77-420 |
1.73e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 129.08 E-value: 1.73e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 77 VTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWgcitAITPLFIYVGSAHLVLM 156
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLF----ALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 157 tFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWvyCM 236
Cdd:pfam07690 90 -VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLA--AV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 237 CKYLLNEKEiiiPLEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAqLCAASTFFTLLSWLPTFFTET-FPDSKGWIFNV 315
Cdd:pfam07690 167 LLLLPRPPP---ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLgLSALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 316 VPWLVAIPTSLFSGFLSDqcinqgykpITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACI---GFQTFNHSGIS 392
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSD---------RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgFGFGLVFPALN 313
|
330 340
....*....|....*....|....*....
gi 637298370 393 VNIQDLAP-SCAGLLFGVANTGGALLGVV 420
Cdd:pfam07690 314 ALVSDLAPkEERGTASGLYNTAGSLGGAL 342
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
90-466 |
5.63e-33 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 130.25 E-value: 5.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 90 FGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITPLFIYVGSAHL-VLMTFSRFFMGLFQG 168
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGM----FLSSVISIVIPWAAGGGiALVVFCRVIQGLAQG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 169 VHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLD-WYGWETVFYFSGL----LTLLWVY--------- 234
Cdd:TIGR00894 147 SVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEsWGGWPMIFYVFGIvgcaWSLLWFVfpaddpsih 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 235 -CMCKyllNEKEIIiplEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTET--FPDSKGW 311
Cdd:TIGR00894 227 pCISK---FEKKYI---NSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVlrVSGKENG 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 312 IFNVVPWLVAIPTSLFSGFLSDQCINQGYKPIT-IRKFMQIVGLGISSIFALGIGYTSS-FCQAVVFASACIGFQTFNHS 389
Cdd:TIGR00894 301 LLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTaARKIFNGIGGLGPGIFAYALPYLSAaFYLTIIILTLANAVSSGPLA 380
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 637298370 390 GISVNIQDLAPSCAGLLFGVANTGGALLGVVCVYLAGHL--IESTGSWVSVFNLVATVNAVGLCTFLIFGKAHRVDTDN 466
Cdd:TIGR00894 381 GVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNIlsQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAK 459
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
73-462 |
8.00e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 114.21 E-value: 8.00e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGcitaiTPLFIYVGSAH 152
Cdd:COG2223 18 FGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG-----IGLLLLALAVS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 153 LVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLW 232
Cdd:COG2223 93 YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 233 VYCMCKYLLNEKEIIIPLEdlvkglslsKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSK--G 310
Cdd:COG2223 173 AVLAWLFLRDPPAGAAAAA---------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAatA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 311 WIFNVVPWLVAIPTSLFSGFLSDQcinqgykpITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSG 390
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDR--------IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637298370 391 ISVNIQDLAPS-CAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGL-CTFLIFGKAHRV 462
Cdd:COG2223 316 VFALVPDIFPTkNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALvLTLLLYRRPRRA 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
85-418 |
1.14e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.15 E-value: 1.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMG 164
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 165 LFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMCKYLLNEK 244
Cdd:COG2814 110 LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 245 EiiipledlvkglSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETF---PDSKGWIFnVVPWLVA 321
Cdd:COG2814 190 P------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLglsASAAGLLL-ALFGLGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 322 IPTSLFSGFLSDQCinqGYKPITirkfmqIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGISVNIQDLAP- 400
Cdd:COG2814 257 VLGALLAGRLADRF---GRRRLL------LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPp 327
|
330
....*....|....*...
gi 637298370 401 SCAGLLFGVANTGGALLG 418
Cdd:COG2814 328 EARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
83-454 |
4.39e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.28 E-value: 4.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 83 VVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFF 162
Cdd:cd06174 19 LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 163 MGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDW--YGWETVFYFSGLLTLLWVYCMCKYL 240
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 241 LNEKEIIIPledlVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSK--GWIFNVVPW 318
Cdd:cd06174 174 PDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVavAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 319 LVAIPTSLFSGFLSDQCINqgykpitiRKFMQIVGLGISSIFALGIGYTSSFcQAVVFASACIGFQTFNHSGISVNIQDL 398
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSL-LLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 637298370 399 A--PSCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFL 454
Cdd:cd06174 321 LfpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
88-456 |
8.00e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.88 E-value: 8.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 88 AHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITPlFIYVGSAHLVLMTFSRFFMGLFQ 167
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL----LLLAVST-LLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 168 GVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSG---LLTLLWVYcmckYLLNEK 244
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAalaLLALVLAL----LLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 245 EIIIPledlvKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSK---GWIFNVVPwLVA 321
Cdd:cd17325 175 RPPPN-----KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPaqiGLLFGAQG-LAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 322 IPTSLFSGFLSDQcINqgykpitiRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGISVNIQDLAPS 401
Cdd:cd17325 249 ALSQPPAGKLSDR-IG--------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 637298370 402 CA-GLLFGVANTGGALLGVVCVYLAGHLIEsTGSWVSVFNLVATVNAVGLCTFLIF 456
Cdd:cd17325 320 EGrGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
85-418 |
2.90e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.06 E-value: 2.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMG 164
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-----APSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 165 LFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMCKYllnek 244
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 245 eiiipLEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETF---PDSKGWIFNVVpWLVA 321
Cdd:cd17324 174 -----LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPgfsSSAIIGLLLLF-GVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 322 IPTSLFSGFLSDQcinqgykpITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQtFNHSGISVNIQDLAPS 401
Cdd:cd17324 248 VVGSPLAGRLADR--------GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF-AAHSALQTRVLRLAPE 318
|
330 340
....*....|....*....|....
gi 637298370 402 CAGLLFG-------VANTGGALLG 418
Cdd:cd17324 319 ARGLASSlylaaynLGGALGAALG 342
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
83-450 |
1.78e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 77.64 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 83 VVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFF 162
Cdd:cd17316 24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL-----LPTPILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 163 MGLFQGVHFPALASLFSRKVRENER----SFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYcMCK 238
Cdd:cd17316 99 QGIGIGGEYPGASTYVAEFAPSKRRgfalGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALL-LRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 239 YllnekeiiipledlvkglslskqtkvpwkqifkkapVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGWIFNVVPW 318
Cdd:cd17316 178 R------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 319 --LVAIPTSLFSGFLSDqcinqgykpITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIgfQTFNHSGISVNIQ 396
Cdd:cd17316 222 isLGALVGALIAGLLSD---------RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI--LSFFVGGVWGALY 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 637298370 397 DLAP-----SCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGL 450
Cdd:cd17316 291 AYLAelfptEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
73-451 |
6.23e-15 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 76.16 E-value: 6.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITPLFIYVgSAH 152
Cdd:cd17312 16 YVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGL----LLSALANIFMGF-STS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 153 LVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLW 232
Cdd:cd17312 91 LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 233 VYCMCKYLLNEkeiiipledlvkglslskqtkvPWKqifkkapVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSK--- 309
Cdd:cd17312 171 AIILFFFLRDS----------------------PPY-------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLida 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 310 GWIFNVVPwLVAIPTSLFSGFLSDQCINQG-YKPITIRKFMQIVGLGISSIFALGIGYTSSF---CQAVVFASACIgfqt 385
Cdd:cd17312 222 GWFSSLYE-VGGIAGTILAGLLSDKLFGGRrAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLlflIGFFVGGPINL---- 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 637298370 386 fnhsgISVNI-QDLAPSCA-GLLFGVANTGGALLGVVCVYLAGHLIESTG-SWVSVFNLVATVNAVGLC 451
Cdd:cd17312 297 -----IGGAAaQDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYGwSTVFYFLISAALLSVLLL 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
73-427 |
8.48e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 75.88 E-value: 8.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWgcitAITPLFiYVGSAH 152
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILC----AIVNLF-FGFSTS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 153 LVLMTFSRFFMGLFQGVHFPA----LASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLldwYGWETVFYFSGLL 228
Cdd:TIGR00881 83 LWVMAALWALNGIFQGMGWPPcgrtVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAEL---YSWHWVFIVPGII 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 229 TLLWVYCMCKYLL--NEKEIIIPLEDL----------VKGLSLSKQTKVPWKQIFKKApVWAVIVAQLCAASTFFTLLSW 296
Cdd:TIGR00881 160 AIIVSLICFLLLRdsPQSCGLPPAEEMpneepdgdaeKKEEELTKKQIFLQYVLLNKV-LWYISLGYVFVYVVRTGILDW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 297 LPTFFTETFPDSK---GWIFnVVPWLVAIPTSLFSGFLSDQCINQGYKPIT-IRKFMQIVGLGISSIFALGIGYTSSFCq 372
Cdd:TIGR00881 239 SPLYLTQEKGFSKekaSWAF-TLYELGGLVGTLLAGWLSDKLFNGRRGPLAvFFMALIIVSLLVYWLNPAANPLMDLIC- 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 373 avVFASACIGFQTFNHSGISVNiqDLAPS-CAGLLFGV----ANTGGALLGVVCVYLAGH 427
Cdd:TIGR00881 317 --LFALGFLVYGPQMLIGVIAS--ELAPKkAAGTAAGFvgffAYLGGILAGLPLGYLADG 372
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
85-383 |
8.81e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 75.86 E-value: 8.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLS-------ATAWGCITAITPLFIYvgsahlvlmt 157
Cdd:TIGR00895 42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSillfsvfTLLCALATNVTQLLIL---------- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 158 fsRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMC 237
Cdd:TIGR00895 112 --RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLM 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 238 KYL------LNEKEIIIPLEDLVK-----------GLSLSKQTKVPWKQIFK--KAPVWAVI-----VAQLCAASTFFTL 293
Cdd:TIGR00895 190 RFLpesidfLVSKRPETVRRIVNAiapqmqaeaqsALPEQKSTQGTKRSVFKalFQGKTARItvllwLLYFMLLVGVYFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 294 LSWLPTFFTET-FPDSKGWIFNVVPWLVAIPTSLFSGFLSDQcinqgYKPITIrkfmqIVGLGISSIFALGIGYTSSFCQ 372
Cdd:TIGR00895 270 TNWLPKLMVELgFSLSLAATGGALFNFGGVIGSIIFGWLADR-----LGPRVT-----ALLLLLGAVFAVLVGSTLFSPT 339
|
330
....*....|.
gi 637298370 373 AVVFASACIGF 383
Cdd:TIGR00895 340 LLLLLGAIAGF 350
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
85-460 |
1.23e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.29 E-value: 1.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawGCITAITPLFIYVGSAhlVLMTFSRFFMG 164
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL---LLLAAGLLLRSLAPSV--ALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 165 LFQGVHFPALASLFSRKVRENeRSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLwvycmckYLLnek 244
Cdd:COG2807 118 AGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL-------ALL--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 245 eIIIPLEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTET-FPDSK-GWIFNVVPwLVAI 322
Cdd:COG2807 187 -LWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAgLSAATaGLLLSLFQ-LAGI 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 323 PTSLFSGFLSDQCINQgykpitiRKFMQIVG-LGISSIFALGIGYTSSFCQAVVFASACIGFqTFnhSGISVNIQDLAPS 401
Cdd:COG2807 265 PGSLLVPLLADRLGDR-------RPLLLLLGlLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG-LF--PLALTLIGLRART 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 637298370 402 C--AGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFLIFGKAH 460
Cdd:COG2807 335 PaeAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
85-331 |
1.74e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 73.69 E-value: 1.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMG 164
Cdd:COG0477 39 SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 165 LFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMckYLLNEK 244
Cdd:COG0477 114 IGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLR--LRLPES 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 245 EIIIPLEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGWIFNVVPWLVAIPT 324
Cdd:COG0477 192 RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLL 271
|
....*..
gi 637298370 325 SLFSGFL 331
Cdd:COG0477 272 LALLLAL 278
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
86-379 |
2.37e-13 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 71.53 E-value: 2.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 86 MSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMGL 165
Cdd:PRK11551 41 MAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQ-----AWDFPSLLVARLLTGV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 166 FQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLwvycmckyllneke 245
Cdd:PRK11551 116 GLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLL-------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 246 iIIPLedLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAAST-------FFT------LLSWLPTFFTE---TFPDSk 309
Cdd:PRK11551 182 -LVPL--LMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATATlllwisyFFTlivlyfLLNWLPSLLVGqglSRSQA- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 310 GWI---FNVvpwlVAIPTSLFSGFLSDQCinqgyKPITIRKFM------QIVGLGISSIF------ALGIGYTSSFCQAV 374
Cdd:PRK11551 258 GLVqiaFNI----GGALGSLLIGALMDRL-----RPRRVVLLIyagilaSLAALAAAPSFagmllaGFAAGLFVVGGQSV 328
|
....*
gi 637298370 375 VFASA 379
Cdd:PRK11551 329 LYALA 333
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
86-231 |
4.67e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.30 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 86 MSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAwgcITAITPLFIYVGSahLVLMTFSRFFMGL 165
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL---SAVALLLLPLATS--FWLLLLLLALLGL 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 637298370 166 FQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLL 231
Cdd:cd17325 301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
85-454 |
1.58e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 68.76 E-value: 1.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSatawgcitaitpLFIYVGSAHLVLMT------- 157
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAG------------LLLFILASLLCALAssieqll 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 158 FSRFFMGLFQGVhfpalASLFSRKV-----RENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYF-SGLLTLL 231
Cdd:cd17320 92 IARFLQGLGAAA-----GSVVARAIvrdlySGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFlALLGLLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 232 WVYCMckYLLNEKeiiIPLEdlvKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETF---PDS 308
Cdd:cd17320 167 LLLVL--LFLPET---LPEE---KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLglsPAQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 309 KGWIFnvvpwLVAIPTSLFSGFLSDQCINQgykpITIRKFMqIVGLGISSIFALGI------GYTSSFCQAVVFASACIG 382
Cdd:cd17320 239 FGLLF-----ALNAIALILGSLLNGRLVRR----FGPRRLL-RLGLLLLLAAALVLllaallGGLSLWPLVAPLFLIFFG 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 637298370 383 FQTfnhsgISVNIQDLA----PSCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFL 454
Cdd:cd17320 309 FGL-----IFPNATSLAlepfPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
99-333 |
2.47e-12 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 68.43 E-value: 2.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 99 VVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITpLFIYVGSAHLVLmtfsRFFMGLFQGVHFPALASLF 178
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT-AAVKNFGGLIAL----RFFLGLFESGVFPGFILYL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 179 SRKVRENER----SFTYSTVGTGSQFGTLV------MGAAGSLlldwYGWETVFYFSGLLTLLW-VYC-------MCK-Y 239
Cdd:cd17327 120 GMWYKREEQakriAFFYAAAGLGSIFGGLLaygvfkILGVGGL----AGWRWLFIIEGLITIIIgLVIffwlpdnPSKaW 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 240 LLNEKEIIIPLEDLV---KGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDS-KGWIFNV 315
Cdd:cd17327 196 FLTEEEKELAVERLRanqTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSlQTNLLSV 275
|
250
....*....|....*...
gi 637298370 316 VPWLVAIPTSLFSGFLSD 333
Cdd:cd17327 276 PIGALGAVSLLIAALLSD 293
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
90-454 |
4.61e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.26 E-value: 4.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 90 FGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIgGEKVLLLSATAwgcITAITPLFIYVGSAHLVLMTFsRFFMGLFQGV 169
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRF-GERRVLAVGLL---LMGAAALLMALVGSYPVLLVL-LFLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 170 HFPALASLFSRKVRENERSFTYSTVGTGSQFGtlvmGAAGSLLLDW----YGWETVFYFSGLLTLLWVYCmckYLLNEKE 245
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALLPPlalhYGWRAAFVVAGLVSILAAVL---FWLFYRE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 246 iiIPLEDLVKGLSLSKQTKVpwKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETF---PDSKGWIFNVVPWLvAI 322
Cdd:cd17475 174 --PPAASAATESASTLLRSL--KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLglsVVAAGALLAVAQLG-GA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 323 PTSLFSGFLSDQCINQGYKPITirKFMQIVGLGISSIFALGIGYTSSFcqAVVFASACIGFQTFNHSGISVN-IQDLAP- 400
Cdd:cd17475 249 LGRIGLGRVSDRVFGGRRRPVL--VITAAIAAAALLVLSLLSPGTPLW--LLVLLLILLGLFAIGWNGLYLTlVAESAGp 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 637298370 401 SCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFL 454
Cdd:cd17475 325 EQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
77-435 |
2.56e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.94 E-value: 2.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 77 VTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAitpLFIYVGSAHLVLM 156
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA---LLGFAHSPWLFAI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 157 TFsrFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDwYGWETVFYFSGLLTLLwvYCM 236
Cdd:cd17329 94 AL--VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLL--AAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 237 CKYLLnekeiiIPLEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSkgwiFNVV 316
Cdd:cd17329 169 VLLFL------LPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG----ESLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 317 PWLVAIPTSLFSGFLSdqCINQGYKPITIRKFMqIVGLGISSIFALGIGYTSSFCQAVVFASAC-IGfQTFNHSGISVNI 395
Cdd:cd17329 239 GLLLALNALLIVLLQF--PVARLVERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLILAMIVLtLG-EMLVFPAVQTLV 314
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 637298370 396 QDLAP-SCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSW 435
Cdd:cd17329 315 AALAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
85-427 |
7.86e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.72 E-value: 7.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITpLFIYVGSAHLVLMTFSRFFMG 164
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL----LLMALG-LLLFALAPSYPLLLLALFLLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 165 LFQGVHFPALASLFSRKVRENERSFTySTVGTGSQFGTLVMGAAGSLLLDW---YGWETVFYFSGLLTLLWVYCMckyll 241
Cdd:COG0738 108 LGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLF----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 242 nekeIIIPLEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETF--PDSKGWIFNVVPWL 319
Cdd:COG0738 182 ----LRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLglSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 320 VAIPTSLFSGFLSDQcinqgykpITIRKFMqIVGLGISSIFALGIGYTSSFCQAVVFASAC-----IGFQTFNHSGISvN 394
Cdd:COG0738 258 GMTIGRFLGGFLLKR--------FGPVRLL-RLSALLAAVGLLLALLAPGPWLALIGLALVglglsLMFPTIFSLALD-G 327
|
330 340 350
....*....|....*....|....*....|...
gi 637298370 395 IQDLAPSCAGLLFGVANTGGALLGVVCVYLAGH 427
Cdd:COG0738 328 LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
96-454 |
5.23e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 5.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 96 QSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITPLFiYVGSAHLVLMTFSRFFMGLFQGVHFPALA 175
Cdd:cd17489 32 VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGL----LIFALATLL-YLLATSVALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 176 SLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMckyllnekeIIIPLEDLVK 255
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV---------FLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 256 GlSLSKQTKVPWKQIFKKApVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGWIFNVVPwLVAIPTSLFSGFLSDQc 335
Cdd:cd17489 178 A-EEAEAGTRAFRRLVEKK-VLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA-IALLLSRPFSGKLSDR- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 336 inqgykpiTIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASAC-IGFQTFNHSGISVNIQDLAPSCAGLLFGVANTGG 414
Cdd:cd17489 254 --------KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYgLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFF 325
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 637298370 415 ALLGVVCVYLAGHLIESTG-SWVSVFNLVATVNAVGLCTFL 454
Cdd:cd17489 326 DLGIGLGGLLLGLVAELFGyRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
85-455 |
1.31e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.52 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMG 164
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF-----AQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 165 LFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLlwvycmckyllnek 244
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL-------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 245 eIIIPLedLVKGLSLskqtkvpwkqifkkapvWAVIVAQLCAastFFTLLSWLPTFFTET-FPDSKGWIFNVVPWLVAIP 323
Cdd:cd17365 165 -ILLPL--LRGTLLL-----------------WVTFFMGLLL---VYLLNSWLPKLMVEAgYSLSQALTITLLLNIGGVI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 324 TSLFSGFLSDQcINqgykpitiRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFnhsGISVNIQDLAP--- 400
Cdd:cd17365 222 GSLLLGWLADR-FG--------PKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVN---GAQVGLYALAArfy 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 637298370 401 --SCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVG-LCTFLI 455
Cdd:cd17365 290 ptEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGaLAVLLL 347
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
85-333 |
1.45e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 59.62 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLS---ATAWGCITAITPLFIyvgsaHLVLMtfsRF 161
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITillFAVFTLLCGFAQNYW-----QLLIL---RA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 162 FMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWY----GWETVFYFSGLLTLLWVYcmC 237
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFLLGALPALLVLF--I 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 238 KYLLNEKEIIIPledlVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQL---CAASTFFTLLSWLPTFFTETFPDSKGW--I 312
Cdd:cd17371 174 RRFVKEPPQWQA----ARAARRHFADRPSLRELFSPPLLRTTLLASLlatGALGGYYGITTWLPSYLTGERGLSFEGsaG 249
|
250 260
....*....|....*....|.
gi 637298370 313 FNVVPWLVAIPTSLFSGFLSD 333
Cdd:cd17371 250 YLVVTILGGFLGYLAGGFLAD 270
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
73-389 |
4.77e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.02 E-value: 4.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAH 152
Cdd:cd17328 12 YMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 153 LVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLD-WYGWETVFYFSGLLTLL 231
Cdd:cd17328 87 FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 232 WVyCMCKYLLNEKEIIIPlEDLVKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSK-- 309
Cdd:cd17328 167 LA-ILLLLFVREPPRGAA-EGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDls 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 310 ----GWIFNVVPWLVAIPTSLFSGFLSDQCinqGYKPITIRKFMQIVGLGISSIFALGIGYTSSfcQAVVFASACIGFQT 385
Cdd:cd17328 245 sadvGLIFGAITCIAGVLGVLLGGILADRL---RRKTPRADPLVCAVGLLAAAPFLFLALVLAL--SNLLLAWVLLFLGE 319
|
....
gi 637298370 386 FNHS 389
Cdd:cd17328 320 FLLS 323
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
110-455 |
5.78e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 5.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 110 VTQIIGGHLSDRIGGEK-----VLLLSATAWGCITAITPLFIYVG-SAHLVLMTFSRFFMGLFQGVHFPALASLFSRKVR 183
Cdd:COG2211 61 ITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSpTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 184 E-NERSFTYSTVGTGSQFGTLVMGAAGSLLLDWY------GWETVFYFSGLLTLLWVYCMCKYLlneKEIIIPLEDLVKG 256
Cdd:COG2211 141 DyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGT---KERPVPEEEKVSL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 257 LSLskqtkvpWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGW--IFNVVPWLVAIPTSLFSGFLSDq 334
Cdd:COG2211 218 KES-------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALvgLLLALYFLAALLGAPLWPRLAK- 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 335 cinqgykpITIRKFMQIVGLGISSIFALG---IGYTSSFCQAVVFASACIGFQTFNhsGISVNIQ-DLAP--------SC 402
Cdd:COG2211 290 --------RFGKKKAFIIGLLLAALGLLLlffLGPGNLWLLLVLAALAGIGLGAIL--VLPWAMLaDVVDydewktgrRR 359
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 637298370 403 AGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFNLVATVNAVGLCTFLI 455
Cdd:COG2211 360 EGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
98-240 |
5.81e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 54.58 E-value: 5.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 98 GVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMGLFQGVHFPALASL 177
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFAL-----SSNITVLIIARFLQGFGAAFALVAGAAL 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 637298370 178 FSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMCKYL 240
Cdd:TIGR00880 76 IADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
97-454 |
1.86e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.02 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 97 SGVVLSSFFwgycvtqiigGHLSDRIGGEKVLLLSATAWGCITAItpLFIYVGSaHLVLMTFSRFFMGLFqGVHFP---A 173
Cdd:cd17471 44 SGIVVSQWL----------GRLSDRGGDRKPLILLALLAGALGYL--LFAFLRN-YWVLLLVGVVLLSLG-AAAFPqlfA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 174 LASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSG---LLTLLWVYCMckyllnekeiiIPL 250
Cdd:cd17471 110 LAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAAllyLVVALLVLFL-----------LPS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 251 EDLVKGLSLSKQTKVPWKqifKKAPVWAVIVAqlcaastfFTLLSW--------LPTFFTETFPDSK---GWIFNVVPwL 319
Cdd:cd17471 179 VKPPAQKATPASSLVKAP---VNRRLLLLFAA--------FTLLFAansmyiiaMPLYVTNELGGSEswvGLLFGLAA-A 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 320 VAIPTSLFSGFLSDQcinqgykpITIRKFMqIVGLGISSIFALGIGYTSSFCQAV---VFASACIGFQtfnhSGISVNI- 395
Cdd:cd17471 247 LEIPIMLLAGLLAKR--------FGKRRLL-LAGFLAGVLFYLGLALATSLWQLIalqLLNAIFIGIT----AGLGISYf 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 637298370 396 QDLAPSCAGL---LFGVANTGGALLGvvcvYLAGHLIESTGSWVSVFNLVATVNAVGLCTFL 454
Cdd:cd17471 314 QDLMPGQPGLattLYSNASRIGSLLG----GLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
86-420 |
2.02e-08 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 56.10 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 86 MSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKV----LLLSAtawgcITAITPLFIYVGSAHLVLMTFSRF 161
Cdd:cd17345 29 LIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFlaigLILSA-----IINILIGFVPSATSSVGLMFILLF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 162 FMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYG---WETVFYFSGLLTLLwVYCMCK 238
Cdd:cd17345 104 LNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAII-VAVIVL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 239 YLL----------------NEKEIIIPLEDLVKGLSlSKQtkVPWKQIFKKAPVWAVivaqlCAASTF-----FTLLSWL 297
Cdd:cd17345 183 FLGkdtpeseglppieeykGDYPEEADGEEEEQELS-AWE--IFVKYVLKNKLLWYI-----AIANVFvylvrYGILDWA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 298 PTFFTETFPDSKG---WIFNVVPWlVAIPTSLFSGFLSDQcINQGYKPITIRKFMQIVglgissIFALgIGYTSSFCQAV 374
Cdd:cd17345 255 PTYLSEVKGFSKAqamWAFSLFEW-AAIPGTLLAGWLSDK-LFKGRRAPTGIIFMILV------IVAL-IVYWLAPNVLV 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 637298370 375 VFASA-CIGF-----QTFnhsgISVNIQDLAP-----SCAGL------LFGvANTGGALLGVV 420
Cdd:cd17345 326 DLIALiALGFliygpVML----IGLQALELVPkkaagTAAGLtglfgyLGG-SVLATALIGII 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
85-332 |
2.12e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 2.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSatawgcitaitpLFIYVGSAHLVLMTFS-RFFM 163
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG------------LLLFGIGGLLCGLSDSfALLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 164 GL--FQGV---HFPALA-----SLFSrkvrENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWyGWETVFYFSGLLTLLWV 233
Cdd:cd17474 92 AGraLQGIgaaGLGPLAltligDLFE----GGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 234 YCMCKYLLNEKEiiipledlvKGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDS---KG 310
Cdd:cd17474 167 LAILFLLPEPKE---------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISpiiIG 237
|
250 260
....*....|....*....|...
gi 637298370 311 WIFnvVPWLVA-IPTSLFSGFLS 332
Cdd:cd17474 238 LLF--AGWSVLlALGSLFVGRLL 258
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
76-451 |
3.65e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.35 E-value: 3.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 76 RVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVL 155
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL-----ATSLWQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 156 MTFSRFFMGLFQ-GVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVY 234
Cdd:cd17355 94 LYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 235 CMCKYLLNEKEIIIPLEDLVKGLSLSKQTkvpWKQIFKKAPVWAVIVAQ-LCAASTFFTLLSwLPTFFTETF--PDSKGW 311
Cdd:cd17355 174 PVLLLLRRRPADLALRAYDDASPASPGST---LKEALRSASFWLLALAFfLCGFAVVGLIVH-LVPYLADRGisPAAAAV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 312 IFNVVpWLVAIPTSLFSGFLSDqcinQGYKPITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGI 391
Cdd:cd17355 250 ALALI-GLFNIVGRLLSGWLGD----RYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 392 SVNIQdlaPSCAGLLFGVANTGGALLGVVCVYLAGHLIESTGSWVSVFnlvatVNAVGLC 451
Cdd:cd17355 325 ARYFG---ARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAW-----ALAVALG 376
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
98-433 |
7.50e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 7.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 98 GVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLFIYVGSAHLVLMTFSRFFMGLFQGVHFPALASL 177
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 178 FSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMC-----KYLLNEKEIIIPLED 252
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLfirrpPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 253 LVKGLSLSKQTKvpwkqifkkaPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGW--IFNVVPWLVAIPTSLFSGF 330
Cdd:cd06173 197 LREGLRYLRRSP----------LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGygLLLAAFGVGALLGALLLGR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 331 LSdqcinqgyKPITIRKFMqIVGLGISSIFALGIGYTSSFCQAVV-FASACIGFQTFNHSGISVNIQDLAPSCAGLLFGV 409
Cdd:cd06173 267 LS--------KRRRRGRLL-LIGALLLGLALLVLGLSPSLWLLLAaLFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV 337
|
330 340
....*....|....*....|....
gi 637298370 410 ANTGGALLGVVCVYLAGHLIESTG 433
Cdd:cd06173 338 YNALNSGAMPLGALLAGLLADALG 361
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
108-231 |
2.98e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 108 YCVTQIIGGHLSDRIGGEKVLLLsatawGCITAITPLFIYVGSAHLVLMTFSRFFMGLFQGVHFPALASLFSRKVRENER 187
Cdd:cd17370 247 YALAAYPAGRLSDRIGRKKLLIL-----GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR 321
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 637298370 188 SFTY----STVGTGSQFGTLVMGaagsLLLDWYGWETVFYFSGLLTLL 231
Cdd:cd17370 322 GTAYglfnTVVGIGWLLASLIAG----YLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
116-456 |
3.71e-07 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 52.30 E-value: 3.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 116 GHLSDRIGGEKVLLLSAT---AWGCITAITPLFIYVGSAHLVLMTFSRFFMGLFQGVHFPALASLFSRKVRENER----S 188
Cdd:cd17367 61 GRLADRIGRRAALTLSVSlmaAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRgfysS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 189 FTYSTVGTGSQFGTLVMGAAGSLL----LDWYGWETVFYFSGLLTLLWVYcmckyllnekeiiipledLVKGLSLSKQTK 264
Cdd:cd17367 141 FQYVTLIGGQLLALGVLLVLQHTLgedqMAAWGWRIPFLLGGVLAVVVLW------------------LRRGLEETESFE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 265 VPWKQIFKKAPVW---------AVIVAQLCAAST--FFTLLSWLPTFFTETFPDSKGWIF--NVVPWLVAIPTSLFSGFL 331
Cdd:cd17367 203 AIAESNEASAGTLrelrrhpreLLLVVGLTAGGTlaFYTWTTYLQKFLVNTAGFSKGDATwiTTAALLVFMLLQPLGGRL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 332 SDQcinqgykpITIRKFMQIVG-LGISSIFAL--GIGYTSSFCQAVVFASACIGFQTFNHSGISVNIQDLAP-----SCA 403
Cdd:cd17367 283 SDR--------IGRRPLLLFFGiGGTLATVPLlsALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPthvraLGV 354
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 637298370 404 GLLFGVANtggALLGVVCVYLAGHLIESTGSWVSVFnLVATVNAVGLCTFLIF 456
Cdd:cd17367 355 GLPYALAV---AIFGGTAPYVALWLKSIGHEWVFFW-YVAGLIAISLVVYLRM 403
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
96-231 |
4.73e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.81 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 96 QSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgcITAITPLFIYVGSAHLVLMTFSRFFMGLFQGVhFPALA 175
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSL-----AGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVAQ 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 637298370 176 SLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLL 231
Cdd:cd17330 109 AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
73-231 |
7.70e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 50.87 E-value: 7.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 73 YCTRVTMPICVVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITaitplfIYVG-SA 151
Cdd:cd17488 16 YLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN------ILFGfSS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 152 HLVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLL 231
Cdd:cd17488 90 SLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAIL 169
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
113-454 |
3.05e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 49.45 E-value: 3.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 113 IIGGHLSDRIGGEKVLLLSATAWGCITA---ITPLFIYVGSAHLVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSF 189
Cdd:cd17369 62 VVFGHFGDRIGRKKTLVLTLLLMGIATFligLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 190 TYSTVGTGSQFG----TLVMGAAGSLL-----LDWyGWETVFYFSGLLTLLWVYCMCKylLNEKEIIIPLEDLVkglsls 260
Cdd:cd17369 142 YGSFPQLGAPVGlllaTGVFLLLSALLsdeafLSW-GWRIPFLLSAVLVAVGLYIRLR--LEETPVFRRAKEAG------ 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 261 KQTKVPWKQIFKKAP--VWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGWIFNVVPW--LVAIPTSLFSGFLSDQcI 336
Cdd:cd17369 213 QVVRAPLVEVLRRHWraLLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIasVVAAITIPLFGWLSDR-V 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 337 NqgykpitiRKFMQIVGLGISSIFA----LGIGYTSSFcqAVVFASACIGFqtFNHSGIsvniqdLAPSCAGL--LF--- 407
Cdd:cd17369 292 G--------RRPVYLAGALLAALFAfpffWLLDTGSTW--LIVLAAVVVLG--VLHGMM------YGPQAAFLaeLFptr 353
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 637298370 408 ----GVA---NTGGALLGVVCVYLAGHLIESTGSWVSVfnlVATVNAVGLCTFL 454
Cdd:cd17369 354 vrytGASlgyQLGAILGGGFAPLIATALVAATGSWWPV---ALYLAALAVISLV 404
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
98-236 |
8.89e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.91 E-value: 8.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 98 GVVLSSFFWgyCVTQIIGGHLSDRIGGEKVLLLSATAwgCITAITPLFIYVGSAHLVLMTFS-----RFFMGLFQGVHFP 172
Cdd:cd17369 269 AVLIASVVA--AITIPLFGWLSDRVGRRPVYLAGALL--AALFAFPFFWLLDTGSTWLIVLAavvvlGVLHGMMYGPQAA 344
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 637298370 173 ALASLFSRKVRenersftYSTVGTGSQFGTLVMGA-----AGSLLLDWYGWETVFYFSGLLTLLWVYCM 236
Cdd:cd17369 345 FLAELFPTRVR-------YTGASLGYQLGAILGGGfapliATALVAATGSWWPVALYLAALAVISLVAA 406
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
86-454 |
1.83e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 86 MSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLFiyvgsAHLVLMTFSRFFMGL 165
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA-----PNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 166 FQGVHFPALASLFSRkVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMCKYLLNEKE 245
Cdd:cd17478 97 GSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 246 IIIPLEDLVKGLSLSKQTKVPWkqifkkAPVWAVIVAQlcaASTFFTLLSWLPTFFTETF--PDSKGWIFNVVPWLVAIp 323
Cdd:cd17478 176 EAKKAAAKSSARSTLKGVWRAL------LLLLIIVFLR---SWVLSSLTTFLPFYLVQRGysLVFAGLLLSLFLFAGAI- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 324 TSLFSGFLSDQcINqgykpitiRKFMQIVGLGISSIFALGIGYTSSFcqAVVFASACIGFqtFNHSGISVNI---QDLAP 400
Cdd:cd17478 246 GTLIGGPLSDR-FG--------RRRVIIASLLLAAPFLLLFLLTPGI--WSYILLVLAGF--LLFASFPVTVvlaQELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 637298370 401 S----CAGLLFGVANTGGALLGVVCVYLAGHliestGSWVSVFNLVATVNAVGLCTFL 454
Cdd:cd17478 313 GnvglASGLMMGLSFGLGGIGAPVLGALADA-----FGLESVLLILALLPLLGALLAF 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
83-235 |
1.89e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 83 VVAMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawGCITAITPLFIYVGSAHLVLMTFsrFF 162
Cdd:COG0738 234 PLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA---LLAAVGLLLALLAPGPWLALIGL--AL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 637298370 163 MGLFQGVHFPALASLFSRKVRENeRSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYC 235
Cdd:COG0738 309 VGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
89-253 |
1.92e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 89 HFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAitpLFIYVGSAHLVLMTFSRFFMGLFQG 168
Cdd:COG2211 258 VLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL---LLFFLGPGNLWLLLVLAALAGIGLG 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 169 VHFPALASLFS-------RKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWE---------------TVFYFSG 226
Cdd:COG2211 335 AILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgirlLFFLLPA 414
|
170 180
....*....|....*....|....*..
gi 637298370 227 LLTLLWVYCMCKYLLNEKEIIIPLEDL 253
Cdd:COG2211 415 VLLLLAALLLLFYPLTRERHAEIRAEL 441
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
86-238 |
4.42e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 86 MSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLsataWGCITAITPLFIYVGSAHLVLMTFSRFFMGL 165
Cdd:cd17330 201 LKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLR----LGLLLAIIGLLLLPFASSVPLLVLAAAILAF 276
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637298370 166 FQGVHFPALASLFSRKVRENERSfTYSTVGTGSQFGTLVMG-AAGSLLLDWYGWETVFYFSGLLTLLWVYCMCK 238
Cdd:cd17330 277 GTGIVFPALSALLSKSVPSKEQG-KAQGIIQSLQSLARIIGpLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
89-231 |
8.10e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 8.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 89 HFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITPLFIYVGSAHLVLMTFSRFFMGLFQG 168
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA----LLGALAALLLPLVPGLPLALLVLLFLWGGAAG 292
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637298370 169 VHFP-ALASLFSRkVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLL 231
Cdd:cd17477 293 PLYTlALALAGDR-LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
97-288 |
1.70e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 97 SGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAwgciTAITPLFI-YVGSAH-LVLMtfsRFFMGLFQGvHFPAL 174
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLG----MAIVIGLMaFVTNVWqLLIL---RLLQGVFSG-YVPNA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 175 ASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSG-------LLTLLWVycmckyllneKEII 247
Cdd:cd17391 110 TALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGgllflafLLTLFFV----------KEDF 179
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 637298370 248 IPLEdlvKGLSLSkqTKVPWKQIFKKAPVWAVIVA----QLCAAS 288
Cdd:cd17391 180 KPVE---KKKMVS--TKEVWNSVPNPSLLISLFVTtfiiQLANQS 219
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
93-459 |
1.76e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 43.86 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 93 DKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGeKVLLLSATAWGCITAItplfIYVGSAHLVLMTFSRFFMGLFQGVHFP 172
Cdd:cd17343 36 DKSDLGLITSSQSLAYAISKFIGGVLSDQISA-RWLFSSGLVLSGLTTV----AFSGSSSVWVFSILWFLNGLAQGLGWP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 173 ALASLFSRKVRENERSFTYSTVGTGSQfgtlVMGAAGSLLLDW----YGWETVFYFSGLLTLLWVYCmCKYLLNEKEIII 248
Cdd:cd17343 111 PCAKILRKWFSPSQFGTWWSVLSTSMN----LAGSLGPILATLlalsYGWRSTLSISGTVAVVMSVV-CLLFIKNEPSDV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 249 PLEDLVKGLSLSKQTKVP-----WKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSK--GWIFNVVPWLVA 321
Cdd:cd17343 186 GLNNIEEEESKGKKKKSPrgestLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSAltGSSFMSSLEVGG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 322 IPTSLFSGFLSDQCI----NQGYKPITI---RKFMQIVGLGISSiFALGIGYTSS--FCQAVVFASACIGFQTFNHSGI- 391
Cdd:cd17343 266 FVGSIAAGYLSDWAVakhgSSSRGNPRMplaLVFMAGLTVSLHL-FRVHITSDSSelFILLLGFLIGFSLYGPIAIFGVi 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 637298370 392 -----SVNIQDLAPSCAGLLfgvANTGGALLGVVCVYLAGHLiestgSWVSVFNLVATVNAVGLCTFLIFGKA 459
Cdd:cd17343 345 anesaPSHLCGTSHAIVALA---ANVGGVLAGLPFSYIAKHY-----DWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
97-250 |
1.91e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.76 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 97 SGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAITPLfiyvgSAHLVLMTFSRFFMGLFQGVhFPALAS 176
Cdd:PRK09874 56 SGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL-----AQNIWQFLILRALLGLLGGF-VPNANA 129
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637298370 177 LFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLwvyCMCKYLLNEKEIIIPL 250
Cdd:PRK09874 130 LIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFL---CFLVTLFCIRENFQPV 200
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
85-231 |
2.48e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.32 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSA---TAWGCITAITPlfiyvgsaHLVLMTFSRF 161
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLalfGLASLLCALAP--------SLAFLIAARA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 162 FMGLFQGVHFPALASLFSRKVRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLL 231
Cdd:cd17321 93 LQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
279-461 |
6.06e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 6.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 279 VIVAQLCAASTFFTLLSWLPTFFTETF---PDSKGWIFNVVPWLVAIpTSLFSGFLSDQcinqgykpITIRKFMqIVGLG 355
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLgisPTEIGLLLTLFSLGYAL-AQPLAGRLSDR--------FGRRRVL-LIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 356 ISSIFALGIGYTSSFCQAVVFASACIGFQTFNHSGISVNIQDLAPSCA-GLLFGVANTGGALLGVVCVYLAGHLIESTGs 434
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFG- 149
|
170 180
....*....|....*....|....*..
gi 637298370 435 WVSVFNLVATVNAVGLCTFLIFGKAHR 461
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPE 176
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
99-192 |
6.08e-04 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 42.24 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 99 VVLSSFFWgycvtQIIGGHLSDRIgGEKVLLLSATAWGCITAITPLFIYVGS---AHL--VLMTFSrFFMGLFQGVHFPA 173
Cdd:PRK15075 283 VGVSNFIW-----LPIGGALSDRI-GRRPVLIAFTVLAILTAYPALSWLVAApsfARMlaVELWLS-FLYGSYNGAMVVA 355
|
90
....*....|....*....
gi 637298370 174 LASLFSRKVRENERSFTYS 192
Cdd:PRK15075 356 LTEVMPAEVRTAGFSLAYS 374
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
114-212 |
7.44e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.59 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 114 IGGHLSDRIGGEKVLLLSATAWgcITAITPLFIYVGSAH------LVLMTFSrFFMGLFQGVHFPALASLFSRKVRENER 187
Cdd:cd17368 277 LGGALSDRIGRRPVLLVITLAA--LVTLYPVFAWLTAAPsfgrllLVLLVLS-FFFGMYGGAMVVALVELFPVRVRSTGF 353
|
90 100 110
....*....|....*....|....*....|
gi 637298370 188 SFTYSTV-----GTGSQFGTLVMGAAGSLL 212
Cdd:cd17368 354 SLVYALAvaifgGFAQFIVTWLIELTGSPL 383
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
98-430 |
1.13e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 98 GVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSATAWGCITAI---TPLFIYVgsahLVLMTFSRFFMGLFQGVHFPAL 174
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALifaTPSIYLF----VVLMFLAGLGAGILDTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 175 ASLFSRKvRENERSFTYSTVGTGSQFGTLVMGAAGSLLLDWYgweTVFYFSGLLTLLWVycMCKYLLNEKEiiipLEDLV 254
Cdd:cd17333 110 GALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWS---WAYLIIGLIYLLLA--ILILLTLFPE----LPSAR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 255 KGLSLSKQTKVPWKQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPDSKGWIFNVVP--WLVAIPTSLFSGFLS 332
Cdd:cd17333 180 NPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSgfWVGITIGRLLGGPIS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 333 DQcinqgykpITIRKFMQIVGLGISSIFALGIGYTSSFCQAVVFasACIG------FQTFNHSGISvNIQDLAPSCAGLL 406
Cdd:cd17333 260 RR--------IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVAT--ALLGlfmaalFPTILSLGIS-NLPYAKGKGTSVL 328
|
330 340
....*....|....*....|....
gi 637298370 407 FGVANTGGAllgvVCVYLAGHLIE 430
Cdd:cd17333 329 LAAGSIGGA----IIPFIMGFIAE 348
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
77-303 |
1.29e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 77 VTMPICVVAMsAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSAtawgCITAITPLFIYVgSAHLVLM 156
Cdd:cd17477 14 LLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGA----AITAVSVLLLAL-TDSPWVW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 157 TFSRFFMGLFQGVHFPALASLFSRKVRENER---SFTYSTVGTGSQfgtlvmgAAGSLLLDWYGWE--TVFYFSGLLTLL 231
Cdd:cd17477 88 FLLRFVMGIGLAGLFVVSESWLNALATNENRgrvLGLYSTVLGLGF-------ALGPLLLALVGTAgaLPFLIAAVLLLL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 637298370 232 WVYCMCKYLLNEKEIiipledlvkglslSKQTKVPWKQIFKKAPVwAVIVAqLCAASTFFTLLSWLPTFFTE 303
Cdd:cd17477 161 ALVPLLLTRRAAPEI-------------EEAESISLRRLLRIAPL-ALLGA-FVAGFLEGAFYSLLPLYGLR 217
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
85-165 |
1.36e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.01 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLSA-----TAWGCitAITPLFIYvgsahlvlMTFS 159
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAvlffiSALGS--AFSPNFTI--------FIIA 95
|
....*.
gi 637298370 160 RFFMGL 165
Cdd:cd17359 96 RIIGGL 101
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
90-180 |
3.30e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.59 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 90 FGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLLLS-ATAWGCITAITPLFIYVGS--AHLVLMTFSRFFMGLF 166
Cdd:TIGR00886 244 FGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNfLGVAMGAFLVVLGLVSDGSlaAFIVLFVALFFFAGAG 323
|
90
....*....|....
gi 637298370 167 QGVHFPALASLFSR 180
Cdd:TIGR00886 324 NGSTFALVPHIFRR 337
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
113-237 |
7.15e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 113 IIGGHLSDRIGGEKVLLLsatAWGCITAITPLFIYVGSaHLVLMTFSRFFMGLFQGVHFPALASLFSRKVRENERSFTYS 192
Cdd:cd17353 267 PFWGWLSDKIGRKNTLSI---AFLIQGVAMFLLPFIGS-VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYG 342
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90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 637298370 193 TVGTGSQFGTLVMGAAGSLLLDWYGWETVFYFSGLLTLLWVYCMC 237
Cdd:cd17353 343 LLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
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| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
85-383 |
7.64e-03 |
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Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 7.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 85 AMSAHFGWDKKQSGVVLSSFFWGYCVTQIIGGHLSDRIGGEKVLL--LSATAWGC-ITAITPLFIyvgsahlvLMTFSRF 161
Cdd:cd17504 21 TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLivLAIYTAGSlLAAFAPNLP--------VLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 162 FMGLFQGVhFPaLASLFSRKVRENERsfTYSTVGTGSqfGTLVMGAA-----GSLLLDWYGWETVFYFSGLLTLLWVycm 236
Cdd:cd17504 93 LQGIGGAV-FP-LAFALVREEFPPER--VPVAQGILS--ATFGIGAGiglplGGWIVQHLGWRWIFWTAAPVAVLLA--- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637298370 237 ckyllnekeIIIPLEDLvkglslskqtkvpwkQIFKKAPVWAVIVAQLCAASTFFTLLSWLPTFFTETFPdSKGWIFNVV 316
Cdd:cd17504 164 ---------ALVPLIDL---------------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTP-TGFGLGITE 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637298370 317 PWLVAIPTSL-------FSGFLSDqciNQGYKPITirkfmqIVGLGISSIFALGIGYTSSFCQAVVFASACIGF 383
Cdd:cd17504 219 AGLLLLPGALvmliagpLAGRLIA---RVGPRRVL------LIGLVISAVGLLLLALLHSSLWALVVALLLIGI 283
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